L2L Microarray Analysis Tool
Results for D09A.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D09A.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 19 | 6.48 | 3.12e-10 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 19 | 6.48 | 3.12e-10 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 5 | 67.42 | 8.51e-09 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 13 | 7.58 | 3.09e-08 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 13 | 7.58 | 3.09e-08 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 4 | 42.58 | 2.18e-06 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 4 | 26.10 | 1.69e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 4 | 23.80 | 2.46e-05 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 3 | 50.57 | 2.57e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 10 | 4.93 | 4.84e-05 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 5 | 12.80 | 4.91e-05 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 19 | 2.91 | 5.08e-05 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 3 | 37.93 | 6.45e-05 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 4 | 18.39 | 6.92e-05 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 5 | 11.62 | 7.79e-05 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 4 | 16.51 | 1.06e-04 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 3 | 28.90 | 1.50e-04 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.53 | 5 | 9.36 | 2.16e-04 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 4 | 13.26 | 2.49e-04 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.55 | 5 | 9.03 | 2.55e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 11 | 3.67 | 2.75e-04 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.34 | 4 | 11.90 | 3.78e-04 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.60 | 5 | 8.29 | 3.79e-04 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 8 | 4.30 | 6.61e-04 |
| hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.19 | 3 | 15.97 | 8.96e-04 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.19 | 3 | 15.97 | 8.96e-04 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 7 | 4.60 | 9.68e-04 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 5 | 6.32 | 1.29e-03 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 4 | 8.52 | 1.33e-03 |
| tpa_sens_early_up | Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells | 97 | 0.48 | 4 | 8.34 | 1.44e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
| pgj2_up | Upregulated by treatment with the prostaglandin 15d-PGJ2 | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.23 | 3 | 12.91 | 1.67e-03 |
| hdaci_colon_sul24hrs_up | Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 102 | 0.50 | 4 | 7.93 | 1.73e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 1.30 | 6 | 4.61 | 2.16e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| 17aag_ovca_up | Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 53 | 0.26 | 3 | 11.45 | 2.35e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.28 | 3 | 10.84 | 2.75e-03 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.95 | 5 | 5.27 | 2.84e-03 |
| oldonly_fibro_dn | Downregulated in fibroblasts from old (but not Werner) individuals, compared to young | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 3 | 8.67 | 5.17e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 5 | 4.40 | 6.07e-03 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 5 | 4.34 | 6.40e-03 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| hbx_nl_dn | Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| mammary_dev_up | Up-regulated in the intact developing mouse mammary gland; higher expression in 5/6 week pubertal glands than in 3 week, mid-pregnant, lactating, involuting or resuckled glands | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 3 | 7.06 | 9.11e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.82 | 4 | 4.87 | 9.68e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.44 | 3 | 6.90 | 9.70e-03 |