L2L Microarray Analysis Tool
Results for D07X.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D07X.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 22 | 24.72 | 8.49e-24 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 6 | 63.87 | 3.75e-10 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.12 | 6 | 50.57 | 1.82e-09 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 7 | 32.18 | 2.36e-09 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 6 | 39.15 | 9.67e-09 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 10 | 8.68 | 3.43e-07 |
| dex_keratinocyte_4hr_dn | Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 69 | 0.34 | 6 | 17.59 | 1.34e-06 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 14 | 4.67 | 3.05e-06 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.23 | 5 | 21.99 | 3.42e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 21 | 3.22 | 4.86e-06 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 4.15 | 16 | 3.86 | 7.05e-06 |
| cmv_all_dn | Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 213 | 1.05 | 8 | 7.60 | 1.34e-05 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 6 | 11.13 | 1.91e-05 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 13 | 4.15 | 2.35e-05 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 5 | 14.45 | 2.74e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 10 | 4.93 | 4.84e-05 |
| adipogenesis_hmsc_class2_up | Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 11 | 4.36 | 6.22e-05 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 6 | 8.99 | 6.36e-05 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 5 | 11.76 | 7.37e-05 |
| alk5_hmvec_2hr_dn | Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 1.00 | 7 | 7.01 | 7.64e-05 |
| alk5_hmvec_4hr_dn | Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 1.00 | 7 | 7.01 | 7.64e-05 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 9 | 5.16 | 8.16e-05 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.71 | 6 | 8.49 | 8.75e-05 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 2.20 | 10 | 4.54 | 9.66e-05 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 5 | 10.65 | 1.18e-04 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 12 | 3.76 | 1.20e-04 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.27 | 4 | 14.98 | 1.55e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 10 | 4.26 | 1.61e-04 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 7 | 6.16 | 1.70e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 12 | 3.60 | 1.79e-04 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 6 | 6.86 | 2.79e-04 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.32 | 4 | 12.45 | 3.18e-04 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.97 | 6 | 6.16 | 4.91e-04 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.16 | 3 | 18.96 | 5.38e-04 |
| bap_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 135 | 0.67 | 5 | 7.49 | 6.01e-04 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
| hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 9 | 3.83 | 7.11e-04 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 7 | 4.74 | 8.15e-04 |
| hdaci_colon_cluster2 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 4 | 9.30 | 9.59e-04 |
| myod_nih3t3_dn | Down-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium | 91 | 0.45 | 4 | 8.89 | 1.13e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.82 | 5 | 6.09 | 1.51e-03 |
| ribavirin_rsv_dn | Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin | 101 | 0.50 | 4 | 8.01 | 1.67e-03 |
| brca_brca1_neg | Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors | 250 | 1.24 | 6 | 4.85 | 1.67e-03 |
| cmv_8hrs_dn | Downregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV | 102 | 0.50 | 4 | 7.93 | 1.73e-03 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.24 | 3 | 12.64 | 1.77e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 9 | 3.35 | 1.80e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 7 | 4.08 | 1.91e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 7 | 4.08 | 1.91e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 1.30 | 6 | 4.63 | 2.12e-03 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 2.27 | 8 | 3.53 | 2.31e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 1.79 | 7 | 3.90 | 2.45e-03 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| sarcomas_synovial_up | Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
| tnfalpha_all_up | Upregulated at any timepoint after TNF-alpha treatment of HeLa cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 4.10 | 11 | 2.68 | 3.31e-03 |
| cmv_hcmv_timecourse_24hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 123 | 0.61 | 4 | 6.58 | 3.40e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 5 | 5.01 | 3.53e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 1.02 | 5 | 4.89 | 3.91e-03 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
| as3_fibro_c5 | Downregulated moderately by sodium arsenite in fibroblasts (Cluster 5) | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| uvb_nhek1_c4 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 8 | 3.17 | 4.40e-03 |
| tnfalpha_30min_up | Upregulated 30min after TNF-alpha treatment of HeLa cells | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 10.34 | 20 | 1.93 | 4.84e-03 |
| cmv_24hrs_dn | Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 6 | 3.82 | 5.42e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 8 | 3.05 | 5.45e-03 |
| tsa_panc50_up | 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| hsc_intermediateprogenitors_shared | Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) | 151 | 0.75 | 4 | 5.36 | 6.99e-03 |
| calres_mouse_dn | Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 6.58 | 14 | 2.13 | 7.69e-03 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.41 | 3 | 7.40 | 8.00e-03 |
| hsc_intermediateprogenitors_adult | Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) | 161 | 0.80 | 4 | 5.03 | 8.72e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| cmv_hcmv_timecourse_20hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
| brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| hsc_intermediateprogenitors_fetal | Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) | 167 | 0.83 | 4 | 4.84 | 9.88e-03 |