Results summary | View all lists in GO:BiolProc | View all genes in D07A.profile.ud50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
regulation of interleukin-6 biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. | 8 | 0.04 | 3 | 75.85 | 6.64e-06 |
interleukin-6 production | The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 10 | 0.05 | 3 | 60.68 | 1.41e-05 |
interleukin-6 biosynthetic process | The chemical reactions and pathways resulting in the formation of interleukin-6. | 10 | 0.05 | 3 | 60.68 | 1.41e-05 |
negative regulation of cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. | 90 | 0.44 | 5 | 11.24 | 9.16e-05 |
response to external stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. | 759 | 3.75 | 13 | 3.46 | 1.42e-04 |
negative regulation of developmental process | Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 110 | 0.54 | 5 | 9.19 | 2.35e-04 |
sodium ion transport | The directed movement of sodium ions (Na+) into, out of, within or between cells. | 124 | 0.61 | 5 | 8.16 | 4.08e-04 |
positive regulation of interleukin-6 biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. | 7 | 0.03 | 2 | 57.79 | 5.05e-04 |
regulation of chemokine biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
signal transduction | The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell. | 4207 | 20.80 | 37 | 1.78 | 8.18e-04 |
regulation of Rho GTPase activity | Any process that modulates the activity of a GTPase of the Rho family. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
chemokine production | The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
chemokine biosynthetic process | The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
chemokine metabolic process | The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
cytokine production | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 153 | 0.76 | 5 | 6.61 | 1.05e-03 |
positive regulation of B cell proliferation | Any process that activates or increases the rate or extent of B cell proliferation. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
regulation of cell differentiation | Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. | 233 | 1.15 | 6 | 5.21 | 1.17e-03 |
apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 5.33 | 14 | 2.63 | 1.22e-03 |
negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
negative regulation of B cell activation | Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 5.37 | 14 | 2.61 | 1.31e-03 |
acute-phase response | Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. | 44 | 0.22 | 3 | 13.79 | 1.38e-03 |
cell communication | Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. | 4669 | 23.08 | 39 | 1.69 | 1.51e-03 |
thermoregulation | A homeostatic process by which an organism modulates its internal body temperature. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
regulation of cell-matrix adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
fibrinolysis | An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
transcription from RNA polymerase II promoter | The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). | 997 | 4.93 | 13 | 2.64 | 1.73e-03 |
locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. | 252 | 1.25 | 6 | 4.82 | 1.74e-03 |
regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
regulation of T-helper cell differentiation | Any process that modulates the frequency, rate or extent of T-helper cell differentiation. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). | 179 | 0.88 | 5 | 5.65 | 2.10e-03 |
taxis | The directed movement of a motile cell or organism in response to an external stimulus. | 179 | 0.88 | 5 | 5.65 | 2.10e-03 |
cytokine production during immune response | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
regulation of production of molecular mediator of immune response | Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
regulation of cytokine production during immune response | Any process that modulates the frequency, rate, or extent of cytokine production during immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
response to wounding | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. | 560 | 2.77 | 9 | 3.25 | 2.19e-03 |
regulation of blood coagulation | Any process that modulates the frequency, rate or extent of blood coagulation. | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
negative regulation of blood coagulation | Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation. | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
erythrocyte differentiation | The process by which a myeloid precursor cell acquires specializes features of an erythrocyte. | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
regulation of B cell proliferation | Any process that modulates the frequency, rate or extent of B cell proliferation. | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
regulation of transcription from RNA polymerase II promoter | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 701 | 3.47 | 10 | 2.89 | 3.01e-03 |
blood vessel development | The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. | 283 | 1.40 | 6 | 4.29 | 3.09e-03 |
cell activation during immune response | A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
lymphocyte activation during immune response | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
T cell activation during immune response | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
T cell differentiation during immune response | The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
CD4-positive, alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
leukocyte activation during immune response | A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
T-helper cell differentiation | The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. | 383 | 1.89 | 7 | 3.70 | 3.29e-03 |
vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. | 288 | 1.42 | 6 | 4.21 | 3.37e-03 |
regulation of Ras GTPase activity | Any process that modulates the activity of a GTPase of the Ras superfamily. | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
adrenal gland development | The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
regulation of isotype switching | Any process that modulates the frequency, rate or extent of isotype switching. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
negative regulation of coagulation | Any process that stops, prevents or reduces the frequency, rate or extent of coagulation. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
response to chemical stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. | 603 | 2.98 | 9 | 3.02 | 3.56e-03 |
CD4-positive, alpha beta T cell differentiation | The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. | 19 | 0.09 | 2 | 21.29 | 3.95e-03 |
regulation of coagulation | Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass. | 19 | 0.09 | 2 | 21.29 | 3.95e-03 |
cell differentiation | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. | 2359 | 11.66 | 22 | 1.89 | 4.32e-03 |
cellular developmental process | A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. | 2359 | 11.66 | 22 | 1.89 | 4.32e-03 |
negative regulation of immune system process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
regulation of immune effector process | Any process that modulates the frequency, rate, or extent of an immune effector process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
T-helper 2 type immune response | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
negative regulation of immune response | Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
regulation of transcription, DNA-dependent | Any process that modulates the frequency, rate or extent of DNA-dependent transcription. | 2510 | 12.41 | 23 | 1.85 | 4.41e-03 |
response to metal ion | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
regulation of transforming growth factor beta receptor signaling pathway | Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway. | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
pattern specification process | The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. | 218 | 1.08 | 5 | 4.64 | 4.86e-03 |
developmental process | A biological process whose specific outcome is the progression of an integrated living unit: a cell, tissue, organ, or organism over time from an initial condition to a later condition. | 4255 | 21.04 | 34 | 1.62 | 5.54e-03 |
cell development | The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. | 1692 | 8.37 | 17 | 2.03 | 5.57e-03 |
myeloid cell differentiation | The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. | 142 | 0.70 | 4 | 5.70 | 5.65e-03 |
negative regulation of biological process | Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. | 1697 | 8.39 | 17 | 2.03 | 5.73e-03 |
regulation of adaptive immune response | Any process that modulates the frequency, rate, or extent of an adaptive immune response. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
transcription, DNA-dependent | The synthesis of RNA on a template of DNA. | 2588 | 12.79 | 23 | 1.80 | 6.26e-03 |
determination of left/right symmetry | The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
neutrophil chemotaxis | The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
RNA biosynthetic process | The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. | 2591 | 12.81 | 23 | 1.80 | 6.34e-03 |
biological regulation | Any process that modulates the frequency, rate or extent of any biological process, quality or function. | 6089 | 30.10 | 45 | 1.49 | 6.51e-03 |
central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. | 332 | 1.64 | 6 | 3.66 | 6.64e-03 |
regulation of defense response | Any process that modulates the frequency, rate or extent of a defense response. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
positive regulation of B cell activation | Any process that activates or increases the frequency, rate or extent of B cell activation. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of the movement of a cell. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
multicellular organismal process | The biological processes, occurring at the level of the organism, pertinent to the function of the organism. | 4325 | 21.38 | 34 | 1.59 | 6.98e-03 |
regulation of biological process | Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. | 5630 | 27.83 | 42 | 1.51 | 7.17e-03 |
determination of symmetry | The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
determination of bilateral symmetry | The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. | 682 | 3.37 | 9 | 2.67 | 7.72e-03 |
response to inorganic substance | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
B cell proliferation | The rapid expansion of a B cell population by cell division. Follows B cell activation. | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
negative regulation of myeloid cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation. | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
negative regulation of apoptosis | Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. | 345 | 1.71 | 6 | 3.52 | 7.94e-03 |
negative regulation of programmed cell death | Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
alpha-beta T cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell. | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
regulation of cytokine biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. | 85 | 0.42 | 3 | 7.14 | 8.83e-03 |
embryo implantation | Attachment of the blastocyst to the uterine lining. | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
regulation of lymphocyte differentiation | Any process that modulates the frequency, rate or extent of lymphocyte differentiation. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |