L2L Microarray Analysis Tool
Results for D08A.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D08A.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 17 | 5.80 | 1.33e-08 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 17 | 5.80 | 1.33e-08 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 5 | 53.23 | 3.24e-08 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.16 | 5 | 31.60 | 5.32e-07 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 7 | 14.90 | 5.45e-07 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 4 | 53.94 | 7.81e-07 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 14 | 4.67 | 3.05e-06 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 7 | 10.49 | 5.75e-06 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 1.32 | 9 | 6.84 | 9.05e-06 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 8 | 8.01 | 9.12e-06 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 10 | 5.83 | 1.18e-05 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 10 | 5.83 | 1.18e-05 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 12 | 4.76 | 1.26e-05 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 4 | 26.10 | 1.69e-05 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 4 | 26.10 | 1.69e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 12 | 4.46 | 2.37e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 4 | 23.80 | 2.46e-05 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 8 | 6.94 | 2.54e-05 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 3 | 50.57 | 2.57e-05 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 11 | 4.68 | 3.30e-05 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 7 | 8.00 | 3.32e-05 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 5 | 12.97 | 4.62e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 10 | 4.93 | 4.84e-05 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.23 | 4 | 17.21 | 8.99e-05 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.24 | 4 | 16.86 | 9.77e-05 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 18 | 2.76 | 1.53e-04 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.27 | 4 | 14.98 | 1.55e-04 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 5 | 9.11 | 2.45e-04 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
| p53genes_all | p53 transcriptional targets | 33 | 0.16 | 3 | 18.39 | 5.90e-04 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 1.40 | 7 | 4.99 | 6.04e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 11 | 3.30 | 6.71e-04 |
| hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 9 | 3.83 | 7.11e-04 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 4 | 9.63 | 8.41e-04 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 4 | 9.41 | 9.19e-04 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 9 | 3.56 | 1.18e-03 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 2.54 | 9 | 3.55 | 1.21e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 5 | 6.36 | 1.25e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.82 | 5 | 6.09 | 1.51e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 9 | 3.43 | 1.51e-03 |
| pgj2_up | Upregulated by treatment with the prostaglandin 15d-PGJ2 | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 10 | 3.13 | 1.68e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 3.23 | 10 | 3.09 | 1.84e-03 |
| et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 1.79 | 7 | 3.90 | 2.45e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| oldonly_fibro_dn | Downregulated in fibroblasts from old (but not Werner) individuals, compared to young | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| stress_genotoxic_specific_up | Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 10 | 2.69 | 4.85e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 3 | 8.20 | 6.03e-03 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 5 | 4.40 | 6.07e-03 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| calres_mouse_dn | Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| werner_fibro_up | Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals | 81 | 0.40 | 3 | 7.49 | 7.74e-03 |
| hbx_nl_dn | Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.41 | 3 | 7.40 | 8.00e-03 |
| bap_hepg2_up | Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 83 | 0.41 | 3 | 7.31 | 8.27e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| oldwerner_fibro_up | Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| uv_unique_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |