L2L Microarray Analysis Tool
Results for C01A.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in C01A.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 12 | 13.71 | 1.35e-10 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 9 | 22.20 | 3.74e-10 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 8 | 24.52 | 1.59e-09 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 8 | 24.52 | 1.59e-09 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.07 | 5 | 72.24 | 5.70e-09 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.12 | 5 | 40.45 | 1.44e-07 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 22 | 3.37 | 1.40e-06 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 13 | 5.36 | 1.56e-06 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 14 | 4.78 | 2.38e-06 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 14 | 4.78 | 2.38e-06 |
| pdgf_es_dn | Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 6 | 0.03 | 3 | 101.14 | 2.39e-06 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 6 | 15.56 | 2.77e-06 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.11 | 4 | 35.18 | 4.91e-06 |
| hdaci_colon_cur30min_up | Upregulated by curcumin at 30 min in SW260 colon carcinoma cells | 9 | 0.04 | 3 | 67.42 | 9.93e-06 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 14 | 4.20 | 1.02e-05 |
| microrna_vertebrate | Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu | 214 | 1.06 | 8 | 7.56 | 1.38e-05 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.15 | 4 | 26.97 | 1.48e-05 |
| stress_genotoxic_specific_up | Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 67 | 0.33 | 5 | 15.09 | 2.21e-05 |
| bep_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 34 | 0.17 | 4 | 23.80 | 2.46e-05 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 9 | 5.72 | 3.67e-05 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 7 | 7.87 | 3.70e-05 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.20 | 4 | 20.23 | 4.74e-05 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.11 | 3 | 26.38 | 1.99e-04 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| uvb_nhek1_c3 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 26 | 0.13 | 3 | 23.34 | 2.89e-04 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 4 | 12.64 | 3.00e-04 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 1.66 | 8 | 4.82 | 3.16e-04 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 3 | 21.67 | 3.61e-04 |
| tnfalpha_30min_up | Upregulated 30min after TNF-alpha treatment of HeLa cells | 68 | 0.34 | 4 | 11.90 | 3.78e-04 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.68 | 5 | 7.38 | 6.43e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.18 | 3 | 16.40 | 8.28e-04 |
| 4nqo-gamma_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 10 | 3.34 | 1.05e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 4.15 | 12 | 2.89 | 1.20e-03 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.23 | 3 | 12.91 | 1.67e-03 |
| uvb_nhek4_1hr_dn | Downregulated at 1 hour by UV-B light in normal human epidermal keratinocytes | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 7 | 4.01 | 2.10e-03 |
| heartfailure_ventricles_up | Upregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 1.32 | 6 | 4.53 | 2.37e-03 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 7 | 3.77 | 2.97e-03 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.29 | 3 | 10.28 | 3.20e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 6.58 | 15 | 2.28 | 3.22e-03 |
| tnfalpha_all_up | Upregulated at any timepoint after TNF-alpha treatment of HeLa cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
| cmv_hcmv_timecourse_8hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours | 63 | 0.31 | 3 | 9.63 | 3.85e-03 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.32 | 3 | 9.34 | 4.20e-03 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 2.63 | 8 | 3.05 | 5.51e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 5 | 4.47 | 5.64e-03 |
| uvb_nhek4_24hrs_dn | Downregulated at 24 hours by UV-B light in normal human epidermal keratinocytes | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| aged_mouse_hippocampus_any_up | Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| pdgf_es_up | Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.79 | 4 | 5.06 | 8.54e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 2.27 | 7 | 3.08 | 8.56e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.81 | 4 | 4.93 | 9.29e-03 |