L2L Microarray Analysis Tool
Results for G01A.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in G01A.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 10 | 23.66 | 2.67e-11 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 11 | 14.88 | 3.90e-10 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 9 | 18.48 | 2.32e-09 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 10 | 11.86 | 2.08e-08 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 7 | 20.82 | 6.23e-08 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 0.85 | 8 | 9.41 | 2.99e-06 |
| dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.04 | 3 | 71.39 | 1.00e-05 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.18 | 4 | 21.87 | 3.74e-05 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.19 | 4 | 21.02 | 4.37e-05 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 6 | 7.93 | 1.32e-04 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 3 | 25.28 | 2.40e-04 |
| stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 18 | 2.60 | 3.17e-04 |
| dac_cgi_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| bleo_human_lymph_high_4hrs_dn | Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| mms_mouse_lymph_low_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of methyl methanesulfonate (MMS) | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| cox2_ko_hippocampus_up | Up-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 6 | 4.97 | 1.51e-03 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 1.34 | 6 | 4.48 | 2.54e-03 |
| scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| uvb_nhek1_c6 | Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 268 | 0.66 | 4 | 6.04 | 4.68e-03 |
| vhl_rcc_up | Upregulated in VHL-null renal carcinoma cells vs. VHL-rescued (Fig. 1a+b) | 153 | 0.38 | 3 | 7.93 | 6.71e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |