L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in L01B.profile.d50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
M phase	Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis.	375	0.93	10	10.79	5.05e-08
mitosis	Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.	284	0.70	9	12.82	5.45e-08
M phase of mitotic cell cycle	Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place.	290	0.72	9	12.55	6.51e-08
cell cycle phase	A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.	474	1.17	10	8.53	4.32e-07
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M.	421	1.04	9	8.65	1.45e-06
cell division	The processes resulting in the physical partitioning and separation of a cell into daughter cells.	297	0.73	7	9.53	1.14e-05
spindle organization and biogenesis	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.	28	0.07	3	43.34	4.72e-05
regulation of mitosis	Any process that modulates the frequency, rate or extent of mitosis.	91	0.22	4	17.78	8.41e-05
mitotic checkpoint	A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.	37	0.09	3	32.80	1.10e-04
microtubule cytoskeleton organization and biogenesis	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.	101	0.25	4	16.02	1.26e-04
snRNA metabolic process	The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.	12	0.03	2	67.42	3.97e-04
snRNA processing	Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.	12	0.03	2	67.42	3.97e-04
mitotic spindle checkpoint	A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).	14	0.03	2	57.79	5.45e-04
cell cycle process	A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.	1144	2.83	10	3.54	6.97e-04
mitotic spindle organization and biogenesis	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.	16	0.04	2	50.57	7.17e-04
spindle checkpoint	A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle.	17	0.04	2	47.59	8.11e-04
chromosome segregation	The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.	79	0.20	3	15.36	1.04e-03
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	1307	3.23	10	3.10	1.86e-03
chromosome condensation	The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.	26	0.06	2	31.12	1.91e-03
cell cycle checkpoint	A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.	112	0.28	3	10.84	2.82e-03
microtubule-based process	Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.	237	0.59	4	6.83	3.03e-03
phosphoinositide-mediated signaling	A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.	124	0.31	3	9.79	3.75e-03
cytokinesis	A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.	40	0.10	2	20.23	4.48e-03
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.	156	0.39	3	7.78	7.08e-03
nuclear import	The directed movement of substances into the nucleus.	159	0.39	3	7.63	7.45e-03
establishment of organelle localization	The directed movement of an organelle to a specific location.	55	0.14	2	14.71	8.32e-03
protein import	The directed movement of proteins into a cell or organelle.	172	0.43	3	7.06	9.23e-03

Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis.

375

0.93

10.79

5.05e-08

Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.

284

0.70

9

12.82

5.45e-08

M phase of mitotic cell cycle

Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place.

290

0.72

9

12.55

6.51e-08

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

474

1.17

10

8.53

4.32e-07

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M.

421

1.04

9

8.65

1.45e-06

cell division

The processes resulting in the physical partitioning and separation of a cell into daughter cells.

297

0.73

7

9.53

1.14e-05

spindle organization and biogenesis

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

28

0.07

3

43.34

4.72e-05

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

91

0.22

4

17.78

8.41e-05

mitotic checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.

37

0.09

3

32.80

1.10e-04

microtubule cytoskeleton organization and biogenesis

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

101

0.25

4

16.02

1.26e-04

snRNA metabolic process

The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.

12

0.03

2

67.42

3.97e-04

snRNA processing

Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.

12

0.03

2

67.42

3.97e-04

mitotic spindle checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

14

0.03

2

57.79

5.45e-04

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

1144

2.83

10

3.54

6.97e-04

mitotic spindle organization and biogenesis

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

16

0.04

2

50.57

7.17e-04

spindle checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle.

17

0.04

2

47.59

8.11e-04

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

79

0.20

3

15.36

1.04e-03

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

1307

3.23

10

3.10

1.86e-03

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

26

0.06

2

31.12

1.91e-03

cell cycle checkpoint

A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

112

0.28

3

10.84

2.82e-03

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

237

0.59

4

6.83

3.03e-03

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

124

0.31

3

9.79

3.75e-03

cytokinesis

A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.

40

0.10

2

20.23

4.48e-03

protein import into nucleus

The directed movement of a protein from the cytoplasm to the nucleus.

156

0.39

3

7.78

7.08e-03