L2L Microarray Analysis Tool

13.95

4.50e-09

cell division

The processes resulting in the physical partitioning and separation of a cell into daughter cells.

297

0.73

13.62

5.65e-09

M phase

Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis.

375

0.93

10.79

5.05e-08

mitosis

Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.

284

0.70

9

12.82

5.45e-08

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M.

421

1.04

9.61

1.47e-07

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

474

1.17

traversing start control point of mitotic cell cycle

8.53

4.32e-07

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

277

0.68

7

10.22

7.25e-06

Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle.

19

0.05

DNA-dependent DNA replication

63.87

1.42e-05

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

922

2.28

11

4.83

2.62e-05

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

140

0.35

5

14.45

2.92e-05

G1 phase of mitotic cell cycle

Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis.

36

0.09

regulation of DNA replication

33.71

1.01e-04

Any process that modulates the frequency, rate or extent of DNA replication.

38

0.09

31.94

1.19e-04

G1 phase

Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.

40

0.10

G2/M transition DNA damage checkpoint

30.34

1.39e-04

cell cycle checkpoint

A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

112

0.28

4

14.45

1.87e-04

A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage.

11

0.03

G2/M transition checkpoint

73.55

3.31e-04

Any cell cycle checkpoint that blocks entry into M phase.

11

0.03

regulation of progression through mitotic cell cycle

73.55

3.31e-04

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

57

0.14

regulation of cyclin-dependent protein kinase activity

21.29

4.00e-04

Any process that modulates the frequency, rate or extent of CDK activity.

65

0.16

regulation of DNA metabolic process

18.67

5.88e-04

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

80

0.20

15.17

1.08e-03

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

91

0.22

negative regulation of progression through cell cycle

13.34

1.56e-03

Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle.

347

0.86

5

5.83

1.87e-03

G2/M transition of mitotic cell cycle

Progression from G2 phase to M phase of the mitotic cell cycle.

26

0.06

31.12

1.91e-03

mitotic checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.

37

0.09

interphase of mitotic cell cycle

21.87

3.84e-03

Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

134

0.33

9.06

4.65e-03

interphase

Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

138

0.34

DNA replication initiation

8.79

5.05e-03

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

44

0.11

18.39

5.40e-03

DNA damage checkpoint

A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.

57

0.14