L2L Microarray Analysis Tool
Results for C01A.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in C01A.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 12 | 27.43 | 4.82e-14 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 9 | 44.40 | 8.58e-13 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 8 | 49.04 | 7.05e-12 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 8 | 49.04 | 7.05e-12 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.03 | 5 | 144.48 | 1.81e-10 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 20 | 6.12 | 3.19e-10 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 14 | 9.55 | 5.48e-10 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 14 | 9.55 | 5.48e-10 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 13 | 10.71 | 5.68e-10 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 5 | 80.91 | 4.71e-09 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 6 | 31.12 | 5.03e-08 |
| microrna_vertebrate | Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu | 214 | 0.53 | 8 | 15.12 | 8.48e-08 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 0.79 | 9 | 11.45 | 1.42e-07 |
| pdgf_es_dn | Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 6 | 0.01 | 3 | 202.27 | 3.00e-07 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.06 | 4 | 70.35 | 3.18e-07 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 7 | 15.73 | 4.19e-07 |
| hdaci_colon_cur30min_up | Upregulated by curcumin at 30 min in SW260 colon carcinoma cells | 9 | 0.02 | 3 | 134.85 | 1.25e-06 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 11 | 6.59 | 1.44e-06 |
| bep_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 34 | 0.08 | 4 | 47.59 | 1.63e-06 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 3.29 | 15 | 4.56 | 1.95e-06 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 0.83 | 8 | 9.63 | 2.52e-06 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.10 | 4 | 40.45 | 3.18e-06 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 10 | 6.68 | 3.84e-06 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.16 | 4 | 25.28 | 2.11e-05 |
| microrna_human | Predicted human MicroRNA targets | 2276 | 5.63 | 18 | 3.20 | 2.45e-05 |
| stress_genotoxic_specific_up | Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 67 | 0.17 | 4 | 24.15 | 2.53e-05 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
| tnfalpha_30min_up | Upregulated 30min after TNF-alpha treatment of HeLa cells | 68 | 0.17 | 4 | 23.80 | 2.68e-05 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 7 | 8.02 | 3.42e-05 |
| uvb_nhek1_c3 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 26 | 0.06 | 3 | 46.68 | 3.76e-05 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.07 | 3 | 40.45 | 5.83e-05 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 0.66 | 6 | 9.06 | 6.39e-05 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 8 | 6.09 | 6.62e-05 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| 4nqo-gamma_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
| tnfalpha_all_up | Upregulated at any timepoint after TNF-alpha treatment of HeLa cells | 122 | 0.30 | 4 | 13.26 | 2.60e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 5 | 8.95 | 2.76e-04 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 1.24 | 7 | 5.63 | 3.02e-04 |
| hsc_hsc_adult | Up-regulated in mouse hematopoietic stem cells from adult bone marrow (HSC Shared + Adult) | 363 | 0.90 | 6 | 6.69 | 3.28e-04 |
| tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 1237 | 3.06 | 11 | 3.60 | 3.35e-04 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 6 | 6.46 | 3.95e-04 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 4 | 11.81 | 4.04e-04 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.15 | 3 | 20.57 | 4.43e-04 |
| uvb_nhek4_1hr_dn | Downregulated at 1 hour by UV-B light in normal human epidermal keratinocytes | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 7 | 5.21 | 4.80e-04 |
| cmv_hcmv_timecourse_8hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours | 63 | 0.16 | 3 | 19.26 | 5.37e-04 |
| heartfailure_ventricles_up | Upregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.16 | 3 | 18.67 | 5.88e-04 |
| hsc_hsc_shared | Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) | 270 | 0.67 | 5 | 7.49 | 6.18e-04 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.40 | 4 | 10.11 | 7.22e-04 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 4 | 9.30 | 9.86e-04 |
| aged_mouse_hippocampus_any_up | Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| hsc_hsc_fetal | Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) | 303 | 0.75 | 5 | 6.68 | 1.03e-03 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 3 | 13.64 | 1.46e-03 |
| uvb_nhek4_24hrs_dn | Downregulated at 24 hours by UV-B light in normal human epidermal keratinocytes | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 6 | 4.76 | 1.88e-03 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| pdgf_es_up | Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| baf57_bt549_up | Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 364 | 0.90 | 5 | 5.56 | 2.30e-03 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
| uvb_nhek4_6hrs_dn | Downregulated at 6 hours by UV-B light in normal human epidermal keratinocytes | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| uvc_high_d1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| uvb_nhek1_c1 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 1 | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| bay_pbmc_4hr_dn | Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 400 | 0.99 | 5 | 5.06 | 3.44e-03 |
| tcell_anergic_up | Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls | 132 | 0.33 | 3 | 9.19 | 4.46e-03 |
| cpr_low_liver_dn | Down-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| vegf_huvec_30min_up | Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
| ad12_any_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
| dox_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 7 | 3.38 | 5.42e-03 |
| stress_arsenic_specific_dn | Genes down-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 3 | 7.40 | 8.11e-03 |