L2L Microarray Analysis Tool
Results for C08E.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in C08E.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 14 | 9.55 | 5.48e-10 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 14 | 9.55 | 5.48e-10 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 19 | 5.82 | 1.99e-09 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 7 | 29.81 | 5.15e-09 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 13 | 8.68 | 6.94e-09 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 12 | 9.16 | 1.45e-08 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 11 | 9.37 | 4.57e-08 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 11 | 8.73 | 9.31e-08 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 10 | 9.87 | 1.15e-07 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 5 | 43.04 | 1.30e-07 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 5 | 37.46 | 2.64e-07 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 10 | 7.92 | 8.50e-07 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 7 | 14.02 | 9.08e-07 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 5 | 25.93 | 1.68e-06 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 5 | 25.60 | 1.79e-06 |
| vegf_hmmec_all_up | Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells | 147 | 0.36 | 6 | 16.51 | 2.14e-06 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 5 | 24.67 | 2.15e-06 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 7 | 12.15 | 2.34e-06 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
| vegf_hmmec_3hrs_up | Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 99 | 0.24 | 5 | 20.43 | 5.44e-06 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 7 | 10.65 | 5.57e-06 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 10 | 6.26 | 6.69e-06 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 6 | 13.48 | 6.86e-06 |
| shh_up | Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells | 16 | 0.04 | 3 | 75.85 | 8.26e-06 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 4 | 29.97 | 1.07e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 9 | 6.69 | 1.13e-05 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 3 | 63.87 | 1.42e-05 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 5 | 16.58 | 1.50e-05 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 6 | 10.74 | 2.48e-05 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 3 | 48.54 | 3.34e-05 |
| cmv_hcmv_timecourse_4hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours | 26 | 0.06 | 3 | 46.68 | 3.76e-05 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 7 | 7.53 | 5.08e-05 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 9 | 5.39 | 6.01e-05 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.08 | 3 | 39.15 | 6.45e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| but_tsa_up | Upregulated by the combination of TSA and butyrate in HT-29 cells | 36 | 0.09 | 3 | 33.71 | 1.01e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
| tpa_sens_late_dn | Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells | 451 | 1.11 | 7 | 6.28 | 1.56e-04 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 6 | 7.61 | 1.65e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 8 | 5.10 | 2.21e-04 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 4 | 13.48 | 2.44e-04 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 6 | 6.99 | 2.58e-04 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 6 | 6.99 | 2.58e-04 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 7 | 5.77 | 2.61e-04 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 4 | 11.99 | 3.82e-04 |
| tnfa_nfkb_ind_dn | Down-regulated at any timepoint following TNFa treatment, independent of NFkB function | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.35 | 4 | 11.32 | 4.74e-04 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 5 | 7.69 | 5.49e-04 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.16 | 3 | 18.67 | 5.88e-04 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 4 | 10.11 | 7.22e-04 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 4 | 9.14 | 1.05e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| ad12_48hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.22 | 3 | 13.79 | 1.42e-03 |
| ad12_24hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| adip_diff_cluster1 | Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) | 96 | 0.24 | 3 | 12.64 | 1.82e-03 |
| metastasis_adenocarc_dn | Down-regulated in adenocarcinoma metastases, compared to similar primary tumors; predictive of metastatic potential | 97 | 0.24 | 3 | 12.51 | 1.87e-03 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 8 | 3.62 | 2.01e-03 |
| ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 4 | 7.26 | 2.44e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 3 | 11.24 | 2.54e-03 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 0.57 | 4 | 7.04 | 2.72e-03 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 7 | 3.77 | 2.99e-03 |
| tpa_sens_middle_dn | Downregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells | 561 | 1.39 | 6 | 4.33 | 3.01e-03 |
| bcrabl_hl60_affy_up | Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by Affymetrix arrays | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 4 | 6.18 | 4.32e-03 |
| hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| cmv_24hrs_up | Upregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
| vegf_huvec_30min_up | Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
| ad12_any_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
| hdaci_colon_tsa48hrs_up | Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 4 | 5.70 | 5.73e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 3 | 7.63 | 7.45e-03 |
| hematop_stem_all_up | Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 4 | 5.25 | 7.58e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 3 | 7.40 | 8.11e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |
| cmv_all_up | Upregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 173 | 0.43 | 3 | 7.02 | 9.38e-03 |