L2L Microarray Analysis Tool
Results for C08E.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in C08E.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 15 | 5.12 | 4.50e-07 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 15 | 5.12 | 4.50e-07 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 7 | 14.90 | 5.45e-07 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 11 | 6.52 | 1.50e-06 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 13 | 4.96 | 3.58e-06 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.23 | 5 | 21.52 | 3.81e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 21 | 3.22 | 4.86e-06 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 14 | 4.47 | 5.09e-06 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 12 | 5.11 | 6.23e-06 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.27 | 5 | 18.73 | 7.63e-06 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 13 | 4.34 | 1.47e-05 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 3 | 50.57 | 2.57e-05 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 13 | 4.07 | 2.85e-05 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 5 | 12.97 | 4.62e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 10 | 4.93 | 4.84e-05 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 5 | 12.80 | 4.91e-05 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 5 | 12.33 | 5.87e-05 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 11 | 4.36 | 6.22e-05 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 11 | 4.35 | 6.33e-05 |
| shh_up | Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells | 16 | 0.08 | 3 | 37.93 | 6.45e-05 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 7 | 7.01 | 7.64e-05 |
| vegf_hmmec_all_up | Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells | 147 | 0.73 | 6 | 8.26 | 1.02e-04 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 3 | 31.94 | 1.10e-04 |
| vegf_hmmec_3hrs_up | Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 99 | 0.49 | 5 | 10.22 | 1.44e-04 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.27 | 4 | 14.98 | 1.55e-04 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 7 | 6.08 | 1.85e-04 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.12 | 3 | 24.27 | 2.56e-04 |
| cmv_hcmv_timecourse_4hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours | 26 | 0.13 | 3 | 23.34 | 2.89e-04 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 6 | 6.74 | 3.05e-04 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.60 | 5 | 8.29 | 3.79e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 1.32 | 7 | 5.32 | 4.10e-04 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 10 | 3.72 | 4.65e-04 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| tpa_skin_up | Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| cmv_24hrs_up | Upregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 133 | 0.66 | 5 | 7.60 | 5.62e-04 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 8 | 4.30 | 6.61e-04 |
| but_tsa_up | Upregulated by the combination of TSA and butyrate in HT-29 cells | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
| uvc_high_d2_dn | Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.18 | 3 | 16.40 | 8.28e-04 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.19 | 3 | 15.97 | 8.96e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 6 | 5.37 | 1.00e-03 |
| cmv_hcmv_timecourse_6hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours | 95 | 0.47 | 4 | 8.52 | 1.33e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.81 | 5 | 6.17 | 1.43e-03 |
| tnfa_nfkb_ind_dn | Down-regulated at any timepoint following TNFa treatment, independent of NFkB function | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
| cmv_all_up | Upregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 173 | 0.86 | 5 | 5.85 | 1.81e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 5 | 5.71 | 2.00e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 4.42 | 12 | 2.71 | 2.04e-03 |
| tpa_sens_late_dn | Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells | 451 | 2.23 | 8 | 3.59 | 2.08e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 1.30 | 6 | 4.63 | 2.12e-03 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 10 | 3.00 | 2.31e-03 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 19 | 2.10 | 2.50e-03 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.59 | 4 | 6.74 | 3.11e-03 |
| uvb_scc_up | Upregulated by UV-B light in squamous cell carcinoma cells | 198 | 0.98 | 5 | 5.11 | 3.24e-03 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 8 | 3.30 | 3.47e-03 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 1.02 | 5 | 4.89 | 3.91e-03 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.32 | 3 | 9.34 | 4.20e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| ad12_48hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.67 | 4 | 5.95 | 4.86e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 1.08 | 5 | 4.62 | 4.95e-03 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 3 | 8.67 | 5.17e-03 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 5 | 4.54 | 5.34e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 6 | 3.80 | 5.50e-03 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.71 | 4 | 5.66 | 5.79e-03 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 9.83 | 19 | 1.93 | 5.96e-03 |
| ad12_24hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| ageing_kidney_specific_dn | Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood | 248 | 1.23 | 5 | 4.08 | 8.26e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 4 | 5.09 | 8.35e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 4 | 5.06 | 8.54e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
| vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.44 | 3 | 6.90 | 9.70e-03 |