#list name	reference	description	total probes	expected	actual	enrichment	bin prob	analysis_name
histone deacetylase complex	GO:0000118	Complex that possesses histone deacetylase activity.	41	0.202699362238592	0	0	1	A07E.profile.ud50
mediator complex	GO:0000119	A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
histone acetyltransferase complex	GO:0000123	Complex that possesses histone acetyltransferase activity.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
Golgi membrane	GO:0000139	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.	188	0.929450734167202	2	2.1518085106383	0.238244761751888	A07E.profile.ud50
ubiquitin ligase complex	GO:0000151	A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex.	97	0.479557027735205	0	0	1	A07E.profile.ud50
nuclear ubiquitin ligase complex	GO:0000152	A ubiquitin ligase complex found in the nucleus.	30	0.148316606516043	0	0	1	A07E.profile.ud50
protein phosphatase type 2A complex	GO:0000159	A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits.	31	0.153260493399911	1	6.52483870967742	0.142419818323349	A07E.profile.ud50
exosome (RNase complex)	GO:0000178	Complex of 3'-5' exoribonucleases.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
nuclear chromosome	GO:0000228	A chromosome found in the nucleus of a eukaryotic cell.	127	0.627873634251248	2	3.18535433070866	0.130851851494473	A07E.profile.ud50
cell fraction	GO:0000267	A generic term for parts of cells prepared by disruptive biochemical techniques.	1358	6.71379838829288	9	1.34052282768778	0.234032325995262	A07E.profile.ud50
integral to membrane of membrane fraction	GO:0000299	Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
organellar ribosome	GO:0000313	A ribosome contained within a subcellular organelle.	43	0.212587136006328	0	0	1	A07E.profile.ud50
organellar small ribosomal subunit	GO:0000314	The smaller of the two subunits of an organellar ribosome.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
organellar large ribosomal subunit	GO:0000315	The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).	11	0.0543827557225491	0	0	1	A07E.profile.ud50
lytic vacuole	GO:0000323	A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.	228	1.12720620952193	1	0.887149122807018	0.676967330670223	A07E.profile.ud50
DNA-directed RNA polymerase complex	GO:0000428	A protein complex that possesses DNA-directed RNA polymerase activity.	41	0.202699362238592	0	0	1	A07E.profile.ud50
proteasome complex (sensu Eukaryota)	GO:0000502	A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and the regulatory particle that caps the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	66	0.326296534335294	0	0	1	A07E.profile.ud50
chromosome, pericentric region	GO:0000775	The central region of a chromosome that includes the centromere and associated proteins.	76	0.375735403173975	0	0	1	A07E.profile.ud50
kinetochore	GO:0000776	A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules.	39	0.192811588470856	0	0	1	A07E.profile.ud50
condensed chromosome kinetochore	GO:0000777	A multisubunit complex that is located at the pericentric region of a condensed chromosome and provides an attachment point for the spindle microtubules.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
condensed chromosome, pericentric region	GO:0000779	The central region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
chromosome, telomeric region	GO:0000781	The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.	34	0.168092154051515	0	0	1	A07E.profile.ud50
chromatin	GO:0000785	The ordered and organized complex of DNA and protein that forms the chromosome.	231	1.14203787017353	2	1.75125541125541	0.316457988622954	A07E.profile.ud50
nucleosome	GO:0000786	A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.	65	0.321352647451426	0	0	1	A07E.profile.ud50
nuclear chromatin	GO:0000790	The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus.	38	0.187867701586988	1	5.3228947368421	0.171661702549689	A07E.profile.ud50
heterochromatin	GO:0000792	A compact and highly condensed form of chromatin.	37	0.18292381470312	0	0	1	A07E.profile.ud50
condensed chromosome	GO:0000793	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.	77	0.380679290057844	1	2.62688311688312	0.31724788495548	A07E.profile.ud50
condensed nuclear chromosome	GO:0000794	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.	42	0.20764324912246	1	4.81595238095238	0.187921468257296	A07E.profile.ud50
synaptonemal complex	GO:0000795	A proteinaceous scaffold found between homologous chromosomes during meiosis.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
sex chromosome	GO:0000803	A chromosome involved in sex determination.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
spindle pole	GO:0000922	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.	35	0.173036040935383	0	0	1	A07E.profile.ud50
gamma-tubulin complex	GO:0000930	A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
voltage-gated sodium channel complex	GO:0001518	A sodium channel in a cell membrane whose opening is governed by the membrane potential.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
cornified envelope	GO:0001533	An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
acrosome	GO:0001669	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
stress fiber	GO:0001725	Bundle of microfilaments and other proteins found in fibroblasts.	30	0.148316606516043	0	0	1	A07E.profile.ud50
ruffle	GO:0001726	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.	55	0.271913778612745	1	3.67763636363636	0.238593697623715	A07E.profile.ud50
sex chromatin	GO:0001739	A condensed mass of compacted chromatin that represents an inactivated X chromosome.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
photoreceptor outer segment	GO:0001750	The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
immunological synapse	GO:0001772	An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.	25	0.123597172096702	0	0	1	A07E.profile.ud50
extracellular region	GO:0005576	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.	1426	7.04998269639591	3	0.425532959326788	0.971729584664657	A07E.profile.ud50
proteinaceous extracellular matrix	GO:0005578	A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.	401	1.98249864043111	2	1.00882793017456	0.589901095406838	A07E.profile.ud50
membrane attack complex	GO:0005579	A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
collagen	GO:0005581	Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures.	75	0.370791516290107	0	0	1	A07E.profile.ud50
fibrillar collagen	GO:0005583	Any collagen polymer in which collagen triple helices associate to form fibrils.	28	0.138428832748307	0	0	1	A07E.profile.ud50
collagen type IV	GO:0005587	A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
FACIT collagen	GO:0005593	Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
basement membrane	GO:0005604	A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.	119	0.588322539180304	1	1.69974789915966	0.445551664870421	A07E.profile.ud50
basal lamina	GO:0005605	A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.	55	0.271913778612745	0	0	1	A07E.profile.ud50
laminin-1 complex	GO:0005606	A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta1 and gamma1.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
extracellular space	GO:0005615	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	647	3.19869481386266	1	0.312627511591963	0.959507073093159	A07E.profile.ud50
intracellular	GO:0005622	The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.	10805	53.4186977801948	56	1.0483220731143	0.379728627803206	A07E.profile.ud50
cell	GO:0005623	The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	14576	72.0620952192614	73	1.01301523051592	0.471634882804654	A07E.profile.ud50
membrane fraction	GO:0005624	That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.	1046	5.17130568052603	9	1.74037284894837	0.0793476751499402	A07E.profile.ud50
soluble fraction	GO:0005625	That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water.	333	1.64631433232808	0	0	1	A07E.profile.ud50
insoluble fraction	GO:0005626	That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.	38	0.187867701586988	0	0	1	A07E.profile.ud50
nucleus	GO:0005634	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	5251	25.9603500271914	31	1.19412873738336	0.183871159868158	A07E.profile.ud50
nuclear envelope	GO:0005635	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	229	1.13215009640579	2	1.76655021834061	0.31284289992326	A07E.profile.ud50
nuclear inner membrane	GO:0005637	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
nuclear outer membrane	GO:0005640	The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.	8	0.0395510950709448	0	0	1	A07E.profile.ud50
nuclear pore	GO:0005643	Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.	114	0.563603104760963	1	1.77429824561404	0.431640369721972	A07E.profile.ud50
nucleoplasm	GO:0005654	That part of the nuclear content other than the chromosomes or the nucleolus.	608	3.0058832253918	2	0.665361842105263	0.80246764066657	A07E.profile.ud50
nucleolar ribonuclease P complex	GO:0005655	A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
replication fork	GO:0005657	The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.	42	0.20764324912246	0	0	1	A07E.profile.ud50
DNA replication factor A complex	GO:0005662	A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.	8	0.0395510950709448	0	0	1	A07E.profile.ud50
DNA replication factor C complex	GO:0005663	A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
DNA-directed RNA polymerase II, core complex	GO:0005665	RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.	30	0.148316606516043	0	0	1	A07E.profile.ud50
DNA-directed RNA polymerase III complex	GO:0005666	RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
transcription factor complex	GO:0005667	Any complex, distinct from RNA polymerase, including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences, and regulating transcription.	244	1.20630839966382	1	0.828975409836066	0.701593966272893	A07E.profile.ud50
transcription factor TFIID complex	GO:0005669	A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.	22	0.108765511445098	0	0	1	A07E.profile.ud50
holo TFIIH complex	GO:0005675	A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3, Tfb1, Tfb2, Ssl1, Tfb4), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of XPD, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB.	5	0.0247194344193405	0	0	1	A07E.profile.ud50
chromatin silencing complex	GO:0005677	Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
chromatin assembly complex	GO:0005678	Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
anaphase-promoting complex	GO:0005680	A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.	22	0.108765511445098	0	0	1	A07E.profile.ud50
spliceosome	GO:0005681	A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron.	192	0.949226281702675	0	0	1	A07E.profile.ud50
U2-dependent spliceosome	GO:0005684	The major (U2-dependent) spliceosome is composed of five snRNP complexes (U1, U2, U4, U5, and U6) as well as many non-snRNP proteins. It acts through many RNA-RNA, RNA-protein, and protein-protein interactions to precisely excise each intron and join the flanking exons.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
U12-dependent spliceosome	GO:0005689	The minor (U12-dependent) spliceosome is composed of the snRNPs, U11, U12, U4atac, U6atac, and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
chromosome	GO:0005694	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.	465	2.29890740099867	3	1.30496774193548	0.403867618499777	A07E.profile.ud50
nuclear heterochromatin	GO:0005720	A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	22	0.108765511445098	0	0	1	A07E.profile.ud50
nucleolus	GO:0005730	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	194	0.959114055470411	2	2.08525773195876	0.249166224326	A07E.profile.ud50
small nucleolar ribonucleoprotein complex	GO:0005732	A complex composed of RNA of the small nucleolar RNA (snoRNA) and protein, found in the nucleolus of a eukaryotic cell. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.	12	0.0593266426064172	1	16.8558333333333	0.0577397605421464	A07E.profile.ud50
cytoplasm	GO:0005737	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	5577	27.5720571513324	25	0.906715079792003	0.714165467907922	A07E.profile.ud50
mitochondrion	GO:0005739	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	984	4.86478469372621	7	1.43891260162602	0.217924038791225	A07E.profile.ud50
mitochondrial envelope	GO:0005740	The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.	339	1.67597765363128	3	1.79	0.236237348839899	A07E.profile.ud50
mitochondrial outer membrane	GO:0005741	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.	52	0.257082117961141	1	3.88980769230769	0.227188188948653	A07E.profile.ud50
mitochondrial inner membrane	GO:0005743	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.	253	1.25080338161863	2	1.59897233201581	0.355874103682851	A07E.profile.ud50
mitochondrial inner membrane presequence translocase complex	GO:0005744	The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
mitochondrial respiratory chain	GO:0005746	The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane.	62	0.306520986799822	0	0	1	A07E.profile.ud50
mitochondrial respiratory chain complex I	GO:0005747	A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.	39	0.192811588470856	0	0	1	A07E.profile.ud50
mitochondrial proton-transporting ATP synthase complex	GO:0005753	A proton-transporting ATP synthase complex found in the mitochondrial membrane.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
mitochondrial intermembrane space	GO:0005758	The region between the inner and outer lipid bilayers of the mitochondrial envelope.	20	0.098877737677362	0	0	1	A07E.profile.ud50
mitochondrial matrix	GO:0005759	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation.	112	0.553715330993227	1	1.80598214285714	0.42597860628403	A07E.profile.ud50
mitochondrial ribosome	GO:0005761	A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.	43	0.212587136006328	0	0	1	A07E.profile.ud50
mitochondrial large ribosomal subunit	GO:0005762	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).	11	0.0543827557225491	0	0	1	A07E.profile.ud50
mitochondrial small ribosomal subunit	GO:0005763	The smaller of the two subunits of a mitochondrial ribosome.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
lysosome	GO:0005764	Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.	228	1.12720620952193	1	0.887149122807018	0.676967330670223	A07E.profile.ud50
lysosomal membrane	GO:0005765	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.	28	0.138428832748307	0	0	1	A07E.profile.ud50
endosome	GO:0005768	A membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.	161	0.795965788302764	0	0	1	A07E.profile.ud50
early endosome	GO:0005769	Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered.	43	0.212587136006328	0	0	1	A07E.profile.ud50
late endosome	GO:0005770	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.	42	0.20764324912246	0	0	1	A07E.profile.ud50
vacuole	GO:0005773	A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.	253	1.25080338161863	1	0.799486166007905	0.714611972721612	A07E.profile.ud50
vacuolar membrane	GO:0005774	The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.	32	0.158204380283779	0	0	1	A07E.profile.ud50
autophagic vacuole	GO:0005776	A double-membrane bound vesicle in which endogenous cellular material is sequestered; known as autophagosome in yeast.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
peroxisome	GO:0005777	A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).	115	0.568546991644831	2	3.51773913043478	0.111311117476486	A07E.profile.ud50
peroxisomal membrane	GO:0005778	The lipid bilayer surrounding a peroxisome.	34	0.168092154051515	1	5.94911764705882	0.155076377218804	A07E.profile.ud50
integral to peroxisomal membrane	GO:0005779	Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.	18	0.0889899639096258	1	11.2372222222222	0.0853471364577099	A07E.profile.ud50
endoplasmic reticulum	GO:0005783	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).	922	4.55826370692639	5	1.09690889370933	0.479179130020881	A07E.profile.ud50
signal recognition particle, endoplasmic reticulum targeting	GO:0005786	A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
endoplasmic reticulum lumen	GO:0005788	The volume enclosed by the membranes of the endoplasmic reticulum.	29	0.143372719632175	0	0	1	A07E.profile.ud50
endoplasmic reticulum membrane	GO:0005789	The lipid bilayer surrounding the endoplasmic reticulum.	159	0.786078014535027	1	1.27213836477987	0.54525915021902	A07E.profile.ud50
smooth endoplasmic reticulum	GO:0005790	The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
rough endoplasmic reticulum	GO:0005791	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
microsome	GO:0005792	Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g.	217	1.07282345379938	4	3.72847926267281	0.0234462343901355	A07E.profile.ud50
ER-Golgi intermediate compartment	GO:0005793	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.	55	0.271913778612745	0	0	1	A07E.profile.ud50
Golgi apparatus	GO:0005794	A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.	514	2.5411578583082	4	1.57408560311284	0.251011229178887	A07E.profile.ud50
Golgi stack	GO:0005795	The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.	35	0.173036040935383	0	0	1	A07E.profile.ud50
Golgi-associated vesicle	GO:0005798	Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.	88	0.435062045780393	2	4.59704545454545	0.0707968002751463	A07E.profile.ud50
cis-Golgi network	GO:0005801	The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
trans-Golgi network	GO:0005802	The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.	42	0.20764324912246	0	0	1	A07E.profile.ud50
centrosome	GO:0005813	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.	109	0.538883670341623	0	0	1	A07E.profile.ud50
centriole	GO:0005814	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
microtubule organizing center	GO:0005815	A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.	127	0.627873634251248	0	0	1	A07E.profile.ud50
spindle	GO:0005819	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.	92	0.454837593315865	0	0	1	A07E.profile.ud50
cytosol	GO:0005829	That part of the cytoplasm that does not contain membranous or particulate subcellular components.	687	3.39645028921738	0	0	1	A07E.profile.ud50
cytosolic ribosome (sensu Eukaryota)	GO:0005830	A ribosome found in the cytosol; this term can also be used to refer to ribosomes associated with the endoplasmic reticulum in eukaryotic cells. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	127	0.627873634251248	0	0	1	A07E.profile.ud50
hemoglobin complex	GO:0005833	An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
heterotrimeric G-protein complex	GO:0005834	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.	40	0.197755475354724	0	0	1	A07E.profile.ud50
proteasome regulatory particle (sensu Eukaryota)	GO:0005838	A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	12	0.0593266426064172	0	0	1	A07E.profile.ud50
proteasome core complex (sensu Eukaryota)	GO:0005839	A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. This complex is involved in the proteolysis of substrates in an ATP dependent manner and consists of four ring-like structures, two outer and two inner, each containing seven subunits. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	27	0.133484945864439	0	0	1	A07E.profile.ud50
ribosome	GO:0005840	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.	252	1.24585949473476	0	0	1	A07E.profile.ud50
cytosolic large ribosomal subunit (sensu Eukaryota)	GO:0005842	The large subunit of a ribosome; has a sedimentation coefficient of 60S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	72	0.355959855638503	0	0	1	A07E.profile.ud50
cytosolic small ribosomal subunit (sensu Eukaryota)	GO:0005843	The small subunit of a eukaryotic cytosolic ribosome; has a sedimentation coefficient of 40S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	50	0.247194344193405	0	0	1	A07E.profile.ud50
polysome	GO:0005844	Several ribosomes bound to one mRNA.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
eukaryotic translation initiation factor 2B complex	GO:0005851	A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
eukaryotic translation initiation factor 3 complex	GO:0005852	A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex.	1	0.0049438868838681	0	0	1	A07E.profile.ud50
eukaryotic translation elongation factor 1 complex	GO:0005853	A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
cytoskeleton	GO:0005856	Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.	1286	6.35783853265437	8	1.25828926905132	0.306347855043004	A07E.profile.ud50
axonemal dynein complex	GO:0005858	A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
muscle myosin complex	GO:0005859	A filament of myosin found in a muscle cell of any type.	30	0.148316606516043	1	6.74233333333333	0.13815897377783	A07E.profile.ud50
troponin complex	GO:0005861	A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
striated muscle thick filament	GO:0005863	Filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.	20	0.098877737677362	0	0	1	A07E.profile.ud50
striated muscle thin filament	GO:0005865	Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
cytoplasmic dynein complex	GO:0005868	Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains.	8	0.0395510950709448	1	25.28375	0.038873443886416	A07E.profile.ud50
dynactin complex	GO:0005869	A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
kinesin complex	GO:0005871	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.	21	0.10382162456123	0	0	1	A07E.profile.ud50
microtubule	GO:0005874	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.	260	1.28541058980571	2	1.55592307692308	0.368250484189562	A07E.profile.ud50
microtubule associated complex	GO:0005875	Any multimeric complex connected to a microtubule.	142	0.70203193750927	2	2.84887323943662	0.156253379773236	A07E.profile.ud50
spindle microtubule	GO:0005876	Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.	33	0.163148267167647	0	0	1	A07E.profile.ud50
cytoplasmic microtubule	GO:0005881	Any microtubule in the cytoplasm of a cell.	20	0.098877737677362	0	0	1	A07E.profile.ud50
intermediate filament	GO:0005882	A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells.	93	0.459781480199733	0	0	1	A07E.profile.ud50
neurofilament	GO:0005883	A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.	10	0.049438868838681	0	0	1	A07E.profile.ud50
actin filament	GO:0005884	A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.	39	0.192811588470856	0	0	1	A07E.profile.ud50
Arp2/3 protein complex	GO:0005885	A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
plasma membrane	GO:0005886	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	2876	14.2186186780046	11	0.773633518776078	0.839010182495061	A07E.profile.ud50
integral to plasma membrane	GO:0005887	Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.	1846	9.12641518762051	8	0.876576381365114	0.691298722615146	A07E.profile.ud50
sodium:potassium-exchanging ATPase complex	GO:0005890	Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.	10	0.049438868838681	0	0	1	A07E.profile.ud50
voltage-gated calcium channel complex	GO:0005891	A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.	33	0.163148267167647	0	0	1	A07E.profile.ud50
nicotinic acetylcholine-gated receptor-channel complex	GO:0005892	A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
caveola	GO:0005901	A small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm.	18	0.0889899639096258	0	0	1	A07E.profile.ud50
microvillus	GO:0005902	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
brush border	GO:0005903	Dense covering of microvilli on the apical surface of epithelial cells in the intestine and kidney; the microvilli aid absorption by increasing the surface area of the cell.	20	0.098877737677362	0	0	1	A07E.profile.ud50
coated pit	GO:0005905	An invagination of the cell membrane of many eukaryotic cells, concerned in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane. During endocytosis it is converted into a coated vesicle. The coat is of clathrin.	93	0.459781480199733	2	4.34989247311828	0.0778721240499321	A07E.profile.ud50
intercellular junction	GO:0005911	A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals.	174	0.860236317793049	1	1.16247126436782	0.5778395432903	A07E.profile.ud50
adherens junction	GO:0005912	A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.	77	0.380679290057844	1	2.62688311688312	0.31724788495548	A07E.profile.ud50
cell-cell adherens junction	GO:0005913	An adherens junction which connects two cells to each other.	34	0.168092154051515	0	0	1	A07E.profile.ud50
gap junction	GO:0005921	Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
connexon complex	GO:0005922	An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
tight junction	GO:0005923	A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.	56	0.276857665496613	0	0	1	A07E.profile.ud50
cell-substrate adherens junction	GO:0005924	An adherens junction which connects a cell to the extracellular matrix.	41	0.202699362238592	1	4.93341463414634	0.183886696399877	A07E.profile.ud50
focal adhesion	GO:0005925	Small region on the surface of a cell that anchors the cell to the extracellular matrix and that are points of termination of actin filaments.	37	0.18292381470312	1	5.46675675675676	0.167546144853806	A07E.profile.ud50
cilium	GO:0005929	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.	41	0.202699362238592	0	0	1	A07E.profile.ud50
axoneme	GO:0005930	The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.	21	0.10382162456123	0	0	1	A07E.profile.ud50
cell cortex	GO:0005938	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.	96	0.474613140851337	1	2.10697916666667	0.378606187185736	A07E.profile.ud50
unlocalized protein complex	GO:0005941	Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products.	32	0.158204380283779	0	0	1	A07E.profile.ud50
phosphoinositide 3-kinase complex	GO:0005942	A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).	21	0.10382162456123	0	0	1	A07E.profile.ud50
cAMP-dependent protein kinase complex	GO:0005952	An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
glycine cleavage complex	GO:0005960	A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.	2	0.00988777376773619	0	0	1	A07E.profile.ud50
synaptic vesicle	GO:0008021	Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.	62	0.306520986799822	0	0	1	A07E.profile.ud50
transcription elongation factor complex	GO:0008023	Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.	10	0.049438868838681	0	0	1	A07E.profile.ud50
voltage-gated potassium channel complex	GO:0008076	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.	89	0.440005932664261	0	0	1	A07E.profile.ud50
spectrin	GO:0008091	Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.	20	0.098877737677362	1	10.1135	0.0943686610871122	A07E.profile.ud50
signalosome	GO:0008180	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
oligosaccharyl transferase complex	GO:0008250	A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
protein serine/threonine phosphatase complex	GO:0008287	A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.	54	0.266969891728877	1	3.74574074074074	0.234810688221538	A07E.profile.ud50
F-actin capping protein complex	GO:0008290	A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
integrin complex	GO:0008305	Any member of a family of heterodimeric transmembrane receptors for cell-adhesion molecules. The alpha and beta subunits are noncovalently bonded.	52	0.257082117961141	2	7.77961538461538	0.0275249794555863	A07E.profile.ud50
microtubule-based flagellum	GO:0009434	A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
external side of plasma membrane	GO:0009897	The side of the plasma membrane that is opposite to the side that faces the cytoplasm.	96	0.474613140851337	2	4.21395833333333	0.0822192143126371	A07E.profile.ud50
basal plasma membrane	GO:0009925	Part of the plasma membrane at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.	18	0.0889899639096258	1	11.2372222222222	0.0853471364577099	A07E.profile.ud50
cell surface	GO:0009986	The external part of the cell wall and/or plasma membrane.	232	1.1469817570574	2	1.74370689655172	0.31826387582967	A07E.profile.ud50
endosome membrane	GO:0010008	The lipid bilayer surrounding an endosome.	10	0.049438868838681	0	0	1	A07E.profile.ud50
endomembrane system	GO:0012505	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.	657	3.24813368270134	5	1.53934550989345	0.227673724366399	A07E.profile.ud50
vesicle membrane	GO:0012506	The lipid bilayer surrounding any membrane-bounded vesicle in the cell.	146	0.721807485044742	2	2.77082191780822	0.163176723439465	A07E.profile.ud50
ER to Golgi transport vesicle membrane	GO:0012507	The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
trans-Golgi network transport vesicle membrane	GO:0012510	The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.	32	0.158204380283779	1	6.3209375	0.146659597735406	A07E.profile.ud50
actin cytoskeleton	GO:0015629	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.	393	1.94294754536016	3	1.54404580152672	0.307846558649974	A07E.profile.ud50
microtubule cytoskeleton	GO:0015630	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.	443	2.19014188955357	2	0.913182844243792	0.643743073233127	A07E.profile.ud50
large ribosomal subunit	GO:0015934	The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).	92	0.454837593315865	0	0	1	A07E.profile.ud50
small ribosomal subunit	GO:0015935	The smaller of the two subunits of a ribosome.	71	0.351015968754635	0	0	1	A07E.profile.ud50
dystrophin-associated glycoprotein complex	GO:0016010	A multiprotein complex that forms the critical link between the cytoskeleton and extracellular matrix; typical of, but not confined, to muscle cells. The constituents of the complex are somewhat tissue specific. The rod-like dystrophin forms a link between the actin cytoskeleton and the plasma membrane; links between dystrophin and the extracellular matrix are provided by the sarcoglycan complex.	27	0.133484945864439	0	0	1	A07E.profile.ud50
dystroglycan complex	GO:0016011	Includes alpha- and beta-dystroglycan; alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
sarcoglycan complex	GO:0016012	Formed of five N-glycosylated sarcoglycans: alpha-, beta-, gamma-, delta-, and epsilon sarcoglycan, single-pass transmembrane proteins that form a complex which is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.	8	0.0395510950709448	0	0	1	A07E.profile.ud50
membrane	GO:0016020	Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.	6445	31.8633509665299	34	1.06705663304887	0.375471166833522	A07E.profile.ud50
integral to membrane	GO:0016021	Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.	4626	22.8704207247738	24	1.04939040207523	0.434084467647087	A07E.profile.ud50
cytoplasmic membrane-bound vesicle	GO:0016023	A membrane-bound vesicle found in the cytoplasm of the cell.	331	1.63642655856034	3	1.83326283987915	0.225860725865751	A07E.profile.ud50
prefoldin complex	GO:0016272	A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
eukaryotic translation initiation factor 4F complex	GO:0016281	The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.	20	0.098877737677362	0	0	1	A07E.profile.ud50
eukaryotic 43S preinitiation complex	GO:0016282	The 43S preinitiation complex is the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound to the initiator tRNA.	57	0.281801552380482	0	0	1	A07E.profile.ud50
eukaryotic 48S initiation complex	GO:0016283	The 48S initiation complex is composed of the 40S ribosomal subunit, the initiator tRNA, and the mRNA.	50	0.247194344193405	0	0	1	A07E.profile.ud50
basolateral plasma membrane	GO:0016323	Part of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.	106	0.524052009690018	2	3.81641509433962	0.097216194684569	A07E.profile.ud50
apical plasma membrane	GO:0016324	Part of the plasma membrane at the apical end of the cell.	47	0.232362683541801	0	0	1	A07E.profile.ud50
apicolateral plasma membrane	GO:0016327	The apical end of the lateral plasma membrane of epithelial cells.	70	0.346072081870767	0	0	1	A07E.profile.ud50
lateral plasma membrane	GO:0016328	The membranes on the sides of epithelial cells which lie at the interface of adjacent cells.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
nuclear matrix	GO:0016363	The dense fibrillar network lying on the inner side of the nuclear membrane.	23	0.113709398328966	0	0	1	A07E.profile.ud50
myosin complex	GO:0016459	A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.	82	0.405398724477184	1	2.46670731707317	0.333959075686894	A07E.profile.ud50
myosin II complex	GO:0016460	A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.	30	0.148316606516043	1	6.74233333333333	0.13815897377783	A07E.profile.ud50
unconventional myosin complex	GO:0016461	A portmanteau term for myosins other than myosin II.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
proton-transporting two-sector ATPase complex	GO:0016469	A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.	60	0.296633213032086	2	6.74233333333333	0.0358051075326368	A07E.profile.ud50
SWI/SNF complex	GO:0016514	Any of a family of protein complexes that regulate transcription by remodeling chromatin. Swi/Snf complexes comprise nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
sarcoplasm	GO:0016528	The cytoplasm of a muscle fiber; includes the sarcoplasmic reticulum.	25	0.123597172096702	0	0	1	A07E.profile.ud50
sarcoplasmic reticulum	GO:0016529	A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle fiber; continuous over large portions of the cell and with the nuclear envelope; an endoplasmic reticulum specialized for the sequestration of calcium ions.	21	0.10382162456123	0	0	1	A07E.profile.ud50
NuRD complex	GO:0016581	An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
chromatin remodeling complex	GO:0016585	Any complex that mediates dynamic changes in eukaryotic chromatin.	61	0.301577099915954	0	0	1	A07E.profile.ud50
DNA-directed RNA polymerase II, holoenzyme	GO:0016591	Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA.	98	0.484500914619074	0	0	1	A07E.profile.ud50
caveolar membrane	GO:0016599	The membrane area of caveolae, the small pits, depressions, or invaginations found in the plasma membrane of cells. Caveolar membrane is characterized by the presence of caveolins, which constitute the major protein component of caveolar membrane in vivo.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
nuclear body	GO:0016604	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.	86	0.425174272012656	0	0	1	A07E.profile.ud50
PML body	GO:0016605	A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.	38	0.187867701586988	0	0	1	A07E.profile.ud50
nuclear speck	GO:0016607	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.	18	0.0889899639096258	0	0	1	A07E.profile.ud50
transcriptional repressor complex	GO:0017053	A protein complex that possesses activity that prevents or downregulates transcription.	10	0.049438868838681	0	0	1	A07E.profile.ud50
virion	GO:0019012	The complete fully infectious extracellular virus particle.	2	0.00988777376773619	0	0	1	A07E.profile.ud50
viral capsid	GO:0019028	The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.	2	0.00988777376773619	0	0	1	A07E.profile.ud50
synaptosome	GO:0019717	Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma.	49	0.242250457309537	1	4.12795918367347	0.215611831112334	A07E.profile.ud50
flagellum	GO:0019861	Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium.	20	0.098877737677362	0	0	1	A07E.profile.ud50
organelle inner membrane	GO:0019866	The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.	266	1.31507391110891	2	1.52082706766917	0.378783418183616	A07E.profile.ud50
outer membrane	GO:0019867	The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.	118	0.583378652296435	2	3.42830508474576	0.116121485187878	A07E.profile.ud50
extrinsic to plasma membrane	GO:0019897	Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region.	50	0.247194344193405	0	0	1	A07E.profile.ud50
extrinsic to membrane	GO:0019898	Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.	67	0.331240421219163	0	0	1	A07E.profile.ud50
myofibril	GO:0030016	The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.	94	0.464725367083601	1	2.1518085106383	0.372416119168002	A07E.profile.ud50
sarcomere	GO:0030017	The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.	71	0.351015968754635	1	2.84887323943662	0.296640072911705	A07E.profile.ud50
Z disc	GO:0030018	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.	33	0.163148267167647	1	6.12939393939394	0.150878416157636	A07E.profile.ud50
lamellipodium	GO:0030027	A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.	55	0.271913778612745	0	0	1	A07E.profile.ud50
cell junction	GO:0030054	A specialized region of connection between two cells or between a cell and the extracellular matrix.	216	1.06787956691551	2	1.87287037037037	0.28925519206512	A07E.profile.ud50
cell-matrix junction	GO:0030055	A specialized region of connection between a cell and the extracellular matrix.	50	0.247194344193405	2	8.0908	0.0255934384911091	A07E.profile.ud50
desmosome	GO:0030057	Button-like point of intercellular contact through which the intermediate filaments of adjacent cells are connected indirectly.	10	0.049438868838681	0	0	1	A07E.profile.ud50
membrane coat	GO:0030117	Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.	91	0.449893706431997	2	4.4454945054945	0.0750159223634117	A07E.profile.ud50
clathrin coat	GO:0030118	A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.	60	0.296633213032086	1	3.37116666666667	0.257230045520317	A07E.profile.ud50
membrane coat adaptor complex	GO:0030119	Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles.	25	0.123597172096702	0	0	1	A07E.profile.ud50
vesicle coat	GO:0030120	A membrane coat found on a coated vesicle.	88	0.435062045780393	2	4.59704545454545	0.0707968002751463	A07E.profile.ud50
AP-1 adaptor complex	GO:0030121	A membrane coat adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network.	8	0.0395510950709448	0	0	1	A07E.profile.ud50
clathrin vesicle coat	GO:0030125	A clathrin coat found on a vesicle.	60	0.296633213032086	1	3.37116666666667	0.257230045520317	A07E.profile.ud50
COPI vesicle coat	GO:0030126	One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.	14	0.0692144163741534	1	14.4478571428571	0.0670335858789568	A07E.profile.ud50
COPII vesicle coat	GO:0030127	One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
clathrin coat of trans-Golgi network vesicle	GO:0030130	A clathrin coat found on a vesicle of the trans-Golgi network.	31	0.153260493399911	1	6.52483870967742	0.142419818323349	A07E.profile.ud50
clathrin adaptor complex	GO:0030131	A membrane coat adaptor complex that links clathrin to a membrane.	21	0.10382162456123	0	0	1	A07E.profile.ud50
clathrin coat of coated pit	GO:0030132	The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
transport vesicle	GO:0030133	Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, and to destinations within or outside the cell.	90	0.444949819548129	1	2.24744444444444	0.359850380184236	A07E.profile.ud50
ER to Golgi transport vesicle	GO:0030134	A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
coated vesicle	GO:0030135	Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.	184	0.90967518663173	2	2.19858695652174	0.230976841091975	A07E.profile.ud50
clathrin-coated vesicle	GO:0030136	A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.	144	0.711919711277006	1	1.40465277777778	0.510164352977931	A07E.profile.ud50
COPI-coated vesicle	GO:0030137	A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.	16	0.0791021901418896	1	12.641875	0.0762357431332417	A07E.profile.ud50
endocytic vesicle	GO:0030139	A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.	43	0.212587136006328	0	0	1	A07E.profile.ud50
trans-Golgi network transport vesicle	GO:0030140	A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.	43	0.212587136006328	1	4.70395348837209	0.19193629265905	A07E.profile.ud50
secretory granule	GO:0030141	A small subcellular vesicle, surrounded by a single-layered membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.	50	0.247194344193405	0	0	1	A07E.profile.ud50
integral to Golgi membrane	GO:0030173	Penetrating at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.	48	0.237306570425669	0	0	1	A07E.profile.ud50
filopodium	GO:0030175	Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
integral to endoplasmic reticulum membrane	GO:0030176	Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.	55	0.271913778612745	0	0	1	A07E.profile.ud50
dynein complex	GO:0030286	Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.	35	0.173036040935383	1	5.77914285714286	0.159253584035342	A07E.profile.ud50
axon	GO:0030424	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.	66	0.326296534335294	0	0	1	A07E.profile.ud50
dendrite	GO:0030425	A branching protoplasmic process of a neuron that receive and integrate signals coming from axons of other neurons, and convey the resulting signal to the body of the cell.	54	0.266969891728877	0	0	1	A07E.profile.ud50
growth cone	GO:0030426	The migrating motile tip of a growing nerve cell axon or dendrite.	31	0.153260493399911	0	0	1	A07E.profile.ud50
site of polarized growth	GO:0030427	Any part of a cell where non-isotropic growth takes place.	34	0.168092154051515	0	0	1	A07E.profile.ud50
midbody	GO:0030496	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
ribonucleoprotein complex	GO:0030529	A macromolecular complex containing both protein and RNA molecules.	574	2.83779107134029	1	0.352386759581881	0.941855799409584	A07E.profile.ud50
heterogeneous nuclear ribonucleoprotein complex	GO:0030530	Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA.	26	0.128541058980571	0	0	1	A07E.profile.ud50
small nuclear ribonucleoprotein complex	GO:0030532	A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.	37	0.18292381470312	0	0	1	A07E.profile.ud50
transport vesicle membrane	GO:0030658	The lipid bilayer surrounding a transport vesicle.	47	0.232362683541801	1	4.3036170212766	0.207798080769809	A07E.profile.ud50
cytoplasmic vesicle membrane	GO:0030659	The lipid bilayer surrounding a cytoplasmic vesicle.	124	0.613041973599644	2	3.26241935483871	0.125894390117096	A07E.profile.ud50
Golgi-associated vesicle membrane	GO:0030660	The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.	49	0.242250457309537	1	4.12795918367347	0.215611831112334	A07E.profile.ud50
coated vesicle membrane	GO:0030662	The lipid bilayer surrounding a coated vesicle.	95	0.469669253967469	2	4.25831578947368	0.0807619697726046	A07E.profile.ud50
COPI coated vesicle membrane	GO:0030663	The lipid bilayer surrounding a COPI-coated vesicle.	14	0.0692144163741534	1	14.4478571428571	0.0670335858789568	A07E.profile.ud50
clathrin coated vesicle membrane	GO:0030665	The lipid bilayer surrounding a clathrin-coated vesicle.	61	0.301577099915954	1	3.31590163934426	0.260902216156001	A07E.profile.ud50
endocytic vesicle membrane	GO:0030666	The lipid bilayer surrounding an endocytic vesicle.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
secretory granule membrane	GO:0030667	The lipid bilayer surrounding a secretory granule.	24	0.118653285212834	0	0	1	A07E.profile.ud50
synaptic vesicle membrane	GO:0030672	The lipid bilayer surrounding a synaptic vesicle.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
ribonuclease P complex	GO:0030677	A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
multimeric ribonuclease P complex	GO:0030681	A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
cortical cytoskeleton	GO:0030863	The portion of the cytoskeleton that lies just beneath the plasma membrane.	41	0.202699362238592	1	4.93341463414634	0.183886696399877	A07E.profile.ud50
cortical actin cytoskeleton	GO:0030864	The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.	31	0.153260493399911	1	6.52483870967742	0.142419818323349	A07E.profile.ud50
RNA polymerase complex	GO:0030880	Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.	42	0.20764324912246	0	0	1	A07E.profile.ud50
replisome	GO:0030894	A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
anchoring collagen	GO:0030934	Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures.	18	0.0889899639096258	0	0	1	A07E.profile.ud50
sheet-forming collagen	GO:0030935	Any collagen polymer in which collagen triple helices associate to form sheet-like networks.	18	0.0889899639096258	0	0	1	A07E.profile.ud50
NADH dehydrogenase complex (quinone)	GO:0030964	Complex that possesses NADH dehydrogenase (quinone) activity.	39	0.192811588470856	0	0	1	A07E.profile.ud50
extracellular matrix	GO:0031012	A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).	406	2.00721807485045	2	0.996403940886699	0.596617488159925	A07E.profile.ud50
organelle membrane	GO:0031090	The lipid bilayer surrounding an organelle.	934	4.6175903495328	7	1.51594218415418	0.183847550559378	A07E.profile.ud50
intrinsic to membrane	GO:0031224	Located in a membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	4637	22.9248034804964	24	1.04690101358637	0.438602070595787	A07E.profile.ud50
anchored to membrane	GO:0031225	Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
intrinsic to plasma membrane	GO:0031226	Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	1855	9.17091016957532	8	0.872323450134771	0.696341863504271	A07E.profile.ud50
intrinsic to endoplasmic reticulum membrane	GO:0031227	Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	58	0.28674543926435	0	0	1	A07E.profile.ud50
intrinsic to Golgi membrane	GO:0031228	Located in the Golgi membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	56	0.276857665496613	0	0	1	A07E.profile.ud50
intrinsic to peroxisomal membrane	GO:0031231	Located in the peroxisomal membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	18	0.0889899639096258	1	11.2372222222222	0.0853471364577099	A07E.profile.ud50
leading edge	GO:0031252	The area of a motile cell closest to the direction of movement.	105	0.51910812280615	1	1.92638095238095	0.40571458228544	A07E.profile.ud50
intrinsic to organelle membrane	GO:0031300	Located in an organelle membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane.	150	0.741583032580215	1	1.34846666666667	0.524516096029259	A07E.profile.ud50
integral to organelle membrane	GO:0031301	Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.	136	0.672368616206061	1	1.48727941176471	0.490352603508563	A07E.profile.ud50
cytoplasmic vesicle	GO:0031410	A vesicle formed of membrane or protein, found in the cytoplasm of a cell.	344	1.70069708805063	3	1.76398255813953	0.242764124841886	A07E.profile.ud50
nonmotile primary cilium	GO:0031513	An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
PcG protein complex	GO:0031519	A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.	18	0.0889899639096258	0	0	1	A07E.profile.ud50
neuromuscular junction	GO:0031594	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
A band	GO:0031672	The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.	20	0.098877737677362	0	0	1	A07E.profile.ud50
microbody membrane	GO:0031903	The lipid bilayer surrounding a microbody.	34	0.168092154051515	1	5.94911764705882	0.155076377218804	A07E.profile.ud50
filamentous actin	GO:0031941	A two-stranded helical polymer of the protein actin.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
nuclear membrane	GO:0031965	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.	147	0.72675137192861	1	1.37598639455782	0.51739357054626	A07E.profile.ud50
mitochondrial membrane	GO:0031966	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.	308	1.52271716023137	3	1.97016233766234	0.196576756938477	A07E.profile.ud50
organelle envelope	GO:0031967	A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.	560	2.76857665496613	5	1.80598214285714	0.146993756987875	A07E.profile.ud50
organelle outer membrane	GO:0031968	The outer, i.e. cytoplasm-facing, lipid bilayer of an organelle envelope.	60	0.296633213032086	1	3.37116666666667	0.257230045520317	A07E.profile.ud50
organelle envelope lumen	GO:0031970	The region between the inner and outer lipid bilayers of an organelle envelope.	27	0.133484945864439	1	7.49148148148148	0.125249000127201	A07E.profile.ud50
membrane-enclosed lumen	GO:0031974	The enclosed volume within a sealed membrane or between two sealed membranes.	945	4.67197310525535	6	1.28425396825397	0.326552516056719	A07E.profile.ud50
envelope	GO:0031975	A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers.	562	2.77846442873387	5	1.79955516014235	0.148517734637942	A07E.profile.ud50
mitochondrial lumen	GO:0031980	The volume enclosed by the mitochondrial inner membrane.	112	0.553715330993227	1	1.80598214285714	0.42597860628403	A07E.profile.ud50
nuclear lumen	GO:0031981	The volume enclosed by the nuclear inner membrane.	771	3.8117367874623	4	1.04939040207523	0.529323961777586	A07E.profile.ud50
vesicle	GO:0031982	Any small, fluid-filled, spherical organelle enclosed by membrane or protein.	357	1.76496761754091	3	1.69974789915966	0.259861109208894	A07E.profile.ud50
organelle subcompartment	GO:0031984	A membrane-enclosed compartment that is a part of an organelle.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
Golgi cisterna	GO:0031985	Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
membrane-bound vesicle	GO:0031988	Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.	343	1.69575320116676	3	1.76912536443149	0.241456395391901	A07E.profile.ud50
integrator complex	GO:0032039	A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
cell division site	GO:0032153	The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
cell division site part	GO:0032155	Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
actin filament bundle	GO:0032432	An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.	30	0.148316606516043	0	0	1	A07E.profile.ud50
myosin filament	GO:0032982	A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.	20	0.098877737677362	0	0	1	A07E.profile.ud50
macromolecular complex	GO:0032991	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.	2816	13.9219854649726	14	1.00560369318182	0.527504755338775	A07E.profile.ud50
proton-transporting two-sector ATPase complex, proton-transporting domain	GO:0033177	A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.	17	0.0840460770257577	2	23.7964705882353	0.00316396724028689	A07E.profile.ud50
proton-transporting two-sector ATPase complex, catalytic domain	GO:0033178	A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
ribosomal subunit	GO:0033279	Either of the two ribonucleoprotein complexes that associate to form a ribosome.	161	0.795965788302764	0	0	1	A07E.profile.ud50
histone methyltransferase complex	GO:0035097	A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
ciliary rootlet	GO:0035253	A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
NuA4 histone acetyltransferase complex	GO:0035267	A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).	13	0.0642705294902853	0	0	1	A07E.profile.ud50
T cell receptor complex	GO:0042101	A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
nuclear envelope-endoplasmic reticulum network	GO:0042175	The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.	170	0.840460770257577	1	1.18982352941176	0.569386875415451	A07E.profile.ud50
sarcolemma	GO:0042383	The outer membrane of a muscle fiber, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.	9	0.0444949819548129	0	0	1	A07E.profile.ud50
melanosome	GO:0042470	A tissue-specific, membrane bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
microbody	GO:0042579	Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).	115	0.568546991644831	2	3.51773913043478	0.111311117476486	A07E.profile.ud50
zymogen granule	GO:0042588	A membrane-bound, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.	15	0.0741583032580215	0	0	1	A07E.profile.ud50
vesicular fraction	GO:0042598	Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.	222	1.09754288821872	4	3.6445045045045	0.0252144492520873	A07E.profile.ud50
MHC protein complex	GO:0042611	A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.	84	0.41528649824492	0	0	1	A07E.profile.ud50
MHC class I protein complex	GO:0042612	A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.	58	0.28674543926435	0	0	1	A07E.profile.ud50
MHC class II protein complex	GO:0042613	A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.	26	0.128541058980571	0	0	1	A07E.profile.ud50
chylomicron	GO:0042627	A particle composed of a central core of triglycerides surrounded by a protein-phospholipid coating. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
mitochondrial intermembrane space protein transporter complex	GO:0042719	Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
presynaptic membrane	GO:0042734	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
GPI-anchor transamidase complex	GO:0042765	An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.	6	0.0296633213032086	0	0	1	A07E.profile.ud50
cell projection	GO:0042995	A prolongation or process extending from a cell, e.g. a flagellum or axon.	323	1.5968754634894	1	0.626222910216718	0.798272178410332	A07E.profile.ud50
neuron projection	GO:0043005	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.	127	0.627873634251248	0	0	1	A07E.profile.ud50
cell soma	GO:0043025	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.	51	0.252138231077273	0	0	1	A07E.profile.ud50
H4/H2A histone acetyltransferase complex	GO:0043189	A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.	14	0.0692144163741534	0	0	1	A07E.profile.ud50
ATP-binding cassette (ABC) transporter complex	GO:0043190	A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
dendritic spine	GO:0043197	Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
fibril	GO:0043205	Extracellular matrix material consisting of polysaccharides and protein.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
organelle	GO:0043226	Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.	8844	43.7237356009295	51	1.1664145183175	0.152220295509113	A07E.profile.ud50
membrane-bound organelle	GO:0043227	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	7809	38.606812676126	47	1.21740171596875	0.103929674919704	A07E.profile.ud50
non-membrane-bound organelle	GO:0043228	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.	2107	10.4167696643101	13	1.24798766018035	0.24909468412976	A07E.profile.ud50
intracellular organelle	GO:0043229	Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.	8838	43.6940722796262	51	1.16720638153428	0.151135859552499	A07E.profile.ud50
intracellular membrane-bound organelle	GO:0043231	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	7804	38.5820932417066	47	1.21818170169144	0.103187000386627	A07E.profile.ud50
intracellular non-membrane-bound organelle	GO:0043232	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.	2107	10.4167696643101	13	1.24798766018035	0.24909468412976	A07E.profile.ud50
organelle lumen	GO:0043233	The volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear membrane lumen.	945	4.67197310525535	6	1.28425396825397	0.326552516056719	A07E.profile.ud50
protein complex	GO:0043234	Any protein group composed of two or more subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.	2341	11.5736391951352	13	1.12324220418625	0.375277521047647	A07E.profile.ud50
receptor complex	GO:0043235	Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	118	0.583378652296435	2	3.42830508474576	0.116121485187878	A07E.profile.ud50
laminin complex	GO:0043256	A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.	19	0.0939338507934939	0	0	1	A07E.profile.ud50
contractile fiber	GO:0043292	Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.	106	0.524052009690018	2	3.81641509433962	0.097216194684569	A07E.profile.ud50
apical junction complex	GO:0043296	A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.	70	0.346072081870767	0	0	1	A07E.profile.ud50
nuclear replication fork	GO:0043596	The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
nuclear replisome	GO:0043601	A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.	13	0.0642705294902853	0	0	1	A07E.profile.ud50
extracellular matrix part	GO:0044420	Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).	187	0.924506847283334	1	1.0816577540107	0.604181591079594	A07E.profile.ud50
extracellular region part	GO:0044421	Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.	983	4.85984080684234	2	0.411536113936928	0.95493544496529	A07E.profile.ud50
organelle part	GO:0044422	Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.	3305	16.3395461511841	19	1.16282299546142	0.286047365754305	A07E.profile.ud50
virion part	GO:0044423	Any constituent part of a virion, a complete fully infectious extracellular virus particle.	2	0.00988777376773619	0	0	1	A07E.profile.ud50
intracellular part	GO:0044424	Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.	10196	50.4078706679191	54	1.07126127893291	0.324415734917199	A07E.profile.ud50
membrane part	GO:0044425	Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.	5232	25.8664161763979	30	1.15980504587156	0.23197293151726	A07E.profile.ud50
chromosomal part	GO:0044427	Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.	389	1.92317199782469	2	1.03994858611825	0.573442852059391	A07E.profile.ud50
nuclear part	GO:0044428	Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.	1318	6.51604291293815	8	1.22773899848255	0.329413547189202	A07E.profile.ud50
mitochondrial part	GO:0044429	Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	435	2.15059079448262	3	1.39496551724138	0.36411001766948	A07E.profile.ud50
cytoskeletal part	GO:0044430	Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.	720	3.55959855638503	4	1.12372222222222	0.476467923404345	A07E.profile.ud50
Golgi apparatus part	GO:0044431	Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.	268	1.32496168487665	3	2.26421641791045	0.148282601865523	A07E.profile.ud50
endoplasmic reticulum part	GO:0044432	Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.	182	0.899787412863994	1	1.11137362637363	0.594250374115268	A07E.profile.ud50
cytoplasmic vesicle part	GO:0044433	Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.	132	0.652593068670589	2	3.06469696969697	0.13921102412912	A07E.profile.ud50
vacuolar part	GO:0044437	Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.	36	0.177979927819252	0	0	1	A07E.profile.ud50
microbody part	GO:0044438	Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).	36	0.177979927819252	1	5.61861111111111	0.163410139213889	A07E.profile.ud50
peroxisomal part	GO:0044439	Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).	36	0.177979927819252	1	5.61861111111111	0.163410139213889	A07E.profile.ud50
endosomal part	GO:0044440	Any constituent part of an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.	10	0.049438868838681	0	0	1	A07E.profile.ud50
cilium part	GO:0044441	Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
cytoplasmic part	GO:0044444	Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	3772	18.6483413259505	20	1.07248144220573	0.407303987671941	A07E.profile.ud50
cytosolic part	GO:0044445	Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.	206	1.01844069807683	0	0	1	A07E.profile.ud50
intracellular organelle part	GO:0044446	A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.	3292	16.2752756216938	19	1.16741494532199	0.280510487513845	A07E.profile.ud50
axoneme part	GO:0044447	Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
cell cortex part	GO:0044448	Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.	57	0.281801552380482	1	3.54859649122807	0.246103700580757	A07E.profile.ud50
contractile fiber part	GO:0044449	Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.	92	0.454837593315865	2	4.39717391304348	0.076439758251729	A07E.profile.ud50
microtubule organizing center part	GO:0044450	Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.	35	0.173036040935383	0	0	1	A07E.profile.ud50
nucleoplasm part	GO:0044451	Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.	489	2.4175606862115	1	0.413640081799591	0.911394073182509	A07E.profile.ud50
nucleolar part	GO:0044452	Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.	31	0.153260493399911	1	6.52483870967742	0.142419818323349	A07E.profile.ud50
nuclear membrane part	GO:0044453	Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells.	133	0.657536955554457	1	1.52082706766917	0.482718324958774	A07E.profile.ud50
nuclear chromosome part	GO:0044454	Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.	86	0.425174272012656	1	2.35197674418605	0.347033044878399	A07E.profile.ud50
mitochondrial membrane part	GO:0044455	Any constituent part of the mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.	112	0.553715330993227	0	0	1	A07E.profile.ud50
synapse part	GO:0044456	The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.	117	0.578434765412567	0	0	1	A07E.profile.ud50
plasma membrane part	GO:0044459	Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	2374	11.7367874623029	11	0.937224094355518	0.625055497974737	A07E.profile.ud50
cell projection part	GO:0044463	Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.	56	0.276857665496613	0	0	1	A07E.profile.ud50
cell part	GO:0044464	Any constituent part of a cell, the basic structural and functional unit of all organisms.	14575	72.0571513323775	73	1.01308473413379	0.471402140600966	A07E.profile.ud50
keratin filament	GO:0045095	A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.	5	0.0247194344193405	0	0	1	A07E.profile.ud50
intermediate filament cytoskeleton	GO:0045111	Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.	93	0.459781480199733	0	0	1	A07E.profile.ud50
pronucleus	GO:0045120	The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.	10	0.049438868838681	0	0	1	A07E.profile.ud50
lipid raft	GO:0045121	Specialized membrane domains composed mainly of cholesterol and sphingolipids, and relatively poor in polyunsaturated lipids such as glycerophospholipids. The formation of these membrane domains is promoted by the presence of cholesterol in the lipid bilayer: the rigid hexagonal rings of cholesterol can pack tightly against the saturated hydrocarbon chains of some membrane lipids, allowing these lipids to assemble into cohesive units floating in the mass of loosely packed polyunsaturated plasma membrane components.	46	0.227418796657932	0	0	1	A07E.profile.ud50
apical part of cell	GO:0045177	The apical region of a cell.	79	0.39056706382558	0	0	1	A07E.profile.ud50
basal part of cell	GO:0045178	The basal region of a cell.	20	0.098877737677362	1	10.1135	0.0943686610871122	A07E.profile.ud50
synapse	GO:0045202	The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.	242	1.19642062589608	0	0	1	A07E.profile.ud50
postsynaptic membrane	GO:0045211	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.	102	0.504276462154546	0	0	1	A07E.profile.ud50
tricarboxylic acid cycle enzyme complex	GO:0045239	Any of the heteromeric enzymes that act in the TCA cycle.	11	0.0543827557225491	0	0	1	A07E.profile.ud50
proton-transporting ATP synthase complex	GO:0045259	A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.	29	0.143372719632175	2	13.9496551724138	0.00908156928373628	A07E.profile.ud50
proton-transporting ATP synthase complex, catalytic core F(1)	GO:0045261	The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.	12	0.0593266426064172	0	0	1	A07E.profile.ud50
proton-transporting ATP synthase complex, coupling factor F(o)	GO:0045263	All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins.	17	0.0840460770257577	2	23.7964705882353	0.00316396724028689	A07E.profile.ud50
respiratory chain complex I	GO:0045271	Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.	39	0.192811588470856	0	0	1	A07E.profile.ud50
clathrin-coated endocytic vesicle	GO:0045334	A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.	20	0.098877737677362	0	0	1	A07E.profile.ud50
anchored to plasma membrane	GO:0046658	Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane.	7	0.0346072081870767	0	0	1	A07E.profile.ud50
pore complex	GO:0046930	Any small opening in a membrane that allows the passage of gases and/or liquids.	127	0.627873634251248	1	1.59267716535433	0.467104981113997	A07E.profile.ud50
perinuclear region of cytoplasm	GO:0048471	Cytoplasm situated near, or occurring around, the nucleus.	87	0.430118158896524	0	0	1	A07E.profile.ud50
coated membrane	GO:0048475	A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes.	91	0.449893706431997	2	4.4454945054945	0.0750159223634117	A07E.profile.ud50
signal recognition particle	GO:0048500	A complex of protein and RNA which facilitates translocation of proteins across membranes.	16	0.0791021901418896	0	0	1	A07E.profile.ud50
pigment granule	GO:0048770	A small, subcellular membrane-bound vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.	17	0.0840460770257577	0	0	1	A07E.profile.ud50
nuclear DNA-directed RNA polymerase complex	GO:0055029	A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity.	41	0.202699362238592	0	0	1	A07E.profile.ud50
neurofilament cytoskeleton	GO:0060053	Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.	10	0.049438868838681	0	0	1	A07E.profile.ud50