L2L Microarray Analysis Tool
Results for L01A.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L01A.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| bay_pbmc_2hr_dn | Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 398 | 0.98 | 7 | 7.12 | 7.24e-05 |
| pdgf_es_dn | Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 6 | 0.01 | 2 | 134.85 | 9.11e-05 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.10 | 3 | 30.34 | 1.39e-04 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 1.24 | 7 | 5.63 | 3.02e-04 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 7 | 5.33 | 4.16e-04 |
| bay_pbmc_4hr_dn | Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 400 | 0.99 | 6 | 6.07 | 5.46e-04 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 4 | 9.87 | 7.92e-04 |
| aged_mouse_hippocampus_any_up | Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 0.79 | 5 | 6.36 | 1.28e-03 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 4 | 7.82 | 1.86e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| brca_brca1_neg | Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors | 250 | 0.62 | 4 | 6.47 | 3.66e-03 |
| bay-il2_pbmc_late_up | Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 130 | 0.32 | 3 | 9.34 | 4.28e-03 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 5 | 4.54 | 5.41e-03 |
| mouse_tissue_prostate | Genes expressed specifically in mouse testis tissue | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
| bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 1.19 | 5 | 4.19 | 7.50e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 3 | 7.10 | 9.09e-03 |
| tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 936 | 2.31 | 7 | 3.03 | 9.55e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 3 | 6.86 | 9.97e-03 |