#list name	reference	description	total probes	expected	actual	enrichment	bin prob	analysis_name
reproduction	GO:0000003	The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.	649	1.6042912938152	2	1.246656394453	0.476695345974431	L01D.profile.d50
regulation of DNA recombination	GO:0000018	Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.	18	0.0444949819548129	0	0	1	L01D.profile.d50
very-long-chain fatty acid metabolic process	GO:0000038	The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater.	8	0.0197755475354724	0	0	1	L01D.profile.d50
transition metal ion transport	GO:0000041	The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	66	0.163148267167647	0	0	1	L01D.profile.d50
autophagic vacuole formation	GO:0000045	The formation of a double membrane-bound structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.	8	0.0197755475354724	0	0	1	L01D.profile.d50
urea cycle	GO:0000050	A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.	9	0.0222474909774064	0	0	1	L01D.profile.d50
urea cycle intermediate metabolic process	GO:0000051	The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.	17	0.0420230385128788	0	0	1	L01D.profile.d50
protein import into nucleus, docking	GO:0000059	The aggregation and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins.	42	0.10382162456123	0	0	1	L01D.profile.d50
protein import into nucleus, translocation	GO:0000060	The vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.	40	0.098877737677362	1	10.1135	0.094257427418219	L01D.profile.d50
mitotic sister chromatid segregation	GO:0000070	The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.	37	0.0914619073515598	1	10.9335135135135	0.0875072495975143	L01D.profile.d50
regulation of progression through cell cycle	GO:0000074	Any process that modulates the rate or extent of progression through the cell cycle.	875	2.16295051169229	8	3.69865142857143	0.00175236384633832	L01D.profile.d50
cell cycle checkpoint	GO:0000075	A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.	112	0.276857665496613	1	3.61196428571429	0.242097415964809	L01D.profile.d50
DNA damage checkpoint	GO:0000077	A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.	57	0.140900776190241	0	0	1	L01D.profile.d50
regulation of cyclin-dependent protein kinase activity	GO:0000079	Any process that modulates the frequency, rate or extent of CDK activity.	65	0.160676323725713	1	6.22369230769231	0.148601717620338	L01D.profile.d50
G1 phase of mitotic cell cycle	GO:0000080	Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis.	36	0.0889899639096258	0	0	1	L01D.profile.d50
G1/S transition of mitotic cell cycle	GO:0000082	Progression from G1 phase to S phase of the mitotic cell cycle.	44	0.108765511445098	0	0	1	L01D.profile.d50
S phase of mitotic cell cycle	GO:0000084	Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.	18	0.0444949819548129	0	0	1	L01D.profile.d50
G2 phase of mitotic cell cycle	GO:0000085	Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis.	16	0.0395510950709448	0	0	1	L01D.profile.d50
G2/M transition of mitotic cell cycle	GO:0000086	Progression from G2 phase to M phase of the mitotic cell cycle.	26	0.0642705294902853	0	0	1	L01D.profile.d50
M phase of mitotic cell cycle	GO:0000087	Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place.	290	0.716863598160874	5	6.9748275862069	0.000851022896466412	L01D.profile.d50
sulfur amino acid metabolic process	GO:0000096	The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.	28	0.0692144163741534	0	0	1	L01D.profile.d50
sulfur amino acid biosynthetic process	GO:0000097	The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.	17	0.0420230385128788	0	0	1	L01D.profile.d50
negative regulation of transcription from RNA polymerase II promoter	GO:0000122	Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.	201	0.496860631828744	0	0	1	L01D.profile.d50
two-component signal transduction system (phosphorelay)	GO:0000160	A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.	7	0.0173036040935383	0	0	1	L01D.profile.d50
MAPKKK cascade	GO:0000165	Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.	229	0.566075048202897	0	0	1	L01D.profile.d50
mRNA catabolic process, nonsense-mediated decay	GO:0000184	The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	30	0.0741583032580215	0	0	1	L01D.profile.d50
activation of MAPKK activity	GO:0000186	The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.	20	0.049438868838681	0	0	1	L01D.profile.d50
activation of MAPK activity	GO:0000187	The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.	68	0.168092154051515	0	0	1	L01D.profile.d50
inactivation of MAPK activity	GO:0000188	Any process that terminates the activity of the active enzyme MAP kinase.	28	0.0692144163741534	0	0	1	L01D.profile.d50
protein polyubiquitination	GO:0000209	Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain.	19	0.0469669253967469	0	0	1	L01D.profile.d50
microtubule cytoskeleton organization and biogenesis	GO:0000226	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.	101	0.249666287635339	1	4.00534653465346	0.221180040732672	L01D.profile.d50
spliceosome assembly	GO:0000245	The aggregation and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.	59	0.145844663074109	0	0	1	L01D.profile.d50
peptidoglycan metabolic process	GO:0000270	The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.	30	0.0741583032580215	0	0	1	L01D.profile.d50
polysaccharide biosynthetic process	GO:0000271	The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.	27	0.0667424729322193	0	0	1	L01D.profile.d50
polysaccharide catabolic process	GO:0000272	The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.	17	0.0420230385128788	0	0	1	L01D.profile.d50
mitotic cell cycle	GO:0000278	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M.	421	1.04068818905423	5	4.80451306413302	0.00425945215108903	L01D.profile.d50
M phase	GO:0000279	Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis.	375	0.926978790725268	6	6.47264	0.000389607400992327	L01D.profile.d50
response to reactive oxygen species	GO:0000302	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.	30	0.0741583032580215	0	0	1	L01D.profile.d50
RNA splicing, via transesterification reactions	GO:0000375	Splicing of RNA via a series of two transesterification reactions.	117	0.289217382706284	0	0	1	L01D.profile.d50
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.	117	0.289217382706284	0	0	1	L01D.profile.d50
spliceosomal snRNP biogenesis	GO:0000387	The formation and assembly from one or more snRNA and multiple protein components of a ribonucleoprotein complex that in involved in formation of the spliceosome.	8	0.0197755475354724	0	0	1	L01D.profile.d50
nuclear mRNA splicing, via spliceosome	GO:0000398	The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	117	0.289217382706284	0	0	1	L01D.profile.d50
embryonic axis specification	GO:0000578	Axis specification in the embryo.	10	0.0247194344193405	0	0	1	L01D.profile.d50
telomere maintenance	GO:0000723	The maintenance of proper telomeric length and structure by processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences.	41	0.101349681119296	0	0	1	L01D.profile.d50
double-strand break repair via homologous recombination	GO:0000724	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.	16	0.0395510950709448	0	0	1	L01D.profile.d50
recombinational repair	GO:0000725	The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.	16	0.0395510950709448	0	0	1	L01D.profile.d50
non-recombinational repair	GO:0000726	The repair of damaged DNA that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.	15	0.0370791516290107	0	0	1	L01D.profile.d50
sister chromatid segregation	GO:0000819	The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.	38	0.0939338507934939	1	10.6457894736842	0.089762880067684	L01D.profile.d50
cell morphogenesis	GO:0000902	Any process that modulates the mass, volume, or shape of a cell.	668	1.65125821921194	3	1.81679640718563	0.229855696052687	L01D.profile.d50
cellular morphogenesis during differentiation	GO:0000904	The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.	214	0.528995896573886	1	1.8903738317757	0.411189453587197	L01D.profile.d50
cytokinesis	GO:0000910	A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.	40	0.098877737677362	0	0	1	L01D.profile.d50
skeletal development	GO:0001501	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).	327	0.808325505512434	1	1.237125382263	0.554842097404517	L01D.profile.d50
cartilage condensation	GO:0001502	The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.	20	0.049438868838681	0	0	1	L01D.profile.d50
ossification	GO:0001503	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.	141	0.348544025312701	1	2.8690780141844	0.294589606515172	L01D.profile.d50
neurotransmitter uptake	GO:0001504	The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of neurotransmitter levels	GO:0001505	Any process that modulates levels of neurotransmitter.	116	0.28674543926435	0	0	1	L01D.profile.d50
regulation of action potential	GO:0001508	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination.	60	0.148316606516043	0	0	1	L01D.profile.d50
selenocysteine incorporation	GO:0001514	The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation, it is not a posttranslational modification of peptidyl-cysteine.	6	0.0148316606516043	0	0	1	L01D.profile.d50
prostaglandin biosynthetic process	GO:0001516	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.	16	0.0395510950709448	0	0	1	L01D.profile.d50
retinoid metabolic process	GO:0001523	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.	12	0.0296633213032086	0	0	1	L01D.profile.d50
angiogenesis	GO:0001525	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	212	0.524052009690018	0	0	1	L01D.profile.d50
ciliary or flagellar motility	GO:0001539	Locomotion due to movement of cilia or flagella.	10	0.0247194344193405	0	0	1	L01D.profile.d50
ovarian follicle development	GO:0001541	The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	26	0.0642705294902853	0	0	1	L01D.profile.d50
ovulation (sensu Mammalia)	GO:0001542	The process leading to the rupture of the follicle, releasing the centrally located oocyte. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674).	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of cell growth	GO:0001558	Any process that modulates the frequency, rate or extent of cell growth.	207	0.511692292480348	1	1.95429951690821	0.400899415254256	L01D.profile.d50
blood vessel development	GO:0001568	The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.	283	0.699559994067336	1	1.42946996466431	0.503626225271111	L01D.profile.d50
patterning of blood vessels	GO:0001569	The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.	18	0.0444949819548129	0	0	1	L01D.profile.d50
vasculogenesis	GO:0001570	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.	30	0.0741583032580215	0	0	1	L01D.profile.d50
ganglioside metabolic process	GO:0001573	The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.	17	0.0420230385128788	0	0	1	L01D.profile.d50
microtubule bundle formation	GO:0001578	A process that results in a parallel arrangement of microtubules.	10	0.0247194344193405	0	0	1	L01D.profile.d50
osteoblast differentiation	GO:0001649	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.	28	0.0692144163741534	1	14.4478571428571	0.0669533735976265	L01D.profile.d50
eye development	GO:0001654	The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.	48	0.118653285212834	0	0	1	L01D.profile.d50
urogenital system development	GO:0001655	The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.	59	0.145844663074109	0	0	1	L01D.profile.d50
metanephros development	GO:0001656	The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is the excretory organ of the fetus which develops into the kidney and is formed from the rear portion of the nephrogenic cord.	41	0.101349681119296	0	0	1	L01D.profile.d50
ureteric bud development	GO:0001657	The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.	35	0.0865180204676917	0	0	1	L01D.profile.d50
ureteric bud branching	GO:0001658	Branching of the ureteric bud.	20	0.049438868838681	0	0	1	L01D.profile.d50
thermoregulation	GO:0001659	A homeostatic process by which an organism modulates its internal body temperature.	12	0.0296633213032086	0	0	1	L01D.profile.d50
response to hypoxia	GO:0001666	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension.	43	0.106293568003164	0	0	1	L01D.profile.d50
long-chain fatty acid metabolic process	GO:0001676	The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.	9	0.0222474909774064	0	0	1	L01D.profile.d50
in utero embryonic development	GO:0001701	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth.	70	0.173036040935383	0	0	1	L01D.profile.d50
gastrulation with mouth forming second	GO:0001702	A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. In Deuterostomes the initial blastopore becomes the anus and the mouth forms second.	19	0.0469669253967469	0	0	1	L01D.profile.d50
formation of primary germ layer	GO:0001704	The formation of the ectoderm, mesoderm and endoderm during gastrulation.	40	0.098877737677362	0	0	1	L01D.profile.d50
mesoderm formation	GO:0001707	The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.	38	0.0939338507934939	0	0	1	L01D.profile.d50
cell fate specification	GO:0001708	The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.	22	0.0543827557225491	0	0	1	L01D.profile.d50
cell fate determination	GO:0001709	Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.	48	0.118653285212834	0	0	1	L01D.profile.d50
mesodermal cell fate commitment	GO:0001710	The process by which a cell becomes committed to become part of the mesoderm.	9	0.0222474909774064	0	0	1	L01D.profile.d50
morphogenesis of a polarized epithelium	GO:0001738	The process by which the anatomical structures of polarized epithelium are generated and organized. Morphogenesis pertains to the creation of form. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.	6	0.0148316606516043	0	0	1	L01D.profile.d50
eye photoreceptor cell differentiation	GO:0001754	The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.	19	0.0469669253967469	0	0	1	L01D.profile.d50
neural crest cell migration	GO:0001755	The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.	26	0.0642705294902853	0	0	1	L01D.profile.d50
somitogenesis	GO:0001756	The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.	24	0.0593266426064172	0	0	1	L01D.profile.d50
induction of an organ	GO:0001759	The close range interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.	17	0.0420230385128788	0	0	1	L01D.profile.d50
morphogenesis of a branching structure	GO:0001763	The process by which the anatomical structures of branches are generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.	66	0.163148267167647	0	0	1	L01D.profile.d50
neuron migration	GO:0001764	The characteristic movement of immature neurons from germinal zones to specific positions where they will reside as they mature.	68	0.168092154051515	1	5.94911764705882	0.154899948263562	L01D.profile.d50
cell activation	GO:0001775	A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.	330	0.815741335838236	1	1.22587878787879	0.558135159184445	L01D.profile.d50
leukocyte homeostasis	GO:0001776	The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.	21	0.051910812280615	0	0	1	L01D.profile.d50
B cell homeostasis	GO:0001782	The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.	8	0.0197755475354724	0	0	1	L01D.profile.d50
cytokine production	GO:0001816	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.378207346615909	1	2.6440522875817	0.315232265525236	L01D.profile.d50
regulation of cytokine production	GO:0001817	Any process that modulates the frequency, rate, or extent of production of a cytokine.	39	0.0964057942354279	1	10.3728205128205	0.0920129347469056	L01D.profile.d50
positive regulation of cytokine production	GO:0001819	Any process that activates or increases the frequency, rate or extent of production of a cytokine.	27	0.0667424729322193	0	0	1	L01D.profile.d50
kidney development	GO:0001822	The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.	52	0.128541058980571	0	0	1	L01D.profile.d50
blastocyst development	GO:0001824	The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.	15	0.0370791516290107	0	0	1	L01D.profile.d50
release of cytochrome c from mitochondria	GO:0001836	The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.	22	0.0543827557225491	1	18.3881818181818	0.0529942199196842	L01D.profile.d50
embryonic epithelial tube formation	GO:0001838	The morphogenesis of an embryonic epithelium into a tube-shaped structure.	35	0.0865180204676917	0	0	1	L01D.profile.d50
neural plate morphogenesis	GO:0001839	The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.	32	0.0791021901418896	0	0	1	L01D.profile.d50
neural plate development	GO:0001840	The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.	34	0.0840460770257577	0	0	1	L01D.profile.d50
neural tube formation	GO:0001841	The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.	31	0.0766302466999555	0	0	1	L01D.profile.d50
neural tube closure	GO:0001843	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.	23	0.0568546991644831	0	0	1	L01D.profile.d50
liver development	GO:0001889	The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.	9	0.0222474909774064	0	0	1	L01D.profile.d50
placenta development	GO:0001890	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	L01D.profile.d50
tissue homeostasis	GO:0001894	A homeostatic process involved in the maintenance of an internal equilibrium within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.	29	0.0716863598160874	0	0	1	L01D.profile.d50
cell killing	GO:0001906	Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.	26	0.0642705294902853	0	0	1	L01D.profile.d50
leukocyte mediated cytotoxicity	GO:0001909	The directed killing of a target cell by a leukocyte.	21	0.051910812280615	0	0	1	L01D.profile.d50
regulation of protein amino acid phosphorylation	GO:0001932	Any process that modulates the frequency, rate or extent of addition of phosphoric groups into an amino acid in a protein.	63	0.155732436841845	0	0	1	L01D.profile.d50
positive regulation of protein amino acid phosphorylation	GO:0001934	Any process that activates or increases the frequency, rate or extent of addition of phosphoric groups to amino acids within a protein.	31	0.0766302466999555	0	0	1	L01D.profile.d50
endothelial cell proliferation	GO:0001935	The multiplication or reproduction of endothelial cells, resulting in the rapid expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.	28	0.0692144163741534	0	0	1	L01D.profile.d50
regulation of endothelial cell proliferation	GO:0001936	Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.	23	0.0568546991644831	0	0	1	L01D.profile.d50
negative regulation of endothelial cell proliferation	GO:0001937	Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.	17	0.0420230385128788	0	0	1	L01D.profile.d50
hair follicle development	GO:0001942	The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.	29	0.0716863598160874	0	0	1	L01D.profile.d50
vasculature development	GO:0001944	The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.	288	0.711919711277006	1	1.40465277777778	0.509731008699558	L01D.profile.d50
heart looping	GO:0001947	The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceeding their future integration.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of cell-matrix adhesion	GO:0001952	Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.	12	0.0296633213032086	0	0	1	L01D.profile.d50
blood vessel remodeling	GO:0001974	The reorganization or renovation of existing blood vessels.	8	0.0197755475354724	0	0	1	L01D.profile.d50
fast regulation of arterial pressure	GO:0001976	The process that modulates the force with which blood moves through the circulatory system that responds to a change within minutes or hours.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of blood pressure by hormones	GO:0001990	The process by which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.	13	0.0321352647451426	0	0	1	L01D.profile.d50
morphogenesis of an epithelium	GO:0002009	The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.	113	0.279329608938548	1	3.58	0.24397090828704	L01D.profile.d50
cardiac inotropy	GO:0002026	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.	11	0.0271913778612745	0	0	1	L01D.profile.d50
somatic diversification of immune receptors	GO:0002200	The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.	34	0.0840460770257577	0	0	1	L01D.profile.d50
somatic recombination of immunoglobulin genes during immune response	GO:0002204	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.	30	0.0741583032580215	0	0	1	L01D.profile.d50
somatic diversification of immunoglobulins during immune response	GO:0002208	The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.	30	0.0741583032580215	0	0	1	L01D.profile.d50
natural killer cell mediated immunity	GO:0002228	The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.	18	0.0444949819548129	0	0	1	L01D.profile.d50
adaptive immune response	GO:0002250	An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).	119	0.294161269590152	0	0	1	L01D.profile.d50
immune effector process	GO:0002252	Any process of the immune system that occurs as part of an immune response.	143	0.353487912196569	0	0	1	L01D.profile.d50
activation of immune response	GO:0002253	Any process that initiates an immune response.	92	0.227418796657932	1	4.39717391304348	0.203637140954062	L01D.profile.d50
lymphocyte homeostasis	GO:0002260	The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.	19	0.0469669253967469	0	0	1	L01D.profile.d50
cell activation during immune response	GO:0002263	A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.	17	0.0420230385128788	0	0	1	L01D.profile.d50
myeloid leukocyte activation	GO:0002274	A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.	43	0.106293568003164	0	0	1	L01D.profile.d50
lymphocyte activation during immune response	GO:0002285	A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.	17	0.0420230385128788	0	0	1	L01D.profile.d50
T cell activation during immune response	GO:0002286	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.	17	0.0420230385128788	0	0	1	L01D.profile.d50
T cell differentiation during immune response	GO:0002292	The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
alpha-beta T cell differentiation during immune response	GO:0002293	The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
CD4-positive, alpha-beta T cell differentiation during immune response	GO:0002294	The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
leukocyte activation during immune response	GO:0002366	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.	17	0.0420230385128788	0	0	1	L01D.profile.d50
cytokine production during immune response	GO:0002367	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	14	0.0346072081870767	0	0	1	L01D.profile.d50
immune system process	GO:0002376	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.	1134	2.80318386315321	2	0.71347442680776	0.769842365897026	L01D.profile.d50
immunoglobulin production	GO:0002377	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	39	0.0964057942354279	0	0	1	L01D.profile.d50
immunoglobulin production during immune response	GO:0002381	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	30	0.0741583032580215	0	0	1	L01D.profile.d50
immune response-activating cell surface receptor signaling pathway	GO:0002429	A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.	48	0.118653285212834	1	8.42791666666667	0.11201477926423	L01D.profile.d50
production of molecular mediator of immune response	GO:0002440	The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.	51	0.126069115538636	0	0	1	L01D.profile.d50
leukocyte mediated immunity	GO:0002443	Any process involved in the carrying out of an immune response by a leukocyte.	124	0.306520986799822	0	0	1	L01D.profile.d50
lymphocyte mediated immunity	GO:0002449	Any process involved in the carrying out of an immune response by a lymphocyte.	116	0.28674543926435	0	0	1	L01D.profile.d50
humoral immune response mediated by circulating immunoglobulin	GO:0002455	An immune response dependent upon secreted immunoglobulin.	38	0.0939338507934939	0	0	1	L01D.profile.d50
T cell mediated immunity	GO:0002456	Any process involved in the carrying out of an immune response by a T cell.	26	0.0642705294902853	0	0	1	L01D.profile.d50
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).	119	0.294161269590152	0	0	1	L01D.profile.d50
antigen processing and presentation of peptide antigen via MHC class I	GO:0002474	The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.	60	0.148316606516043	0	0	1	L01D.profile.d50
antigen processing and presentation of endogenous peptide antigen	GO:0002483	The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.	8	0.0197755475354724	0	0	1	L01D.profile.d50
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.	29	0.0716863598160874	0	0	1	L01D.profile.d50
immune system development	GO:0002520	The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.	346	0.855292430909181	0	0	1	L01D.profile.d50
leukocyte differentiation	GO:0002521	The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages.	183	0.452365649873931	0	0	1	L01D.profile.d50
acute inflammatory response	GO:0002526	Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.	96	0.237306570425669	0	0	1	L01D.profile.d50
activation of plasma proteins during acute inflammatory response	GO:0002541	Any process activating plasma proteins via proteolysis during an acute inflammatory response.	44	0.108765511445098	0	0	1	L01D.profile.d50
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.	31	0.0766302466999555	0	0	1	L01D.profile.d50
myeloid leukocyte differentiation	GO:0002573	The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.	66	0.163148267167647	0	0	1	L01D.profile.d50
regulation of immune system process	GO:0002682	Any process that modulates the frequency, rate, or extent of an immune system process.	134	0.331240421219163	1	3.0189552238806	0.282261872180867	L01D.profile.d50
negative regulation of immune system process	GO:0002683	Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.	20	0.049438868838681	0	0	1	L01D.profile.d50
positive regulation of immune system process	GO:0002684	Any process that activates or increases the frequency, rate, or extent of an immune system process.	109	0.269441835170811	1	3.71137614678899	0.236449037089975	L01D.profile.d50
regulation of immune effector process	GO:0002697	Any process that modulates the frequency, rate, or extent of an immune effector process.	20	0.049438868838681	0	0	1	L01D.profile.d50
positive regulation of immune effector process	GO:0002699	Any process that activates or increases the frequency, rate, or extent of an immune effector process.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of production of molecular mediator of immune response	GO:0002700	Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of leukocyte mediated immunity	GO:0002703	Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.	17	0.0420230385128788	0	0	1	L01D.profile.d50
positive regulation of leukocyte mediated immunity	GO:0002705	Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of lymphocyte mediated immunity	GO:0002706	Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.	17	0.0420230385128788	0	0	1	L01D.profile.d50
positive regulation of lymphocyte mediated immunity	GO:0002708	Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of T cell mediated immunity	GO:0002709	Any process that modulates the frequency, rate, or extent of T cell mediated immunity.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of cytokine production during immune response	GO:0002718	Any process that modulates the frequency, rate, or extent of cytokine production during immune response.	14	0.0346072081870767	0	0	1	L01D.profile.d50
immune response-activating signal transduction	GO:0002757	The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response.	48	0.118653285212834	1	8.42791666666667	0.11201477926423	L01D.profile.d50
regulation of myeloid leukocyte differentiation	GO:0002761	Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.	40	0.098877737677362	0	0	1	L01D.profile.d50
negative regulation of myeloid leukocyte differentiation	GO:0002762	Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of myeloid leukocyte differentiation	GO:0002763	Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.	23	0.0568546991644831	0	0	1	L01D.profile.d50
immune response-regulating signal transduction	GO:0002764	The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.	52	0.128541058980571	1	7.77961538461538	0.12076247362875	L01D.profile.d50
immune response-regulating cell surface receptor signaling pathway	GO:0002768	A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.	52	0.128541058980571	1	7.77961538461538	0.12076247362875	L01D.profile.d50
peptide secretion	GO:0002790	The regulated release of a peptide from a cell or group of cells.	27	0.0667424729322193	0	0	1	L01D.profile.d50
regulation of adaptive immune response	GO:0002819	Any process that modulates the frequency, rate, or extent of an adaptive immune response.	23	0.0568546991644831	0	0	1	L01D.profile.d50
positive regulation of adaptive immune response	GO:0002821	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	GO:0002822	Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	23	0.0568546991644831	0	0	1	L01D.profile.d50
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	13	0.0321352647451426	0	0	1	L01D.profile.d50
generation of a signal involved in cell-cell signaling	GO:0003001	The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.	96	0.237306570425669	0	0	1	L01D.profile.d50
regionalization	GO:0003002	The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.	153	0.378207346615909	1	2.6440522875817	0.315232265525236	L01D.profile.d50
reproductive developmental process	GO:0003006	A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.	116	0.28674543926435	0	0	1	L01D.profile.d50
heart morphogenesis	GO:0003007	The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	7	0.0173036040935383	0	0	1	L01D.profile.d50
detection of calcium ion	GO:0005513	The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.	9	0.0222474909774064	0	0	1	L01D.profile.d50
carbohydrate metabolic process	GO:0005975	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	593	1.46586246106689	0	0	1	L01D.profile.d50
polysaccharide metabolic process	GO:0005976	The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages.	70	0.173036040935383	0	0	1	L01D.profile.d50
glycogen metabolic process	GO:0005977	The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages.	43	0.106293568003164	0	0	1	L01D.profile.d50
glycogen biosynthetic process	GO:0005978	The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.	14	0.0346072081870767	0	0	1	L01D.profile.d50
glycogen catabolic process	GO:0005980	The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.	7	0.0173036040935383	0	0	1	L01D.profile.d50
monosaccharide metabolic process	GO:0005996	The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.	220	0.543827557225491	0	0	1	L01D.profile.d50
fructose metabolic process	GO:0006000	The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.	20	0.049438868838681	0	0	1	L01D.profile.d50
fucose metabolic process	GO:0006004	The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose.	27	0.0667424729322193	0	0	1	L01D.profile.d50
glucose metabolic process	GO:0006006	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.	150	0.370791516290107	0	0	1	L01D.profile.d50
glucose catabolic process	GO:0006007	The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.	86	0.212587136006328	0	0	1	L01D.profile.d50
galactose metabolic process	GO:0006012	The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.	13	0.0321352647451426	0	0	1	L01D.profile.d50
mannose metabolic process	GO:0006013	The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.	12	0.0296633213032086	0	0	1	L01D.profile.d50
inositol metabolic process	GO:0006020	The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.	7	0.0173036040935383	0	0	1	L01D.profile.d50
aminoglycan metabolic process	GO:0006022	The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.	64	0.158204380283779	0	0	1	L01D.profile.d50
aminoglycan biosynthetic process	GO:0006023	The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.	24	0.0593266426064172	0	0	1	L01D.profile.d50
glycosaminoglycan biosynthetic process	GO:0006024	The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.	23	0.0568546991644831	0	0	1	L01D.profile.d50
aminoglycan catabolic process	GO:0006026	The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.	7	0.0173036040935383	0	0	1	L01D.profile.d50
glycosaminoglycan catabolic process	GO:0006027	The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.	7	0.0173036040935383	0	0	1	L01D.profile.d50
proteoglycan metabolic process	GO:0006029	The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.	33	0.0815741335838236	0	0	1	L01D.profile.d50
chitin metabolic process	GO:0006030	The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues.	10	0.0247194344193405	0	0	1	L01D.profile.d50
chitin catabolic process	GO:0006032	The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues.	9	0.0222474909774064	0	0	1	L01D.profile.d50
amino sugar metabolic process	GO:0006040	The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.	33	0.0815741335838236	0	0	1	L01D.profile.d50
glucosamine metabolic process	GO:0006041	The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.	26	0.0642705294902853	0	0	1	L01D.profile.d50
glucosamine catabolic process	GO:0006043	The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.	10	0.0247194344193405	0	0	1	L01D.profile.d50
N-acetylglucosamine metabolic process	GO:0006044	The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein.	25	0.0617985860483512	0	0	1	L01D.profile.d50
N-acetylglucosamine catabolic process	GO:0006046	The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein.	9	0.0222474909774064	0	0	1	L01D.profile.d50
alcohol metabolic process	GO:0006066	The chemical reactions and pathways involving alcohols, any of a class of alkyl compounds containing a hydroxyl group.	408	1.00855292430909	0	0	1	L01D.profile.d50
glycerol metabolic process	GO:0006071	The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.	24	0.0593266426064172	0	0	1	L01D.profile.d50
glycerol-3-phosphate metabolic process	GO:0006072	The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.	14	0.0346072081870767	0	0	1	L01D.profile.d50
glucan metabolic process	GO:0006073	The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.	44	0.108765511445098	0	0	1	L01D.profile.d50
aldehyde metabolic process	GO:0006081	The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O.	24	0.0593266426064172	0	0	1	L01D.profile.d50
organic acid metabolic process	GO:0006082	The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.	681	1.68339348395709	0	0	1	L01D.profile.d50
acetyl-CoA metabolic process	GO:0006084	The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.	44	0.108765511445098	0	0	1	L01D.profile.d50
pyruvate metabolic process	GO:0006090	The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.	32	0.0791021901418896	0	0	1	L01D.profile.d50
generation of precursor metabolites and energy	GO:0006091	The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.	646	1.5968754634894	0	0	1	L01D.profile.d50
gluconeogenesis	GO:0006094	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.	31	0.0766302466999555	0	0	1	L01D.profile.d50
glycolysis	GO:0006096	The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle.	69	0.170564097493449	0	0	1	L01D.profile.d50
pentose-phosphate shunt	GO:0006098	The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.	14	0.0346072081870767	0	0	1	L01D.profile.d50
tricarboxylic acid cycle	GO:0006099	A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.	36	0.0889899639096258	0	0	1	L01D.profile.d50
tricarboxylic acid cycle intermediate metabolic process	GO:0006100	The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle.	38	0.0939338507934939	0	0	1	L01D.profile.d50
malate metabolic process	GO:0006108	The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of carbohydrate metabolic process	GO:0006109	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.	10	0.0247194344193405	0	0	1	L01D.profile.d50
energy reserve metabolic process	GO:0006112		66	0.163148267167647	0	0	1	L01D.profile.d50
electron transport	GO:0006118	The transport of electrons from an electron donor to an electron acceptor.	423	1.0456320759381	0	0	1	L01D.profile.d50
oxidative phosphorylation	GO:0006119	The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.	105	0.259554061403075	0	0	1	L01D.profile.d50
mitochondrial electron transport, NADH to ubiquinone	GO:0006120	The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.	38	0.0939338507934939	0	0	1	L01D.profile.d50
mitochondrial electron transport, ubiquinol to cytochrome c	GO:0006122	The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.	4	0.00988777376773619	0	0	1	L01D.profile.d50
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	GO:0006139	The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	4320	10.6787956691551	20	1.87287037037037	0.0068226727170541	L01D.profile.d50
regulation of nucleotide metabolic process	GO:0006140	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.	13	0.0321352647451426	0	0	1	L01D.profile.d50
purine base metabolic process	GO:0006144	The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.	16	0.0395510950709448	0	0	1	L01D.profile.d50
purine nucleotide metabolic process	GO:0006163	The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	115	0.284273495822416	0	0	1	L01D.profile.d50
purine nucleotide biosynthetic process	GO:0006164	The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	100	0.247194344193405	0	0	1	L01D.profile.d50
cAMP biosynthetic process	GO:0006171	The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).	28	0.0692144163741534	0	0	1	L01D.profile.d50
cGMP biosynthetic process	GO:0006182	The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.	15	0.0370791516290107	0	0	1	L01D.profile.d50
GTP biosynthetic process	GO:0006183	The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.	12	0.0296633213032086	0	0	1	L01D.profile.d50
pyrimidine base metabolic process	GO:0006206	The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases.	17	0.0420230385128788	0	0	1	L01D.profile.d50
pyrimidine nucleoside metabolic process	GO:0006213	The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).	8	0.0197755475354724	0	0	1	L01D.profile.d50
pyrimidine nucleotide metabolic process	GO:0006220	The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	39	0.0964057942354279	0	0	1	L01D.profile.d50
pyrimidine nucleotide biosynthetic process	GO:0006221	The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	21	0.051910812280615	0	0	1	L01D.profile.d50
UTP biosynthetic process	GO:0006228	The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate.	9	0.0222474909774064	0	0	1	L01D.profile.d50
CTP biosynthetic process	GO:0006241	The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.	10	0.0247194344193405	0	0	1	L01D.profile.d50
DNA metabolic process	GO:0006259	The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.	922	2.27913185346319	7	3.07134490238612	0.00884740723182626	L01D.profile.d50
DNA replication	GO:0006260	The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.	277	0.684728333415731	1	1.46043321299639	0.49620006069683	L01D.profile.d50
DNA-dependent DNA replication	GO:0006261	The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.	140	0.346072081870767	1	2.88957142857143	0.292841550824324	L01D.profile.d50
DNA topological change	GO:0006265	The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.	12	0.0296633213032086	0	0	1	L01D.profile.d50
DNA ligation	GO:0006266	The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.	11	0.0271913778612745	0	0	1	L01D.profile.d50
DNA unwinding during replication	GO:0006268	The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.	24	0.0593266426064172	0	0	1	L01D.profile.d50
DNA replication initiation	GO:0006270	The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.	44	0.108765511445098	1	9.19409090909091	0.103180052494472	L01D.profile.d50
regulation of DNA replication	GO:0006275	Any process that modulates the frequency, rate or extent of DNA replication.	38	0.0939338507934939	0	0	1	L01D.profile.d50
RNA-dependent DNA replication	GO:0006278	The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands.	2	0.0049438868838681	0	0	1	L01D.profile.d50
DNA repair	GO:0006281	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.	325	0.803381618628566	3	3.73421538461538	0.0476959111205779	L01D.profile.d50
regulation of DNA repair	GO:0006282	Any process that modulates the frequency, rate or extent of DNA repair.	11	0.0271913778612745	0	0	1	L01D.profile.d50
transcription-coupled nucleotide-excision repair	GO:0006283	The preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the general nucleotide excision repair pathway.	6	0.0148316606516043	0	0	1	L01D.profile.d50
base-excision repair	GO:0006284	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.	41	0.101349681119296	1	9.86682926829268	0.0964963718305929	L01D.profile.d50
nucleotide-excision repair	GO:0006289	In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).	30	0.0741583032580215	0	0	1	L01D.profile.d50
mismatch repair	GO:0006298	A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.	34	0.0840460770257577	0	0	1	L01D.profile.d50
postreplication repair	GO:0006301	Pathways for DNA repair which occur after DNA has replicated, e.g. mismatch repair, and which involve translesion synthesis (TLS-type) DNA polymerases.	10	0.0247194344193405	0	0	1	L01D.profile.d50
double-strand break repair	GO:0006302	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.	51	0.126069115538636	0	0	1	L01D.profile.d50
double-strand break repair via nonhomologous end joining	GO:0006303	The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.	15	0.0370791516290107	0	0	1	L01D.profile.d50
DNA modification	GO:0006304	The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.	25	0.0617985860483512	0	0	1	L01D.profile.d50
DNA alkylation	GO:0006305	The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.	18	0.0444949819548129	0	0	1	L01D.profile.d50
DNA methylation	GO:0006306	The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.	18	0.0444949819548129	0	0	1	L01D.profile.d50
DNA catabolic process	GO:0006308	The chemical reactions and pathways resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.	24	0.0593266426064172	1	16.8558333333333	0.0576703226918033	L01D.profile.d50
DNA fragmentation during apoptosis	GO:0006309	The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.	15	0.0370791516290107	1	26.9693333333333	0.0364443706720598	L01D.profile.d50
DNA recombination	GO:0006310	The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.	158	0.39056706382558	1	2.56037974683544	0.323654061620407	L01D.profile.d50
mitotic recombination	GO:0006312	The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles.	13	0.0321352647451426	1	31.1184615384615	0.0316629388039029	L01D.profile.d50
transposition, DNA-mediated	GO:0006313	Any process involved in a type of transpositional recombination which occurs via a DNA intermediate.	2	0.0049438868838681	0	0	1	L01D.profile.d50
DNA packaging	GO:0006323	Any process by which DNA and associated proteins are formed into a compact, orderly structure.	371	0.917091016957532	2	2.18080862533693	0.233739200289932	L01D.profile.d50
establishment and/or maintenance of chromatin architecture	GO:0006325	The specification, formation and maintenance of the physical structure of eukaryotic chromatin.	365	0.902259356305928	2	2.21665753424658	0.228299971693476	L01D.profile.d50
chromatin assembly or disassembly	GO:0006333	The formation or destruction of chromatin structures.	171	0.422702328570722	0	0	1	L01D.profile.d50
nucleosome assembly	GO:0006334	The aggregation and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.	93	0.229890740099867	0	0	1	L01D.profile.d50
nucleosome disassembly	GO:0006337	The disassembly of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.	12	0.0296633213032086	0	0	1	L01D.profile.d50
chromatin remodeling	GO:0006338	Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.	84	0.20764324912246	0	0	1	L01D.profile.d50
chromatin silencing	GO:0006342	Repression of transcription by conversion of large regions of DNA into an inaccessible state often called heterochromatin.	15	0.0370791516290107	0	0	1	L01D.profile.d50
imprinting	GO:0006349	Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself.	10	0.0247194344193405	0	0	1	L01D.profile.d50
transcription	GO:0006350	The synthesis of either RNA on a template of DNA or DNA on a template of RNA.	2826	6.98571216690562	15	2.14723991507431	0.0055560670620598	L01D.profile.d50
transcription, DNA-dependent	GO:0006351	The synthesis of RNA on a template of DNA.	2588	6.39738962772532	13	2.03207882534776	0.0141598078750196	L01D.profile.d50
transcription initiation	GO:0006352	Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.	61	0.150788549957977	0	0	1	L01D.profile.d50
transcription termination	GO:0006353	The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.	8	0.0197755475354724	0	0	1	L01D.profile.d50
RNA elongation	GO:0006354	The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase.	17	0.0420230385128788	0	0	1	L01D.profile.d50
regulation of transcription, DNA-dependent	GO:0006355	Any process that modulates the frequency, rate or extent of DNA-dependent transcription.	2510	6.20457803925446	13	2.09522709163347	0.0112802521989234	L01D.profile.d50
regulation of transcription from RNA polymerase II promoter	GO:0006357	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	701	1.73283235279577	5	2.88544935805991	0.0315624005861307	L01D.profile.d50
regulation of transcription from RNA polymerase III promoter	GO:0006359	Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter.	11	0.0271913778612745	0	0	1	L01D.profile.d50
transcription from RNA polymerase I promoter	GO:0006360	The synthesis of RNA from a DNA template by RNA polymerase I (Pol I), originating at a Pol I-specific promoter.	17	0.0420230385128788	0	0	1	L01D.profile.d50
rRNA processing	GO:0006364	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.	77	0.190339645028922	1	5.25376623376623	0.173516468788228	L01D.profile.d50
35S primary transcript processing	GO:0006365		6	0.0148316606516043	0	0	1	L01D.profile.d50
transcription from RNA polymerase II promoter	GO:0006366	The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	997	2.46452761160825	5	2.02878635907723	0.103884947223678	L01D.profile.d50
transcription initiation from RNA polymerase II promoter	GO:0006367	Processes involved in starting transcription from the RNA polymerase II promoter.	28	0.0692144163741534	0	0	1	L01D.profile.d50
RNA elongation from RNA polymerase II promoter	GO:0006368	The extension of an RNA molecule after transcription initiation at an RNA polymerase II-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.	13	0.0321352647451426	0	0	1	L01D.profile.d50
mRNA splice site selection	GO:0006376	Selection of a splice site by components of the assembling spliceosome.	30	0.0741583032580215	0	0	1	L01D.profile.d50
mRNA polyadenylation	GO:0006378	The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.	21	0.051910812280615	0	0	1	L01D.profile.d50
mRNA cleavage	GO:0006379	Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.	12	0.0296633213032086	0	0	1	L01D.profile.d50
mRNA editing	GO:0006381	The insertion, deletion or substitution of nucleotides within nascent mRNA transcripts to produce mRNA molecules with sequences that differ from those coded genetically.	4	0.00988777376773619	0	0	1	L01D.profile.d50
transcription from RNA polymerase III promoter	GO:0006383	The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter.	49	0.121125228654768	0	0	1	L01D.profile.d50
RNA processing	GO:0006396	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.	622	1.53754882088298	1	0.650385852090032	0.785501455309278	L01D.profile.d50
mRNA processing	GO:0006397	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.	382	0.944282394818807	0	0	1	L01D.profile.d50
tRNA metabolic process	GO:0006399	The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.	100	0.247194344193405	0	0	1	L01D.profile.d50
RNA catabolic process	GO:0006401	The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.	64	0.158204380283779	0	0	1	L01D.profile.d50
mRNA catabolic process	GO:0006402	The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.	41	0.101349681119296	0	0	1	L01D.profile.d50
RNA localization	GO:0006403	A process by which RNA is transported to, or maintained in, a specific location.	92	0.227418796657932	0	0	1	L01D.profile.d50
RNA export from nucleus	GO:0006405	The directed movement of RNA from the nucleus to the cytoplasm.	40	0.098877737677362	0	0	1	L01D.profile.d50
mRNA export from nucleus	GO:0006406	The directed movement of mRNA from the nucleus to the cytoplasm.	30	0.0741583032580215	0	0	1	L01D.profile.d50
translation	GO:0006412	The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.	570	1.40900776190241	3	2.12915789473684	0.16850560735083	L01D.profile.d50
translational initiation	GO:0006413	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	79	0.19528353191279	0	0	1	L01D.profile.d50
translational elongation	GO:0006414	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.	29	0.0716863598160874	0	0	1	L01D.profile.d50
translational termination	GO:0006415	The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of translation	GO:0006417	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.	211	0.521580066248084	2	3.83450236966825	0.0966339021332214	L01D.profile.d50
tRNA aminoacylation for protein translation	GO:0006418	The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.	56	0.138428832748307	0	0	1	L01D.profile.d50
regulation of translational initiation	GO:0006446	Any process that modulates the frequency, rate or extent of translational initiation.	48	0.118653285212834	0	0	1	L01D.profile.d50
translational readthrough	GO:0006451	The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.	6	0.0148316606516043	0	0	1	L01D.profile.d50
protein folding	GO:0006457	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.	319	0.788549957976962	1	1.26815047021944	0.545940118724207	L01D.profile.d50
protein complex assembly	GO:0006461	The aggregation and bonding together of a set of components to form a protein complex.	431	1.06540762347357	1	0.93860788863109	0.655866842674364	L01D.profile.d50
protein modification process	GO:0006464	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).	2143	5.29737479606467	5	0.943863742417172	0.610314504597299	L01D.profile.d50
signal peptide processing	GO:0006465	The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.	9	0.0222474909774064	0	0	1	L01D.profile.d50
protein amino acid phosphorylation	GO:0006468	The process of introducing a phosphoric group on to a protein.	909	2.24699658871805	1	0.445038503850385	0.894577416194397	L01D.profile.d50
negative regulation of protein kinase activity	GO:0006469	Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.	75	0.185395758145054	0	0	1	L01D.profile.d50
protein amino acid dephosphorylation	GO:0006470	The process of removing one or more phosphoric residues from a protein.	203	0.501804518712612	0	0	1	L01D.profile.d50
protein amino acid ADP-ribosylation	GO:0006471	The transfer, from NAD, of ADP-ribose to protein amino acids.	41	0.101349681119296	1	9.86682926829268	0.0964963718305929	L01D.profile.d50
protein amino acid acetylation	GO:0006473	The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.	40	0.098877737677362	0	0	1	L01D.profile.d50
protein amino acid deacetylation	GO:0006476	The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.	16	0.0395510950709448	0	0	1	L01D.profile.d50
protein amino acid sulfation	GO:0006477	The addition of a sulfate group as an ester to a protein amino acid.	9	0.0222474909774064	0	0	1	L01D.profile.d50
protein amino acid methylation	GO:0006479	The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.	30	0.0741583032580215	0	0	1	L01D.profile.d50
protein amino acid glycosylation	GO:0006486	The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins.	156	0.385623176941712	0	0	1	L01D.profile.d50
protein amino acid N-linked glycosylation	GO:0006487	The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine or the N1' atom peptidyl-tryptophan.	49	0.121125228654768	0	0	1	L01D.profile.d50
N-glycan processing	GO:0006491	The conversion of N-linked glycan structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.	10	0.0247194344193405	0	0	1	L01D.profile.d50
protein amino acid O-linked glycosylation	GO:0006493	The formation of O-glycans by addition of glycosyl groups either to the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or to the phenol group of peptidyl-tyrosine.	39	0.0964057942354279	0	0	1	L01D.profile.d50
protein amino acid lipidation	GO:0006497	The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein.	49	0.121125228654768	0	0	1	L01D.profile.d50
GPI anchor metabolic process	GO:0006505	The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.	32	0.0791021901418896	0	0	1	L01D.profile.d50
GPI anchor biosynthetic process	GO:0006506	The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.	27	0.0667424729322193	0	0	1	L01D.profile.d50
proteolysis	GO:0006508	The hydrolysis of a peptide bond or bonds within a protein.	799	1.9750828101053	1	0.50630788485607	0.86158903153106	L01D.profile.d50
membrane protein ectodomain proteolysis	GO:0006509	The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).	14	0.0346072081870767	0	0	1	L01D.profile.d50
ATP-dependent proteolysis	GO:0006510	The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP.	4	0.00988777376773619	0	0	1	L01D.profile.d50
ubiquitin-dependent protein catabolic process	GO:0006511	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein.	219	0.541355613783557	1	1.84721461187215	0.41843109496561	L01D.profile.d50
ubiquitin cycle	GO:0006512	The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein.	503	1.24338755129283	2	1.60850894632207	0.353102448446249	L01D.profile.d50
misfolded or incompletely synthesized protein catabolic process	GO:0006515	The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.	16	0.0395510950709448	0	0	1	L01D.profile.d50
glycoprotein catabolic process	GO:0006516	The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	25	0.0617985860483512	0	0	1	L01D.profile.d50
peptide metabolic process	GO:0006518	The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.	31	0.0766302466999555	0	0	1	L01D.profile.d50
amino acid and derivative metabolic process	GO:0006519	The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids.	440	1.08765511445098	0	0	1	L01D.profile.d50
amino acid metabolic process	GO:0006520	The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.	344	0.850348544025313	0	0	1	L01D.profile.d50
regulation of amino acid metabolic process	GO:0006521	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.	64	0.158204380283779	0	0	1	L01D.profile.d50
arginine metabolic process	GO:0006525	The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid.	16	0.0395510950709448	0	0	1	L01D.profile.d50
arginine biosynthetic process	GO:0006526	The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins.	6	0.0148316606516043	0	0	1	L01D.profile.d50
arginine catabolic process	GO:0006527	The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins.	10	0.0247194344193405	0	0	1	L01D.profile.d50
glutamate metabolic process	GO:0006536	The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.	17	0.0420230385128788	0	0	1	L01D.profile.d50
glutamine metabolic process	GO:0006541	The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.	25	0.0617985860483512	0	0	1	L01D.profile.d50
glycine metabolic process	GO:0006544	The chemical reactions and pathways involving glycine, aminoethanoic acid.	19	0.0469669253967469	0	0	1	L01D.profile.d50
glycine catabolic process	GO:0006546	The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.	8	0.0197755475354724	0	0	1	L01D.profile.d50
histidine metabolic process	GO:0006547	The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.	7	0.0173036040935383	0	0	1	L01D.profile.d50
histidine catabolic process	GO:0006548	The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.	4	0.00988777376773619	0	0	1	L01D.profile.d50
methionine metabolic process	GO:0006555	The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.	12	0.0296633213032086	0	0	1	L01D.profile.d50
L-phenylalanine metabolic process	GO:0006558	The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.	13	0.0321352647451426	0	0	1	L01D.profile.d50
L-phenylalanine catabolic process	GO:0006559	The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.	13	0.0321352647451426	0	0	1	L01D.profile.d50
proline metabolic process	GO:0006560	The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.	9	0.0222474909774064	0	0	1	L01D.profile.d50
proline biosynthetic process	GO:0006561	The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.	5	0.0123597172096702	0	0	1	L01D.profile.d50
L-serine metabolic process	GO:0006563	The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.	13	0.0321352647451426	0	0	1	L01D.profile.d50
tryptophan metabolic process	GO:0006568	The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.	7	0.0173036040935383	0	0	1	L01D.profile.d50
tyrosine metabolic process	GO:0006570	The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.	18	0.0444949819548129	0	0	1	L01D.profile.d50
amino acid derivative metabolic process	GO:0006575	The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.	115	0.284273495822416	0	0	1	L01D.profile.d50
biogenic amine metabolic process	GO:0006576	The chemical reactions and pathways involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.	92	0.227418796657932	0	0	1	L01D.profile.d50
melanin metabolic process	GO:0006582	The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.	12	0.0296633213032086	0	0	1	L01D.profile.d50
melanin biosynthetic process from tyrosine	GO:0006583	The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.	10	0.0247194344193405	0	0	1	L01D.profile.d50
catecholamine metabolic process	GO:0006584	The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.	36	0.0889899639096258	0	0	1	L01D.profile.d50
indolalkylamine metabolic process	GO:0006586	The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.	15	0.0370791516290107	0	0	1	L01D.profile.d50
polyamine metabolic process	GO:0006595	The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.	17	0.0420230385128788	0	0	1	L01D.profile.d50
polyamine biosynthetic process	GO:0006596	The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.	9	0.0222474909774064	0	0	1	L01D.profile.d50
protein targeting	GO:0006605	The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif.	360	0.889899639096258	3	3.37116666666667	0.0609805047867976	L01D.profile.d50
protein import into nucleus	GO:0006606	The directed movement of a protein from the cytoplasm to the nucleus.	156	0.385623176941712	3	7.77961538461538	0.00707656644405327	L01D.profile.d50
NLS-bearing substrate import into nucleus	GO:0006607	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.	37	0.0914619073515598	0	0	1	L01D.profile.d50
protein export from nucleus	GO:0006611	The directed movement of a protein from the nucleus into the cytoplasm.	27	0.0667424729322193	0	0	1	L01D.profile.d50
protein targeting to membrane	GO:0006612	The process of directing proteins towards a membrane using signals contained within the protein.	38	0.0939338507934939	0	0	1	L01D.profile.d50
cotranslational protein targeting to membrane	GO:0006613	The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner.	20	0.049438868838681	0	0	1	L01D.profile.d50
protein retention in ER	GO:0006621	The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.	14	0.0346072081870767	0	0	1	L01D.profile.d50
protein targeting to peroxisome	GO:0006625	The process of directing proteins towards the peroxisome using signals contained within the protein.	12	0.0296633213032086	0	0	1	L01D.profile.d50
protein targeting to mitochondrion	GO:0006626	The process of directing proteins towards and into the mitochondrion, mediated by mitochondrial proteins that recognize signals contained within the imported protein.	29	0.0716863598160874	0	0	1	L01D.profile.d50
lipid metabolic process	GO:0006629	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.	877	2.16789439857616	2	0.922554161915621	0.637893441881889	L01D.profile.d50
fatty acid metabolic process	GO:0006631	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.	234	0.578434765412567	0	0	1	L01D.profile.d50
fatty acid biosynthetic process	GO:0006633	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.	91	0.224946853215998	0	0	1	L01D.profile.d50
fatty acid beta-oxidation	GO:0006635	The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A.	32	0.0791021901418896	0	0	1	L01D.profile.d50
acyl-CoA metabolic process	GO:0006637	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.	11	0.0271913778612745	0	0	1	L01D.profile.d50
neutral lipid metabolic process	GO:0006638	The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.	20	0.049438868838681	0	0	1	L01D.profile.d50
acylglycerol metabolic process	GO:0006639	The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.	20	0.049438868838681	0	0	1	L01D.profile.d50
triacylglycerol metabolic process	GO:0006641	The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins.	15	0.0370791516290107	0	0	1	L01D.profile.d50
membrane lipid metabolic process	GO:0006643	The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.	216	0.533939783457755	0	0	1	L01D.profile.d50
phospholipid metabolic process	GO:0006644	The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.	145	0.358431799080437	0	0	1	L01D.profile.d50
glycerophospholipid metabolic process	GO:0006650	The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.	66	0.163148267167647	0	0	1	L01D.profile.d50
phosphatidylcholine biosynthetic process	GO:0006656	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.	7	0.0173036040935383	0	0	1	L01D.profile.d50
phosphatidylinositol biosynthetic process	GO:0006661	The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.	3	0.00741583032580215	0	0	1	L01D.profile.d50
glycerol ether metabolic process	GO:0006662	The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.	23	0.0568546991644831	0	0	1	L01D.profile.d50
glycolipid metabolic process	GO:0006664	The chemical reactions and pathways involving glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.	42	0.10382162456123	0	0	1	L01D.profile.d50
sphingolipid metabolic process	GO:0006665	The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	75	0.185395758145054	0	0	1	L01D.profile.d50
ceramide metabolic process	GO:0006672	The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.	45	0.111237454887032	0	0	1	L01D.profile.d50
sphingomyelin metabolic process	GO:0006684	The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.	9	0.0222474909774064	0	0	1	L01D.profile.d50
glycosphingolipid metabolic process	GO:0006687	The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.	32	0.0791021901418896	0	0	1	L01D.profile.d50
glycosphingolipid biosynthetic process	GO:0006688	The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.	12	0.0296633213032086	0	0	1	L01D.profile.d50
icosanoid metabolic process	GO:0006690	The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.	58	0.143372719632175	0	0	1	L01D.profile.d50
leukotriene metabolic process	GO:0006691	The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.	26	0.0642705294902853	0	0	1	L01D.profile.d50
prostanoid metabolic process	GO:0006692	The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.	31	0.0766302466999555	0	0	1	L01D.profile.d50
prostaglandin metabolic process	GO:0006693	The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.	31	0.0766302466999555	0	0	1	L01D.profile.d50
steroid biosynthetic process	GO:0006694	The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.	99	0.244722400751471	0	0	1	L01D.profile.d50
cholesterol biosynthetic process	GO:0006695	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.	37	0.0914619073515598	0	0	1	L01D.profile.d50
C21-steroid hormone biosynthetic process	GO:0006700	The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.	12	0.0296633213032086	0	0	1	L01D.profile.d50
estrogen biosynthetic process	GO:0006703	The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.	6	0.0148316606516043	0	0	1	L01D.profile.d50
steroid catabolic process	GO:0006706	The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	15	0.0370791516290107	0	0	1	L01D.profile.d50
cholesterol catabolic process	GO:0006707	The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.	5	0.0123597172096702	0	0	1	L01D.profile.d50
isoprenoid metabolic process	GO:0006720	The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.	27	0.0667424729322193	0	0	1	L01D.profile.d50
terpenoid metabolic process	GO:0006721	The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.	14	0.0346072081870767	0	0	1	L01D.profile.d50
aromatic compound metabolic process	GO:0006725	The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons.	159	0.393039007267514	0	0	1	L01D.profile.d50
tetrahydrobiopterin biosynthetic process	GO:0006729	The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.	5	0.0123597172096702	0	0	1	L01D.profile.d50
one-carbon compound metabolic process	GO:0006730	The chemical reactions and pathways involving compounds containing a single carbon atom.	108	0.266969891728877	0	0	1	L01D.profile.d50
coenzyme metabolic process	GO:0006732	The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	201	0.496860631828744	0	0	1	L01D.profile.d50
oxidoreduction coenzyme metabolic process	GO:0006733		43	0.106293568003164	0	0	1	L01D.profile.d50
NADP metabolic process	GO:0006739	The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.	22	0.0543827557225491	0	0	1	L01D.profile.d50
NADPH regeneration	GO:0006740		14	0.0346072081870767	0	0	1	L01D.profile.d50
ubiquinone metabolic process	GO:0006743	The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.	10	0.0247194344193405	0	0	1	L01D.profile.d50
ubiquinone biosynthetic process	GO:0006744	The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.	10	0.0247194344193405	0	0	1	L01D.profile.d50
glutathione metabolic process	GO:0006749	The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.	16	0.0395510950709448	0	0	1	L01D.profile.d50
glutathione biosynthetic process	GO:0006750	The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.	10	0.0247194344193405	0	0	1	L01D.profile.d50
group transfer coenzyme metabolic process	GO:0006752		78	0.192811588470856	0	0	1	L01D.profile.d50
nucleoside phosphate metabolic process	GO:0006753		59	0.145844663074109	0	0	1	L01D.profile.d50
ATP biosynthetic process	GO:0006754	The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	59	0.145844663074109	0	0	1	L01D.profile.d50
folic acid and derivative metabolic process	GO:0006760	The chemical reactions and pathways involving folic acid and its derivatives.	11	0.0271913778612745	0	0	1	L01D.profile.d50
vitamin metabolic process	GO:0006766	The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.	83	0.205171305680526	0	0	1	L01D.profile.d50
water-soluble vitamin metabolic process	GO:0006767	The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.	58	0.143372719632175	0	0	1	L01D.profile.d50
nicotinamide metabolic process	GO:0006769	The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.	29	0.0716863598160874	0	0	1	L01D.profile.d50
fat-soluble vitamin metabolic process	GO:0006775	The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.	20	0.049438868838681	0	0	1	L01D.profile.d50
vitamin A metabolic process	GO:0006776	The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.	16	0.0395510950709448	0	0	1	L01D.profile.d50
Mo-molybdopterin cofactor biosynthetic process	GO:0006777	The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.	8	0.0197755475354724	0	0	1	L01D.profile.d50
porphyrin metabolic process	GO:0006778	The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	30	0.0741583032580215	0	0	1	L01D.profile.d50
porphyrin biosynthetic process	GO:0006779	The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	21	0.051910812280615	0	0	1	L01D.profile.d50
heme biosynthetic process	GO:0006783	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.	19	0.0469669253967469	0	0	1	L01D.profile.d50
sulfur metabolic process	GO:0006790	The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	89	0.22000296633213	0	0	1	L01D.profile.d50
phosphorus metabolic process	GO:0006793	The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).	1301	3.2159984179562	1	0.310945426594927	0.960044137183456	L01D.profile.d50
phosphate metabolic process	GO:0006796	The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.	1301	3.2159984179562	1	0.310945426594927	0.960044137183456	L01D.profile.d50
oxygen and reactive oxygen species metabolic process	GO:0006800	The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH).	121	0.29910515647402	0	0	1	L01D.profile.d50
superoxide metabolic process	GO:0006801	The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.	23	0.0568546991644831	0	0	1	L01D.profile.d50
xenobiotic metabolic process	GO:0006805	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.	46	0.113709398328966	0	0	1	L01D.profile.d50
nitrogen compound metabolic process	GO:0006807	The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.	580	1.43372719632175	0	0	1	L01D.profile.d50
nitric oxide biosynthetic process	GO:0006809	The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.	38	0.0939338507934939	0	0	1	L01D.profile.d50
transport	GO:0006810	The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	3015	7.45290947743116	3	0.40252736318408	0.979106416208203	L01D.profile.d50
ion transport	GO:0006811	The directed movement of charged atoms or small charged molecules into, out of, within or between cells.	901	2.22722104118258	0	0	1	L01D.profile.d50
cation transport	GO:0006812	The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells.	570	1.40900776190241	0	0	1	L01D.profile.d50
potassium ion transport	GO:0006813	The directed movement of potassium ions (K+) into, out of, within or between cells.	158	0.39056706382558	0	0	1	L01D.profile.d50
sodium ion transport	GO:0006814	The directed movement of sodium ions (Na+) into, out of, within or between cells.	124	0.306520986799822	0	0	1	L01D.profile.d50
calcium ion transport	GO:0006816	The directed movement of calcium (Ca) ions into, out of, within or between cells.	152	0.375735403173975	0	0	1	L01D.profile.d50
phosphate transport	GO:0006817	The directed movement of phosphate into, out of, within or between cells.	113	0.279329608938548	0	0	1	L01D.profile.d50
hydrogen transport	GO:0006818	The directed movement of hydrogen (H2 or H+), into, out of, within or between cells.	104	0.257082117961141	0	0	1	L01D.profile.d50
anion transport	GO:0006820	The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells.	236	0.583378652296435	0	0	1	L01D.profile.d50
chloride transport	GO:0006821	The directed movement of chloride into, out of, within or between cells.	63	0.155732436841845	0	0	1	L01D.profile.d50
copper ion transport	GO:0006825	The directed movement of copper (Cu) ions into, out of, within or between cells.	10	0.0247194344193405	0	0	1	L01D.profile.d50
iron ion transport	GO:0006826	The directed movement of iron (Fe) ions into, out of, within or between cells.	44	0.108765511445098	0	0	1	L01D.profile.d50
zinc ion transport	GO:0006829	The directed movement of zinc (Zn) ions into, out of, within or between cells.	11	0.0271913778612745	0	0	1	L01D.profile.d50
water transport	GO:0006833	The directed movement of water (H2O) into, out of, within or between cells.	18	0.0444949819548129	0	0	1	L01D.profile.d50
dicarboxylic acid transport	GO:0006835	The directed movement of dicarboxylic acids into, out of, within or between cells.	19	0.0469669253967469	0	0	1	L01D.profile.d50
neurotransmitter transport	GO:0006836	The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.	59	0.145844663074109	0	0	1	L01D.profile.d50
mitochondrial transport	GO:0006839	Transport of substances into, out of or within a mitochondrion.	75	0.185395758145054	0	0	1	L01D.profile.d50
oligopeptide transport	GO:0006857	The directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.	11	0.0271913778612745	0	0	1	L01D.profile.d50
amino acid transport	GO:0006865	The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells.	62	0.153260493399911	0	0	1	L01D.profile.d50
lipid transport	GO:0006869	The directed movement of lipids into, out of, within or between cells. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	120	0.296633213032086	0	0	1	L01D.profile.d50
cell ion homeostasis	GO:0006873	The regulation of the levels, transport, and metabolism of ions within a cell or between a cell and its external environment.	257	0.63528946457705	1	1.57408560311284	0.470634394839307	L01D.profile.d50
calcium ion homeostasis	GO:0006874	The regulation of the levels, transport, and metabolism of calcium ions within a cell or between a cell and its external environment.	169	0.417758441686854	0	0	1	L01D.profile.d50
metal ion homeostasis	GO:0006875	The regulation of the levels, transport, and metabolism of metal ions within a cell or between a cell and its external environment.	226	0.558659217877095	1	1.79	0.428420012483677	L01D.profile.d50
copper ion homeostasis	GO:0006878	The regulation of the levels, transport, and metabolism of copper ions within a cell or between a cell and its external environment.	10	0.0247194344193405	0	0	1	L01D.profile.d50
iron ion homeostasis	GO:0006879	The regulation of the levels, transport, and metabolism of iron ions within a cell or between a cell and its external environment.	40	0.098877737677362	1	10.1135	0.094257427418219	L01D.profile.d50
regulation of cell volume	GO:0006884	Any process that modulates the volume of a cell.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of pH	GO:0006885	Any process that modulates the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.	32	0.0791021901418896	0	0	1	L01D.profile.d50
intracellular protein transport	GO:0006886	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.	566	1.39911998813467	3	2.14420494699647	0.166109727287688	L01D.profile.d50
exocytosis	GO:0006887	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells.	118	0.291689326148218	0	0	1	L01D.profile.d50
ER to Golgi vesicle-mediated transport	GO:0006888	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.	119	0.294161269590152	0	0	1	L01D.profile.d50
retrograde vesicle-mediated transport, Golgi to ER	GO:0006890	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by COP I vesicles.	22	0.0543827557225491	0	0	1	L01D.profile.d50
intra-Golgi vesicle-mediated transport	GO:0006891	The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).	27	0.0667424729322193	0	0	1	L01D.profile.d50
post-Golgi vesicle-mediated transport	GO:0006892	The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.	39	0.0964057942354279	0	0	1	L01D.profile.d50
Golgi to endosome transport	GO:0006895	The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.	12	0.0296633213032086	0	0	1	L01D.profile.d50
endocytosis	GO:0006897	The uptake of external materials by cells by the invagination of small region of the plasma membrane to form a new intracellular membrane-limited vesicle.	272	0.672368616206061	0	0	1	L01D.profile.d50
receptor-mediated endocytosis	GO:0006898	The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.	72	0.177979927819252	0	0	1	L01D.profile.d50
vesicle targeting	GO:0006903	The process by which vesicles are directed to specific destination membranes, mediated by microtubules that grow between molecules at the vesicle membrane and target membrane surfaces.	21	0.051910812280615	0	0	1	L01D.profile.d50
vesicle docking during exocytosis	GO:0006904	The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during exocytosis.	22	0.0543827557225491	0	0	1	L01D.profile.d50
phagocytosis	GO:0006909	The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.	39	0.0964057942354279	0	0	1	L01D.profile.d50
nucleocytoplasmic transport	GO:0006913	The directed movement of molecules between the nucleus and the cytoplasm.	242	0.59821031294804	3	5.01495867768595	0.0227682017732241	L01D.profile.d50
autophagy	GO:0006914	The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of nutrient limitation and remodeling the intracellular structure for cell differentiation.	23	0.0568546991644831	0	0	1	L01D.profile.d50
apoptosis	GO:0006915	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.	1078	2.6647550304049	3	1.12580705009276	0.497906018508187	L01D.profile.d50
anti-apoptosis	GO:0006916	A process which directly inhibits any of the steps required for cell death by apoptosis.	278	0.687200276857665	2	2.91035971223022	0.151233967882829	L01D.profile.d50
induction of apoptosis	GO:0006917	A process that directly activates any of the steps required for cell death by apoptosis.	341	0.842932713699511	1	1.18633431085044	0.570002667929242	L01D.profile.d50
caspase activation	GO:0006919	Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	54	0.133484945864439	1	7.49148148148148	0.125103951918425	L01D.profile.d50
cell structure disassembly during apoptosis	GO:0006921	The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.	22	0.0543827557225491	1	18.3881818181818	0.0529942199196842	L01D.profile.d50
cell motility	GO:0006928	Any process involved in the controlled movement of a cell.	622	1.53754882088298	3	1.9511575562701	0.200490368518214	L01D.profile.d50
substrate-bound cell migration	GO:0006929	The orderly movement of cells from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.	13	0.0321352647451426	0	0	1	L01D.profile.d50
chemotaxis	GO:0006935	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).	179	0.442477876106195	0	0	1	L01D.profile.d50
muscle contraction	GO:0006936	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	246	0.608098086715776	0	0	1	L01D.profile.d50
regulation of muscle contraction	GO:0006937	Any process that modulates the frequency, rate or extent of muscle contraction.	42	0.10382162456123	0	0	1	L01D.profile.d50
smooth muscle contraction	GO:0006939	A process leading to shortening and/or development of tension in smooth muscle tissue.	49	0.121125228654768	0	0	1	L01D.profile.d50
regulation of smooth muscle contraction	GO:0006940	Any process that modulates the frequency, rate or extent of smooth muscle contraction.	16	0.0395510950709448	0	0	1	L01D.profile.d50
striated muscle contraction	GO:0006941	A process leading to shortening and/or development of tension in striated muscle tissue.	54	0.133484945864439	0	0	1	L01D.profile.d50
regulation of striated muscle contraction	GO:0006942	Any process that modulates the frequency, rate or extent of striated muscle contraction.	11	0.0271913778612745	0	0	1	L01D.profile.d50
membrane fusion	GO:0006944	The joining of two lipid bilayers to form a single membrane.	52	0.128541058980571	0	0	1	L01D.profile.d50
response to stress	GO:0006950	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).	1358	3.35689919414644	5	1.48946980854197	0.247693487722919	L01D.profile.d50
defense response	GO:0006952	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.	683	1.68833737084096	0	0	1	L01D.profile.d50
acute-phase response	GO:0006953	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	44	0.108765511445098	0	0	1	L01D.profile.d50
inflammatory response	GO:0006954	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.	383	0.946754338260741	0	0	1	L01D.profile.d50
immune response	GO:0006955	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.	838	2.07148860434073	1	0.482744630071599	0.874324630941048	L01D.profile.d50
complement activation	GO:0006956	Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.	44	0.108765511445098	0	0	1	L01D.profile.d50
complement activation, alternative pathway	GO:0006957	Processes involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.	12	0.0296633213032086	0	0	1	L01D.profile.d50
complement activation, classical pathway	GO:0006958	Processes involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.	36	0.0889899639096258	0	0	1	L01D.profile.d50
humoral immune response	GO:0006959	An immune response mediated through a body fluid.	95	0.234834626983735	0	0	1	L01D.profile.d50
cellular defense response	GO:0006968	A defense response that is mediated by cells.	114	0.281801552380482	0	0	1	L01D.profile.d50
response to DNA damage stimulus	GO:0006974	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.	412	1.01844069807683	4	3.92757281553398	0.0199839252647405	L01D.profile.d50
response to oxidative stress	GO:0006979	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	92	0.227418796657932	0	0	1	L01D.profile.d50
ER-nuclear signaling pathway	GO:0006984	Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.	20	0.049438868838681	0	0	1	L01D.profile.d50
response to unfolded protein	GO:0006986	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.	83	0.205171305680526	1	4.87397590361446	0.185699087804022	L01D.profile.d50
organelle organization and biogenesis	GO:0006996	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of any organelle within a cell.	1437	3.55218272605923	7	1.97061934585943	0.0691440518274975	L01D.profile.d50
nuclear organization and biogenesis	GO:0006997	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the nucleus.	42	0.10382162456123	1	9.63190476190476	0.0987297816990099	L01D.profile.d50
chromosome organization and biogenesis (sensu Eukaryota)	GO:0007001	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of eukaryotic chromosomes, structures composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	477	1.17911702180254	3	2.54427672955975	0.115798599262712	L01D.profile.d50
telomere maintenance via telomerase	GO:0007004	The maintenace of proper telomeric length by the addition of telomeric repeats by telomerase.	20	0.049438868838681	0	0	1	L01D.profile.d50
mitochondrion organization and biogenesis	GO:0007005	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphology and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.	63	0.155732436841845	1	6.42126984126984	0.144376841800035	L01D.profile.d50
mitochondrial membrane organization and biogenesis	GO:0007006	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the mitochondrial membrane, the lipid bilayer surrounding a mitochondrion.	28	0.0692144163741534	0	0	1	L01D.profile.d50
inner mitochondrial membrane organization and biogenesis	GO:0007007	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.	10	0.0247194344193405	0	0	1	L01D.profile.d50
plasma membrane organization and biogenesis	GO:0007009	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the plasma membrane.	21	0.051910812280615	0	0	1	L01D.profile.d50
cytoskeleton organization and biogenesis	GO:0007010	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.	661	1.63395461511841	3	1.8360363086233	0.225334111258763	L01D.profile.d50
actin filament organization	GO:0007015	Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.	60	0.148316606516043	2	13.4846666666667	0.00983448060187444	L01D.profile.d50
cytoskeletal anchoring	GO:0007016	Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane.	16	0.0395510950709448	0	0	1	L01D.profile.d50
microtubule-based process	GO:0007017	Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.	237	0.58585059573837	1	1.70691983122363	0.443771382118974	L01D.profile.d50
microtubule-based movement	GO:0007018	Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.	110	0.271913778612745	0	0	1	L01D.profile.d50
microtubule depolymerization	GO:0007019	The removal of tubulin heterodimers from one or both ends of a microtubule.	27	0.0667424729322193	0	0	1	L01D.profile.d50
microtubule nucleation	GO:0007020	The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.	12	0.0296633213032086	0	0	1	L01D.profile.d50
tubulin folding	GO:0007021	Folding of the microtubule constituent proteins alpha- and beta-tubulin into the native alpha-beta heterodimer.	15	0.0370791516290107	0	0	1	L01D.profile.d50
negative regulation of microtubule depolymerization	GO:0007026	Any process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.	25	0.0617985860483512	0	0	1	L01D.profile.d50
cytoplasm organization and biogenesis	GO:0007028	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cytoplasm and its components.	43	0.106293568003164	0	0	1	L01D.profile.d50
Golgi organization and biogenesis	GO:0007030	The assembly and arrangement of the Golgi apparatus.	15	0.0370791516290107	0	0	1	L01D.profile.d50
peroxisome organization and biogenesis	GO:0007031	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a peroxisome.	33	0.0815741335838236	0	0	1	L01D.profile.d50
endosome organization and biogenesis	GO:0007032	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of endosomes.	11	0.0271913778612745	0	0	1	L01D.profile.d50
vacuole organization and biogenesis	GO:0007033	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a vacuole.	43	0.106293568003164	0	0	1	L01D.profile.d50
vacuolar transport	GO:0007034	The directed movement of substances into, out of or within a vacuole.	22	0.0543827557225491	0	0	1	L01D.profile.d50
lysosome organization and biogenesis	GO:0007040	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of lysosomes.	41	0.101349681119296	0	0	1	L01D.profile.d50
lysosomal transport	GO:0007041	The directed movement of substances into, out of or within a lysosome.	18	0.0444949819548129	0	0	1	L01D.profile.d50
intercellular junction assembly	GO:0007043	The aggregation and bonding together of a set of components to form a junction between cells.	22	0.0543827557225491	0	0	1	L01D.profile.d50
cell cycle	GO:0007049	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	1307	3.2308300786078	13	4.0237337413925	3.3150877192391e-05	L01D.profile.d50
cell cycle arrest	GO:0007050	Any process by which progression through the cell cycle is halted during one of the normal phases (G1, S, G2, M).	135	0.333712364661097	1	2.99659259259259	0.284036080238956	L01D.profile.d50
spindle organization and biogenesis	GO:0007051	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.	28	0.0692144163741534	1	14.4478571428571	0.0669533735976265	L01D.profile.d50
mitotic spindle organization and biogenesis	GO:0007052	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.	16	0.0395510950709448	0	0	1	L01D.profile.d50
chromosome segregation	GO:0007059	The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.	79	0.19528353191279	1	5.12075949367089	0.177597459646681	L01D.profile.d50
sister chromatid cohesion	GO:0007062	The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome.	9	0.0222474909774064	0	0	1	L01D.profile.d50
mitosis	GO:0007067	Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.	284	0.70203193750927	5	7.12218309859155	0.000775357302621011	L01D.profile.d50
mitotic chromosome condensation	GO:0007076	The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.	22	0.0543827557225491	0	0	1	L01D.profile.d50
regulation of mitosis	GO:0007088	Any process that modulates the frequency, rate or extent of mitosis.	91	0.224946853215998	0	0	1	L01D.profile.d50
traversing start control point of mitotic cell cycle	GO:0007089	Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle.	19	0.0469669253967469	0	0	1	L01D.profile.d50
regulation of S phase of mitotic cell cycle	GO:0007090	A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle.	11	0.0271913778612745	0	0	1	L01D.profile.d50
mitotic metaphase/anaphase transition	GO:0007091	The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins.	16	0.0395510950709448	0	0	1	L01D.profile.d50
mitotic checkpoint	GO:0007093	A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.	37	0.0914619073515598	0	0	1	L01D.profile.d50
mitotic spindle checkpoint	GO:0007094	A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of exit from mitosis	GO:0007096	Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.	10	0.0247194344193405	0	0	1	L01D.profile.d50
centrosome cycle	GO:0007098	The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.	14	0.0346072081870767	0	0	1	L01D.profile.d50
meiosis	GO:0007126	Progression through meiosis, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.	97	0.239778513867603	1	4.17051546391753	0.213431419041356	L01D.profile.d50
meiosis I	GO:0007127	Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.	50	0.123597172096702	1	8.0908	0.116399451712513	L01D.profile.d50
synapsis	GO:0007129	The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate.	8	0.0197755475354724	0	0	1	L01D.profile.d50
synaptonemal complex assembly	GO:0007130	The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.	8	0.0197755475354724	0	0	1	L01D.profile.d50
meiotic recombination	GO:0007131	The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.	37	0.0914619073515598	1	10.9335135135135	0.0875072495975143	L01D.profile.d50
male meiosis	GO:0007140	Meiosis in the male germline.	11	0.0271913778612745	0	0	1	L01D.profile.d50
cell communication	GO:0007154	Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.	4669	11.5415039303901	10	0.866438209466695	0.715569021029749	L01D.profile.d50
cell adhesion	GO:0007155	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.	1042	2.57576506649528	2	0.776468330134357	0.728282207172399	L01D.profile.d50
homophilic cell adhesion	GO:0007156	The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell.	150	0.370791516290107	1	2.69693333333333	0.310128934718548	L01D.profile.d50
heterophilic cell adhesion	GO:0007157	The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.	39	0.0964057942354279	1	10.3728205128205	0.0920129347469056	L01D.profile.d50
neuron adhesion	GO:0007158	The attachment of an adhesion molecule on a neuronal cell to a nonidentical adhesion molecule in an adjacent cell.	7	0.0173036040935383	0	0	1	L01D.profile.d50
leukocyte adhesion	GO:0007159	The attachment of an adhesion molecule on a leukocyte cell to a nonidentical adhesion molecule in an adjacent cell.	15	0.0370791516290107	0	0	1	L01D.profile.d50
cell-matrix adhesion	GO:0007160	The binding of a cell to the extracellular matrix via adhesion molecules.	132	0.326296534335294	0	0	1	L01D.profile.d50
negative regulation of cell adhesion	GO:0007162	Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion.	38	0.0939338507934939	0	0	1	L01D.profile.d50
establishment and/or maintenance of cell polarity	GO:0007163	The specification, formation and maintenance of anisotropic intracellular organization or cell growth patterns.	56	0.138428832748307	0	0	1	L01D.profile.d50
establishment of tissue polarity	GO:0007164	Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.	8	0.0197755475354724	0	0	1	L01D.profile.d50
signal transduction	GO:0007165	The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.	4207	10.3994660602165	10	0.961587829807464	0.591155629381939	L01D.profile.d50
cell surface receptor linked signal transduction	GO:0007166	Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.	1801	4.45197013892322	5	1.12309827873404	0.458862998765957	L01D.profile.d50
enzyme linked receptor protein signaling pathway	GO:0007167	Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.	438	1.08271122756711	2	1.84721461187215	0.294672966305596	L01D.profile.d50
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.	306	0.756414693231819	1	1.32202614379085	0.531093149822299	L01D.profile.d50
signal complex assembly	GO:0007172	The aggregation and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors.	20	0.049438868838681	1	20.227	0.0482949130209605	L01D.profile.d50
epidermal growth factor receptor signaling pathway	GO:0007173	The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.	38	0.0939338507934939	0	0	1	L01D.profile.d50
transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.	104	0.257082117961141	1	3.88980769230769	0.226941372220565	L01D.profile.d50
transforming growth factor beta receptor signaling pathway	GO:0007179	The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.	67	0.165620210609581	1	6.03791044776119	0.152805731948608	L01D.profile.d50
transmembrane receptor protein tyrosine phosphatase signaling pathway	GO:0007185	The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand.	22	0.0543827557225491	0	0	1	L01D.profile.d50
G-protein coupled receptor protein signaling pathway	GO:0007186	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.	776	1.91822811094082	0	0	1	L01D.profile.d50
G-protein signaling, coupled to cyclic nucleotide second messenger	GO:0007187	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.	171	0.422702328570722	0	0	1	L01D.profile.d50
G-protein signaling, coupled to cAMP nucleotide second messenger	GO:0007188	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.	125	0.308992930241756	0	0	1	L01D.profile.d50
G-protein signaling, adenylate cyclase activating pathway	GO:0007189	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.	58	0.143372719632175	0	0	1	L01D.profile.d50
adenylate cyclase activation	GO:0007190	Any process that initiates the activity of the inactive enzyme adenylate cyclase.	46	0.113709398328966	0	0	1	L01D.profile.d50
G-protein signaling, adenylate cyclase inhibiting pathway	GO:0007193	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.	26	0.0642705294902853	0	0	1	L01D.profile.d50
negative regulation of adenylate cyclase activity	GO:0007194	Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity.	24	0.0593266426064172	0	0	1	L01D.profile.d50
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	GO:0007200	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.	102	0.252138231077273	0	0	1	L01D.profile.d50
phospholipase C activation	GO:0007202	The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.	32	0.0791021901418896	0	0	1	L01D.profile.d50
elevation of cytosolic calcium ion concentration	GO:0007204	Any process that increases the concentration of calcium ions in the cytosol.	87	0.215059079448262	0	0	1	L01D.profile.d50
protein kinase C activation	GO:0007205	The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.	35	0.0865180204676917	0	0	1	L01D.profile.d50
dopamine receptor signaling pathway	GO:0007212	The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.	17	0.0420230385128788	0	0	1	L01D.profile.d50
acetylcholine receptor signaling, muscarinic pathway	GO:0007213	The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine.	13	0.0321352647451426	0	0	1	L01D.profile.d50
gamma-aminobutyric acid signaling pathway	GO:0007214	The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.	15	0.0370791516290107	0	0	1	L01D.profile.d50
glutamate signaling pathway	GO:0007215	The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.	36	0.0889899639096258	0	0	1	L01D.profile.d50
metabotropic glutamate receptor signaling pathway	GO:0007216	The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins.	9	0.0222474909774064	0	0	1	L01D.profile.d50
tachykinin signaling pathway	GO:0007217	The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor.	7	0.0173036040935383	0	0	1	L01D.profile.d50
neuropeptide signaling pathway	GO:0007218	The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.	89	0.22000296633213	0	0	1	L01D.profile.d50
Notch signaling pathway	GO:0007219	The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.	66	0.163148267167647	0	0	1	L01D.profile.d50
Notch receptor processing	GO:0007220	The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor.	10	0.0247194344193405	0	0	1	L01D.profile.d50
Wnt receptor signaling pathway, calcium modulating pathway	GO:0007223	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).	18	0.0444949819548129	0	0	1	L01D.profile.d50
smoothened signaling pathway	GO:0007224	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.	22	0.0543827557225491	0	0	1	L01D.profile.d50
integrin-mediated signaling pathway	GO:0007229	Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.	95	0.234834626983735	1	4.25831578947368	0.209528246287221	L01D.profile.d50
intracellular signaling cascade	GO:0007242	A series of reactions within the cell that occur as a result of a single trigger reaction or compound.	1897	4.68927670934889	4	0.853010015814444	0.688955774384773	L01D.profile.d50
protein kinase cascade	GO:0007243	A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.	565	1.39664804469274	0	0	1	L01D.profile.d50
I-kappaB kinase/NF-kappaB cascade	GO:0007249	A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.	190	0.469669253967469	0	0	1	L01D.profile.d50
activation of NF-kappaB-inducing kinase	GO:0007250	The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.	25	0.0617985860483512	0	0	1	L01D.profile.d50
JNK cascade	GO:0007254	A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.	86	0.212587136006328	0	0	1	L01D.profile.d50
activation of JNK activity	GO:0007257	The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK).	23	0.0568546991644831	0	0	1	L01D.profile.d50
JAK-STAT cascade	GO:0007259	The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.	65	0.160676323725713	0	0	1	L01D.profile.d50
tyrosine phosphorylation of STAT protein	GO:0007260	The process of introducing a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.	28	0.0692144163741534	0	0	1	L01D.profile.d50
small GTPase mediated signal transduction	GO:0007264	Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.	584	1.44361497008948	1	0.692705479452055	0.764348717500477	L01D.profile.d50
Ras protein signal transduction	GO:0007265	A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.	306	0.756414693231819	0	0	1	L01D.profile.d50
Rho protein signal transduction	GO:0007266	A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.	150	0.370791516290107	0	0	1	L01D.profile.d50
cell-cell signaling	GO:0007267	Any process that mediates the transfer of information from one cell to another.	900	2.22474909774064	0	0	1	L01D.profile.d50
synaptic transmission	GO:0007268	The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.	386	0.954170168586543	0	0	1	L01D.profile.d50
neurotransmitter secretion	GO:0007269	The regulated release of neurotransmitter into the synaptic cleft.	60	0.148316606516043	0	0	1	L01D.profile.d50
nerve-nerve synaptic transmission	GO:0007270	The process of communication from a neuron to another neuron across a synapse.	20	0.049438868838681	0	0	1	L01D.profile.d50
synaptic transmission, cholinergic	GO:0007271	The process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.	23	0.0568546991644831	0	0	1	L01D.profile.d50
ensheathment of neurons	GO:0007272	The process whereby glial cells envelop neuronal cell bodies and/or axons to form and insulating layer. This can take the form of myelinating or non-myelinating ensheathment.	44	0.108765511445098	0	0	1	L01D.profile.d50
neuromuscular synaptic transmission	GO:0007274	The process of communication from a neuron to a muscle, across a synapse.	14	0.0346072081870767	0	0	1	L01D.profile.d50
multicellular organismal development	GO:0007275	The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	3036	7.50482028971177	4	0.532990777338603	0.941257629525263	L01D.profile.d50
gamete generation	GO:0007276	The generation and maintenance of gametes. A gamete is a haploid reproductive cell.	297	0.734167202254412	2	2.72417508417508	0.167648340240575	L01D.profile.d50
germ cell development	GO:0007281	The process whose specific outcome is the progression of the immature germ cell over time, from its formation to the mature structure (gamete).	35	0.0865180204676917	1	11.5582857142857	0.0829792059813095	L01D.profile.d50
spermatogenesis	GO:0007283	The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.	225	0.556187274435161	1	1.79795555555556	0.427003597784969	L01D.profile.d50
spermatid development	GO:0007286	The process whose specific outcome is the progression of a male gamete over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.	33	0.0815741335838236	0	0	1	L01D.profile.d50
female gamete generation	GO:0007292	The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell.	38	0.0939338507934939	1	10.6457894736842	0.089762880067684	L01D.profile.d50
single fertilization	GO:0007338	The union of male and female gametes to form a zygote.	47	0.1161813417709	0	0	1	L01D.profile.d50
binding of sperm to zona pellucida	GO:0007339	The process by which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.	9	0.0222474909774064	0	0	1	L01D.profile.d50
acrosome reaction	GO:0007340	The discharge, by sperm, of a single, anterior secretory granule following their attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the disperasl of the acrosomal contents into the egg.	11	0.0271913778612745	0	0	1	L01D.profile.d50
fusion of sperm to egg plasma membrane	GO:0007342	The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of progression through mitotic cell cycle	GO:0007346	Any process that modulates the rate or extent of progress through the mitotic cell cycle.	57	0.140900776190241	1	7.09719298245614	0.131576007610459	L01D.profile.d50
blastoderm segmentation	GO:0007350	The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.	10	0.0247194344193405	0	0	1	L01D.profile.d50
tripartite regional subdivision	GO:0007351	Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.	10	0.0247194344193405	0	0	1	L01D.profile.d50
determination of left/right symmetry	GO:0007368	The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	24	0.0593266426064172	0	0	1	L01D.profile.d50
gastrulation	GO:0007369	A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.	61	0.150788549957977	0	0	1	L01D.profile.d50
segment specification	GO:0007379	The process during which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.	7	0.0173036040935383	0	0	1	L01D.profile.d50
compartment specification	GO:0007386	The regionalization process by which embryonic segments are divided into compartments that will result in differences in cell differentiation.	12	0.0296633213032086	0	0	1	L01D.profile.d50
pattern specification process	GO:0007389	The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.	218	0.538883670341623	1	1.8556880733945	0.416989927039173	L01D.profile.d50
ectoderm development	GO:0007398	The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.	180	0.444949819548129	0	0	1	L01D.profile.d50
nervous system development	GO:0007399	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.	1045	2.58318089682108	2	0.774239234449761	0.729732505602144	L01D.profile.d50
neuroblast proliferation	GO:0007405	The rapid expansion of a neuroblast population by cell division. Neuroblasts are embryonic cells that develop into nerve cells or neurons.	28	0.0692144163741534	0	0	1	L01D.profile.d50
axonogenesis	GO:0007409	Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.	186	0.459781480199733	1	2.17494623655914	0.368937703913973	L01D.profile.d50
axon guidance	GO:0007411	The process by which the migration of an axon growth cone is directed to a specific target site in response to a combination of attractive and repulsive cues.	104	0.257082117961141	1	3.88980769230769	0.226941372220565	L01D.profile.d50
synaptogenesis	GO:0007416	The biosynthesis of a synapse.	31	0.0766302466999555	0	0	1	L01D.profile.d50
central nervous system development	GO:0007417	The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.	332	0.820685222722104	1	1.21849397590361	0.56031698895835	L01D.profile.d50
brain development	GO:0007420	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).	183	0.452365649873931	1	2.21060109289617	0.364234620672142	L01D.profile.d50
peripheral nervous system development	GO:0007422	The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.	33	0.0815741335838236	0	0	1	L01D.profile.d50
sensory organ development	GO:0007423	The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.	101	0.249666287635339	0	0	1	L01D.profile.d50
ectodermal gut development	GO:0007439	The process whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. The ectodermal gut includes those portions of the gut that are derived from ectoderm.	6	0.0148316606516043	0	0	1	L01D.profile.d50
endoderm development	GO:0007492	The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.	12	0.0296633213032086	0	0	1	L01D.profile.d50
mesoderm development	GO:0007498	The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	82	0.202699362238592	0	0	1	L01D.profile.d50
heart development	GO:0007507	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	178	0.440005932664261	0	0	1	L01D.profile.d50
adult heart development	GO:0007512	The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.	7	0.0173036040935383	0	0	1	L01D.profile.d50
hemocyte development	GO:0007516	The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.	10	0.0247194344193405	0	0	1	L01D.profile.d50
muscle development	GO:0007517	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.	256	0.632817521135116	1	1.580234375	0.469322590296608	L01D.profile.d50
striated muscle development	GO:0007519	The developmental sequence of events leading to the formation of adult muscle that occurs in the animal and in cultured cells. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.	137	0.338656251544965	1	2.95284671532847	0.287571349970517	L01D.profile.d50
myoblast fusion	GO:0007520	The fusion of myoblasts to form myotubes.	11	0.0271913778612745	0	0	1	L01D.profile.d50
neuromuscular junction development	GO:0007528	The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure.	20	0.049438868838681	0	0	1	L01D.profile.d50
sex determination	GO:0007530	Any process that establishes and transmits the specification of sexual status of an individual organism.	26	0.0642705294902853	0	0	1	L01D.profile.d50
sex differentiation	GO:0007548	The establishment of the sex of an organism by physical differentiation.	106	0.262026004845009	0	0	1	L01D.profile.d50
female pregnancy	GO:0007565	The physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.	118	0.291689326148218	0	0	1	L01D.profile.d50
embryo implantation	GO:0007566	Attachment of the blastocyst to the uterine lining.	29	0.0716863598160874	0	0	1	L01D.profile.d50
parturition	GO:0007567	The process of giving birth to live offspring or eggs.	17	0.0420230385128788	0	0	1	L01D.profile.d50
aging	GO:0007568	The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility.	35	0.0865180204676917	0	0	1	L01D.profile.d50
cell aging	GO:0007569	Progression of the cell from its inception to the end of its lifespan.	21	0.051910812280615	0	0	1	L01D.profile.d50
response to nutrient	GO:0007584	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.	30	0.0741583032580215	0	0	1	L01D.profile.d50
respiratory gaseous exchange	GO:0007585	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.	52	0.128541058980571	0	0	1	L01D.profile.d50
digestion	GO:0007586	The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	106	0.262026004845009	0	0	1	L01D.profile.d50
excretion	GO:0007588	The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.	72	0.177979927819252	0	0	1	L01D.profile.d50
fluid secretion	GO:0007589	The regulated release of a fluid by a cell or group of cells.	19	0.0469669253967469	0	0	1	L01D.profile.d50
lactation	GO:0007595	The secretion of milk by the mammary gland.	24	0.0593266426064172	0	0	1	L01D.profile.d50
blood coagulation	GO:0007596	The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.	142	0.351015968754635	0	0	1	L01D.profile.d50
hemostasis	GO:0007599	The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.	150	0.370791516290107	0	0	1	L01D.profile.d50
sensory perception	GO:0007600	The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.	504	1.24585949473476	0	0	1	L01D.profile.d50
visual perception	GO:0007601	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.	237	0.58585059573837	0	0	1	L01D.profile.d50
phototransduction	GO:0007602	The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.	24	0.0593266426064172	0	0	1	L01D.profile.d50
sensory perception of sound	GO:0007605	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.	190	0.469669253967469	0	0	1	L01D.profile.d50
sensory perception of chemical stimulus	GO:0007606	The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal.	78	0.192811588470856	0	0	1	L01D.profile.d50
sensory perception of smell	GO:0007608	The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors.	62	0.153260493399911	0	0	1	L01D.profile.d50
behavior	GO:0007610	The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.	445	1.10001483166065	0	0	1	L01D.profile.d50
learning and/or memory	GO:0007611	The acquisition and processing of information and/or the storage and retrieval of this information over time.	86	0.212587136006328	0	0	1	L01D.profile.d50
learning	GO:0007612	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.	28	0.0692144163741534	0	0	1	L01D.profile.d50
memory	GO:0007613	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).	17	0.0420230385128788	0	0	1	L01D.profile.d50
mating behavior	GO:0007617	The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.	9	0.0222474909774064	0	0	1	L01D.profile.d50
mating	GO:0007618	The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.	21	0.051910812280615	0	0	1	L01D.profile.d50
copulation	GO:0007620	The act of sexual union between male and female, involving the transfer of sperm.	10	0.0247194344193405	0	0	1	L01D.profile.d50
circadian rhythm	GO:0007623	The biological processes in an organism that recur with a regularity of approximately 24 hours.	34	0.0840460770257577	0	0	1	L01D.profile.d50
locomotory behavior	GO:0007626	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.	252	0.62292974736738	0	0	1	L01D.profile.d50
adult walking behavior	GO:0007628	The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.	14	0.0346072081870767	0	0	1	L01D.profile.d50
feeding behavior	GO:0007631	Behavior associated with the intake of food.	43	0.106293568003164	0	0	1	L01D.profile.d50
visual behavior	GO:0007632	The actions or reactions of an organism in response to a visual stimulus.	11	0.0271913778612745	0	0	1	L01D.profile.d50
circulation	GO:0008015	The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.	228	0.563603104760963	0	0	1	L01D.profile.d50
regulation of heart contraction	GO:0008016	Any process that modulates the frequency, rate or extent of heart contraction.	76	0.187867701586988	0	0	1	L01D.profile.d50
tRNA processing	GO:0008033	The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.	48	0.118653285212834	0	0	1	L01D.profile.d50
cell recognition	GO:0008037	The process by which a cell in a multicellular organism interprets its surroundings.	55	0.135956889306373	0	0	1	L01D.profile.d50
neuron recognition	GO:0008038	The process by which a neuronal cell in a multicellular organism interprets its surroundings.	22	0.0543827557225491	0	0	1	L01D.profile.d50
regulation of actin polymerization and/or depolymerization	GO:0008064	Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.	66	0.163148267167647	1	6.12939393939394	0.15070632602094	L01D.profile.d50
axon cargo transport	GO:0008088	The directed movement of organelles along microtubules in nerve cell axons.	21	0.051910812280615	0	0	1	L01D.profile.d50
protein localization	GO:0008104	The processes by which a protein is transported to, or maintained in, a specific location.	998	2.46699955505018	3	1.21605210420842	0.447843425636376	L01D.profile.d50
asymmetric protein localization	GO:0008105	The processes by which a protein is transported to, or maintained in, a specific asymmetric distribution.	12	0.0296633213032086	0	0	1	L01D.profile.d50
metabolic process	GO:0008152	Processes that cause many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.	9690	23.9531319523409	29	1.21069762641899	0.174637344395657	L01D.profile.d50
actin polymerization and/or depolymerization	GO:0008154	Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.	99	0.244722400751471	1	4.08626262626263	0.217315318801261	L01D.profile.d50
negative regulation of DNA replication	GO:0008156	Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.	18	0.0444949819548129	0	0	1	L01D.profile.d50
steroid metabolic process	GO:0008202	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	234	0.578434765412567	0	0	1	L01D.profile.d50
cholesterol metabolic process	GO:0008203	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.	106	0.262026004845009	0	0	1	L01D.profile.d50
bile acid metabolic process	GO:0008206	The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.	20	0.049438868838681	0	0	1	L01D.profile.d50
C21-steroid hormone metabolic process	GO:0008207	The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.	20	0.049438868838681	0	0	1	L01D.profile.d50
androgen metabolic process	GO:0008209	The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.	13	0.0321352647451426	0	0	1	L01D.profile.d50
estrogen metabolic process	GO:0008210	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.	8	0.0197755475354724	0	0	1	L01D.profile.d50
protein amino acid alkylation	GO:0008213	The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom.	30	0.0741583032580215	0	0	1	L01D.profile.d50
blood pressure regulation	GO:0008217	The process that modulates the force with which blood travels through the circulatory system.	65	0.160676323725713	0	0	1	L01D.profile.d50
cell death	GO:0008219	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1152	2.84767884510802	4	1.40465277777778	0.318644681625691	L01D.profile.d50
sulfate transport	GO:0008272	The directed movement of sulfate into, out of, within or between cells.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of G-protein coupled receptor protein signaling pathway	GO:0008277	Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.	64	0.158204380283779	0	0	1	L01D.profile.d50
cell proliferation	GO:0008283	The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.	1154	2.85262273199189	4	1.40221837088388	0.319749393815592	L01D.profile.d50
positive regulation of cell proliferation	GO:0008284	Any process that activates or increases the rate or extent of cell proliferation.	338	0.835516883373708	2	2.39372781065089	0.20395357672569	L01D.profile.d50
negative regulation of cell proliferation	GO:0008285	Any process that stops, prevents or reduces the rate or extent of cell proliferation.	353	0.872596035002719	1	1.14600566572238	0.582585822902794	L01D.profile.d50
insulin receptor signaling pathway	GO:0008286	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	51	0.126069115538636	0	0	1	L01D.profile.d50
isoprenoid biosynthetic process	GO:0008299	The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.	15	0.0370791516290107	0	0	1	L01D.profile.d50
endosome to lysosome transport	GO:0008333	The directed movement of substances from endosomes to lysosomes.	11	0.0271913778612745	0	0	1	L01D.profile.d50
adult feeding behavior	GO:0008343	Feeding behavior in a fully developed and mature organism.	5	0.0123597172096702	0	0	1	L01D.profile.d50
adult locomotory behavior	GO:0008344	Locomotory behavior in a fully developed and mature organism.	24	0.0593266426064172	0	0	1	L01D.profile.d50
germ cell migration	GO:0008354	The orderly movement of a germ cell, a cell specialized to produce haploid gametes, through the embryo from its site of production to the place where the gonads will form.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of cell shape	GO:0008360	Any process that modulates the shape of a cell.	58	0.143372719632175	0	0	1	L01D.profile.d50
regulation of cell size	GO:0008361	Any process that modulates the size of a cell.	282	0.697088050625402	1	1.4345390070922	0.50239617676358	L01D.profile.d50
axon ensheathment	GO:0008366	The processes by which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.	44	0.108765511445098	0	0	1	L01D.profile.d50
RNA splicing	GO:0008380	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.	347	0.857764374351115	1	1.16582132564841	0.576340959590959	L01D.profile.d50
gonad development	GO:0008406	The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.	75	0.185395758145054	0	0	1	L01D.profile.d50
cytochrome c oxidase complex assembly	GO:0008535	The aggregation and bonding together of a set of components to form cytochrome c oxidase, the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.	7	0.0173036040935383	0	0	1	L01D.profile.d50
fibroblast growth factor receptor signaling pathway	GO:0008543	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.	28	0.0692144163741534	0	0	1	L01D.profile.d50
epidermis development	GO:0008544	The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.	158	0.39056706382558	0	0	1	L01D.profile.d50
male gonad development	GO:0008584	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.	27	0.0667424729322193	0	0	1	L01D.profile.d50
female gonad development	GO:0008585	The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.	46	0.113709398328966	0	0	1	L01D.profile.d50
regulation of smoothened signaling pathway	GO:0008589	Any process that modulates the frequency, rate or extent of smoothened signaling.	10	0.0247194344193405	0	0	1	L01D.profile.d50
determination of anterior/posterior axis, embryo	GO:0008595	The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.	10	0.0247194344193405	0	0	1	L01D.profile.d50
lipid biosynthetic process	GO:0008610	The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	299	0.739111089138281	0	0	1	L01D.profile.d50
induction of apoptosis by extracellular signals	GO:0008624	Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis.	73	0.180451871261186	0	0	1	L01D.profile.d50
induction of apoptosis via death domain receptors	GO:0008625		18	0.0444949819548129	0	0	1	L01D.profile.d50
induction of apoptosis by intracellular signals	GO:0008629	Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis.	59	0.145844663074109	1	6.85661016949152	0.135864091087461	L01D.profile.d50
DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630	A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).	36	0.0889899639096258	0	0	1	L01D.profile.d50
induction of apoptosis by oxidative stress	GO:0008631	The activation, by oxidative stress, of any of the steps required for cell death by apoptosis.	5	0.0123597172096702	0	0	1	L01D.profile.d50
apoptotic program	GO:0008632	The intracellular signaling cascade that results when a cell is triggered to undergo apoptosis.	117	0.289217382706284	1	3.45760683760684	0.251418680243775	L01D.profile.d50
negative regulation of survival gene product activity	GO:0008634	Any process that stops, prevents or reduces the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	L01D.profile.d50
caspase activation via cytochrome c	GO:0008635	Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c.	11	0.0271913778612745	0	0	1	L01D.profile.d50
apoptotic mitochondrial changes	GO:0008637	The morphological and physiological alterations undergone by mitochondria during apoptosis.	26	0.0642705294902853	1	15.5592307692308	0.0623233359141062	L01D.profile.d50
carbohydrate transport	GO:0008643	The directed movement of carbohydrate into, out of, within or between cells. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.	55	0.135956889306373	0	0	1	L01D.profile.d50
hexose transport	GO:0008645	The directed movement of hexose into, out of, within or between cells. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.	40	0.098877737677362	0	0	1	L01D.profile.d50
amino acid biosynthetic process	GO:0008652	The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.	56	0.138428832748307	0	0	1	L01D.profile.d50
lipopolysaccharide metabolic process	GO:0008653	The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.	6	0.0148316606516043	0	0	1	L01D.profile.d50
phospholipid biosynthetic process	GO:0008654	The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.	70	0.173036040935383	0	0	1	L01D.profile.d50
catabolic process	GO:0009056	The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.	833	2.05912888713106	2	0.971284513805522	0.610106359483557	L01D.profile.d50
macromolecule catabolic process	GO:0009057	The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates.	511	1.2631630988283	2	1.58332681017613	0.360188270841092	L01D.profile.d50
biosynthetic process	GO:0009058	The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes.	1553	3.83892816532358	3	0.781468126207341	0.737693806324519	L01D.profile.d50
macromolecule biosynthetic process	GO:0009059	The chemical reactions and pathways resulting in the formation of macromolecules, large molecules including proteins, nucleic acids and carbohydrates.	888	2.19508577643744	3	1.36668918918919	0.376032917028173	L01D.profile.d50
aerobic respiration	GO:0009060	The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.	49	0.121125228654768	0	0	1	L01D.profile.d50
fatty acid catabolic process	GO:0009062	The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.	11	0.0271913778612745	0	0	1	L01D.profile.d50
amino acid catabolic process	GO:0009063	The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.	81	0.200227418796658	0	0	1	L01D.profile.d50
glutamine family amino acid metabolic process	GO:0009064	The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	60	0.148316606516043	0	0	1	L01D.profile.d50
glutamine family amino acid catabolic process	GO:0009065	The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	29	0.0716863598160874	0	0	1	L01D.profile.d50
aspartate family amino acid metabolic process	GO:0009066	The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.	23	0.0568546991644831	0	0	1	L01D.profile.d50
aspartate family amino acid biosynthetic process	GO:0009067	The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.	13	0.0321352647451426	0	0	1	L01D.profile.d50
aspartate family amino acid catabolic process	GO:0009068	The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.	8	0.0197755475354724	0	0	1	L01D.profile.d50
serine family amino acid metabolic process	GO:0009069	The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	34	0.0840460770257577	0	0	1	L01D.profile.d50
serine family amino acid biosynthetic process	GO:0009070	The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	12	0.0296633213032086	0	0	1	L01D.profile.d50
serine family amino acid catabolic process	GO:0009071	The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	10	0.0247194344193405	0	0	1	L01D.profile.d50
aromatic amino acid family metabolic process	GO:0009072	The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).	31	0.0766302466999555	0	0	1	L01D.profile.d50
aromatic amino acid family catabolic process	GO:0009074	The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).	18	0.0444949819548129	0	0	1	L01D.profile.d50
histidine family amino acid metabolic process	GO:0009075	The chemical reactions and pathways involving amino acids of the histidine family.	7	0.0173036040935383	0	0	1	L01D.profile.d50
histidine family amino acid catabolic process	GO:0009077	The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family.	4	0.00988777376773619	0	0	1	L01D.profile.d50
branched chain family amino acid metabolic process	GO:0009081	The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.	20	0.049438868838681	0	0	1	L01D.profile.d50
branched chain family amino acid catabolic process	GO:0009083	The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.	13	0.0321352647451426	0	0	1	L01D.profile.d50
glutamine family amino acid biosynthetic process	GO:0009084	The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	20	0.049438868838681	0	0	1	L01D.profile.d50
methionine biosynthetic process	GO:0009086	The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.	9	0.0222474909774064	0	0	1	L01D.profile.d50
glycoprotein metabolic process	GO:0009100	The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	199	0.491916744944876	0	0	1	L01D.profile.d50
glycoprotein biosynthetic process	GO:0009101	The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	164	0.405398724477184	0	0	1	L01D.profile.d50
lipopolysaccharide biosynthetic process	GO:0009103	The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.	5	0.0123597172096702	0	0	1	L01D.profile.d50
coenzyme biosynthetic process	GO:0009108	The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	113	0.279329608938548	0	0	1	L01D.profile.d50
coenzyme catabolic process	GO:0009109	The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	38	0.0939338507934939	0	0	1	L01D.profile.d50
vitamin biosynthetic process	GO:0009110	The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.	21	0.051910812280615	0	0	1	L01D.profile.d50
nucleobase metabolic process	GO:0009112	The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.	33	0.0815741335838236	0	0	1	L01D.profile.d50
nucleoside metabolic process	GO:0009116	The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).	32	0.0791021901418896	0	0	1	L01D.profile.d50
nucleotide metabolic process	GO:0009117	The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	280	0.692144163741534	0	0	1	L01D.profile.d50
ribonucleoside metabolic process	GO:0009119	The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.	12	0.0296633213032086	0	0	1	L01D.profile.d50
deoxyribonucleoside metabolic process	GO:0009120	The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).	5	0.0123597172096702	0	0	1	L01D.profile.d50
nucleoside monophosphate metabolic process	GO:0009123	The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.	32	0.0791021901418896	0	0	1	L01D.profile.d50
nucleoside monophosphate biosynthetic process	GO:0009124	The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.	32	0.0791021901418896	0	0	1	L01D.profile.d50
purine nucleoside monophosphate metabolic process	GO:0009126	The chemical reactions and pathways involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety.	20	0.049438868838681	0	0	1	L01D.profile.d50
purine nucleoside monophosphate biosynthetic process	GO:0009127	The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety.	20	0.049438868838681	0	0	1	L01D.profile.d50
nucleoside diphosphate metabolic process	GO:0009132	The chemical reactions and pathways involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety.	9	0.0222474909774064	0	0	1	L01D.profile.d50
nucleoside triphosphate metabolic process	GO:0009141	The chemical reactions and pathways involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety.	91	0.224946853215998	0	0	1	L01D.profile.d50
nucleoside triphosphate biosynthetic process	GO:0009142	The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety.	73	0.180451871261186	0	0	1	L01D.profile.d50
purine nucleoside triphosphate metabolic process	GO:0009144	The chemical reactions and pathways involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	85	0.210115192564394	0	0	1	L01D.profile.d50
purine nucleoside triphosphate biosynthetic process	GO:0009145	The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	71	0.175507984377317	0	0	1	L01D.profile.d50
pyrimidine nucleoside triphosphate metabolic process	GO:0009147	The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	14	0.0346072081870767	0	0	1	L01D.profile.d50
purine ribonucleotide metabolic process	GO:0009150	The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	108	0.266969891728877	0	0	1	L01D.profile.d50
purine ribonucleotide biosynthetic process	GO:0009152	The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	94	0.232362683541801	0	0	1	L01D.profile.d50
ribonucleoside monophosphate biosynthetic process	GO:0009156	The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety.	30	0.0741583032580215	0	0	1	L01D.profile.d50
ribonucleoside monophosphate metabolic process	GO:0009161	The chemical reactions and pathways involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety.	30	0.0741583032580215	0	0	1	L01D.profile.d50
nucleotide biosynthetic process	GO:0009165	The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	183	0.452365649873931	0	0	1	L01D.profile.d50
nucleotide catabolic process	GO:0009166	The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	22	0.0543827557225491	0	0	1	L01D.profile.d50
purine ribonucleoside monophosphate metabolic process	GO:0009167	The chemical reactions and pathways involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety.	20	0.049438868838681	0	0	1	L01D.profile.d50
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety.	20	0.049438868838681	0	0	1	L01D.profile.d50
ribonucleoside diphosphate metabolic process	GO:0009185	The chemical reactions and pathways involving a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety.	6	0.0148316606516043	0	0	1	L01D.profile.d50
cyclic nucleotide metabolic process	GO:0009187	The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.	69	0.170564097493449	0	0	1	L01D.profile.d50
cyclic nucleotide biosynthetic process	GO:0009190	The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.	43	0.106293568003164	0	0	1	L01D.profile.d50
ribonucleoside triphosphate metabolic process	GO:0009199	The chemical reactions and pathways involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	85	0.210115192564394	0	0	1	L01D.profile.d50
deoxyribonucleoside triphosphate metabolic process	GO:0009200	The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety.	5	0.0123597172096702	0	0	1	L01D.profile.d50
ribonucleoside triphosphate biosynthetic process	GO:0009201	The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	72	0.177979927819252	0	0	1	L01D.profile.d50
purine ribonucleoside triphosphate metabolic process	GO:0009205	The chemical reactions and pathways involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	84	0.20764324912246	0	0	1	L01D.profile.d50
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	71	0.175507984377317	0	0	1	L01D.profile.d50
pyrimidine ribonucleoside triphosphate metabolic process	GO:0009208	The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	10	0.0247194344193405	0	0	1	L01D.profile.d50
pyrimidine ribonucleoside triphosphate biosynthetic process	GO:0009209	The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	10	0.0247194344193405	0	0	1	L01D.profile.d50
pyrimidine ribonucleotide metabolic process	GO:0009218	The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	18	0.0444949819548129	0	0	1	L01D.profile.d50
pyrimidine deoxyribonucleotide metabolic process	GO:0009219	The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	8	0.0197755475354724	0	0	1	L01D.profile.d50
pyrimidine ribonucleotide biosynthetic process	GO:0009220	The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	16	0.0395510950709448	0	0	1	L01D.profile.d50
nucleotide-sugar metabolic process	GO:0009225	The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.	13	0.0321352647451426	0	0	1	L01D.profile.d50
glycolipid biosynthetic process	GO:0009247	The chemical reactions and pathways resulting in the formation of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.	15	0.0370791516290107	0	0	1	L01D.profile.d50
glucan biosynthetic process	GO:0009250	The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.	14	0.0346072081870767	0	0	1	L01D.profile.d50
glucan catabolic process	GO:0009251	The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.	8	0.0197755475354724	0	0	1	L01D.profile.d50
peptidoglycan catabolic process	GO:0009253	The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.	2	0.0049438868838681	0	0	1	L01D.profile.d50
ribonucleotide metabolic process	GO:0009259	The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	122	0.301577099915954	0	0	1	L01D.profile.d50
ribonucleotide biosynthetic process	GO:0009260	The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	106	0.262026004845009	0	0	1	L01D.profile.d50
ribonucleotide catabolic process	GO:0009261	The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	9	0.0222474909774064	0	0	1	L01D.profile.d50
deoxyribonucleotide metabolic process	GO:0009262	The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	13	0.0321352647451426	0	0	1	L01D.profile.d50
deoxyribonucleotide biosynthetic process	GO:0009263	The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	4	0.00988777376773619	0	0	1	L01D.profile.d50
response to temperature stimulus	GO:0009266	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.	39	0.0964057942354279	0	0	1	L01D.profile.d50
cellular response to starvation	GO:0009267	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.	9	0.0222474909774064	0	0	1	L01D.profile.d50
response to pH	GO:0009268	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus.	6	0.0148316606516043	0	0	1	L01D.profile.d50
rRNA transcription	GO:0009303	The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.	10	0.0247194344193405	0	0	1	L01D.profile.d50
protein secretion	GO:0009306	The regulated release of proteins from a cell or group of cells.	66	0.163148267167647	0	0	1	L01D.profile.d50
amine metabolic process	GO:0009308	The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	538	1.32990557176052	0	0	1	L01D.profile.d50
amine biosynthetic process	GO:0009309	The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	94	0.232362683541801	0	0	1	L01D.profile.d50
amine catabolic process	GO:0009310	The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	96	0.237306570425669	0	0	1	L01D.profile.d50
oligosaccharide metabolic process	GO:0009311	The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.	33	0.0815741335838236	0	0	1	L01D.profile.d50
oligosaccharide biosynthetic process	GO:0009312	The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.	15	0.0370791516290107	0	0	1	L01D.profile.d50
response to radiation	GO:0009314	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.	117	0.289217382706284	1	3.45760683760684	0.251418680243775	L01D.profile.d50
phospholipid catabolic process	GO:0009395	The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.	11	0.0271913778612745	0	0	1	L01D.profile.d50
folic acid and derivative biosynthetic process	GO:0009396	The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.	5	0.0123597172096702	0	0	1	L01D.profile.d50
pathogenesis	GO:0009405	The specific processes that generate the ability of an organism to cause disease in another.	15	0.0370791516290107	0	0	1	L01D.profile.d50
response to heat	GO:0009408	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.	15	0.0370791516290107	0	0	1	L01D.profile.d50
response to cold	GO:0009409	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.	14	0.0346072081870767	0	0	1	L01D.profile.d50
response to xenobiotic stimulus	GO:0009410	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.	49	0.121125228654768	0	0	1	L01D.profile.d50
response to UV	GO:0009411	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.	32	0.0791021901418896	0	0	1	L01D.profile.d50
response to light stimulus	GO:0009416	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.	81	0.200227418796658	0	0	1	L01D.profile.d50
NAD biosynthetic process	GO:0009435	The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.	7	0.0173036040935383	0	0	1	L01D.profile.d50
RNA modification	GO:0009451	The covalent alteration of one or more nucleotides within RNA, resulting in a change in the properties of the RNA.	23	0.0568546991644831	0	0	1	L01D.profile.d50
fertilization	GO:0009566	The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).	48	0.118653285212834	0	0	1	L01D.profile.d50
detection of external stimulus	GO:0009581	The series of events in which an external stimulus is received by a cell and converted into a molecular signal.	44	0.108765511445098	0	0	1	L01D.profile.d50
detection of abiotic stimulus	GO:0009582	The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.	43	0.106293568003164	0	0	1	L01D.profile.d50
detection of light stimulus	GO:0009583	The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.	26	0.0642705294902853	0	0	1	L01D.profile.d50
detection of visible light	GO:0009584	The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.	26	0.0642705294902853	0	0	1	L01D.profile.d50
detection of chemical stimulus	GO:0009593	The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.	12	0.0296633213032086	0	0	1	L01D.profile.d50
detection of biotic stimulus	GO:0009595	The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.	13	0.0321352647451426	0	0	1	L01D.profile.d50
response to external stimulus	GO:0009605	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.	759	1.87620507242794	0	0	1	L01D.profile.d50
response to biotic stimulus	GO:0009607	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.	282	0.697088050625402	1	1.4345390070922	0.50239617676358	L01D.profile.d50
response to wounding	GO:0009611	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.	560	1.38428832748307	0	0	1	L01D.profile.d50
response to mechanical stimulus	GO:0009612	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.	15	0.0370791516290107	0	0	1	L01D.profile.d50
response to virus	GO:0009615	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.	124	0.306520986799822	0	0	1	L01D.profile.d50
response to bacterium	GO:0009617	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.	67	0.165620210609581	0	0	1	L01D.profile.d50
response to fungus	GO:0009620	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.	16	0.0395510950709448	0	0	1	L01D.profile.d50
response to abiotic stimulus	GO:0009628	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.	187	0.462253423641667	1	2.16331550802139	0.370497654218235	L01D.profile.d50
response to toxin	GO:0009636	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus.	26	0.0642705294902853	0	0	1	L01D.profile.d50
anatomical structure morphogenesis	GO:0009653	The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.	1460	3.60903742522371	6	1.66249315068493	0.156889915372455	L01D.profile.d50
response to endogenous stimulus	GO:0009719	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus.	453	1.11979037919612	4	3.57209713024283	0.0270505691216799	L01D.profile.d50
response to hormone stimulus	GO:0009725	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.	36	0.0889899639096258	0	0	1	L01D.profile.d50
response to carbohydrate stimulus	GO:0009743	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.	16	0.0395510950709448	0	0	1	L01D.profile.d50
response to hexose stimulus	GO:0009746	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.	10	0.0247194344193405	0	0	1	L01D.profile.d50
response to glucose stimulus	GO:0009749	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.	10	0.0247194344193405	0	0	1	L01D.profile.d50
hormone-mediated signaling	GO:0009755	A series of molecular signals mediated by the detection of a hormone.	10	0.0247194344193405	0	0	1	L01D.profile.d50
embryonic development	GO:0009790	The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.	397	0.981361546447817	0	0	1	L01D.profile.d50
post-embryonic development	GO:0009791	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.	8	0.0197755475354724	0	0	1	L01D.profile.d50
embryonic development ending in birth or egg hatching	GO:0009792	The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.	137	0.338656251544965	0	0	1	L01D.profile.d50
axis specification	GO:0009798	The establishment, maintenance and elaboration of a pattern along a line or a point.	25	0.0617985860483512	0	0	1	L01D.profile.d50
determination of symmetry	GO:0009799	The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.	26	0.0642705294902853	0	0	1	L01D.profile.d50
determination of bilateral symmetry	GO:0009855	The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	26	0.0642705294902853	0	0	1	L01D.profile.d50
embryonic pattern specification	GO:0009880	The process that results in the patterns of cell differentiation that will arise in an embryo.	41	0.101349681119296	0	0	1	L01D.profile.d50
organ morphogenesis	GO:0009887	Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	569	1.40653581846047	2	1.42193321616872	0.410594888769081	L01D.profile.d50
tissue development	GO:0009888	The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.	419	1.03574430217037	1	0.965489260143198	0.645492779962168	L01D.profile.d50
regulation of biosynthetic process	GO:0009889	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.	253	0.625401690809314	2	3.19794466403162	0.130179090914386	L01D.profile.d50
negative regulation of biosynthetic process	GO:0009890	Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.	52	0.128541058980571	0	0	1	L01D.profile.d50
positive regulation of biosynthetic process	GO:0009891	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.	92	0.227418796657932	0	0	1	L01D.profile.d50
negative regulation of metabolic process	GO:0009892	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.	615	1.52024521678944	1	0.657788617886179	0.781752884125092	L01D.profile.d50
positive regulation of metabolic process	GO:0009893	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.	567	1.40159193157661	3	2.14042328042328	0.166707750291373	L01D.profile.d50
regulation of catabolic process	GO:0009894	Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.	24	0.0593266426064172	0	0	1	L01D.profile.d50
negative regulation of catabolic process	GO:0009895	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.	10	0.0247194344193405	0	0	1	L01D.profile.d50
epidermal cell differentiation	GO:0009913	The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.	25	0.0617985860483512	0	0	1	L01D.profile.d50
anterior/posterior axis specification	GO:0009948	The establishment, maintenance and elaboration of the anterior/posterior axis.	14	0.0346072081870767	0	0	1	L01D.profile.d50
anterior/posterior pattern formation	GO:0009952	The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis.	99	0.244722400751471	1	4.08626262626263	0.217315318801261	L01D.profile.d50
dorsal/ventral pattern formation	GO:0009953	The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation.	37	0.0914619073515598	0	0	1	L01D.profile.d50
proximal/distal pattern formation	GO:0009954	The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of signal transduction	GO:0009966	Any process that modulates the frequency, rate or extent of signal transduction.	682	1.68586542739902	3	1.77950146627566	0.238947737150941	L01D.profile.d50
positive regulation of signal transduction	GO:0009967	Any process that activates or increases the frequency, rate or extent of signal transduction.	191	0.472141197409403	0	0	1	L01D.profile.d50
negative regulation of signal transduction	GO:0009968	Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.	150	0.370791516290107	1	2.69693333333333	0.310128934718548	L01D.profile.d50
cellular process	GO:0009987	Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	13870	34.2858555396253	39	1.13749531362653	0.231333644179441	L01D.profile.d50
cell-cell recognition	GO:0009988	Cell recognition between cells, usually involving the formation of specialized cell junctions.	14	0.0346072081870767	0	0	1	L01D.profile.d50
response to extracellular stimulus	GO:0009991	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.	46	0.113709398328966	0	0	1	L01D.profile.d50
oocyte differentiation	GO:0009994	The process whereby a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.	9	0.0222474909774064	1	44.9488888888889	0.0220287769316943	L01D.profile.d50
glial cell differentiation	GO:0010001	The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell.	56	0.138428832748307	0	0	1	L01D.profile.d50
gastrulation (sensu Mammalia)	GO:0010003	The process of gastrulation, as in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674).	17	0.0420230385128788	0	0	1	L01D.profile.d50
response to organic substance	GO:0010033	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.	44	0.108765511445098	0	0	1	L01D.profile.d50
response to inorganic substance	GO:0010035	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.	27	0.0667424729322193	0	0	1	L01D.profile.d50
response to metal ion	GO:0010038	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.	21	0.051910812280615	0	0	1	L01D.profile.d50
specification of organ identity	GO:0010092	The regionalization process by which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	17	0.0420230385128788	0	0	1	L01D.profile.d50
response to ionizing radiation	GO:0010212	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.	18	0.0444949819548129	0	0	1	L01D.profile.d50
membrane invagination	GO:0010324	The infolding of a membrane, resulting in formation of a vesicle.	272	0.672368616206061	0	0	1	L01D.profile.d50
programmed cell death	GO:0012501	Cell death resulting from activation of endogenous cellular processes.	1086	2.68453057794038	4	1.49001841620626	0.282414206081497	L01D.profile.d50
induction of programmed cell death	GO:0012502	A process which directly activates any of the steps required for programmed cell death.	343	0.847876600583379	1	1.17941690962099	0.572125898598784	L01D.profile.d50
oligodendrocyte development	GO:0014003	The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.	8	0.0197755475354724	0	0	1	L01D.profile.d50
primary neural tube formation	GO:0014020	The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.	25	0.0617985860483512	0	0	1	L01D.profile.d50
mesenchymal cell development	GO:0014031	The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	38	0.0939338507934939	0	0	1	L01D.profile.d50
neural crest cell development	GO:0014032	The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	33	0.0815741335838236	0	0	1	L01D.profile.d50
neural crest cell differentiation	GO:0014033	The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell.	33	0.0815741335838236	0	0	1	L01D.profile.d50
heparan sulfate proteoglycan biosynthetic process	GO:0015012	The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.	11	0.0271913778612745	0	0	1	L01D.profile.d50
protein transport	GO:0015031	The directed movement of proteins into, out of, within or between cells.	881	2.1777821723439	3	1.37754824063564	0.371381879491538	L01D.profile.d50
DNA integration	GO:0015074	The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome.	4	0.00988777376773619	0	0	1	L01D.profile.d50
gas transport	GO:0015669	The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells.	14	0.0346072081870767	0	0	1	L01D.profile.d50
oxygen transport	GO:0015671	The directed movement of oxygen (O2) into, out of, within or between cells.	14	0.0346072081870767	0	0	1	L01D.profile.d50
monovalent inorganic cation transport	GO:0015672	The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	344	0.850348544025313	0	0	1	L01D.profile.d50
di-, tri-valent inorganic cation transport	GO:0015674	The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	201	0.496860631828744	0	0	1	L01D.profile.d50
organic cation transport	GO:0015695	The directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.	8	0.0197755475354724	0	0	1	L01D.profile.d50
inorganic anion transport	GO:0015698	The directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.	191	0.472141197409403	0	0	1	L01D.profile.d50
organic anion transport	GO:0015711	The directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.	28	0.0692144163741534	0	0	1	L01D.profile.d50
monocarboxylic acid transport	GO:0015718	The directed movement of monocarboxylic acids into, out of, within or between cells.	23	0.0568546991644831	0	0	1	L01D.profile.d50
monosaccharide transport	GO:0015749	The directed movement of monosaccharides into, out of, within or between cells. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.	40	0.098877737677362	0	0	1	L01D.profile.d50
glucose transport	GO:0015758	The directed movement of the hexose monosaccharide glucose into, out of, within or between cells.	38	0.0939338507934939	0	0	1	L01D.profile.d50
nucleotide-sugar transport	GO:0015780	The directed movement of nucleotide-sugars into, out of, within or between cells. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.	10	0.0247194344193405	0	0	1	L01D.profile.d50
acidic amino acid transport	GO:0015800	The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells.	12	0.0296633213032086	0	0	1	L01D.profile.d50
neutral amino acid transport	GO:0015804	The directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells.	19	0.0469669253967469	0	0	1	L01D.profile.d50
L-amino acid transport	GO:0015807	The directed movement of levorotatory isomer amino acids into, out of, within or between cells.	16	0.0395510950709448	0	0	1	L01D.profile.d50
glutamate transport	GO:0015813	The directed movement of glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells.	12	0.0296633213032086	0	0	1	L01D.profile.d50
peptide transport	GO:0015833	The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells.	43	0.106293568003164	0	0	1	L01D.profile.d50
amine transport	GO:0015837	The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells.	79	0.19528353191279	0	0	1	L01D.profile.d50
monoamine transport	GO:0015844	The directed movement of monoamines, organic compounds containing one amino group, into, out of, within or between cells.	11	0.0271913778612745	0	0	1	L01D.profile.d50
organic acid transport	GO:0015849	The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells.	97	0.239778513867603	0	0	1	L01D.profile.d50
folic acid transport	GO:0015884	The directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.	12	0.0296633213032086	0	0	1	L01D.profile.d50
drug transport	GO:0015893	The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of, within or between cells.	6	0.0148316606516043	0	0	1	L01D.profile.d50
tetracycline transport	GO:0015904	The directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).	2	0.0049438868838681	0	0	1	L01D.profile.d50
fatty acid transport	GO:0015908	The directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.	9	0.0222474909774064	0	0	1	L01D.profile.d50
phospholipid transport	GO:0015914	The directed movement of phospholipids into, out of, within or between cells. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.	21	0.051910812280615	0	0	1	L01D.profile.d50
sterol transport	GO:0015918	The directed movement of sterols into, out of, within or between cells. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	16	0.0395510950709448	0	0	1	L01D.profile.d50
nucleobase, nucleoside, nucleotide and nucleic acid transport	GO:0015931	The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells.	99	0.244722400751471	0	0	1	L01D.profile.d50
coenzyme A metabolic process	GO:0015936	The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.	8	0.0197755475354724	0	0	1	L01D.profile.d50
coenzyme A biosynthetic process	GO:0015937	The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.	5	0.0123597172096702	0	0	1	L01D.profile.d50
energy derivation by oxidation of organic compounds	GO:0015980		127	0.313936817125624	0	0	1	L01D.profile.d50
energy coupled proton transport, down electrochemical gradient	GO:0015985		56	0.138428832748307	0	0	1	L01D.profile.d50
ATP synthesis coupled proton transport	GO:0015986	The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.	56	0.138428832748307	0	0	1	L01D.profile.d50
energy coupled proton transport, against electrochemical gradient	GO:0015988		9	0.0222474909774064	0	0	1	L01D.profile.d50
ATP hydrolysis coupled proton transport	GO:0015991		7	0.0173036040935383	0	0	1	L01D.profile.d50
proton transport	GO:0015992	The directed movement of protons (hydrogen ions) into, out of, within or between cells.	101	0.249666287635339	0	0	1	L01D.profile.d50
viral reproduction	GO:0016032	The process by which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.	83	0.205171305680526	0	0	1	L01D.profile.d50
lipid catabolic process	GO:0016042	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	130	0.321352647451426	0	0	1	L01D.profile.d50
cellular component organization and biogenesis	GO:0016043	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component; includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	3495	8.6394423295595	11	1.27323032904149	0.2520244022546	L01D.profile.d50
membrane organization and biogenesis	GO:0016044	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of membranes inside and surrounding the cell.	394	0.973945716122015	0	0	1	L01D.profile.d50
detection of bacterium	GO:0016045	The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.	6	0.0148316606516043	0	0	1	L01D.profile.d50
cell growth	GO:0016049	The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.	278	0.687200276857665	1	1.45517985611511	0.497445425652838	L01D.profile.d50
vesicle organization and biogenesis	GO:0016050	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of any vesicle.	10	0.0247194344193405	0	0	1	L01D.profile.d50
carbohydrate biosynthetic process	GO:0016051	The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	120	0.296633213032086	0	0	1	L01D.profile.d50
carbohydrate catabolic process	GO:0016052	The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	132	0.326296534335294	0	0	1	L01D.profile.d50
organic acid biosynthetic process	GO:0016053	The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.	100	0.247194344193405	0	0	1	L01D.profile.d50
organic acid catabolic process	GO:0016054	The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.	16	0.0395510950709448	0	0	1	L01D.profile.d50
Wnt receptor signaling pathway	GO:0016055	The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.	145	0.358431799080437	1	2.78993103448276	0.301538725013617	L01D.profile.d50
immunoglobulin mediated immune response	GO:0016064	An immune response mediated by immunoglobulins, whether cell-bound or in solution.	79	0.19528353191279	0	0	1	L01D.profile.d50
RNA metabolic process	GO:0016070	The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.	3263	8.0659514510308	15	1.85966901624272	0.0182707347020533	L01D.profile.d50
mRNA metabolic process	GO:0016071	The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.	453	1.11979037919612	1	0.893024282560706	0.674103910895334	L01D.profile.d50
rRNA metabolic process	GO:0016072	The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.	78	0.192811588470856	1	5.18641025641026	0.175559489333073	L01D.profile.d50
snRNA metabolic process	GO:0016073	The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.	12	0.0296633213032086	0	0	1	L01D.profile.d50
synaptic vesicle exocytosis	GO:0016079	Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.	12	0.0296633213032086	0	0	1	L01D.profile.d50
diterpenoid metabolic process	GO:0016101	The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.	12	0.0296633213032086	0	0	1	L01D.profile.d50
sterol metabolic process	GO:0016125	The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	117	0.289217382706284	0	0	1	L01D.profile.d50
sterol biosynthetic process	GO:0016126	The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	49	0.121125228654768	0	0	1	L01D.profile.d50
sterol catabolic process	GO:0016127	The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	5	0.0123597172096702	0	0	1	L01D.profile.d50
snRNA processing	GO:0016180	Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.	12	0.0296633213032086	0	0	1	L01D.profile.d50
vesicle-mediated transport	GO:0016192	The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.	656	1.62159489790874	0	0	1	L01D.profile.d50
endosome transport	GO:0016197	The directed movement of substances into, out of or mediated by an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.	50	0.123597172096702	0	0	1	L01D.profile.d50
regulation of striated muscle development	GO:0016202	Any process that modulates the frequency, rate or extent of striated muscle development.	16	0.0395510950709448	0	0	1	L01D.profile.d50
macroautophagy	GO:0016236	The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.	10	0.0247194344193405	0	0	1	L01D.profile.d50
death	GO:0016265	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.	1152	2.84767884510802	4	1.40465277777778	0.318644681625691	L01D.profile.d50
phosphorylation	GO:0016310	The process of introducing a phosphoric group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.	1058	2.61531616156622	1	0.382362948960302	0.92709178482093	L01D.profile.d50
dephosphorylation	GO:0016311	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.	228	0.563603104760963	0	0	1	L01D.profile.d50
morphogenesis of embryonic epithelium	GO:0016331	The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.	46	0.113709398328966	0	0	1	L01D.profile.d50
cell-cell adhesion	GO:0016337	The attachment of one cell to another cell via adhesion molecules.	325	0.803381618628566	1	1.24473846153846	0.552633099691207	L01D.profile.d50
calcium-independent cell-cell adhesion	GO:0016338	The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.	23	0.0568546991644831	0	0	1	L01D.profile.d50
calcium-dependent cell-cell adhesion	GO:0016339	The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.	23	0.0568546991644831	0	0	1	L01D.profile.d50
dendrite development	GO:0016358	The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell.	40	0.098877737677362	0	0	1	L01D.profile.d50
somatic cell DNA recombination	GO:0016444	Recombination occurring within or between DNA molecules in somatic cells.	31	0.0766302466999555	0	0	1	L01D.profile.d50
somatic diversification of immunoglobulins	GO:0016445	The somatic process by means of which sequence diversity of immunoglobulins is generated.	34	0.0840460770257577	0	0	1	L01D.profile.d50
somatic recombination of immunoglobulin gene segments	GO:0016447	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.	31	0.0766302466999555	0	0	1	L01D.profile.d50
gene silencing	GO:0016458	Any mechanism, at the level of transcription or post-transcription, causing long-term gene inactivation.	34	0.0840460770257577	0	0	1	L01D.profile.d50
cell migration	GO:0016477	The orderly movement of cells from one site to another, often during the development of a multicellular organism.	385	0.951698225144609	3	3.15225974025974	0.0714077260219353	L01D.profile.d50
negative regulation of transcription	GO:0016481	Any process that stops, prevents or reduces the frequency, rate or extent of transcription.	439	1.08518317100905	1	0.921503416856492	0.662613675319198	L01D.profile.d50
protein processing	GO:0016485	The posttranslational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations.	114	0.281801552380482	0	0	1	L01D.profile.d50
peptide hormone processing	GO:0016486	The generation of a mature peptide hormone by posttranslational processing of a prohormone.	8	0.0197755475354724	0	0	1	L01D.profile.d50
negative regulation of angiogenesis	GO:0016525	Any process that stops, prevents or reduces the frequency, rate or extent of angiogenesis.	33	0.0815741335838236	0	0	1	L01D.profile.d50
protein autoprocessing	GO:0016540	Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.	67	0.165620210609581	0	0	1	L01D.profile.d50
RNA editing	GO:0016547	The insertion, deletion or substitution of nucleotides within nascent RNA transcripts to produce RNA molecules with sequences that differ from those coded genetically.	5	0.0123597172096702	0	0	1	L01D.profile.d50
mRNA modification	GO:0016556	The covalent alteration of one or more nucleotides within mRNA, resulting in a change in the properties of the mRNA.	4	0.00988777376773619	0	0	1	L01D.profile.d50
protein ubiquitination	GO:0016567	The process by which one or more ubiquitin moieties are added to a protein.	96	0.237306570425669	0	0	1	L01D.profile.d50
chromatin modification	GO:0016568	The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure.	256	0.632817521135116	1	1.580234375	0.469322590296608	L01D.profile.d50
covalent chromatin modification	GO:0016569	The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups.	69	0.170564097493449	0	0	1	L01D.profile.d50
histone modification	GO:0016570	The covalent alteration of one or more amino acid residues within a histone protein.	68	0.168092154051515	0	0	1	L01D.profile.d50
histone methylation	GO:0016571	The modification of histones by addition of methyl groups.	10	0.0247194344193405	0	0	1	L01D.profile.d50
histone acetylation	GO:0016573	The modification of histones by addition of acetyl groups.	31	0.0766302466999555	0	0	1	L01D.profile.d50
histone ubiquitination	GO:0016574	The modification of histones by addition of ubiquitin groups.	10	0.0247194344193405	0	0	1	L01D.profile.d50
histone deacetylation	GO:0016575	The modification of histones by removal of acetyl groups.	13	0.0321352647451426	0	0	1	L01D.profile.d50
protein deubiquitination	GO:0016579	The removal of one or more ubiquitin moieties from a protein.	13	0.0321352647451426	0	0	1	L01D.profile.d50
protein sumoylation	GO:0016925	The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.	12	0.0296633213032086	0	0	1	L01D.profile.d50
cell wall catabolic process	GO:0016998	The chemical reactions and pathways resulting in the breakdown of a cell wall.	3	0.00741583032580215	0	0	1	L01D.profile.d50
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.	21	0.051910812280615	0	0	1	L01D.profile.d50
protein import	GO:0017038	The directed movement of proteins into a cell or organelle.	172	0.425174272012656	3	7.05593023255814	0.00922973922102534	L01D.profile.d50
drug metabolic process	GO:0017144	The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.	3	0.00741583032580215	0	0	1	L01D.profile.d50
stem cell division	GO:0017145	The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.	7	0.0173036040935383	0	0	1	L01D.profile.d50
negative regulation of protein biosynthetic process	GO:0017148	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.	38	0.0939338507934939	0	0	1	L01D.profile.d50
calcium ion-dependent exocytosis	GO:0017156	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions.	26	0.0642705294902853	0	0	1	L01D.profile.d50
regulation of exocytosis	GO:0017157	Any process that modulates the frequency, rate or extent of exocytosis.	19	0.0469669253967469	0	0	1	L01D.profile.d50
peptidyl-serine phosphorylation	GO:0018105	The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.	12	0.0296633213032086	0	0	1	L01D.profile.d50
peptidyl-tyrosine phosphorylation	GO:0018108	The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.	75	0.185395758145054	0	0	1	L01D.profile.d50
peptide cross-linking	GO:0018149	The formation of a covalent cross-link between or within protein chains.	21	0.051910812280615	0	0	1	L01D.profile.d50
peptidyl-amino acid modification	GO:0018193	The alteration of an amino acid residue in a peptide.	151	0.373263459732041	0	0	1	L01D.profile.d50
peptidyl-asparagine modification	GO:0018196	The modification of peptidyl-asparagine.	14	0.0346072081870767	0	0	1	L01D.profile.d50
peptidyl-histidine modification	GO:0018202	The modification of peptidyl-histidine.	10	0.0247194344193405	0	0	1	L01D.profile.d50
peptidyl-serine modification	GO:0018209	The modification of peptidyl-serine.	12	0.0296633213032086	0	0	1	L01D.profile.d50
peptidyl-tyrosine modification	GO:0018212	The modification of peptidyl-tyrosine.	77	0.190339645028922	0	0	1	L01D.profile.d50
protein amino acid N-linked glycosylation via asparagine	GO:0018279	The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.	14	0.0346072081870767	0	0	1	L01D.profile.d50
protein-chromophore linkage	GO:0018298	The covalent or noncovalent linking of a chromophore to a protein.	13	0.0321352647451426	0	0	1	L01D.profile.d50
protein prenylation	GO:0018342	The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added.	8	0.0197755475354724	0	0	1	L01D.profile.d50
protein palmitoylation	GO:0018345	The covalent or non-covalent attachment of a palmitoyl moiety to a protein.	5	0.0123597172096702	0	0	1	L01D.profile.d50
protein amino acid prenylation	GO:0018346	The covalent attachment of a prenyl moiety to a protein amino acid.	7	0.0173036040935383	0	0	1	L01D.profile.d50
peptide or protein amino-terminal blocking	GO:0018409		11	0.0271913778612745	0	0	1	L01D.profile.d50
phenol metabolic process	GO:0018958	The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers.	37	0.0914619073515598	0	0	1	L01D.profile.d50
virus-host interaction	GO:0019048	Interactions, directly with the host cell macromolecular machinery, to allow virus replication.	10	0.0247194344193405	0	0	1	L01D.profile.d50
viral infectious cycle	GO:0019058	A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.	69	0.170564097493449	0	0	1	L01D.profile.d50
initiation of viral infection	GO:0019059	Processes involved in the start of virus infection of cells.	18	0.0444949819548129	0	0	1	L01D.profile.d50
viral genome replication	GO:0019079	Any process involved directly in viral genome replication, including viral nucleotide metabolism.	52	0.128541058980571	0	0	1	L01D.profile.d50
reproductive behavior	GO:0019098	The specific actions or reactions of an organism that are associated with reproduction.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of lipid metabolic process	GO:0019216	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.	33	0.0815741335838236	0	0	1	L01D.profile.d50
regulation of fatty acid metabolic process	GO:0019217	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of steroid metabolic process	GO:0019218	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	GO:0019219	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	2802	6.9263855242992	14	2.0212562455389	0.0116996213104067	L01D.profile.d50
regulation of phosphate metabolic process	GO:0019220	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.	80	0.197755475354724	0	0	1	L01D.profile.d50
cytokine and chemokine mediated signaling pathway	GO:0019221	Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.	50	0.123597172096702	0	0	1	L01D.profile.d50
regulation of metabolic process	GO:0019222	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.	3184	7.87066791911801	17	2.15991834170854	0.00313124763228499	L01D.profile.d50
transmission of nerve impulse	GO:0019226	The sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.	448	1.10743066198645	0	0	1	L01D.profile.d50
regulation of vasoconstriction	GO:0019229	Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.	12	0.0296633213032086	0	0	1	L01D.profile.d50
sensory perception of pain	GO:0019233	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances.	15	0.0370791516290107	0	0	1	L01D.profile.d50
fucose catabolic process	GO:0019317	The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose).	17	0.0420230385128788	0	0	1	L01D.profile.d50
hexose metabolic process	GO:0019318	The chemical reactions and pathways involving a hexose, any aldose with a chain of six carbon atoms in the molecule.	215	0.53146784001582	0	0	1	L01D.profile.d50
hexose biosynthetic process	GO:0019319	The chemical reactions and pathways resulting in the formation of hexose, any aldose with a chain of six carbon atoms in the molecule.	39	0.0964057942354279	0	0	1	L01D.profile.d50
hexose catabolic process	GO:0019320	The chemical reactions and pathways resulting in the breakdown of hexose, any aldose with a chain of six carbon atoms in the molecule.	103	0.254610174519207	0	0	1	L01D.profile.d50
pentose metabolic process	GO:0019321	The chemical reactions and pathways involving a pentose, any aldose with a chain of five carbon atoms in the molecule.	8	0.0197755475354724	0	0	1	L01D.profile.d50
pyridine nucleotide metabolic process	GO:0019362	The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.	33	0.0815741335838236	0	0	1	L01D.profile.d50
pyridine nucleotide biosynthetic process	GO:0019363	The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.	14	0.0346072081870767	0	0	1	L01D.profile.d50
leukotriene biosynthetic process	GO:0019370	The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.	23	0.0568546991644831	0	0	1	L01D.profile.d50
glycolipid catabolic process	GO:0019377	The chemical reactions and pathways resulting in the breakdown of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.	15	0.0370791516290107	0	0	1	L01D.profile.d50
fatty acid oxidation	GO:0019395	The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.	45	0.111237454887032	0	0	1	L01D.profile.d50
aromatic compound biosynthetic process	GO:0019438	The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.	13	0.0321352647451426	0	0	1	L01D.profile.d50
aromatic compound catabolic process	GO:0019439	The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.	25	0.0617985860483512	0	0	1	L01D.profile.d50
protein metabolic process	GO:0019538	The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.	4109	10.157215602907	10	0.984521781455342	0.561754788925864	L01D.profile.d50
urea metabolic process	GO:0019627	The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals.	9	0.0222474909774064	0	0	1	L01D.profile.d50
NAD metabolic process	GO:0019674	The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.	7	0.0173036040935383	0	0	1	L01D.profile.d50
Mo-molybdopterin cofactor metabolic process	GO:0019720	The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.	8	0.0197755475354724	0	0	1	L01D.profile.d50
calcium-mediated signaling	GO:0019722	A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response.	47	0.1161813417709	0	0	1	L01D.profile.d50
B cell mediated immunity	GO:0019724	Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.	79	0.19528353191279	0	0	1	L01D.profile.d50
cell homeostasis	GO:0019725	The processes involved in the maintenance of an internal equilibrium at the level of the cell.	363	0.89731546942206	1	1.11443526170799	0.592790041109877	L01D.profile.d50
secondary metabolic process	GO:0019748	The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.	69	0.170564097493449	0	0	1	L01D.profile.d50
polyol metabolic process	GO:0019751	The chemical reactions and pathways involving a polyol, any polyhydric alcohol.	25	0.0617985860483512	0	0	1	L01D.profile.d50
carboxylic acid metabolic process	GO:0019752	The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).	679	1.67844959707322	0	0	1	L01D.profile.d50
cytolysis	GO:0019835	The rupture of cell membranes and the loss of cytoplasm.	16	0.0395510950709448	0	0	1	L01D.profile.d50
antigen processing and presentation	GO:0019882	The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.	110	0.271913778612745	0	0	1	L01D.profile.d50
antigen processing and presentation of endogenous antigen	GO:0019883	The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.	10	0.0247194344193405	0	0	1	L01D.profile.d50
antigen processing and presentation of exogenous antigen	GO:0019884	The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.	13	0.0321352647451426	0	0	1	L01D.profile.d50
antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:0019885	The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.	8	0.0197755475354724	0	0	1	L01D.profile.d50
sequestering of lipid	GO:0019915	The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.	20	0.049438868838681	0	0	1	L01D.profile.d50
second-messenger-mediated signaling	GO:0019932	A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.	330	0.815741335838236	1	1.22587878787879	0.558135159184445	L01D.profile.d50
cAMP-mediated signaling	GO:0019933	A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.	134	0.331240421219163	0	0	1	L01D.profile.d50
cyclic-nucleotide-mediated signaling	GO:0019935	A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.	183	0.452365649873931	0	0	1	L01D.profile.d50
modification-dependent protein catabolic process	GO:0019941	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.	220	0.543827557225491	1	1.83881818181818	0.419868700406443	L01D.profile.d50
sexual reproduction	GO:0019953	The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.	344	0.850348544025313	2	2.35197674418605	0.209341460025057	L01D.profile.d50
hemoglobin metabolic process	GO:0020027	The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.	10	0.0247194344193405	0	0	1	L01D.profile.d50
spinal cord development	GO:0021510	The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.	14	0.0346072081870767	0	0	1	L01D.profile.d50
developmental maturation	GO:0021700	A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.	119	0.294161269590152	1	3.39949579831933	0.255115007402593	L01D.profile.d50
glial cell development	GO:0021782	The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.	10	0.0247194344193405	0	0	1	L01D.profile.d50
neural tube development	GO:0021915	The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.	33	0.0815741335838236	0	0	1	L01D.profile.d50
central nervous system neuron differentiation	GO:0021953	The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.	10	0.0247194344193405	0	0	1	L01D.profile.d50
central nervous system neuron development	GO:0021954	The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.	7	0.0173036040935383	0	0	1	L01D.profile.d50
neurogenesis	GO:0022008	Generation of cells within the nervous system.	420	1.0382162456123	2	1.92638095238095	0.278313946729731	L01D.profile.d50
cell cycle process	GO:0022402	A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.	1144	2.82790329757255	11	3.88980769230769	0.000173404133945764	L01D.profile.d50
cell cycle phase	GO:0022403	A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.	474	1.17170119147674	6	5.12075949367089	0.00130439583254721	L01D.profile.d50
molting cycle process	GO:0022404	A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin.	29	0.0716863598160874	0	0	1	L01D.profile.d50
hair cycle process	GO:0022405	A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.	29	0.0716863598160874	0	0	1	L01D.profile.d50
membrane docking	GO:0022406	The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.	23	0.0568546991644831	0	0	1	L01D.profile.d50
regulation of cell-cell adhesion	GO:0022407	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.	13	0.0321352647451426	0	0	1	L01D.profile.d50
negative regulation of cell-cell adhesion	GO:0022408	Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.	11	0.0271913778612745	0	0	1	L01D.profile.d50
cellular component disassembly	GO:0022411	A cellular process that results in the breakdown of a part of the cell.	52	0.128541058980571	1	7.77961538461538	0.12076247362875	L01D.profile.d50
reproductive process	GO:0022414	A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.	396	0.978889603005883	0	0	1	L01D.profile.d50
viral reproductive process	GO:0022415	A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.	78	0.192811588470856	0	0	1	L01D.profile.d50
digestive process	GO:0022600	A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	30	0.0741583032580215	0	0	1	L01D.profile.d50
menstrual cycle phase	GO:0022601	The progression of physiological phases, occurring in the endometrium, that recur at regular intervals during the reproductive years.	39	0.0964057942354279	0	0	1	L01D.profile.d50
menstrual cycle process	GO:0022602	A process involved in the sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.	39	0.0964057942354279	0	0	1	L01D.profile.d50
regulation of anatomical structure morphogenesis	GO:0022603		58	0.143372719632175	0	0	1	L01D.profile.d50
regulation of cell morphogenesis	GO:0022604	Any process that modulates the frequency, rate or extent of cell morphogenesis.	58	0.143372719632175	0	0	1	L01D.profile.d50
cellular component assembly	GO:0022607	A cellular process that results in the assembly of a part of the cell.	811	2.00474613140851	1	0.49881627620222	0.865639397745884	L01D.profile.d50
biological adhesion	GO:0022610	The attachment of a cell or organism to a substrate or other organism.	1042	2.57576506649528	2	0.776468330134357	0.728282207172399	L01D.profile.d50
ribonucleoprotein complex biogenesis and assembly	GO:0022613	The cellular process by which a complex containing RNA and proteins, is synthesized, aggregates, and bonds together.	239	0.590794482622238	1	1.6926359832636	0.446517914649942	L01D.profile.d50
protein-RNA complex assembly	GO:0022618	The aggregation and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.	154	0.380679290057844	0	0	1	L01D.profile.d50
metal ion transport	GO:0030001	The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells.	466	1.15192564394127	0	0	1	L01D.profile.d50
anion homeostasis	GO:0030002	The regulation of the levels, transport, and metabolism of anions within a cell or between a cell and its external environment.	6	0.0148316606516043	0	0	1	L01D.profile.d50
cation homeostasis	GO:0030003	The regulation of the levels, transport, and metabolism of cations within a cell or between a cell and its external environment.	244	0.603154199831908	1	1.65795081967213	0.453325059657619	L01D.profile.d50
monovalent inorganic cation homeostasis	GO:0030004	The regulation of the levels, transport, and metabolism of monovalent inorganic cations within a cell or between a cell and its external environment.	24	0.0593266426064172	0	0	1	L01D.profile.d50
di-, tri-valent inorganic cation homeostasis	GO:0030005	The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic cations within a cell or between a cell and its external environment.	218	0.538883670341623	1	1.8556880733945	0.416989927039173	L01D.profile.d50
establishment of cell polarity	GO:0030010	The specification and formation of anisotropic intracellular organization or cell growth patterns.	11	0.0271913778612745	0	0	1	L01D.profile.d50
actin filament-based process	GO:0030029	Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.	339	0.837988826815642	2	2.38666666666667	0.204850507743026	L01D.profile.d50
cell projection organization and biogenesis	GO:0030030	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.	296	0.731695258812478	2	2.73337837837838	0.16677681687862	L01D.profile.d50
cell projection biogenesis	GO:0030031	Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.	72	0.177979927819252	1	5.61861111111111	0.163225173489614	L01D.profile.d50
lamellipodium biogenesis	GO:0030032	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.	9	0.0222474909774064	1	44.9488888888889	0.0220287769316943	L01D.profile.d50
microspike biogenesis	GO:0030035	Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell.	15	0.0370791516290107	0	0	1	L01D.profile.d50
actin cytoskeleton organization and biogenesis	GO:0030036	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.	313	0.773718297325357	2	2.58492012779553	0.18169300466379	L01D.profile.d50
actin filament polymerization	GO:0030041	Assembly of actin filaments by the addition of actin monomers to a filament.	42	0.10382162456123	1	9.63190476190476	0.0987297816990099	L01D.profile.d50
actin filament depolymerization	GO:0030042	Disassembly of actin filaments by the removal of actin monomers from a filament.	45	0.111237454887032	0	0	1	L01D.profile.d50
actin filament-based movement	GO:0030048	Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.	29	0.0716863598160874	0	0	1	L01D.profile.d50
regulation of mitotic metaphase/anaphase transition	GO:0030071	Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle.	12	0.0296633213032086	0	0	1	L01D.profile.d50
peptide hormone secretion	GO:0030072	The regulated release of a peptide hormone from secretory granules.	27	0.0667424729322193	0	0	1	L01D.profile.d50
insulin secretion	GO:0030073	The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.	21	0.051910812280615	0	0	1	L01D.profile.d50
hemopoiesis	GO:0030097	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.	303	0.748998862906017	0	0	1	L01D.profile.d50
lymphocyte differentiation	GO:0030098	The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells.	128	0.316408760567558	0	0	1	L01D.profile.d50
myeloid cell differentiation	GO:0030099	The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.	142	0.351015968754635	0	0	1	L01D.profile.d50
regulation of endocytosis	GO:0030100	Any process that modulates the frequency, rate or extent of endocytosis.	37	0.0914619073515598	0	0	1	L01D.profile.d50
natural killer cell activation	GO:0030101	The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.	23	0.0568546991644831	0	0	1	L01D.profile.d50
regulation of Wnt receptor signaling pathway	GO:0030111	Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.	44	0.108765511445098	1	9.19409090909091	0.103180052494472	L01D.profile.d50
sphingolipid biosynthetic process	GO:0030148	The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	21	0.051910812280615	0	0	1	L01D.profile.d50
sphingolipid catabolic process	GO:0030149	The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	23	0.0568546991644831	0	0	1	L01D.profile.d50
cell differentiation	GO:0030154	The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.	2359	5.83131457952242	8	1.37190334887664	0.2329475858674	L01D.profile.d50
regulation of cell adhesion	GO:0030155	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.	108	0.266969891728877	0	0	1	L01D.profile.d50
regulation of proteolysis	GO:0030162	Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.	27	0.0667424729322193	0	0	1	L01D.profile.d50
protein catabolic process	GO:0030163	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	294	0.72675137192861	1	1.37598639455782	0.516957722978443	L01D.profile.d50
proteoglycan biosynthetic process	GO:0030166	The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.	24	0.0593266426064172	0	0	1	L01D.profile.d50
platelet activation	GO:0030168	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.	28	0.0692144163741534	0	0	1	L01D.profile.d50
regulation of DNA replication initiation	GO:0030174	Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.	13	0.0321352647451426	0	0	1	L01D.profile.d50
negative regulation of Wnt receptor signaling pathway	GO:0030178	Any process that stops, prevents or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity.	24	0.0593266426064172	0	0	1	L01D.profile.d50
neuron differentiation	GO:0030182	The process whereby a relatively unspecialized cell acquires specialized features of a neuron.	335	0.828101053047906	1	1.20758208955224	0.563569550151811	L01D.profile.d50
B cell differentiation	GO:0030183	The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell.	57	0.140900776190241	0	0	1	L01D.profile.d50
regulation of blood coagulation	GO:0030193	Any process that modulates the frequency, rate or extent of blood coagulation.	15	0.0370791516290107	0	0	1	L01D.profile.d50
negative regulation of blood coagulation	GO:0030195	Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.	15	0.0370791516290107	0	0	1	L01D.profile.d50
extracellular matrix organization and biogenesis	GO:0030198	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an extracellular matrix.	83	0.205171305680526	0	0	1	L01D.profile.d50
collagen fibril organization	GO:0030199	Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.	13	0.0321352647451426	0	0	1	L01D.profile.d50
heparan sulfate proteoglycan metabolic process	GO:0030201	The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.	14	0.0346072081870767	0	0	1	L01D.profile.d50
glycosaminoglycan metabolic process	GO:0030203	The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.	63	0.155732436841845	0	0	1	L01D.profile.d50
chondroitin sulfate metabolic process	GO:0030204	The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.	10	0.0247194344193405	0	0	1	L01D.profile.d50
chondroitin sulfate biosynthetic process	GO:0030206	The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.	10	0.0247194344193405	0	0	1	L01D.profile.d50
hyaluronan metabolic process	GO:0030212	The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.	6	0.0148316606516043	0	0	1	L01D.profile.d50
keratinocyte differentiation	GO:0030216	The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte.	40	0.098877737677362	0	0	1	L01D.profile.d50
T cell differentiation	GO:0030217	The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell.	81	0.200227418796658	0	0	1	L01D.profile.d50
erythrocyte differentiation	GO:0030218	The process by which a myeloid precursor cell acquires specializes features of an erythrocyte.	54	0.133484945864439	0	0	1	L01D.profile.d50
macrophage differentiation	GO:0030225	The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.	21	0.051910812280615	0	0	1	L01D.profile.d50
male sex determination	GO:0030238	The specification of male sex of an individual organism.	11	0.0271913778612745	0	0	1	L01D.profile.d50
myofibril assembly	GO:0030239	Formation of myofibrils, the repeating units of striated muscle.	21	0.051910812280615	0	0	1	L01D.profile.d50
lipid modification	GO:0030258	The covalent alteration of one or more fatty acids in a lipid, resulting in a change in that lipid.	41	0.101349681119296	0	0	1	L01D.profile.d50
entry into host cell	GO:0030260	The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
chromosome condensation	GO:0030261	The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.	26	0.0642705294902853	0	0	1	L01D.profile.d50
apoptotic nuclear changes	GO:0030262	The morphological and physiological alterations undergone by the nucleus during apoptosis.	22	0.0543827557225491	1	18.3881818181818	0.0529942199196842	L01D.profile.d50
regulation of ossification	GO:0030278	Any process that modulates the frequency, rate or extent of bone formation.	31	0.0766302466999555	0	0	1	L01D.profile.d50
negative regulation of ossification	GO:0030279	Any process that stops, prevents or reduces the frequency, rate or extent of bone formation.	9	0.0222474909774064	0	0	1	L01D.profile.d50
bone mineralization	GO:0030282	The deposition of calcium phosphate in bone tissue.	29	0.0716863598160874	0	0	1	L01D.profile.d50
cholesterol absorption	GO:0030299	Uptake of cholesterol into the blood by absorption from the small intestine.	15	0.0370791516290107	0	0	1	L01D.profile.d50
cholesterol transport	GO:0030301	The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of cell growth	GO:0030307	Any process that activates or increases the frequency, rate or extent of cell growth.	10	0.0247194344193405	0	0	1	L01D.profile.d50
negative regulation of cell growth	GO:0030308	Any process that stops, prevents or reduces the frequency, rate or extent of cell growth.	68	0.168092154051515	0	0	1	L01D.profile.d50
osteoclast differentiation	GO:0030316	The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.	28	0.0692144163741534	0	0	1	L01D.profile.d50
sperm motility	GO:0030317	Any process involved in the controlled movement of a sperm cell.	12	0.0296633213032086	0	0	1	L01D.profile.d50
melanocyte differentiation	GO:0030318	The process whereby a relatively unspecialized cell acquires specialized features of a melanocyte.	24	0.0593266426064172	0	0	1	L01D.profile.d50
respiratory tube development	GO:0030323	The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.	70	0.173036040935383	0	0	1	L01D.profile.d50
lung development	GO:0030324	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the oesophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.	67	0.165620210609581	0	0	1	L01D.profile.d50
adrenal gland development	GO:0030325	The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.	18	0.0444949819548129	0	0	1	L01D.profile.d50
embryonic limb morphogenesis	GO:0030326	The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping.	73	0.180451871261186	0	0	1	L01D.profile.d50
DNA damage response, signal transduction by p53 class mediator	GO:0030330	A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.	35	0.0865180204676917	0	0	1	L01D.profile.d50
regulation of cell migration	GO:0030334	Any process that modulates the frequency, rate or extent of cell migration.	91	0.224946853215998	0	0	1	L01D.profile.d50
positive regulation of cell migration	GO:0030335	Any process that activates or increases the frequency, rate or extent of cell migration.	17	0.0420230385128788	0	0	1	L01D.profile.d50
negative regulation of cell migration	GO:0030336	Any process that stops, prevents or reduces the frequency, rate or extent of cell migration.	33	0.0815741335838236	0	0	1	L01D.profile.d50
phosphoinositide metabolic process	GO:0030384	The chemical reactions and pathways involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes.	48	0.118653285212834	0	0	1	L01D.profile.d50
ER-associated protein catabolic process	GO:0030433	The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of bone mineralization	GO:0030500	Any process that modulates the frequency, rate or extent of bone mineralization.	17	0.0420230385128788	0	0	1	L01D.profile.d50
regulation of cell redox homeostasis	GO:0030503	Any process that modulates the redox environment of a cell or compartment within a cell.	9	0.0222474909774064	0	0	1	L01D.profile.d50
BMP signaling pathway	GO:0030509	A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.	28	0.0692144163741534	1	14.4478571428571	0.0669533735976265	L01D.profile.d50
regulation of BMP signaling pathway	GO:0030510	Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.	10	0.0247194344193405	1	40.454	0.0244462664829582	L01D.profile.d50
negative regulation of BMP signaling pathway	GO:0030514	Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway activity.	9	0.0222474909774064	1	44.9488888888889	0.0220287769316943	L01D.profile.d50
regulation of axon extension	GO:0030516	Any process that modulates the rate, direction or extent of axon extension.	25	0.0617985860483512	0	0	1	L01D.profile.d50
negative regulation of axon extension	GO:0030517	Any process that stops, prevents or reduces the frequency, rate or extent of axon outgrowth.	12	0.0296633213032086	0	0	1	L01D.profile.d50
steroid hormone receptor signaling pathway	GO:0030518	Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor.	83	0.205171305680526	0	0	1	L01D.profile.d50
estrogen receptor signaling pathway	GO:0030520	Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.	27	0.0667424729322193	0	0	1	L01D.profile.d50
androgen receptor signaling pathway	GO:0030521	Any series of molecular signals generated as a consequence of an androgen binding to its receptor.	54	0.133484945864439	0	0	1	L01D.profile.d50
intracellular receptor-mediated signaling pathway	GO:0030522	Any series of molecular signals initiated by a ligand entering the target cell, where it binds to an intracellular receptor.	88	0.217531022890196	0	0	1	L01D.profile.d50
adult behavior	GO:0030534	Behavior in a fully developed and mature organism.	40	0.098877737677362	0	0	1	L01D.profile.d50
male genitalia development	GO:0030539	The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.	6	0.0148316606516043	0	0	1	L01D.profile.d50
collagen catabolic process	GO:0030574	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.	23	0.0568546991644831	0	0	1	L01D.profile.d50
neutrophil chemotaxis	GO:0030593	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	24	0.0593266426064172	0	0	1	L01D.profile.d50
leukocyte chemotaxis	GO:0030595	The movement of a leukocyte in response to an external stimulus.	32	0.0791021901418896	0	0	1	L01D.profile.d50
hydrogen ion homeostasis	GO:0030641	The regulation of the levels, transport, and metabolism of hydrogen ions (protons) within a cell or between a cell and its external environment.	20	0.049438868838681	0	0	1	L01D.profile.d50
cytoskeleton-dependent intracellular transport	GO:0030705	The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.	139	0.343600138428833	0	0	1	L01D.profile.d50
ovulation	GO:0030728	The release of a mature ovum/oocyte from an ovary.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of cyclic nucleotide metabolic process	GO:0030799	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of cyclic nucleotide biosynthetic process	GO:0030802	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of nucleotide biosynthetic process	GO:0030808	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of cAMP metabolic process	GO:0030814	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of actin filament length	GO:0030832	Any process that controls the length of actin filaments in a cell.	73	0.180451871261186	1	5.54164383561644	0.165293633534382	L01D.profile.d50
regulation of actin filament polymerization	GO:0030833	Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.	18	0.0444949819548129	1	22.4744444444444	0.0435722868502822	L01D.profile.d50
regulation of actin filament depolymerization	GO:0030834	Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.	45	0.111237454887032	0	0	1	L01D.profile.d50
negative regulation of actin filament depolymerization	GO:0030835	Any process that stops, prevents or reduces the frequency, rate or extent of actin depolymerization.	43	0.106293568003164	0	0	1	L01D.profile.d50
positive regulation of actin filament polymerization	GO:0030838	Any process that activates or increases the frequency, rate or extent of actin polymerization.	8	0.0197755475354724	1	50.5675	0.0196052966743015	L01D.profile.d50
granulocyte differentiation	GO:0030851	The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.	15	0.0370791516290107	0	0	1	L01D.profile.d50
epithelial cell differentiation	GO:0030855	The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.	52	0.128541058980571	1	7.77961538461538	0.12076247362875	L01D.profile.d50
regulation of epithelial cell differentiation	GO:0030856	Any process that modulates the frequency, rate or extent of epithelial cell differentiation.	11	0.0271913778612745	0	0	1	L01D.profile.d50
cortical cytoskeleton organization and biogenesis	GO:0030865	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.	28	0.0692144163741534	0	0	1	L01D.profile.d50
cortical actin cytoskeleton organization and biogenesis	GO:0030866	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.	26	0.0642705294902853	0	0	1	L01D.profile.d50
thyroid gland development	GO:0030878	The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.	10	0.0247194344193405	0	0	1	L01D.profile.d50
mammary gland development	GO:0030879	The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.	18	0.0444949819548129	0	0	1	L01D.profile.d50
regulation of B cell proliferation	GO:0030888	Any process that modulates the frequency, rate or extent of B cell proliferation.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of B cell proliferation	GO:0030890	Any process that activates or increases the rate or extent of B cell proliferation.	10	0.0247194344193405	0	0	1	L01D.profile.d50
forebrain development	GO:0030900	The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).	56	0.138428832748307	1	7.22392857142857	0.12942399295915	L01D.profile.d50
midbrain development	GO:0030901	The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).	8	0.0197755475354724	0	0	1	L01D.profile.d50
hindbrain development	GO:0030902	The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).	37	0.0914619073515598	0	0	1	L01D.profile.d50
unfolded protein response	GO:0030968	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.	15	0.0370791516290107	0	0	1	L01D.profile.d50
pancreas development	GO:0031016	The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.	15	0.0370791516290107	0	0	1	L01D.profile.d50
microtubule organizing center organization and biogenesis	GO:0031023	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.	18	0.0444949819548129	0	0	1	L01D.profile.d50
actomyosin structure organization and biogenesis	GO:0031032	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments.	27	0.0667424729322193	0	0	1	L01D.profile.d50
hair follicle morphogenesis	GO:0031069	The process by which the anatomical structures of the hair follicle are generated and organized.	7	0.0173036040935383	0	0	1	L01D.profile.d50
stress-activated protein kinase signaling pathway	GO:0031098	A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.	89	0.22000296633213	0	0	1	L01D.profile.d50
regeneration	GO:0031099	The regrowth of a lost or destroyed body part, such as an organ or tissue.	8	0.0197755475354724	0	0	1	L01D.profile.d50
microtubule polymerization or depolymerization	GO:0031109	Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.	30	0.0741583032580215	0	0	1	L01D.profile.d50
regulation of microtubule polymerization or depolymerization	GO:0031110	Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.	27	0.0667424729322193	0	0	1	L01D.profile.d50
negative regulation of microtubule polymerization or depolymerization	GO:0031111	Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.	27	0.0667424729322193	0	0	1	L01D.profile.d50
regulation of microtubule depolymerization	GO:0031114	Any process that modulates the frequency, rate or extent of microtubule depolymerization.	25	0.0617985860483512	0	0	1	L01D.profile.d50
RNA 3'-end processing	GO:0031123	Any process involved in forming the mature 3' end of an RNA molecule.	29	0.0716863598160874	0	0	1	L01D.profile.d50
mRNA 3'-end processing	GO:0031124	Any process involved in forming the mature 3' end of an mRNA molecule.	26	0.0642705294902853	0	0	1	L01D.profile.d50
induction	GO:0031128	Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.	17	0.0420230385128788	0	0	1	L01D.profile.d50
neurite development	GO:0031175	The process whose specific outcome is the progression of the neurite over time, from its formation to the mature structure. The neurite is any process extending from a neural cell, such as axons or dendrites.	224	0.553715330993227	1	1.80598214285714	0.425583673112781	L01D.profile.d50
biomineral formation	GO:0031214	Formation of hard tissues that consist mainly of norganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.	144	0.355959855638503	1	2.80930555555556	0.299807889718513	L01D.profile.d50
regulation of cyclase activity	GO:0031279	Any process that modulates the frequency, rate or extent of cyclase activity.	73	0.180451871261186	0	0	1	L01D.profile.d50
negative regulation of cyclase activity	GO:0031280	Any process that stops or reduces the activity of a cyclase.	24	0.0593266426064172	0	0	1	L01D.profile.d50
positive regulation of cyclase activity	GO:0031281	Any process that activates or increases the activity of a cyclase.	48	0.118653285212834	0	0	1	L01D.profile.d50
lymphocyte costimulation	GO:0031294	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.	7	0.0173036040935383	0	0	1	L01D.profile.d50
T cell costimulation	GO:0031295	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of cellular metabolic process	GO:0031323	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.	3041	7.51718000692144	16	2.1284577441631	0.00465320936670176	L01D.profile.d50
negative regulation of cellular metabolic process	GO:0031324	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.	536	1.32496168487665	1	0.754738805970149	0.734622517360969	L01D.profile.d50
positive regulation of cellular metabolic process	GO:0031325	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.	539	1.33237751520245	2	1.50107606679035	0.384748573813608	L01D.profile.d50
regulation of cellular biosynthetic process	GO:0031326	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	225	0.556187274435161	2	3.59591111111111	0.107520546542514	L01D.profile.d50
negative regulation of cellular biosynthetic process	GO:0031327	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	41	0.101349681119296	0	0	1	L01D.profile.d50
positive regulation of cellular biosynthetic process	GO:0031328	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	75	0.185395758145054	0	0	1	L01D.profile.d50
regulation of cell projection organization and biogenesis	GO:0031344	Any process that modulates the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of cell projection organization and biogenesis	GO:0031346	Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of defense response	GO:0031347	Any process that modulates the frequency, rate or extent of a defense response.	25	0.0617985860483512	0	0	1	L01D.profile.d50
negative regulation of defense response	GO:0031348	Any process that stops, prevents or reduces the frequency, rate or extent of a defense response.	11	0.0271913778612745	0	0	1	L01D.profile.d50
positive regulation of defense response	GO:0031349	Any process that activates or increases the frequency, rate or extent of a defense response.	9	0.0222474909774064	0	0	1	L01D.profile.d50
N-terminal protein amino acid modification	GO:0031365	The alteration of the N-terminal amino acid residue in a protein.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of protein modification	GO:0031399	Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.	10	0.0247194344193405	0	0	1	L01D.profile.d50
keratinization	GO:0031424	The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.	15	0.0370791516290107	0	0	1	L01D.profile.d50
chromatin assembly	GO:0031497	The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.	108	0.266969891728877	0	0	1	L01D.profile.d50
chromatin disassembly	GO:0031498	The disassembly of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins.	12	0.0296633213032086	0	0	1	L01D.profile.d50
heterochromatin formation	GO:0031507	The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.	15	0.0370791516290107	0	0	1	L01D.profile.d50
actin cytoskeleton reorganization	GO:0031532	Dynamic structural changes to the assembly and arrangement of the actin cytoskeleton, comprising actin filaments and their associated proteins.	12	0.0296633213032086	0	0	1	L01D.profile.d50
DNA integrity checkpoint	GO:0031570	Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.	61	0.150788549957977	0	0	1	L01D.profile.d50
G1 DNA damage checkpoint	GO:0031571	A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage.	16	0.0395510950709448	0	0	1	L01D.profile.d50
G2/M transition DNA damage checkpoint	GO:0031572	A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage.	11	0.0271913778612745	0	0	1	L01D.profile.d50
G2/M transition checkpoint	GO:0031576	Any cell cycle checkpoint that blocks entry into M phase.	11	0.0271913778612745	0	0	1	L01D.profile.d50
spindle checkpoint	GO:0031577	A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle.	17	0.0420230385128788	0	0	1	L01D.profile.d50
cell-substrate adhesion	GO:0031589	The attachment of a cell to the underlying substrate via adhesion molecules.	135	0.333712364661097	0	0	1	L01D.profile.d50
regulation of neurological process	GO:0031644	Any process that modulates the frequency, rate or extent of a neurophysiological process.	47	0.1161813417709	0	0	1	L01D.profile.d50
regulation of protein stability	GO:0031647	Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.	21	0.051910812280615	0	0	1	L01D.profile.d50
response to nutrient levels	GO:0031667	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.	43	0.106293568003164	0	0	1	L01D.profile.d50
cellular response to extracellular stimulus	GO:0031668	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.	9	0.0222474909774064	0	0	1	L01D.profile.d50
cellular response to nutrient levels	GO:0031669	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.	9	0.0222474909774064	0	0	1	L01D.profile.d50
ARF protein signal transduction	GO:0032011	A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state.	26	0.0642705294902853	0	0	1	L01D.profile.d50
regulation of ARF protein signal transduction	GO:0032012	Any process that modulates the frequency, rate or extent of ARF protein signal transduction.	23	0.0568546991644831	0	0	1	L01D.profile.d50
activation of protein kinase activity	GO:0032147	Any process that initiates the activity of an inactive protein kinase.	90	0.222474909774064	0	0	1	L01D.profile.d50
transposition	GO:0032196	Any process involved in mediating the movement of discrete segments of DNA between nonhomolgous sites.	2	0.0049438868838681	0	0	1	L01D.profile.d50
telomere organization and biogenesis	GO:0032200	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that includes the telomeric DNA repeats and associated proteins.	41	0.101349681119296	0	0	1	L01D.profile.d50
methylation	GO:0032259	The process by which a methyl group is covalently attached to a molecule.	57	0.140900776190241	0	0	1	L01D.profile.d50
regulation of Rab GTPase activity	GO:0032313	Any process that modulates the activity of a GTPase of the Rab family.	43	0.106293568003164	0	0	1	L01D.profile.d50
regulation of Ras GTPase activity	GO:0032318	Any process that modulates the activity of a GTPase of the Ras superfamily.	61	0.150788549957977	0	0	1	L01D.profile.d50
regulation of Rho GTPase activity	GO:0032319	Any process that modulates the activity of a GTPase of the Rho family.	9	0.0222474909774064	0	0	1	L01D.profile.d50
molybdopterin cofactor biosynthetic process	GO:0032324	The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of intracellular transport	GO:0032386	Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.	37	0.0914619073515598	0	0	1	L01D.profile.d50
DNA geometric change	GO:0032392	The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.	24	0.0593266426064172	0	0	1	L01D.profile.d50
protein modification by small protein conjugation	GO:0032446	A process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.	108	0.266969891728877	0	0	1	L01D.profile.d50
Rab protein signal transduction	GO:0032482	Any process that modulates the frequency, rate or extent of Rab protein signal transduction.	43	0.106293568003164	0	0	1	L01D.profile.d50
regulation of Rab protein signal transduction	GO:0032483	Any process that modulates the frequency, rate or extent of Rab protein signal transduction.	43	0.106293568003164	0	0	1	L01D.profile.d50
Cdc42 protein signal transduction	GO:0032488	A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of Cdc42 protein signal transduction	GO:0032489	Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.	7	0.0173036040935383	0	0	1	L01D.profile.d50
multicellular organismal process	GO:0032501	The biological processes, occurring at the level of the organism, pertinent to the function of the organism.	4325	10.6911553863648	6	0.561211560693642	0.955131516099996	L01D.profile.d50
developmental process	GO:0032502	A biological process whose specific outcome is the progression of an integrated living unit: a cell, tissue, organ, or organism over time from an initial condition to a later condition.	4255	10.5181193454294	11	1.04581433607521	0.481579715933917	L01D.profile.d50
multicellular organism reproduction	GO:0032504	The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.	83	0.205171305680526	0	0	1	L01D.profile.d50
maintenance of cellular protein localization	GO:0032507	The processes by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.	33	0.0815741335838236	0	0	1	L01D.profile.d50
DNA duplex unwinding	GO:0032508	The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.	24	0.0593266426064172	0	0	1	L01D.profile.d50
chemokine production	GO:0032602	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	9	0.0222474909774064	0	0	1	L01D.profile.d50
interferon type I production	GO:0032606	The appearance of interferon type I due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	7	0.0173036040935383	0	0	1	L01D.profile.d50
interferon-gamma production	GO:0032609	The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	20	0.049438868838681	0	0	1	L01D.profile.d50
interleukin-12 production	GO:0032615	The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	18	0.0444949819548129	0	0	1	L01D.profile.d50
interleukin-2 production	GO:0032623	The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	28	0.0692144163741534	0	0	1	L01D.profile.d50
interleukin-6 production	GO:0032635	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.0247194344193405	0	0	1	L01D.profile.d50
interleukin-8 production	GO:0032637	The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	12	0.0296633213032086	0	0	1	L01D.profile.d50
RNA biosynthetic process	GO:0032774	The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.	2591	6.40480545805112	13	2.02972597452721	0.0142808162912539	L01D.profile.d50
monocarboxylic acid metabolic process	GO:0032787	The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).	307	0.758886636673753	0	0	1	L01D.profile.d50
secretion by cell	GO:0032940	The regulated release of a substance by a cell.	411	1.01596875463489	0	0	1	L01D.profile.d50
mononuclear cell proliferation	GO:0032943	The rapid expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.	91	0.224946853215998	1	4.4454945054945	0.201663698769778	L01D.profile.d50
regulation of mononuclear cell proliferation	GO:0032944	Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.	62	0.153260493399911	1	6.52483870967742	0.142256548500238	L01D.profile.d50
negative regulation of mononuclear cell proliferation	GO:0032945	Any process that stops, prevents or reduces the frequency, rate or extent of mononuclear cell proliferation.	26	0.0642705294902853	0	0	1	L01D.profile.d50
positive regulation of mononuclear cell proliferation	GO:0032946	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.	43	0.106293568003164	1	9.40790697674418	0.100957670704549	L01D.profile.d50
collagen metabolic process	GO:0032963	The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).	28	0.0692144163741534	0	0	1	L01D.profile.d50
macromolecular complex disassembly	GO:0032984	The disaggregation of a macromolecular complex into its constituent components.	30	0.0741583032580215	0	0	1	L01D.profile.d50
cellular structure morphogenesis	GO:0032989	The process by which cellular structures are generated and organized. Morphogenesis pertains to the creation of form.	668	1.65125821921194	3	1.81679640718563	0.229855696052687	L01D.profile.d50
cell part morphogenesis	GO:0032990	The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form.	296	0.731695258812478	2	2.73337837837838	0.16677681687862	L01D.profile.d50
muscle cell proliferation	GO:0033002	The rapid expansion of a muscle cell population by cell division.	13	0.0321352647451426	0	0	1	L01D.profile.d50
tetrapyrrole metabolic process	GO:0033013	The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	30	0.0741583032580215	0	0	1	L01D.profile.d50
tetrapyrrole biosynthetic process	GO:0033014	The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	21	0.051910812280615	0	0	1	L01D.profile.d50
macromolecule localization	GO:0033036	The processes by which a macromolecule is transported to, or maintained in, a specific location.	1070	2.64497948286943	3	1.13422429906542	0.493001019134412	L01D.profile.d50
cellular pigmentation	GO:0033059	The deposition or aggregation of coloring matter in an cell.	11	0.0271913778612745	0	0	1	L01D.profile.d50
T cell differentiation in the thymus	GO:0033077	The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of intracellular protein transport	GO:0033157	Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.	34	0.0840460770257577	0	0	1	L01D.profile.d50
regulation of amine metabolic process	GO:0033238	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amines.	64	0.158204380283779	0	0	1	L01D.profile.d50
positive regulation of amine metabolic process	GO:0033240	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.	31	0.0766302466999555	0	0	1	L01D.profile.d50
regulation of progression through S phase	GO:0033261	A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the cell cycle.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of Rho protein signal transduction	GO:0035023	Any process that modulates the frequency, rate or extent of Rho protein signal transduction.	111	0.274385722054679	0	0	1	L01D.profile.d50
sperm-egg recognition	GO:0035036	The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.	9	0.0222474909774064	0	0	1	L01D.profile.d50
embryonic heart tube development	GO:0035050	The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure.	6	0.0148316606516043	0	0	1	L01D.profile.d50
cardiac cell differentiation	GO:0035051	The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.	12	0.0296633213032086	0	0	1	L01D.profile.d50
sensory cilium biogenesis	GO:0035058	The assembly of a sensory cilium, a primary cilium found on sensory neurons that contains an a 9+0 axonemal arrangement of microtubules.	7	0.0173036040935383	0	0	1	L01D.profile.d50
establishment and/or maintenance of apical/basal cell polarity	GO:0035088	Polarization of a cells architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.	16	0.0395510950709448	0	0	1	L01D.profile.d50
appendage morphogenesis	GO:0035107	The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch.	76	0.187867701586988	0	0	1	L01D.profile.d50
limb morphogenesis	GO:0035108	The process by which the anatomical structures of limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin.	76	0.187867701586988	0	0	1	L01D.profile.d50
embryonic appendage morphogenesis	GO:0035113	The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch.	73	0.180451871261186	0	0	1	L01D.profile.d50
embryonic forelimb morphogenesis	GO:0035115	The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an animal.	10	0.0247194344193405	0	0	1	L01D.profile.d50
embryonic hindlimb morphogenesis	GO:0035116	The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. Morphogenesis pertains to the creation of form. The hindlimbs are the posterior limbs of an animal.	12	0.0296633213032086	0	0	1	L01D.profile.d50
forelimb morphogenesis	GO:0035136	The process by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form.	11	0.0271913778612745	0	0	1	L01D.profile.d50
hindlimb morphogenesis	GO:0035137	The process by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form.	15	0.0370791516290107	0	0	1	L01D.profile.d50
tube morphogenesis	GO:0035239	The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.	100	0.247194344193405	0	0	1	L01D.profile.d50
multicellular organism growth	GO:0035264	The increase in size or mass of an entire multicellular organism, as opposed to cell growth.	38	0.0939338507934939	0	0	1	L01D.profile.d50
endocrine system development	GO:0035270	Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.	47	0.1161813417709	0	0	1	L01D.profile.d50
exocrine system development	GO:0035272	Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.	23	0.0568546991644831	0	0	1	L01D.profile.d50
segmentation	GO:0035282	The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.	38	0.0939338507934939	0	0	1	L01D.profile.d50
tube development	GO:0035295	The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.	152	0.375735403173975	0	0	1	L01D.profile.d50
growth	GO:0040007	The increase in size or mass of an entire organism, a part of an organism or a cell.	403	0.996193207099422	1	1.00382133995037	0.631172604253939	L01D.profile.d50
regulation of growth	GO:0040008	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.	262	0.647649181786721	1	1.54404580152672	0.477144936972078	L01D.profile.d50
locomotion	GO:0040011	Self-propelled movement of a cell or organism from one location to another.	112	0.276857665496613	0	0	1	L01D.profile.d50
regulation of locomotion	GO:0040012	Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.	108	0.266969891728877	0	0	1	L01D.profile.d50
negative regulation of locomotion	GO:0040013	Any process that stops, prevents or reduces the frequency, rate or extent of locomotion of a cell or organism.	37	0.0914619073515598	0	0	1	L01D.profile.d50
regulation of body size	GO:0040014	Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.	33	0.0815741335838236	0	0	1	L01D.profile.d50
positive regulation of locomotion	GO:0040017	Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.	25	0.0617985860483512	0	0	1	L01D.profile.d50
positive regulation of body size	GO:0040018	Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of gene expression, epigenetic	GO:0040029	Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.	75	0.185395758145054	0	0	1	L01D.profile.d50
chemokine biosynthetic process	GO:0042033	The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of cytokine biosynthetic process	GO:0042035	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	85	0.210115192564394	0	0	1	L01D.profile.d50
negative regulation of cytokine biosynthetic process	GO:0042036	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	24	0.0593266426064172	0	0	1	L01D.profile.d50
fluid transport	GO:0042044	The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells.	18	0.0444949819548129	0	0	1	L01D.profile.d50
wound healing	GO:0042060	The series of events that restore integrity to a damaged tissue, following an injury.	177	0.437533989222327	0	0	1	L01D.profile.d50
gliogenesis	GO:0042063	The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia.	59	0.145844663074109	0	0	1	L01D.profile.d50
T-helper 1 type immune response	GO:0042088	An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.	15	0.0370791516290107	0	0	1	L01D.profile.d50
cytokine biosynthetic process	GO:0042089	The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	99	0.244722400751471	0	0	1	L01D.profile.d50
interleukin-12 biosynthetic process	GO:0042090	The chemical reactions and pathways resulting in the formation of interleukin-12.	13	0.0321352647451426	0	0	1	L01D.profile.d50
T-helper 2 type immune response	GO:0042092	An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.	20	0.049438868838681	0	0	1	L01D.profile.d50
T-helper cell differentiation	GO:0042093	The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.	17	0.0420230385128788	0	0	1	L01D.profile.d50
interleukin-2 biosynthetic process	GO:0042094	The chemical reactions and pathways resulting in the formation of interleukin-2.	28	0.0692144163741534	0	0	1	L01D.profile.d50
interferon-gamma biosynthetic process	GO:0042095	The chemical reactions and pathways resulting in the formation of interferon-gamma.	13	0.0321352647451426	0	0	1	L01D.profile.d50
T cell proliferation	GO:0042098	The rapid expansion of a T cell population by cell division. Follows T cell activation.	68	0.168092154051515	1	5.94911764705882	0.154899948263562	L01D.profile.d50
B cell proliferation	GO:0042100	The rapid expansion of a B cell population by cell division. Follows B cell activation.	27	0.0667424729322193	0	0	1	L01D.profile.d50
positive regulation of T cell proliferation	GO:0042102	Any process that activates or increases the rate or extent of T cell proliferation.	35	0.0865180204676917	1	11.5582857142857	0.0829792059813095	L01D.profile.d50
positive regulation of activated T cell proliferation	GO:0042104	Any process that activates or increases the rate or extent of activated T cell proliferation.	14	0.0346072081870767	0	0	1	L01D.profile.d50
cytokine metabolic process	GO:0042107	The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	100	0.247194344193405	0	0	1	L01D.profile.d50
positive regulation of cytokine biosynthetic process	GO:0042108	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	58	0.143372719632175	0	0	1	L01D.profile.d50
T cell activation	GO:0042110	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	173	0.42764621545459	1	2.33838150289017	0.348303063701255	L01D.profile.d50
B cell activation	GO:0042113	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	115	0.284273495822416	0	0	1	L01D.profile.d50
macrophage activation	GO:0042116	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of cell proliferation	GO:0042127	Any process that modulates the frequency, rate or extent of cell proliferation.	704	1.74024818312157	3	1.72389204545455	0.25335164310371	L01D.profile.d50
regulation of T cell proliferation	GO:0042129	Any process that modulates the frequency, rate or extent of T cell proliferation.	47	0.1161813417709	1	8.60723404255319	0.109814290537621	L01D.profile.d50
negative regulation of T cell proliferation	GO:0042130	Any process that stops, prevents or reduces the rate or extent of T cell proliferation.	19	0.0469669253967469	0	0	1	L01D.profile.d50
neurotransmitter metabolic process	GO:0042133	The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	53	0.131013002422505	0	0	1	L01D.profile.d50
neurotransmitter catabolic process	GO:0042135	The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	15	0.0370791516290107	0	0	1	L01D.profile.d50
neurotransmitter biosynthetic process	GO:0042136	The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	22	0.0543827557225491	0	0	1	L01D.profile.d50
lipoprotein metabolic process	GO:0042157	The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	81	0.200227418796658	0	0	1	L01D.profile.d50
lipoprotein biosynthetic process	GO:0042158	The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	49	0.121125228654768	0	0	1	L01D.profile.d50
heme metabolic process	GO:0042168	The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.	28	0.0692144163741534	0	0	1	L01D.profile.d50
regulation of protein catabolic process	GO:0042176	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	16	0.0395510950709448	0	0	1	L01D.profile.d50
negative regulation of protein catabolic process	GO:0042177	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	7	0.0173036040935383	0	0	1	L01D.profile.d50
amino acid derivative catabolic process	GO:0042219	The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.	27	0.0667424729322193	0	0	1	L01D.profile.d50
response to chemical stimulus	GO:0042221	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.	603	1.49058189548623	1	0.670878938640133	0.775173717838305	L01D.profile.d50
interleukin-6 biosynthetic process	GO:0042226	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.0247194344193405	0	0	1	L01D.profile.d50
interleukin-8 biosynthetic process	GO:0042228	The chemical reactions and pathways resulting in the formation of interleukin-8.	8	0.0197755475354724	0	0	1	L01D.profile.d50
tissue regeneration	GO:0042246	The regrowth of lost or destroyed tissues.	8	0.0197755475354724	0	0	1	L01D.profile.d50
ribosome biogenesis and assembly	GO:0042254	The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis.	89	0.22000296633213	1	4.54539325842697	0.19770213130442	L01D.profile.d50
ribosome assembly	GO:0042255	The aggregation and bonding together of the mature ribosome and of its subunits.	6	0.0148316606516043	0	0	1	L01D.profile.d50
natural killer cell mediated cytotoxicity	GO:0042267	The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.	18	0.0444949819548129	0	0	1	L01D.profile.d50
purine nucleoside metabolic process	GO:0042278	The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).	10	0.0247194344193405	0	0	1	L01D.profile.d50
molting cycle	GO:0042303	The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.	30	0.0741583032580215	0	0	1	L01D.profile.d50
regulation of protein import into nucleus	GO:0042306	Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.	34	0.0840460770257577	0	0	1	L01D.profile.d50
positive regulation of protein import into nucleus	GO:0042307	Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.	14	0.0346072081870767	0	0	1	L01D.profile.d50
negative regulation of protein import into nucleus	GO:0042308	Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.	16	0.0395510950709448	0	0	1	L01D.profile.d50
vasoconstriction	GO:0042310	A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.	20	0.049438868838681	0	0	1	L01D.profile.d50
vasodilation	GO:0042311	An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.	20	0.049438868838681	0	0	1	L01D.profile.d50
regulation of vasodilation	GO:0042312	Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of phosphorylation	GO:0042325	Any process that modulates the frequency, rate or extent of addition of phosphoric groups into a molecule.	73	0.180451871261186	0	0	1	L01D.profile.d50
negative regulation of phosphorylation	GO:0042326	Any process that stops, prevents or decreases the rate of addition of phosphoric groups to a molecule.	14	0.0346072081870767	0	0	1	L01D.profile.d50
positive regulation of phosphorylation	GO:0042327	Any process that activates or increases the frequency, rate or extent of addition of phosphoric groups to a molecule.	35	0.0865180204676917	0	0	1	L01D.profile.d50
taxis	GO:0042330	The directed movement of a motile cell or organism in response to an external stimulus.	179	0.442477876106195	0	0	1	L01D.profile.d50
regulation of NF-kappaB import into nucleus	GO:0042345	Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	22	0.0543827557225491	0	0	1	L01D.profile.d50
positive regulation of NF-kappaB import into nucleus	GO:0042346	Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	11	0.0271913778612745	0	0	1	L01D.profile.d50
negative regulation of NF-kappaB import into nucleus	GO:0042347	Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	11	0.0271913778612745	0	0	1	L01D.profile.d50
NF-kappaB import into nucleus	GO:0042348	The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	22	0.0543827557225491	0	0	1	L01D.profile.d50
L-fucose metabolic process	GO:0042354	The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants.	21	0.051910812280615	0	0	1	L01D.profile.d50
L-fucose catabolic process	GO:0042355	The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).	17	0.0420230385128788	0	0	1	L01D.profile.d50
water-soluble vitamin biosynthetic process	GO:0042364	The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water.	19	0.0469669253967469	0	0	1	L01D.profile.d50
quinone cofactor metabolic process	GO:0042375	The chemical reactions and pathways involving quinone cofactors.	11	0.0271913778612745	0	0	1	L01D.profile.d50
cilium biogenesis	GO:0042384	The assembly of a cilium, a specialized eukaryotic locomotor organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.	11	0.0271913778612745	0	0	1	L01D.profile.d50
hemocyte differentiation	GO:0042386	The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of membrane potential	GO:0042391	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.	26	0.0642705294902853	0	0	1	L01D.profile.d50
amino acid derivative biosynthetic process	GO:0042398	The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.	46	0.113709398328966	0	0	1	L01D.profile.d50
biogenic amine biosynthetic process	GO:0042401	The chemical reactions and pathways resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.	36	0.0889899639096258	0	0	1	L01D.profile.d50
biogenic amine catabolic process	GO:0042402	The chemical reactions and pathways resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.	21	0.051910812280615	0	0	1	L01D.profile.d50
thyroid hormone metabolic process	GO:0042403	The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.	14	0.0346072081870767	0	0	1	L01D.profile.d50
dopamine metabolic process	GO:0042417	The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.	25	0.0617985860483512	0	0	1	L01D.profile.d50
catecholamine biosynthetic process	GO:0042423	The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.	15	0.0370791516290107	0	0	1	L01D.profile.d50
indole and derivative metabolic process	GO:0042430	The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan) formed in degradation of tryptophan, and compounds derived from it.	15	0.0370791516290107	0	0	1	L01D.profile.d50
indole derivative metabolic process	GO:0042434	The chemical reactions and pathways involving compounds derived from indole (2,3-benzopyrrole).	15	0.0370791516290107	0	0	1	L01D.profile.d50
melanin biosynthetic process	GO:0042438	The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.	12	0.0296633213032086	0	0	1	L01D.profile.d50
pigment metabolic process	GO:0042440	The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.	58	0.143372719632175	0	0	1	L01D.profile.d50
hormone metabolic process	GO:0042445	The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.	95	0.234834626983735	0	0	1	L01D.profile.d50
hormone biosynthetic process	GO:0042446	The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.	45	0.111237454887032	0	0	1	L01D.profile.d50
photoreceptor cell development	GO:0042461	Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.	20	0.049438868838681	0	0	1	L01D.profile.d50
eye photoreceptor cell development	GO:0042462	Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.	19	0.0469669253967469	0	0	1	L01D.profile.d50
ear morphogenesis	GO:0042471	The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.	45	0.111237454887032	0	0	1	L01D.profile.d50
inner ear morphogenesis	GO:0042472	The process by which the anatomical structures of the inner ear are generated and organized. Morphogenesis pertains to the creation of form. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.	42	0.10382162456123	0	0	1	L01D.profile.d50
odontogenesis (sensu Vertebrata)	GO:0042475	The process whose specific outcome is the progression of a tooth over time, from its formation to the mature structure. Teeth are the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates, and which usually aid in the prehension and mastication of food. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	46	0.113709398328966	0	0	1	L01D.profile.d50
odontogenesis	GO:0042476	The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s).	53	0.131013002422505	0	0	1	L01D.profile.d50
mechanoreceptor differentiation	GO:0042490	The process whereby a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.	28	0.0692144163741534	0	0	1	L01D.profile.d50
auditory receptor cell differentiation	GO:0042491	The process whereby a relatively unspecialized cell acquires specialized features of an auditory hair cell.	20	0.049438868838681	0	0	1	L01D.profile.d50
response to drug	GO:0042493	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.	57	0.140900776190241	0	0	1	L01D.profile.d50
tyrosine phosphorylation of Stat3 protein	GO:0042503	The process of introducing a phosphoric group to a tyrosine residue of a Stat3 protein.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of tyrosine phosphorylation of STAT protein	GO:0042509	Any process that modulates the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.	18	0.0444949819548129	0	0	1	L01D.profile.d50
regulation of tyrosine phosphorylation of Stat3 protein	GO:0042516	Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat3 protein.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.	7	0.0173036040935383	0	0	1	L01D.profile.d50
response to hydrogen peroxide	GO:0042542	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	16	0.0395510950709448	0	0	1	L01D.profile.d50
neuron maturation	GO:0042551	A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.	23	0.0568546991644831	0	0	1	L01D.profile.d50
myelination	GO:0042552	The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.	35	0.0865180204676917	0	0	1	L01D.profile.d50
superoxide release	GO:0042554	The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.	11	0.0271913778612745	0	0	1	L01D.profile.d50
pteridine and derivative metabolic process	GO:0042558	The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.	16	0.0395510950709448	0	0	1	L01D.profile.d50
pteridine and derivative biosynthetic process	GO:0042559	The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.	13	0.0321352647451426	0	0	1	L01D.profile.d50
retinol metabolic process	GO:0042572	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.	7	0.0173036040935383	0	0	1	L01D.profile.d50
retinoic acid metabolic process	GO:0042573	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.	7	0.0173036040935383	0	0	1	L01D.profile.d50
homeostatic process	GO:0042592	The biological processes involved in the maintenance of an internal equilibrium.	495	1.22361200375735	1	0.817252525252525	0.706279560629199	L01D.profile.d50
glucose homeostasis	GO:0042593	Any of the processes involved in the maintenance of an internal equilibrium of glucose within an organism or cell.	25	0.0617985860483512	0	0	1	L01D.profile.d50
response to starvation	GO:0042594	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.	10	0.0247194344193405	0	0	1	L01D.profile.d50
fear response	GO:0042596	The response of an organism to a perceived external threat.	7	0.0173036040935383	0	0	1	L01D.profile.d50
cholesterol homeostasis	GO:0042632	Any of the processes involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell.	27	0.0667424729322193	0	0	1	L01D.profile.d50
hair cycle	GO:0042633	The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.	30	0.0741583032580215	0	0	1	L01D.profile.d50
anagen	GO:0042640	The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.	12	0.0296633213032086	0	0	1	L01D.profile.d50
muscle cell differentiation	GO:0042692	The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.	74	0.18292381470312	0	0	1	L01D.profile.d50
menstrual cycle	GO:0042698	The type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.	43	0.106293568003164	0	0	1	L01D.profile.d50
fibrinolysis	GO:0042730	An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.	12	0.0296633213032086	0	0	1	L01D.profile.d50
embryonic digit morphogenesis	GO:0042733	The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. Morphogenesis pertains to the creation of form. A digit is one of the terminal divisions of an appendage. For example a finger or toe.	11	0.0271913778612745	0	0	1	L01D.profile.d50
defense response to bacterium	GO:0042742	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.	55	0.135956889306373	0	0	1	L01D.profile.d50
hydrogen peroxide metabolic process	GO:0042743	The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.	14	0.0346072081870767	0	0	1	L01D.profile.d50
hydrogen peroxide catabolic process	GO:0042744	The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).	14	0.0346072081870767	0	0	1	L01D.profile.d50
DNA damage response, signal transduction	GO:0042770	A cascade of processes induced by the detection of DNA damage within a cell.	90	0.222474909774064	0	0	1	L01D.profile.d50
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771	A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death).	16	0.0395510950709448	0	0	1	L01D.profile.d50
ATP synthesis coupled electron transport	GO:0042773	The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.	45	0.111237454887032	0	0	1	L01D.profile.d50
organelle ATP synthesis coupled electron transport	GO:0042775	The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).	45	0.111237454887032	0	0	1	L01D.profile.d50
regulation of apoptosis	GO:0042981	Any process that modulates the occurrence or rate of cell death by apoptosis.	785	1.94047560191823	2	1.03067515923567	0.577967354081442	L01D.profile.d50
amyloid precursor protein metabolic process	GO:0042982	The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease.	19	0.0469669253967469	0	0	1	L01D.profile.d50
amyloid precursor protein catabolic process	GO:0042987	The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of transcription factor import into nucleus	GO:0042990	Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.	32	0.0791021901418896	0	0	1	L01D.profile.d50
transcription factor import into nucleus	GO:0042991	The directed movement of a transcription factor from the cytoplasm to the nucleus.	32	0.0791021901418896	0	0	1	L01D.profile.d50
negative regulation of transcription factor import into nucleus	GO:0042992	Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of transcription factor import into nucleus	GO:0042993	Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.	14	0.0346072081870767	0	0	1	L01D.profile.d50
cytoplasmic sequestering of transcription factor	GO:0042994	The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.	13	0.0321352647451426	0	0	1	L01D.profile.d50
chordate embryonic development	GO:0043009	The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.	136	0.336184308103031	0	0	1	L01D.profile.d50
camera-type eye development	GO:0043010	The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.	11	0.0271913778612745	0	0	1	L01D.profile.d50
T cell homeostasis	GO:0043029	The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.	12	0.0296633213032086	0	0	1	L01D.profile.d50
amino acid activation	GO:0043038	The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.	56	0.138428832748307	0	0	1	L01D.profile.d50
tRNA aminoacylation	GO:0043039	The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.	56	0.138428832748307	0	0	1	L01D.profile.d50
peptide biosynthetic process	GO:0043043	The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.	6	0.0148316606516043	0	0	1	L01D.profile.d50
extracellular structure organization and biogenesis	GO:0043062	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.	126	0.31146487368369	0	0	1	L01D.profile.d50
positive regulation of apoptosis	GO:0043065	Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.	396	0.978889603005883	1	1.02156565656566	0.624726985941584	L01D.profile.d50
negative regulation of apoptosis	GO:0043066	Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.	345	0.852820487467247	2	2.34515942028985	0.210240857165395	L01D.profile.d50
regulation of programmed cell death	GO:0043067	Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	793	1.9602511494537	3	1.53041614123581	0.312552712587102	L01D.profile.d50
positive regulation of programmed cell death	GO:0043068	Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	400	0.988777376773619	1	1.01135	0.628423864621069	L01D.profile.d50
negative regulation of programmed cell death	GO:0043069	Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	347	0.857764374351115	3	3.49746397694524	0.0558631509543291	L01D.profile.d50
positive regulation of enzyme activity	GO:0043085	Any process that activates or increases the activity of an enzyme.	318	0.786078014535027	1	1.27213836477987	0.544814926968059	L01D.profile.d50
negative regulation of enzyme activity	GO:0043086	Any process that stops or reduces the activity of an enzyme.	110	0.271913778612745	1	3.67763636363636	0.238336491885323	L01D.profile.d50
regulation of GTPase activity	GO:0043087	Any process that modulates the rate of GTP hydrolysis by a GTPase.	114	0.281801552380482	0	0	1	L01D.profile.d50
regulation of Cdc42 GTPase activity	GO:0043088	Any process that modulates the activity of the GTPase Cdc42.	7	0.0173036040935383	0	0	1	L01D.profile.d50
metabolic compound salvage	GO:0043094	Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis.	8	0.0197755475354724	0	0	1	L01D.profile.d50
receptor metabolic process	GO:0043112	The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	22	0.0543827557225491	0	0	1	L01D.profile.d50
regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043122	Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.	142	0.351015968754635	0	0	1	L01D.profile.d50
positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123	Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.	133	0.328768477777228	0	0	1	L01D.profile.d50
negative regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043124	Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.	5	0.0123597172096702	0	0	1	L01D.profile.d50
negative regulation of caspase activity	GO:0043154	Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity.	14	0.0346072081870767	0	0	1	L01D.profile.d50
proteasomal ubiquitin-dependent protein catabolic process	GO:0043161	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	25	0.0617985860483512	0	0	1	L01D.profile.d50
macromolecule metabolic process	GO:0043170	The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates.	7752	19.1625055618727	27	1.40900154798762	0.052449818775955	L01D.profile.d50
positive regulation of gene-specific transcription	GO:0043193	Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes.	12	0.0296633213032086	0	0	1	L01D.profile.d50
protein complex disassembly	GO:0043241	The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.	30	0.0741583032580215	0	0	1	L01D.profile.d50
regulation of ion transport	GO:0043269	Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of caspase activity	GO:0043280	Any process that activates or increases the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	60	0.148316606516043	1	6.74233333333333	0.138000186180437	L01D.profile.d50
regulation of caspase activity	GO:0043281	Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	75	0.185395758145054	1	5.39386666666667	0.169415226914524	L01D.profile.d50
biopolymer metabolic process	GO:0043283	The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.	5812	14.3669352845207	22	1.53129387474191	0.0363167762938057	L01D.profile.d50
biopolymer biosynthetic process	GO:0043284	The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.	56	0.138428832748307	0	0	1	L01D.profile.d50
biopolymer catabolic process	GO:0043285	The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.	396	0.978889603005883	2	2.04313131313131	0.256465813400744	L01D.profile.d50
leukocyte degranulation	GO:0043299	The regulated exocytosis of secretory granules by a leukocyte.	11	0.0271913778612745	0	0	1	L01D.profile.d50
CD4-positive, alpha beta T cell differentiation	GO:0043367	The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.	19	0.0469669253967469	0	0	1	L01D.profile.d50
positive T cell selection	GO:0043368	The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.	6	0.0148316606516043	0	0	1	L01D.profile.d50
regulation of protein binding	GO:0043393	Any process that modulates the frequency, rate or extent of protein binding.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of MAPK activity	GO:0043405	Any process that modulates the frequency, rate or extent of MAP kinase activity.	122	0.301577099915954	0	0	1	L01D.profile.d50
positive regulation of MAPK activity	GO:0043406	Any process that activates or increases the frequency, rate or extent of MAP kinase activity.	79	0.19528353191279	0	0	1	L01D.profile.d50
negative regulation of MAPK activity	GO:0043407	Any process that stops, prevents or reduces the frequency, rate or extent of MAP kinase activity.	39	0.0964057942354279	0	0	1	L01D.profile.d50
regulation of MAPKKK cascade	GO:0043408	Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.	30	0.0741583032580215	0	0	1	L01D.profile.d50
positive regulation of MAPKKK cascade	GO:0043410	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.	13	0.0321352647451426	0	0	1	L01D.profile.d50
biopolymer modification	GO:0043412	The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.	2200	5.43827557225491	5	0.919409090909091	0.633065591237721	L01D.profile.d50
biopolymer glycosylation	GO:0043413	The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.	158	0.39056706382558	0	0	1	L01D.profile.d50
biopolymer methylation	GO:0043414	The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.	47	0.1161813417709	0	0	1	L01D.profile.d50
negative regulation of transcription factor activity	GO:0043433	Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	17	0.0420230385128788	0	0	1	L01D.profile.d50
alkene metabolic process	GO:0043449	The chemical reactions and pathways involving an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond.	26	0.0642705294902853	0	0	1	L01D.profile.d50
alkene biosynthetic process	GO:0043450	The chemical reactions and pathways resulting in the formation of an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond.	23	0.0568546991644831	0	0	1	L01D.profile.d50
pigmentation	GO:0043473	The deposition or aggregation of coloring matter in an organism, tissue or cell.	53	0.131013002422505	0	0	1	L01D.profile.d50
regulation of RNA stability	GO:0043487	Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.	27	0.0667424729322193	1	14.982962962963	0.0646412195945478	L01D.profile.d50
regulation of mRNA stability	GO:0043488	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.	26	0.0642705294902853	1	15.5592307692308	0.0623233359141062	L01D.profile.d50
regulation of JNK activity	GO:0043506	Any process that modulates the frequency, rate or extent of JUN kinase activity.	30	0.0741583032580215	0	0	1	L01D.profile.d50
positive regulation of JNK activity	GO:0043507	Any process that activates or increases the frequency, rate or extent of JUN kinase activity.	23	0.0568546991644831	0	0	1	L01D.profile.d50
regulation of neuron apoptosis	GO:0043523	Any process that modulates the occurrence or rate of cell death by apoptosis in neurons.	30	0.0741583032580215	0	0	1	L01D.profile.d50
negative regulation of neuron apoptosis	GO:0043524	Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis in neurons.	17	0.0420230385128788	0	0	1	L01D.profile.d50
endothelial cell migration	GO:0043542	The orderly movement of endothelial cells into the extracellular matrix to form an endothelium.	9	0.0222474909774064	0	0	1	L01D.profile.d50
protein amino acid acylation	GO:0043543	The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.	52	0.128541058980571	0	0	1	L01D.profile.d50
molybdopterin cofactor metabolic process	GO:0043545	The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of kinase activity	GO:0043549	Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	305	0.753942749789885	1	1.3263606557377	0.529931166251457	L01D.profile.d50
peroxisomal transport	GO:0043574	Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.	13	0.0321352647451426	0	0	1	L01D.profile.d50
ear development	GO:0043583	The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.	57	0.140900776190241	0	0	1	L01D.profile.d50
skin development	GO:0043588	The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.	8	0.0197755475354724	0	0	1	L01D.profile.d50
amide metabolic process	GO:0043603	The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.	9	0.0222474909774064	0	0	1	L01D.profile.d50
cellular protein complex assembly	GO:0043623	The aggregation and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell.	97	0.239778513867603	1	4.17051546391753	0.213431419041356	L01D.profile.d50
cellular protein complex disassembly	GO:0043624	The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.	29	0.0716863598160874	0	0	1	L01D.profile.d50
RNA polyadenylation	GO:0043631	The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.	24	0.0593266426064172	0	0	1	L01D.profile.d50
modification-dependent macromolecule catabolic process	GO:0043632	The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.	220	0.543827557225491	1	1.83881818181818	0.419868700406443	L01D.profile.d50
dicarboxylic acid metabolic process	GO:0043648	The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).	19	0.0469669253967469	0	0	1	L01D.profile.d50
protein import into mitochondrion	GO:0043681	The directed movement of a protein from the cytoplasm to the mitochondrion.	11	0.0271913778612745	0	0	1	L01D.profile.d50
post-translational protein modification	GO:0043687	The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.	1835	4.53601621594898	4	0.8818310626703	0.664060962507266	L01D.profile.d50
multicellular organismal metabolic process	GO:0044236	The chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.	28	0.0692144163741534	0	0	1	L01D.profile.d50
cellular metabolic process	GO:0044237	The chemical reactions and pathways by which individual cells transform chemical substances.	8889	21.9731052553518	29	1.31979525255934	0.085874495781489	L01D.profile.d50
primary metabolic process	GO:0044238	Reactions involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.	8941	22.1016463143323	29	1.31211944972598	0.0904700803507687	L01D.profile.d50
lipid digestion	GO:0044241	The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.	15	0.0370791516290107	0	0	1	L01D.profile.d50
cellular lipid catabolic process	GO:0044242	The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.	58	0.143372719632175	0	0	1	L01D.profile.d50
multicellular organismal catabolic process	GO:0044243	The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.	24	0.0593266426064172	0	0	1	L01D.profile.d50
cellular polysaccharide catabolic process	GO:0044247	The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
cellular catabolic process	GO:0044248	The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.	690	1.70564097493449	2	1.17257971014493	0.508774886025132	L01D.profile.d50
cellular biosynthetic process	GO:0044249	The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	811	2.00474613140851	2	0.997632552404439	0.595613010205401	L01D.profile.d50
multicellular organismal protein catabolic process	GO:0044254	The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level.	23	0.0568546991644831	0	0	1	L01D.profile.d50
cellular lipid metabolic process	GO:0044255	The chemical reactions and pathways involving lipids, as carried out by individual cells.	723	1.78721510851832	0	0	1	L01D.profile.d50
protein digestion	GO:0044256	The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism.	23	0.0568546991644831	0	0	1	L01D.profile.d50
cellular protein catabolic process	GO:0044257	The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.	223	0.551243387551293	1	1.81408071748879	0.424160229769154	L01D.profile.d50
multicellular organismal macromolecule metabolic process	GO:0044259	The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.	23	0.0568546991644831	0	0	1	L01D.profile.d50
cellular macromolecule metabolic process	GO:0044260	The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, as carried out by individual cells.	3884	9.60102832847184	10	1.04155509783728	0.49136697858512	L01D.profile.d50
cellular carbohydrate metabolic process	GO:0044262	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.	423	1.0456320759381	0	0	1	L01D.profile.d50
cellular polysaccharide metabolic process	GO:0044264	The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells.	68	0.168092154051515	0	0	1	L01D.profile.d50
cellular macromolecule catabolic process	GO:0044265	The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.	418	1.03327235872843	1	0.967799043062201	0.644614286578519	L01D.profile.d50
multicellular organismal macromolecule catabolic process	GO:0044266	The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.	23	0.0568546991644831	0	0	1	L01D.profile.d50
cellular protein metabolic process	GO:0044267	The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.	3821	9.44529589163	10	1.05872808165402	0.471124226274847	L01D.profile.d50
multicellular organismal protein metabolic process	GO:0044268	The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level.	23	0.0568546991644831	0	0	1	L01D.profile.d50
nitrogen compound catabolic process	GO:0044270	The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.	98	0.242250457309537	0	0	1	L01D.profile.d50
nitrogen compound biosynthetic process	GO:0044271	The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.	132	0.326296534335294	0	0	1	L01D.profile.d50
sulfur compound biosynthetic process	GO:0044272	The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	49	0.121125228654768	0	0	1	L01D.profile.d50
cellular carbohydrate catabolic process	GO:0044275	The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.	130	0.321352647451426	0	0	1	L01D.profile.d50
symbiosis, encompassing mutualism through parasitism	GO:0044403	An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs.	40	0.098877737677362	0	0	1	L01D.profile.d50
entry into host	GO:0044409	Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
interspecies interaction between organisms	GO:0044419	The processes by which an organism has an observable effect on an organism of a different species.	40	0.098877737677362	0	0	1	L01D.profile.d50
maintenance of fidelity during DNA-dependent DNA replication	GO:0045005	The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair.	35	0.0865180204676917	0	0	1	L01D.profile.d50
glycerolipid biosynthetic process	GO:0045017	The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone.	8	0.0197755475354724	0	0	1	L01D.profile.d50
plasma membrane fusion	GO:0045026	The joining of two or more lipid bilayer membranes that surround a cell.	11	0.0271913778612745	0	0	1	L01D.profile.d50
protein import into mitochondrial inner membrane	GO:0045039	The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known.	7	0.0173036040935383	0	0	1	L01D.profile.d50
secretory pathway	GO:0045045	The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.	355	0.877539921886587	0	0	1	L01D.profile.d50
protein targeting to ER	GO:0045047	The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.	20	0.049438868838681	0	0	1	L01D.profile.d50
regulated secretory pathway	GO:0045055	The regulated secretory pathway is a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.	72	0.177979927819252	0	0	1	L01D.profile.d50
T cell selection	GO:0045058	The process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.	18	0.0444949819548129	0	0	1	L01D.profile.d50
positive thymic T cell selection	GO:0045059	The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.	6	0.0148316606516043	0	0	1	L01D.profile.d50
thymic T cell selection	GO:0045061	The process of T cell selection that occurs in the thymus.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of viral genome replication	GO:0045069	Any process that modulates the frequency, rate or extent of viral genome replication.	22	0.0543827557225491	0	0	1	L01D.profile.d50
regulation of interferon-gamma biosynthetic process	GO:0045072	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of chemokine biosynthetic process	GO:0045073	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of interleukin-12 biosynthetic process	GO:0045075	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of interleukin-2 biosynthetic process	GO:0045076	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.	21	0.051910812280615	0	0	1	L01D.profile.d50
positive regulation of interferon-gamma biosynthetic process	GO:0045078	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.	8	0.0197755475354724	0	0	1	L01D.profile.d50
positive regulation of interleukin-12 biosynthetic process	GO:0045084	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.	8	0.0197755475354724	0	0	1	L01D.profile.d50
positive regulation of interleukin-2 biosynthetic process	GO:0045086	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.	17	0.0420230385128788	0	0	1	L01D.profile.d50
innate immune response	GO:0045087	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.	97	0.239778513867603	0	0	1	L01D.profile.d50
regulation of innate immune response	GO:0045088	Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.	5	0.0123597172096702	0	0	1	L01D.profile.d50
positive regulation of innate immune response	GO:0045089	Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.	5	0.0123597172096702	0	0	1	L01D.profile.d50
regulation of bone resorption	GO:0045124	Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).	9	0.0222474909774064	0	0	1	L01D.profile.d50
development of primary sexual characteristics	GO:0045137	The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.	79	0.19528353191279	0	0	1	L01D.profile.d50
neuronal ion channel clustering	GO:0045161	The process by which voltage-gated sodium and potassium ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.	10	0.0247194344193405	0	0	1	L01D.profile.d50
cell fate commitment	GO:0045165	The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.	111	0.274385722054679	0	0	1	L01D.profile.d50
cell-cell signaling during cell fate commitment	GO:0045168	Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.	17	0.0420230385128788	0	0	1	L01D.profile.d50
apical protein localization	GO:0045176	The processes by which a protein is transported to, or maintained in, apical regions of the cell.	10	0.0247194344193405	0	0	1	L01D.profile.d50
establishment of protein localization	GO:0045184	The directed movement of a protein to a specific location.	937	2.3162110050922	3	1.29521878335112	0.408358958386652	L01D.profile.d50
maintenance of protein localization	GO:0045185	The processes by which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.	34	0.0840460770257577	0	0	1	L01D.profile.d50
isotype switching	GO:0045190	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.	30	0.0741583032580215	0	0	1	L01D.profile.d50
regulation of isotype switching	GO:0045191	Any process that modulates the frequency, rate or extent of isotype switching.	18	0.0444949819548129	0	0	1	L01D.profile.d50
intercellular junction assembly and maintenance	GO:0045216	The assembly and maintenance of junctions between cells.	26	0.0642705294902853	0	0	1	L01D.profile.d50
leukocyte activation	GO:0045321	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.	305	0.753942749789885	1	1.3263606557377	0.529931166251457	L01D.profile.d50
cellular respiration	GO:0045333	The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).	55	0.135956889306373	0	0	1	L01D.profile.d50
interferon type I biosynthetic process	GO:0045351	The chemical reactions and pathways resulting in the formation of interferon type I.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of interleukin-6 biosynthetic process	GO:0045408	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.0197755475354724	0	0	1	L01D.profile.d50
positive regulation of interleukin-6 biosynthetic process	GO:0045410	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of interleukin-8 biosynthetic process	GO:0045414	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.	7	0.0173036040935383	0	0	1	L01D.profile.d50
positive regulation of interleukin-8 biosynthetic process	GO:0045416	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.	7	0.0173036040935383	0	0	1	L01D.profile.d50
quinone cofactor biosynthetic process	GO:0045426	The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1).	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of nitric oxide biosynthetic process	GO:0045428	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.	20	0.049438868838681	0	0	1	L01D.profile.d50
fat cell differentiation	GO:0045444	The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.	31	0.0766302466999555	0	0	1	L01D.profile.d50
myoblast differentiation	GO:0045445	The process whereby a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a cell type that gives rise to mature contractile cells called myocytes. Fusion of myoblasts gives rise to the myotubes that eventually develop into skeletal muscle fibers.	55	0.135956889306373	0	0	1	L01D.profile.d50
endothelial cell differentiation	GO:0045446	The process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.	18	0.0444949819548129	0	0	1	L01D.profile.d50
regulation of transcription	GO:0045449	Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.	2702	6.6791911801058	13	1.94634344929682	0.0193396676240471	L01D.profile.d50
bone resorption	GO:0045453	The physiologic processes by which bone tissue is lost.	20	0.049438868838681	0	0	1	L01D.profile.d50
cell redox homeostasis	GO:0045454	The processes that maintain the redox environment of a cell or compartment within a cell.	60	0.148316606516043	0	0	1	L01D.profile.d50
mast cell activation	GO:0045576	The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of B cell differentiation	GO:0045577	Any process that modulates the frequency, rate or extent of B cell differentiation.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of T cell differentiation	GO:0045580	Any process that modulates the frequency, rate or extent of T cell differentiation.	23	0.0568546991644831	0	0	1	L01D.profile.d50
positive regulation of T cell differentiation	GO:0045582	Any process that activates or increases the frequency, rate or extent of T cell differentiation.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of cell differentiation	GO:0045595	Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.	233	0.575962821970633	1	1.73622317596567	0.438237362243702	L01D.profile.d50
negative regulation of cell differentiation	GO:0045596	Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.	90	0.222474909774064	1	4.49488888888889	0.199685366259419	L01D.profile.d50
positive regulation of cell differentiation	GO:0045597	Any process that activates or increases the frequency, rate or extent of cell differentiation.	81	0.200227418796658	0	0	1	L01D.profile.d50
regulation of epidermal cell differentiation	GO:0045604	Any process that modulates the frequency, rate or extent of epidermal cell differentiation.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of lymphocyte differentiation	GO:0045619	Any process that modulates the frequency, rate or extent of lymphocyte differentiation.	30	0.0741583032580215	0	0	1	L01D.profile.d50
positive regulation of lymphocyte differentiation	GO:0045621	Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of T-helper cell differentiation	GO:0045622	Any process that modulates the frequency, rate or extent of T-helper cell differentiation.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of myeloid cell differentiation	GO:0045637	Any process that modulates the frequency, rate or extent of myeloid cell differentiation.	74	0.18292381470312	0	0	1	L01D.profile.d50
negative regulation of myeloid cell differentiation	GO:0045638	Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.	27	0.0667424729322193	0	0	1	L01D.profile.d50
positive regulation of myeloid cell differentiation	GO:0045639	Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.	48	0.118653285212834	0	0	1	L01D.profile.d50
regulation of erythrocyte differentiation	GO:0045646	Any process that modulates the frequency, rate or extent of erythrocyte differentiation.	26	0.0642705294902853	0	0	1	L01D.profile.d50
positive regulation of erythrocyte differentiation	GO:0045648	Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.	19	0.0469669253967469	0	0	1	L01D.profile.d50
regulation of myoblast differentiation	GO:0045661	Any process that modulates the frequency, rate or extent of myoblast differentiation.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of neuron differentiation	GO:0045664	Any process that modulates the frequency, rate or extent of neuron differentiation.	27	0.0667424729322193	0	0	1	L01D.profile.d50
negative regulation of neuron differentiation	GO:0045665	Any process that stops, prevents or reduces the frequency, rate or extent of neuron differentiation.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of osteoblast differentiation	GO:0045667	Any process that modulates the frequency, rate or extent of osteoblast differentiation.	7	0.0173036040935383	1	57.7914285714286	0.0171758108653961	L01D.profile.d50
regulation of osteoclast differentiation	GO:0045670	Any process that modulates the frequency, rate or extent of osteoclast differentiation.	23	0.0568546991644831	0	0	1	L01D.profile.d50
negative regulation of osteoclast differentiation	GO:0045671	Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast differentiation.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of epidermis development	GO:0045682	Any process that modulates the frequency, rate or extent of epidermis development.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of protein biosynthetic process	GO:0045727	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.	69	0.170564097493449	0	0	1	L01D.profile.d50
negative regulation of cyclin-dependent protein kinase activity	GO:0045736	Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of adenylate cyclase activity	GO:0045761	Any process that modulates the frequency, rate or extent of adenylate cyclase activity.	72	0.177979927819252	0	0	1	L01D.profile.d50
positive regulation of adenylate cyclase activity	GO:0045762	Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.	48	0.118653285212834	0	0	1	L01D.profile.d50
positive regulation of amino acid metabolic process	GO:0045764	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.	31	0.0766302466999555	0	0	1	L01D.profile.d50
regulation of angiogenesis	GO:0045765	Any process that modulates the frequency, rate or extent of angiogenesis.	68	0.168092154051515	0	0	1	L01D.profile.d50
positive regulation of angiogenesis	GO:0045766	Any process that activates or increases angiogenesis.	23	0.0568546991644831	0	0	1	L01D.profile.d50
regulation of anti-apoptosis	GO:0045767	Any process that modulates the frequency, rate or extent of anti-apoptosis.	23	0.0568546991644831	0	0	1	L01D.profile.d50
positive regulation of anti-apoptosis	GO:0045768	Any process that activates or increases the frequency, rate or extent of anti-apoptosis.	20	0.049438868838681	0	0	1	L01D.profile.d50
positive regulation of ossification	GO:0045778	Any process that activates or increases the frequency, rate or extent of bone formation.	6	0.0148316606516043	0	0	1	L01D.profile.d50
positive regulation of cell adhesion	GO:0045785	Any process that activates or increases the frequency, rate or extent of cell adhesion.	14	0.0346072081870767	0	0	1	L01D.profile.d50
negative regulation of progression through cell cycle	GO:0045786	Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle.	347	0.857764374351115	1	1.16582132564841	0.576340959590959	L01D.profile.d50
positive regulation of progression through cell cycle	GO:0045787	Any process that activates or increases the frequency, rate or extent of progression through the cell cycle.	33	0.0815741335838236	0	0	1	L01D.profile.d50
negative regulation of cell size	GO:0045792	Any process that reduces cell size.	68	0.168092154051515	0	0	1	L01D.profile.d50
positive regulation of cell size	GO:0045793	Any process that increases cell size.	10	0.0247194344193405	0	0	1	L01D.profile.d50
positive regulation of endocytosis	GO:0045807	Any process that activates or increases the frequency, rate or extent of endocytosis.	17	0.0420230385128788	0	0	1	L01D.profile.d50
negative regulation of gene expression, epigenetic	GO:0045814	Any epigenetic process that stops, prevents or reduces the rate of gene expression.	19	0.0469669253967469	0	0	1	L01D.profile.d50
positive regulation of gene expression, epigenetic	GO:0045815	Any epigenetic process that activates or increases the rate of gene expression.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of isotype switching	GO:0045830	Any process that activates or increases the frequency, rate or extent of isotype switching.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of lipid metabolic process	GO:0045834	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.	11	0.0271913778612745	0	0	1	L01D.profile.d50
positive regulation of mitosis	GO:0045840	Any process that activates or increases the frequency, rate or extent of mitosis.	11	0.0271913778612745	0	0	1	L01D.profile.d50
negative regulation of striated muscle development	GO:0045843	Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle development.	7	0.0173036040935383	0	0	1	L01D.profile.d50
pH reduction	GO:0045851	Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of protein kinase activity	GO:0045859	Any process that modulates the frequency, rate or extent of protein kinase activity.	300	0.741583032580215	1	1.34846666666667	0.524077913287435	L01D.profile.d50
positive regulation of protein kinase activity	GO:0045860	Any process that activates or increases the frequency, rate or extent of protein kinase activity.	172	0.425174272012656	0	0	1	L01D.profile.d50
regulation of survival gene product activity	GO:0045884	Any process that modulates the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.	21	0.051910812280615	1	19.2638095238095	0.0506474741693736	L01D.profile.d50
positive regulation of survival gene product activity	GO:0045885	Any process that activates or increases the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.	8	0.0197755475354724	0	0	1	L01D.profile.d50
negative regulation of transcription, DNA-dependent	GO:0045892	Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription.	292	0.721807485044742	1	1.38541095890411	0.514560732429357	L01D.profile.d50
positive regulation of transcription, DNA-dependent	GO:0045893	Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription.	368	0.90967518663173	2	2.19858695652174	0.231018581997075	L01D.profile.d50
regulation of transcriptional preinitiation complex assembly	GO:0045898	Any process that modulates the frequency, rate or extent of transcriptional preinitiation complex assebly.	11	0.0271913778612745	0	0	1	L01D.profile.d50
positive regulation of carbohydrate metabolic process	GO:0045913	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.	9	0.0222474909774064	0	0	1	L01D.profile.d50
negative regulation of growth	GO:0045926	Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.	83	0.205171305680526	0	0	1	L01D.profile.d50
positive regulation of growth	GO:0045927	Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.	27	0.0667424729322193	0	0	1	L01D.profile.d50
negative regulation of progression through mitotic cell cycle	GO:0045930	Any process that stops, prevents or reduces the frequency, rate or extent of progression through the mitotic cell cycle.	18	0.0444949819548129	0	0	1	L01D.profile.d50
positive regulation of muscle contraction	GO:0045933	Any process that activates or increases the frequency, rate or extent of muscle contraction.	6	0.0148316606516043	0	0	1	L01D.profile.d50
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	GO:0045934	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	478	1.18158896524448	1	0.846317991631799	0.693657581196551	L01D.profile.d50
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	GO:0045935	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	450	1.11237454887032	2	1.79795555555556	0.305549845187417	L01D.profile.d50
negative regulation of phosphate metabolic process	GO:0045936	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.	14	0.0346072081870767	0	0	1	L01D.profile.d50
positive regulation of phosphate metabolic process	GO:0045937	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.	35	0.0865180204676917	0	0	1	L01D.profile.d50
positive regulation of transcription	GO:0045941	Any process that activates or increases the frequency, rate or extent of transcription.	439	1.08518317100905	2	1.84300683371298	0.29558042821886	L01D.profile.d50
positive regulation of transcription from RNA polymerase II promoter	GO:0045944	Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter.	226	0.558659217877095	2	3.58	0.108310290575842	L01D.profile.d50
negative regulation of translational initiation	GO:0045947	Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation.	5	0.0123597172096702	0	0	1	L01D.profile.d50
negative regulation of nucleotide metabolic process	GO:0045980	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of embryonic development	GO:0045995	Any process that modulates the frequency, rate or extent of embryonic development.	13	0.0321352647451426	0	0	1	L01D.profile.d50
regulation of activated T cell proliferation	GO:0046006	Any process that modulates the frequency, rate or extent of activated T cell proliferation.	17	0.0420230385128788	0	0	1	L01D.profile.d50
ATP metabolic process	GO:0046034	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.	72	0.177979927819252	0	0	1	L01D.profile.d50
CTP metabolic process	GO:0046036	The chemical reactions and pathways involving CTP, cytidine triphosphate.	10	0.0247194344193405	0	0	1	L01D.profile.d50
GTP metabolic process	GO:0046039	The chemical reactions and pathways involving GTP, guanosine triphosphate.	12	0.0296633213032086	0	0	1	L01D.profile.d50
UTP metabolic process	GO:0046051	The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate.	9	0.0222474909774064	0	0	1	L01D.profile.d50
cAMP metabolic process	GO:0046058	The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).	37	0.0914619073515598	0	0	1	L01D.profile.d50
cGMP metabolic process	GO:0046068	The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate.	22	0.0543827557225491	0	0	1	L01D.profile.d50
nucleobase biosynthetic process	GO:0046112	The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.	19	0.0469669253967469	0	0	1	L01D.profile.d50
pyrimidine deoxyribonucleoside metabolic process	GO:0046125	The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).	5	0.0123597172096702	0	0	1	L01D.profile.d50
purine ribonucleoside metabolic process	GO:0046128	The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.	10	0.0247194344193405	0	0	1	L01D.profile.d50
tetrahydrobiopterin metabolic process	GO:0046146	The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.	5	0.0123597172096702	0	0	1	L01D.profile.d50
pigment biosynthetic process	GO:0046148	The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.	49	0.121125228654768	0	0	1	L01D.profile.d50
alcohol catabolic process	GO:0046164	The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of alkyl compounds containing a hydroxyl group.	106	0.262026004845009	0	0	1	L01D.profile.d50
alcohol biosynthetic process	GO:0046165	The chemical reactions and pathways resulting in the formation of alcohols, any of a class of alkyl compounds containing a hydroxyl group.	39	0.0964057942354279	0	0	1	L01D.profile.d50
nitric oxide metabolic process	GO:0046209	The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.	38	0.0939338507934939	0	0	1	L01D.profile.d50
regulation of JNK cascade	GO:0046328	Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.	25	0.0617985860483512	0	0	1	L01D.profile.d50
positive regulation of JNK cascade	GO:0046330	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.	12	0.0296633213032086	0	0	1	L01D.profile.d50
diacylglycerol metabolic process	GO:0046339	The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction.	8	0.0197755475354724	0	0	1	L01D.profile.d50
amino sugar catabolic process	GO:0046348	The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group.	10	0.0247194344193405	0	0	1	L01D.profile.d50
acetyl-CoA catabolic process	GO:0046356	The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.	36	0.0889899639096258	0	0	1	L01D.profile.d50
monosaccharide biosynthetic process	GO:0046364	The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.	39	0.0964057942354279	0	0	1	L01D.profile.d50
monosaccharide catabolic process	GO:0046365	The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.	103	0.254610174519207	0	0	1	L01D.profile.d50
carboxylic acid biosynthetic process	GO:0046394	The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.	100	0.247194344193405	0	0	1	L01D.profile.d50
carboxylic acid catabolic process	GO:0046395	The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of JAK-STAT cascade	GO:0046425	Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.	18	0.0444949819548129	0	0	1	L01D.profile.d50
positive regulation of JAK-STAT cascade	GO:0046427	Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.	7	0.0173036040935383	0	0	1	L01D.profile.d50
icosanoid biosynthetic process	GO:0046456	The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.	42	0.10382162456123	0	0	1	L01D.profile.d50
prostanoid biosynthetic process	GO:0046457	The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure.	16	0.0395510950709448	0	0	1	L01D.profile.d50
neutral lipid biosynthetic process	GO:0046460	The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity.	7	0.0173036040935383	0	0	1	L01D.profile.d50
acylglycerol biosynthetic process	GO:0046463	The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.	7	0.0173036040935383	0	0	1	L01D.profile.d50
membrane lipid catabolic process	GO:0046466	The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane.	30	0.0741583032580215	0	0	1	L01D.profile.d50
membrane lipid biosynthetic process	GO:0046467	The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.	90	0.222474909774064	0	0	1	L01D.profile.d50
phosphatidylcholine metabolic process	GO:0046470	The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.	7	0.0173036040935383	0	0	1	L01D.profile.d50
glycerophospholipid biosynthetic process	GO:0046474	The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.	43	0.106293568003164	0	0	1	L01D.profile.d50
heterocycle metabolic process	GO:0046483	The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).	102	0.252138231077273	0	0	1	L01D.profile.d50
glycerolipid metabolic process	GO:0046486	The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.	21	0.051910812280615	0	0	1	L01D.profile.d50
phosphatidylinositol metabolic process	GO:0046488	The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.	7	0.0173036040935383	0	0	1	L01D.profile.d50
phosphoinositide biosynthetic process	GO:0046489	The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol.	30	0.0741583032580215	0	0	1	L01D.profile.d50
glycerol ether biosynthetic process	GO:0046504	The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.	8	0.0197755475354724	0	0	1	L01D.profile.d50
ceramide biosynthetic process	GO:0046513	The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.	8	0.0197755475354724	0	0	1	L01D.profile.d50
sphingoid metabolic process	GO:0046519	The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.	49	0.121125228654768	0	0	1	L01D.profile.d50
sphingoid biosynthetic process	GO:0046520	The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.	10	0.0247194344193405	0	0	1	L01D.profile.d50
photoreceptor cell differentiation	GO:0046530	The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.	20	0.049438868838681	0	0	1	L01D.profile.d50
development of primary female sexual characteristics	GO:0046545	The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.	47	0.1161813417709	0	0	1	L01D.profile.d50
development of primary male sexual characteristics	GO:0046546	The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion.	31	0.0766302466999555	0	0	1	L01D.profile.d50
regulation of Ras protein signal transduction	GO:0046578	Any process that modulates the frequency, rate or extent of Ras protein signal transduction.	202	0.499332575270678	0	0	1	L01D.profile.d50
alpha-beta T cell activation	GO:0046631	The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	36	0.0889899639096258	0	0	1	L01D.profile.d50
alpha-beta T cell differentiation	GO:0046632	The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell.	28	0.0692144163741534	0	0	1	L01D.profile.d50
alpha-beta T cell proliferation	GO:0046633	The rapid expansion of an alpha-beta T cell population by cell division.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of alpha-beta T cell activation	GO:0046634	Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.	6	0.0148316606516043	0	0	1	L01D.profile.d50
lymphocyte activation	GO:0046649	A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.	269	0.664952785880259	1	1.50386617100372	0.48612539664466	L01D.profile.d50
lymphocyte proliferation	GO:0046651	The rapid expansion of a lymphocyte population by cell division.	91	0.224946853215998	1	4.4454945054945	0.201663698769778	L01D.profile.d50
female sex differentiation	GO:0046660	The establishment of the sex of a female organism by physical differentiation.	47	0.1161813417709	0	0	1	L01D.profile.d50
male sex differentiation	GO:0046661	The establishment of the sex of a male organism by physical differentiation.	41	0.101349681119296	0	0	1	L01D.profile.d50
entry of virus into host cell	GO:0046718	The process by which a virion enters a host cell, including virion attachment and penetration.	18	0.0444949819548129	0	0	1	L01D.profile.d50
protein amino acid autophosphorylation	GO:0046777	The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.	64	0.158204380283779	0	0	1	L01D.profile.d50
regulation of nucleocytoplasmic transport	GO:0046822	Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.	48	0.118653285212834	0	0	1	L01D.profile.d50
negative regulation of nucleocytoplasmic transport	GO:0046823	Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.	17	0.0420230385128788	0	0	1	L01D.profile.d50
positive regulation of nucleocytoplasmic transport	GO:0046824	Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.	16	0.0395510950709448	0	0	1	L01D.profile.d50
phospholipid dephosphorylation	GO:0046839	The process of removing one or more phosphoric groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.	32	0.0791021901418896	0	0	1	L01D.profile.d50
filopodium formation	GO:0046847	The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon.	7	0.0173036040935383	0	0	1	L01D.profile.d50
bone remodeling	GO:0046849	The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.	155	0.383151233499778	1	2.60993548387097	0.318613495469961	L01D.profile.d50
regulation of bone remodeling	GO:0046850	Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.	38	0.0939338507934939	0	0	1	L01D.profile.d50
negative regulation of bone remodeling	GO:0046851	Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling.	16	0.0395510950709448	0	0	1	L01D.profile.d50
positive regulation of bone remodeling	GO:0046852	Any process that activates or increases the frequency, rate or extent of bone remodeling.	7	0.0173036040935383	0	0	1	L01D.profile.d50
hormone secretion	GO:0046879	The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.	36	0.0889899639096258	0	0	1	L01D.profile.d50
regulation of hormone secretion	GO:0046883	Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.	19	0.0469669253967469	0	0	1	L01D.profile.d50
regulation of lipid biosynthetic process	GO:0046890	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.	9	0.0222474909774064	0	0	1	L01D.profile.d50
secretion	GO:0046903	The regulated release of a substance by a cell, a group of cells, or a tissue.	465	1.14945370049933	0	0	1	L01D.profile.d50
intracellular transport	GO:0046907	The directed movement of substances within a cell.	982	2.42744845997924	3	1.23586558044807	0.4375834790738	L01D.profile.d50
transition metal ion homeostasis	GO:0046916	The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	55	0.135956889306373	1	7.35527272727273	0.127266645466854	L01D.profile.d50
regulation of neurotransmitter secretion	GO:0046928	Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
carboxylic acid transport	GO:0046942	The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).	97	0.239778513867603	0	0	1	L01D.profile.d50
antigen processing and presentation of peptide antigen	GO:0048002	The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.	72	0.177979927819252	0	0	1	L01D.profile.d50
insulin-like growth factor receptor signaling pathway	GO:0048009	The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.	13	0.0321352647451426	0	0	1	L01D.profile.d50
phosphoinositide-mediated signaling	GO:0048015	A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.	124	0.306520986799822	1	3.26241935483871	0.264276171409276	L01D.profile.d50
focal adhesion formation	GO:0048041	Establishment and maturation of focal adhesions, complexes of intracellular signaling and structural proteins which provide a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.	25	0.0617985860483512	0	0	1	L01D.profile.d50
pigmentation during development	GO:0048066	The deposition of coloring matter in an organism, tissue or cell, occurring during development.	39	0.0964057942354279	0	0	1	L01D.profile.d50
fibroblast proliferation	GO:0048144	The multiplication or reproduction of fibroblast cells, resulting in the rapid expansion of the fibroblast population.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of fibroblast proliferation	GO:0048145	Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of synaptic plasticity	GO:0048167	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.	30	0.0741583032580215	0	0	1	L01D.profile.d50
regulation of neuronal synaptic plasticity	GO:0048168	A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.	17	0.0420230385128788	0	0	1	L01D.profile.d50
Golgi vesicle transport	GO:0048193	The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.	183	0.452365649873931	0	0	1	L01D.profile.d50
male gamete generation	GO:0048232	Generation of the male gamete; specialised haploid cells produced by meiosis and involved in sexual reproduction.	225	0.556187274435161	1	1.79795555555556	0.427003597784969	L01D.profile.d50
regulation of receptor mediated endocytosis	GO:0048259	Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.	10	0.0247194344193405	0	0	1	L01D.profile.d50
response to pain	GO:0048265	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.	21	0.051910812280615	0	0	1	L01D.profile.d50
gastrulation (sensu Vertebrata)	GO:0048276	The process of gastrulation, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	19	0.0469669253967469	0	0	1	L01D.profile.d50
vesicle docking	GO:0048278	The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.	23	0.0568546991644831	0	0	1	L01D.profile.d50
organelle fusion	GO:0048284	The creation of a single organelle from two or more organelles.	12	0.0296633213032086	0	0	1	L01D.profile.d50
organelle fission	GO:0048285	The creation of two or more organelles by division of one organelle.	8	0.0197755475354724	0	0	1	L01D.profile.d50
immunoglobulin secretion	GO:0048305	The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.	10	0.0247194344193405	0	0	1	L01D.profile.d50
mesoderm morphogenesis	GO:0048332	The process by which the anatomical structures of the mesoderm are generated and organized. Morphogenesis pertains to the creation of form.	40	0.098877737677362	0	0	1	L01D.profile.d50
mesodermal cell differentiation	GO:0048333	The process whereby a relatively unspecialized cell acquires the specialized features of a mesoderm cell.	9	0.0222474909774064	0	0	1	L01D.profile.d50
paraxial mesoderm development	GO:0048339	The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.	10	0.0247194344193405	0	0	1	L01D.profile.d50
cell development	GO:0048468	The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.	1692	4.18252830375241	6	1.4345390070922	0.243843640279026	L01D.profile.d50
cell maturation	GO:0048469	A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.	94	0.232362683541801	1	4.3036170212766	0.207569402668961	L01D.profile.d50
oogenesis	GO:0048477	The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell.	13	0.0321352647451426	1	31.1184615384615	0.0316629388039029	L01D.profile.d50
synaptic vesicle transport	GO:0048489	The directed movement of substances in synaptic membrane-bound vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body.	29	0.0716863598160874	0	0	1	L01D.profile.d50
rhythmic process	GO:0048511	Those processes pertinent to the generation and maintenance of rhythms in the physiology of an organism.	94	0.232362683541801	0	0	1	L01D.profile.d50
organ development	GO:0048513	Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	1733	4.28387798487171	3	0.700300057703404	0.800971689758832	L01D.profile.d50
blood vessel morphogenesis	GO:0048514	The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.	248	0.613041973599644	1	1.63120967741935	0.458710448043807	L01D.profile.d50
spermatid differentiation	GO:0048515	The process whereby a relatively unspecialized cell acquires the specialized features of a spermatid cell.	37	0.0914619073515598	0	0	1	L01D.profile.d50
positive regulation of biological process	GO:0048518	Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	1501	3.71038710634301	4	1.0780546302465	0.508195746065071	L01D.profile.d50
negative regulation of biological process	GO:0048519	Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	1697	4.19488802096208	5	1.19192692987625	0.409225803988339	L01D.profile.d50
positive regulation of cellular process	GO:0048522	Any process that activates or increases the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1371	3.38903445889158	4	1.18027716994894	0.439349498905841	L01D.profile.d50
negative regulation of cellular process	GO:0048523	Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1642	4.05893113165571	5	1.23185140073082	0.382688750683409	L01D.profile.d50
hemopoietic or lymphoid organ development	GO:0048534	The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.	323	0.798437731744698	0	0	1	L01D.profile.d50
lymph node development	GO:0048535	The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.	11	0.0271913778612745	0	0	1	L01D.profile.d50
thymus development	GO:0048538	The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.	13	0.0321352647451426	0	0	1	L01D.profile.d50
digestive tract morphogenesis	GO:0048546	The process by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines.	11	0.0271913778612745	0	0	1	L01D.profile.d50
gut morphogenesis	GO:0048547	The process by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.	8	0.0197755475354724	0	0	1	L01D.profile.d50
embryonic organ morphogenesis	GO:0048562	Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	13	0.0321352647451426	0	0	1	L01D.profile.d50
gut development	GO:0048565	The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.	14	0.0346072081870767	0	0	1	L01D.profile.d50
ectodermal gut morphogenesis	GO:0048567	The process by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. The ectodermal gut includes those portions of the gut that are derived from ectoderm.	6	0.0148316606516043	0	0	1	L01D.profile.d50
embryonic organ development	GO:0048568	Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	29	0.0716863598160874	0	0	1	L01D.profile.d50
regulation of response to stimulus	GO:0048583	Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.	32	0.0791021901418896	0	0	1	L01D.profile.d50
developmental growth	GO:0048589	The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.	46	0.113709398328966	0	0	1	L01D.profile.d50
eye morphogenesis	GO:0048592	The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form.	33	0.0815741335838236	0	0	1	L01D.profile.d50
embryonic morphogenesis	GO:0048598	The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.	161	0.397982894151382	0	0	1	L01D.profile.d50
oocyte development	GO:0048599	The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	9	0.0222474909774064	1	44.9488888888889	0.0220287769316943	L01D.profile.d50
reproductive structure development	GO:0048608	The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.	75	0.185395758145054	0	0	1	L01D.profile.d50
reproductive process in a multicellular organism	GO:0048609	The process, occurring above the cellular level, that is pertinent to the reproductive function of an organism. This includes the integrated processes at the level of tissues and organs.	83	0.205171305680526	0	0	1	L01D.profile.d50
myoblast development	GO:0048627	The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure.	32	0.0791021901418896	0	0	1	L01D.profile.d50
myoblast maturation	GO:0048628	A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state.	32	0.0791021901418896	0	0	1	L01D.profile.d50
skeletal muscle development	GO:0048637	The process whose specific outcome is the progression of the skeletal muscle over time, from its formation to the mature structure.	85	0.210115192564394	1	4.75929411764706	0.189719923614059	L01D.profile.d50
muscle morphogenesis	GO:0048644	The process by which the anatomical structures of muscle are generated and organized. Morphogenesis pertains to the creation of form.	6	0.0148316606516043	0	0	1	L01D.profile.d50
anatomical structure formation	GO:0048646	The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.	265	0.655065012112523	0	0	1	L01D.profile.d50
smooth muscle cell proliferation	GO:0048659	The multiplication or reproduction of smooth muscle cells, resulting in the rapid expansion of a cell population.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of smooth muscle cell proliferation	GO:0048660	Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.	10	0.0247194344193405	0	0	1	L01D.profile.d50
neuron fate commitment	GO:0048663	The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron.	19	0.0469669253967469	0	0	1	L01D.profile.d50
neuron development	GO:0048666	The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.	270	0.667424729322193	1	1.4982962962963	0.487395665600401	L01D.profile.d50
neuron morphogenesis during differentiation	GO:0048667	The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.	195	0.482028971177139	1	2.0745641025641	0.382839234464455	L01D.profile.d50
axon extension	GO:0048675	Long distance growth of a single process.	35	0.0865180204676917	0	0	1	L01D.profile.d50
generation of neurons	GO:0048699	The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.	380	0.939338507934939	2	2.12915789473684	0.241911330936539	L01D.profile.d50
embryonic skeletal morphogenesis	GO:0048704	The process by which the anatomical structures of skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.	7	0.0173036040935383	0	0	1	L01D.profile.d50
skeletal morphogenesis	GO:0048705	The process by which the anatomical structures of skeleton are generated and organized. Morphogenesis pertains to the creation of form.	13	0.0321352647451426	0	0	1	L01D.profile.d50
embryonic skeletal development	GO:0048706	The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.	8	0.0197755475354724	0	0	1	L01D.profile.d50
astrocyte differentiation	GO:0048708	The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.	9	0.0222474909774064	0	0	1	L01D.profile.d50
oligodendrocyte differentiation	GO:0048709	The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.	10	0.0247194344193405	0	0	1	L01D.profile.d50
tissue morphogenesis	GO:0048729	The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.	66	0.163148267167647	0	0	1	L01D.profile.d50
epidermis morphogenesis	GO:0048730	The process by which the anatomical structures of the epidermis are generated and organized. Morphogenesis pertains to the creation of form. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.	31	0.0766302466999555	0	0	1	L01D.profile.d50
system development	GO:0048731	The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.	2362	5.83873040984822	4	0.685080440304826	0.834153978504797	L01D.profile.d50
gland development	GO:0048732	The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.	81	0.200227418796658	0	0	1	L01D.profile.d50
appendage development	GO:0048736	The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch.	76	0.187867701586988	0	0	1	L01D.profile.d50
skeletal muscle fiber development	GO:0048741	The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure.	79	0.19528353191279	0	0	1	L01D.profile.d50
muscle fiber development	GO:0048747	The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure.	79	0.19528353191279	0	0	1	L01D.profile.d50
branching morphogenesis of a tube	GO:0048754	The process by which the anatomical structures of branches in a tube are generated and organized. Morphogenesis pertains to the creation of form. A tube is a long hollow cylinder.	65	0.160676323725713	0	0	1	L01D.profile.d50
mesenchymal cell differentiation	GO:0048762	The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell.	39	0.0964057942354279	0	0	1	L01D.profile.d50
tissue remodeling	GO:0048771	The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.	161	0.397982894151382	1	2.51267080745342	0.328657340112603	L01D.profile.d50
genitalia development	GO:0048806	The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.	7	0.0173036040935383	0	0	1	L01D.profile.d50
neurite morphogenesis	GO:0048812	The process by which the anatomical structures of neurites are generated and organized. Morphogenesis pertains to the creation of form. A neurite is any process extending from a neural cell, such as axons or dendrites.	195	0.482028971177139	1	2.0745641025641	0.382839234464455	L01D.profile.d50
dendrite morphogenesis	GO:0048813	The process by which the anatomical structures of dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell.	10	0.0247194344193405	0	0	1	L01D.profile.d50
hair follicle maturation	GO:0048820	A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state.	17	0.0420230385128788	0	0	1	L01D.profile.d50
inner ear development	GO:0048839	The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.	53	0.131013002422505	0	0	1	L01D.profile.d50
anatomical structure development	GO:0048856	The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.	2828	6.99065605378949	7	1.00133663366337	0.549078680927689	L01D.profile.d50
cell projection morphogenesis	GO:0048858	The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.	296	0.731695258812478	2	2.73337837837838	0.16677681687862	L01D.profile.d50
cellular developmental process	GO:0048869	A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.	2359	5.83131457952242	8	1.37190334887664	0.2329475858674	L01D.profile.d50
multicellular organismal homeostasis	GO:0048871	The processes involved in the maintenance of an internal equilibrium at the level of the multicellular organism.	29	0.0716863598160874	0	0	1	L01D.profile.d50
homeostasis of number of cells	GO:0048872	The biological processes involved in the maintenance of the equilibrium of cell number within a population of cells.	21	0.051910812280615	0	0	1	L01D.profile.d50
chemical homeostasis	GO:0048878	The biological processes involved in the maintenance of an internal equilibrium of a chemical.	323	0.798437731744698	1	1.25244582043344	0.550413140314926	L01D.profile.d50
chromosome localization	GO:0050000	The processes by which a chromosome is transported to, or maintained in, a specific location.	8	0.0197755475354724	0	0	1	L01D.profile.d50
beta-amyloid metabolic process	GO:0050435	The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).	20	0.049438868838681	0	0	1	L01D.profile.d50
chondroitin sulfate proteoglycan biosynthetic process	GO:0050650	The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.	12	0.0296633213032086	0	0	1	L01D.profile.d50
chondroitin sulfate proteoglycan metabolic process	GO:0050654	The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.	12	0.0296633213032086	0	0	1	L01D.profile.d50
nucleic acid transport	GO:0050657	The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells.	86	0.212587136006328	0	0	1	L01D.profile.d50
RNA transport	GO:0050658	The directed movement of RNA, ribonucleic acids, into, out of, within or between cells.	86	0.212587136006328	0	0	1	L01D.profile.d50
cytokine secretion	GO:0050663	The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	21	0.051910812280615	0	0	1	L01D.profile.d50
regulation of lymphocyte proliferation	GO:0050670	Any process that modulates the frequency, rate or extent of lymphocyte proliferation.	62	0.153260493399911	1	6.52483870967742	0.142256548500238	L01D.profile.d50
positive regulation of lymphocyte proliferation	GO:0050671	Any process that activates or increases the rate or extent of lymphocyte proliferation.	43	0.106293568003164	1	9.40790697674418	0.100957670704549	L01D.profile.d50
negative regulation of lymphocyte proliferation	GO:0050672	Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.	26	0.0642705294902853	0	0	1	L01D.profile.d50
epithelial cell proliferation	GO:0050673	The multiplication or reproduction of epithelial cells, resulting in the rapid expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.	36	0.0889899639096258	0	0	1	L01D.profile.d50
regulation of epithelial cell proliferation	GO:0050678	Any process that modulates the frequency, rate or extent of epithelial cell proliferation.	35	0.0865180204676917	0	0	1	L01D.profile.d50
positive regulation of epithelial cell proliferation	GO:0050679	Any process that activates or increases the rate or extent of epithelial cell proliferation.	25	0.0617985860483512	0	0	1	L01D.profile.d50
regulation of mRNA processing	GO:0050684	Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.	5	0.0123597172096702	0	0	1	L01D.profile.d50
interleukin-1 secretion	GO:0050701	The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response.	9	0.0222474909774064	0	0	1	L01D.profile.d50
interleukin-1 beta secretion	GO:0050702	The regulated release of interleukin 1 beta from a cell or group of cells.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of interleukin-1 secretion	GO:0050704	Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of interleukin-1 beta secretion	GO:0050706	Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of cytokine secretion	GO:0050707	Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells.	18	0.0444949819548129	0	0	1	L01D.profile.d50
regulation of protein secretion	GO:0050708	Any process that modulates the frequency, rate or extent of the regulated release of a protein from a cell or group of cells.	32	0.0791021901418896	0	0	1	L01D.profile.d50
positive regulation of protein secretion	GO:0050714	Any process that activates or increases the frequency, rate or extent of the regulated release of a protein from a cell or group of cells.	19	0.0469669253967469	0	0	1	L01D.profile.d50
positive regulation of cytokine secretion	GO:0050715	Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells.	15	0.0370791516290107	0	0	1	L01D.profile.d50
positive regulation of interleukin-1 secretion	GO:0050716	Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells.	9	0.0222474909774064	0	0	1	L01D.profile.d50
positive regulation of interleukin-1 beta secretion	GO:0050718	Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of inflammatory response	GO:0050727	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.	25	0.0617985860483512	0	0	1	L01D.profile.d50
negative regulation of inflammatory response	GO:0050728	Any process that stops, prevents or reduces the frequency, rate or extent of the inflammatory response.	11	0.0271913778612745	0	0	1	L01D.profile.d50
positive regulation of inflammatory response	GO:0050729	Any process that activates or increases the frequency, rate or extent of the inflammatory response.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of peptidyl-tyrosine phosphorylation	GO:0050730	Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.	53	0.131013002422505	0	0	1	L01D.profile.d50
positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.	26	0.0642705294902853	0	0	1	L01D.profile.d50
chemokine metabolic process	GO:0050755	The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of phagocytosis	GO:0050764	Any process that modulates the frequency, rate or extent of phagocytosis, the process whereby phagocytes engulf external particulate material.	8	0.0197755475354724	0	0	1	L01D.profile.d50
positive regulation of phagocytosis	GO:0050766	Any process that activates or increases the frequency, rate or extent of phagocytosis.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of neurogenesis	GO:0050767	Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.	48	0.118653285212834	0	0	1	L01D.profile.d50
negative regulation of neurogenesis	GO:0050768	Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.	20	0.049438868838681	0	0	1	L01D.profile.d50
positive regulation of neurogenesis	GO:0050769	Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons.	19	0.0469669253967469	0	0	1	L01D.profile.d50
regulation of axonogenesis	GO:0050770	Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.	39	0.0964057942354279	0	0	1	L01D.profile.d50
negative regulation of axonogenesis	GO:0050771	Any process that stops, prevents or reduces the frequency, rate or extent of axonogenesis.	15	0.0370791516290107	0	0	1	L01D.profile.d50
positive regulation of axonogenesis	GO:0050772	Any process that activates or increases the frequency, rate or extent of axonogenesis.	17	0.0420230385128788	0	0	1	L01D.profile.d50
regulation of immune response	GO:0050776	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	134	0.331240421219163	1	3.0189552238806	0.282261872180867	L01D.profile.d50
negative regulation of immune response	GO:0050777	Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	20	0.049438868838681	0	0	1	L01D.profile.d50
positive regulation of immune response	GO:0050778	Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	109	0.269441835170811	1	3.71137614678899	0.236449037089975	L01D.profile.d50
regulation of biological process	GO:0050789	Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	5630	13.9170415780887	25	1.79635879218472	0.00462251352843052	L01D.profile.d50
regulation of catalytic activity	GO:0050790	Any process that modulates the activity of an enzyme.	602	1.4881099520443	3	2.01598006644518	0.188015844146878	L01D.profile.d50
regulation of viral life cycle	GO:0050792	Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.	26	0.0642705294902853	0	0	1	L01D.profile.d50
regulation of developmental process	GO:0050793	Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	363	0.89731546942206	1	1.11443526170799	0.592790041109877	L01D.profile.d50
regulation of cellular process	GO:0050794	Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	5188	12.8244425767538	25	1.94940246723207	0.00164853688653511	L01D.profile.d50
regulation of insulin secretion	GO:0050796	Any process that modulates the frequency, rate or extent of the regulated release of insulin.	12	0.0296633213032086	0	0	1	L01D.profile.d50
activated T cell proliferation	GO:0050798	The rapid expansion of a T cell population following activation by an antigenic stimulus.	24	0.0593266426064172	0	0	1	L01D.profile.d50
ion homeostasis	GO:0050801	Any of the processes involved in the maintenance of an internal equilibrium of ions within an organism or cell.	272	0.672368616206061	1	1.48727941176471	0.489926791174822	L01D.profile.d50
regulation of synaptic transmission	GO:0050804	Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.	40	0.098877737677362	0	0	1	L01D.profile.d50
synapse organization and biogenesis	GO:0050808	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).	48	0.118653285212834	0	0	1	L01D.profile.d50
coagulation	GO:0050817	The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.	145	0.358431799080437	0	0	1	L01D.profile.d50
regulation of coagulation	GO:0050818	Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.	19	0.0469669253967469	0	0	1	L01D.profile.d50
negative regulation of coagulation	GO:0050819	Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.	18	0.0444949819548129	0	0	1	L01D.profile.d50
protein stabilization	GO:0050821	The processes involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.	13	0.0321352647451426	0	0	1	L01D.profile.d50
defense response to Gram-positive bacterium	GO:0050830	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.	5	0.0123597172096702	0	0	1	L01D.profile.d50
defense response to fungus	GO:0050832	Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of calcium-mediated signaling	GO:0050848	Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process by which a cell uses calcium ions to convert an extracellular signal into a response.	8	0.0197755475354724	0	0	1	L01D.profile.d50
positive regulation of calcium-mediated signaling	GO:0050850	Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.	8	0.0197755475354724	0	0	1	L01D.profile.d50
antigen receptor-mediated signaling pathway	GO:0050851	A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.	48	0.118653285212834	1	8.42791666666667	0.11201477926423	L01D.profile.d50
T cell receptor signaling pathway	GO:0050852	A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.	41	0.101349681119296	1	9.86682926829268	0.0964963718305929	L01D.profile.d50
B cell receptor signaling pathway	GO:0050853	A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.	7	0.0173036040935383	0	0	1	L01D.profile.d50
regulation of antigen receptor-mediated signaling pathway	GO:0050854	Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.	22	0.0543827557225491	1	18.3881818181818	0.0529942199196842	L01D.profile.d50
regulation of T cell receptor signaling pathway	GO:0050856	Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.	19	0.0469669253967469	1	21.2915789473684	0.0459365220634866	L01D.profile.d50
regulation of T cell activation	GO:0050863	Any process that modulates the frequency, rate or extent of T cell activation.	90	0.222474909774064	1	4.49488888888889	0.199685366259419	L01D.profile.d50
regulation of B cell activation	GO:0050864	Any process that modulates the frequency, rate or extent of B cell activation.	38	0.0939338507934939	0	0	1	L01D.profile.d50
regulation of cell activation	GO:0050865	Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.	117	0.289217382706284	1	3.45760683760684	0.251418680243775	L01D.profile.d50
negative regulation of T cell activation	GO:0050868	Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation.	22	0.0543827557225491	0	0	1	L01D.profile.d50
negative regulation of B cell activation	GO:0050869	Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation.	11	0.0271913778612745	0	0	1	L01D.profile.d50
positive regulation of T cell activation	GO:0050870	Any process that activates or increases the frequency, rate or extent of T cell activation.	65	0.160676323725713	1	6.22369230769231	0.148601717620338	L01D.profile.d50
positive regulation of B cell activation	GO:0050871	Any process that activates or increases the frequency, rate or extent of B cell activation.	25	0.0617985860483512	0	0	1	L01D.profile.d50
neurological process	GO:0050877	The processes pertaining to the functions of the nervous system of an organism.	935	2.31126711820834	0	0	1	L01D.profile.d50
regulation of body fluids	GO:0050878	Any process that modulates the levels of body fluids.	175	0.432590102338459	0	0	1	L01D.profile.d50
multicellular organismal movement	GO:0050879	Physiological processes involved in the relocation of an organism or an anatomical part of an organism.	41	0.101349681119296	0	0	1	L01D.profile.d50
regulation of blood vessel size	GO:0050880	Any process that modulates the size of blood vessels.	43	0.106293568003164	0	0	1	L01D.profile.d50
musculoskeletal movement	GO:0050881	The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.	34	0.0840460770257577	0	0	1	L01D.profile.d50
regulation of balance	GO:0050885	The processes that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.	34	0.0840460770257577	0	0	1	L01D.profile.d50
endocrine process	GO:0050886	The hormonal, neural, and secretory processes that release products into the blood or lymph. These products have specific effects on other organs.	13	0.0321352647451426	0	0	1	L01D.profile.d50
intestinal absorption	GO:0050892	The processes by which nutrients are taken up from the contents of the intestine.	21	0.051910812280615	0	0	1	L01D.profile.d50
response to stimulus	GO:0050896	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.	2860	7.06975824393138	7	0.990132867132867	0.560825748804986	L01D.profile.d50
leukocyte migration	GO:0050900	The movement of leukocytes within or between different tissues and organs of the body.	39	0.0964057942354279	0	0	1	L01D.profile.d50
neuromuscular process	GO:0050905	The processes pertaining to the functions of the nervous and muscular systems of an organism.	13	0.0321352647451426	0	0	1	L01D.profile.d50
detection of stimulus during sensory perception	GO:0050906	The series of events during sensory perception in which a sensory stimulus is received by a cell and converted into a molecular signal.	37	0.0914619073515598	0	0	1	L01D.profile.d50
detection of light stimulus during visual perception	GO:0050908	The series of events during visual perception in which a sensory light stimulus is received by a cell and converted into a molecular signal.	25	0.0617985860483512	0	0	1	L01D.profile.d50
sensory perception of taste	GO:0050909	The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of chemotaxis	GO:0050920	Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.	16	0.0395510950709448	0	0	1	L01D.profile.d50
pigment cell differentiation	GO:0050931	The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.	24	0.0593266426064172	0	0	1	L01D.profile.d50
sensory perception of light stimulus	GO:0050953	The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal.	237	0.58585059573837	0	0	1	L01D.profile.d50
sensory perception of mechanical stimulus	GO:0050954	The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal.	191	0.472141197409403	0	0	1	L01D.profile.d50
detection of light stimulus during sensory perception	GO:0050962	The series of events in which a sensory light stimulus is received by a cell and converted into a molecular signal.	25	0.0617985860483512	0	0	1	L01D.profile.d50
barbed-end actin filament capping	GO:0051016	The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.	42	0.10382162456123	0	0	1	L01D.profile.d50
actin filament bundle formation	GO:0051017	The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.	28	0.0692144163741534	1	14.4478571428571	0.0669533735976265	L01D.profile.d50
mRNA transport	GO:0051028	The directed movement of mRNA, messenger ribonucleic acid, into, out of, within or between cells.	77	0.190339645028922	0	0	1	L01D.profile.d50
regulation of secretion	GO:0051046	Any process that modulates the frequency, rate or extent of the regulated release of a substance from a cell or group of cells.	72	0.177979927819252	0	0	1	L01D.profile.d50
positive regulation of secretion	GO:0051047	Any process that activates or increases the frequency, rate or extent of the regulated release of a substance from a cell or group of cells.	24	0.0593266426064172	0	0	1	L01D.profile.d50
negative regulation of secretion	GO:0051048	Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a substance from a cell or group of cells.	10	0.0247194344193405	0	0	1	L01D.profile.d50
regulation of transport	GO:0051049	Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	136	0.336184308103031	0	0	1	L01D.profile.d50
positive regulation of transport	GO:0051050	Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	44	0.108765511445098	0	0	1	L01D.profile.d50
negative regulation of transport	GO:0051051	Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	33	0.0815741335838236	0	0	1	L01D.profile.d50
regulation of DNA metabolic process	GO:0051052	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.	80	0.197755475354724	0	0	1	L01D.profile.d50
negative regulation of DNA metabolic process	GO:0051053	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.	28	0.0692144163741534	0	0	1	L01D.profile.d50
positive regulation of DNA metabolic process	GO:0051054	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of small GTPase mediated signal transduction	GO:0051056	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.	260	0.642705294902853	1	1.55592307692308	0.47455038427092	L01D.profile.d50
positive regulation of small GTPase mediated signal transduction	GO:0051057	Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.	8	0.0197755475354724	0	0	1	L01D.profile.d50
negative regulation of small GTPase mediated signal transduction	GO:0051058	Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction.	9	0.0222474909774064	0	0	1	L01D.profile.d50
posttranslational protein folding	GO:0051084	The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.	15	0.0370791516290107	1	26.9693333333333	0.0364443706720598	L01D.profile.d50
chaperone cofactor-dependent protein folding	GO:0051085	The process of assisting in the correct noncovalent assembly of posttranslational proteins and is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	L01D.profile.d50
regulation of transcription factor activity	GO:0051090	Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	63	0.155732436841845	0	0	1	L01D.profile.d50
positive regulation of transcription factor activity	GO:0051091	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	38	0.0939338507934939	0	0	1	L01D.profile.d50
activation of NF-kappaB transcription factor	GO:0051092	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.	34	0.0840460770257577	0	0	1	L01D.profile.d50
negative regulation of developmental process	GO:0051093	Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	110	0.271913778612745	1	3.67763636363636	0.238336491885323	L01D.profile.d50
positive regulation of developmental process	GO:0051094	Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	109	0.269441835170811	0	0	1	L01D.profile.d50
regulation of binding	GO:0051098	Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.	41	0.101349681119296	0	0	1	L01D.profile.d50
positive regulation of binding	GO:0051099	Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.	8	0.0197755475354724	0	0	1	L01D.profile.d50
regulation of DNA binding	GO:0051101	Any process that modulates the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid.	18	0.0444949819548129	0	0	1	L01D.profile.d50
transcriptional preinitiation complex assembly	GO:0051123	The aggregation and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the RNA polymerase II promoter.	11	0.0271913778612745	0	0	1	L01D.profile.d50
regulation of cellular component organization and biogenesis	GO:0051128	Any process that modulates the frequency, rate or extent of the processes involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	119	0.294161269590152	1	3.39949579831933	0.255115007402593	L01D.profile.d50
negative regulation of cell organization and biogenesis	GO:0051129	Any process that stops, prevents or reduces the frequency, rate or extent of the processes involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	77	0.190339645028922	0	0	1	L01D.profile.d50
positive regulation of cell organization and biogenesis	GO:0051130	Any process that activates or increases the frequency, rate or extent of the processes involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	14	0.0346072081870767	0	0	1	L01D.profile.d50
smooth muscle cell differentiation	GO:0051145	The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.	6	0.0148316606516043	0	0	1	L01D.profile.d50
striated muscle cell differentiation	GO:0051146	The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.	26	0.0642705294902853	0	0	1	L01D.profile.d50
nuclear export	GO:0051168	The directed movement of substances out of the nucleus.	67	0.165620210609581	0	0	1	L01D.profile.d50
nuclear transport	GO:0051169	The directed movement of substances into, out of, or within the nucleus.	222	0.548771444109359	3	5.46675675675676	0.0182009191427217	L01D.profile.d50
nuclear import	GO:0051170	The directed movement of substances into the nucleus.	159	0.393039007267514	3	7.63283018867924	0.00745468516277976	L01D.profile.d50
regulation of phosphorus metabolic process	GO:0051174	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.	80	0.197755475354724	0	0	1	L01D.profile.d50
localization	GO:0051179	The processes by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.	3683	9.1041676966431	6	0.659038827043171	0.890784559097304	L01D.profile.d50
vitamin transport	GO:0051180	The directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.	18	0.0444949819548129	0	0	1	L01D.profile.d50
cofactor transport	GO:0051181	The directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein.	16	0.0395510950709448	0	0	1	L01D.profile.d50
cofactor metabolic process	GO:0051186	The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.	247	0.61057003015771	0	0	1	L01D.profile.d50
cofactor catabolic process	GO:0051187	The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein.	47	0.1161813417709	0	0	1	L01D.profile.d50
cofactor biosynthetic process	GO:0051188	The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.	134	0.331240421219163	0	0	1	L01D.profile.d50
protein insertion into membrane	GO:0051205	The process by which a protein is incorporated into a biological membrane.	11	0.0271913778612745	0	0	1	L01D.profile.d50
sequestering of calcium ion	GO:0051208	The process of binding or confining calcium ions such that they are separated from other components of a biological system.	14	0.0346072081870767	0	0	1	L01D.profile.d50
cartilage development	GO:0051216	The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.	49	0.121125228654768	0	0	1	L01D.profile.d50
cytoplasmic sequestering of protein	GO:0051220	The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.	13	0.0321352647451426	0	0	1	L01D.profile.d50
positive regulation of protein transport	GO:0051222	Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells.	14	0.0346072081870767	0	0	1	L01D.profile.d50
regulation of protein transport	GO:0051223	Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells.	40	0.098877737677362	0	0	1	L01D.profile.d50
negative regulation of protein transport	GO:0051224	Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells.	17	0.0420230385128788	0	0	1	L01D.profile.d50
establishment of localization	GO:0051234	The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.	3109	7.68527216097296	3	0.390357027983274	0.982532827668714	L01D.profile.d50
maintenance of localization	GO:0051235	The processes by which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.	56	0.138428832748307	0	0	1	L01D.profile.d50
establishment of RNA localization	GO:0051236	The directed movement of RNA to a specific location.	86	0.212587136006328	0	0	1	L01D.profile.d50
sequestering of metal ion	GO:0051238	The process of binding or confining metal ions such that they are separated from other components of a biological system.	19	0.0469669253967469	0	0	1	L01D.profile.d50
regulation of multicellular organismal process	GO:0051239	Any process that modulates the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.	405	1.00113709398329	2	1.99772839506173	0.264659761472102	L01D.profile.d50
positive regulation of multicellular organismal process	GO:0051240	Any process that activates or increases the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.	135	0.333712364661097	1	2.99659259259259	0.284036080238956	L01D.profile.d50
negative regulation of multicellular organismal process	GO:0051241	Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.	46	0.113709398328966	0	0	1	L01D.profile.d50
regulation of protein metabolic process	GO:0051246	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.	398	0.983833489889751	3	3.04929648241206	0.0771241342097498	L01D.profile.d50
positive regulation of protein metabolic process	GO:0051247	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.	106	0.262026004845009	1	3.81641509433962	0.230758562852774	L01D.profile.d50
negative regulation of protein metabolic process	GO:0051248	Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.	139	0.343600138428833	0	0	1	L01D.profile.d50
regulation of lymphocyte activation	GO:0051249	Any process that modulates the frequency, rate or extent of lymphocyte activation.	114	0.281801552380482	1	3.54859649122807	0.245839769442211	L01D.profile.d50
negative regulation of lymphocyte activation	GO:0051250	Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation.	34	0.0840460770257577	0	0	1	L01D.profile.d50
positive regulation of lymphocyte activation	GO:0051251	Any process that activates or increases the frequency, rate or extent of lymphocyte activation.	78	0.192811588470856	1	5.18641025641026	0.175559489333073	L01D.profile.d50
regulation of RNA metabolic process	GO:0051252	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.	35	0.0865180204676917	1	11.5582857142857	0.0829792059813095	L01D.profile.d50
protein polymerization	GO:0051258	The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.	82	0.202699362238592	1	4.93341463414634	0.183681193884718	L01D.profile.d50
protein oligomerization	GO:0051259	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.	77	0.190339645028922	0	0	1	L01D.profile.d50
protein homooligomerization	GO:0051260	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.	35	0.0865180204676917	0	0	1	L01D.profile.d50
protein depolymerization	GO:0051261	The process by which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.	72	0.177979927819252	0	0	1	L01D.profile.d50
protein tetramerization	GO:0051262	The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.	28	0.0692144163741534	0	0	1	L01D.profile.d50
regulation of cell motility	GO:0051270	Any process that modulates the frequency, rate or extent of the movement of a cell.	104	0.257082117961141	0	0	1	L01D.profile.d50
negative regulation of cell motility	GO:0051271	Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a cell.	37	0.0914619073515598	0	0	1	L01D.profile.d50
positive regulation of cell motility	GO:0051272	Any process that activates or increases the frequency, rate or extent of the movement of a cell.	25	0.0617985860483512	0	0	1	L01D.profile.d50
chromosome organization and biogenesis	GO:0051276	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.	493	1.21866811687349	3	2.46170385395537	0.124373701150191	L01D.profile.d50
protein homotetramerization	GO:0051289	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.	10	0.0247194344193405	0	0	1	L01D.profile.d50
protein heterooligomerization	GO:0051291	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of nonidentical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.	14	0.0346072081870767	0	0	1	L01D.profile.d50
centrosome organization and biogenesis	GO:0051297	A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.	18	0.0444949819548129	0	0	1	L01D.profile.d50
centrosome duplication	GO:0051298	The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.	5	0.0123597172096702	0	0	1	L01D.profile.d50
cell division	GO:0051301	The processes resulting in the physical partitioning and separation of a cell into daughter cells.	297	0.734167202254412	6	8.17252525252525	0.000111968627426722	L01D.profile.d50
establishment of chromosome localization	GO:0051303	The directed movement of a chromosome to a specific location.	8	0.0197755475354724	0	0	1	L01D.profile.d50
G1 phase	GO:0051318	Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.	40	0.098877737677362	0	0	1	L01D.profile.d50
G2 phase	GO:0051319	Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).	16	0.0395510950709448	0	0	1	L01D.profile.d50
S phase	GO:0051320	Progression through S phase, the part of the cell cycle during which DNA synthesis takes place.	18	0.0444949819548129	0	0	1	L01D.profile.d50
meiotic cell cycle	GO:0051321	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell.	98	0.242250457309537	1	4.12795918367347	0.215375772086689	L01D.profile.d50
prophase	GO:0051324	Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.	6	0.0148316606516043	0	0	1	L01D.profile.d50
interphase	GO:0051325	Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.	138	0.341128194986899	0	0	1	L01D.profile.d50
M phase of meiotic cell cycle	GO:0051327	Progression through M phase, the part of the meiotic cell cycle during which meiosis and cytokinesis take place.	97	0.239778513867603	1	4.17051546391753	0.213431419041356	L01D.profile.d50
interphase of mitotic cell cycle	GO:0051329	Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.	134	0.331240421219163	0	0	1	L01D.profile.d50
regulation of hydrolase activity	GO:0051336	Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.	230	0.568546991644831	1	1.75886956521739	0.434050744751412	L01D.profile.d50
regulation of transferase activity	GO:0051338	Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.	306	0.756414693231819	1	1.32202614379085	0.531093149822299	L01D.profile.d50
regulation of lyase activity	GO:0051339	Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.	73	0.180451871261186	0	0	1	L01D.profile.d50
regulation of oxidoreductase activity	GO:0051341	Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.	12	0.0296633213032086	0	0	1	L01D.profile.d50
positive regulation of hydrolase activity	GO:0051345	Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.	102	0.252138231077273	1	3.96607843137255	0.22310523962343	L01D.profile.d50
positive regulation of transferase activity	GO:0051347	Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.	175	0.432590102338459	0	0	1	L01D.profile.d50
negative regulation of transferase activity	GO:0051348	Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.	75	0.185395758145054	0	0	1	L01D.profile.d50
positive regulation of lyase activity	GO:0051349	Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.	48	0.118653285212834	0	0	1	L01D.profile.d50
negative regulation of lyase activity	GO:0051350	Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.	24	0.0593266426064172	0	0	1	L01D.profile.d50
neuron apoptosis	GO:0051402	The process of apoptosis in neurons, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.	42	0.10382162456123	0	0	1	L01D.profile.d50
cellular pH reduction	GO:0051452	Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.	16	0.0395510950709448	0	0	1	L01D.profile.d50
regulation of cellular pH	GO:0051453	Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.	16	0.0395510950709448	0	0	1	L01D.profile.d50
cytosolic calcium ion homeostasis	GO:0051480	The regulation of the levels, transport, and metabolism of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.	89	0.22000296633213	0	0	1	L01D.profile.d50
proteolysis involved in cellular protein catabolic process	GO:0051603	The hydrolysis of a peptide bond or bonds within a protein during the chemical reactions and pathways resulting in the breakdown of a protein.	222	0.548771444109359	1	1.82225225225225	0.422733259034578	L01D.profile.d50
protein maturation	GO:0051604	The process leading to the attainment of the full functional capacity of a protein.	17	0.0420230385128788	0	0	1	L01D.profile.d50
protein maturation via proteolysis	GO:0051605	The hydrolysis of a peptide bond or bonds within a protein during protein maturation, the process leading to the attainment of the full functional capacity of a protein.	16	0.0395510950709448	0	0	1	L01D.profile.d50
detection of stimulus	GO:0051606	The series of events in which a stimulus is received by a cell and converted into a molecular signal.	73	0.180451871261186	0	0	1	L01D.profile.d50
defense response to virus	GO:0051607	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.	17	0.0420230385128788	0	0	1	L01D.profile.d50
organelle localization	GO:0051640	The processes by which an organelle is transported to, and/or maintained in, a specific location.	63	0.155732436841845	0	0	1	L01D.profile.d50
cellular localization	GO:0051641	The processes by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.	1214	3.00093933850794	3	0.999686985172982	0.577297781793009	L01D.profile.d50
vesicle localization	GO:0051648	The processes by which a vesicle or vesicles are transported to, and/or maintained in, a specific location.	32	0.0791021901418896	0	0	1	L01D.profile.d50
establishment of cellular localization	GO:0051649	The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.	1183	2.92430909180798	3	1.02588334742181	0.55990262928	L01D.profile.d50
establishment of vesicle localization	GO:0051650	The directed movement of a vesicle to a specific location.	30	0.0741583032580215	0	0	1	L01D.profile.d50
maintenance of cellular localization	GO:0051651	The processes by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.	36	0.0889899639096258	0	0	1	L01D.profile.d50
establishment of organelle localization	GO:0051656	The directed movement of an organelle to a specific location.	55	0.135956889306373	0	0	1	L01D.profile.d50
localization within membrane	GO:0051668	The processes by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.	15	0.0370791516290107	0	0	1	L01D.profile.d50
localization of cell	GO:0051674	The processes by which a cell is transported to, and/or maintained in, a specific location.	622	1.53754882088298	3	1.9511575562701	0.200490368518214	L01D.profile.d50
actin filament capping	GO:0051693	The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.	42	0.10382162456123	0	0	1	L01D.profile.d50
interaction with host	GO:0051701	An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.	30	0.0741583032580215	0	0	1	L01D.profile.d50
multi-organism process	GO:0051704	The processes by which an organism has an effect on another organism of the same or different species.	368	0.90967518663173	0	0	1	L01D.profile.d50
behavioral interaction between organisms	GO:0051705	The processes by which an organism has an observable behavioral effect on another organism of the same or different species.	15	0.0370791516290107	0	0	1	L01D.profile.d50
response to other organism	GO:0051707	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.	189	0.467197310525535	0	0	1	L01D.profile.d50
cellular response to stimulus	GO:0051716	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.	15	0.0370791516290107	0	0	1	L01D.profile.d50
regulation of cell cycle	GO:0051726	A cell cycle process that modulates the rate, extent or mode of the cell cycle.	880	2.17531022890196	8	3.67763636363636	0.00181492188027591	L01D.profile.d50
response to protein stimulus	GO:0051789	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.	83	0.205171305680526	1	4.87397590361446	0.185699087804022	L01D.profile.d50
entry into cell of other organism during symbiotic interaction	GO:0051806	The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
entry into other organism during symbiotic interaction	GO:0051828	Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
regulation of mitochondrial membrane potential	GO:0051881	Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.	12	0.0296633213032086	0	0	1	L01D.profile.d50
sulfation	GO:0051923	The addition of a sulfate group to a molecule.	9	0.0222474909774064	0	0	1	L01D.profile.d50
regulation of calcium ion transport	GO:0051924	Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells.	12	0.0296633213032086	0	0	1	L01D.profile.d50
regulation of transmission of nerve impulse	GO:0051969	Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.	42	0.10382162456123	0	0	1	L01D.profile.d50
movement in host environment	GO:0052126	The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
movement in environment of other organism during symbiotic interaction	GO:0052192	The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction.	18	0.0444949819548129	0	0	1	L01D.profile.d50
muscle cell development	GO:0055001	The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.	21	0.051910812280615	0	0	1	L01D.profile.d50
striated muscle cell development	GO:0055002	The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.	21	0.051910812280615	0	0	1	L01D.profile.d50
heart contraction	GO:0060047	The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.	76	0.187867701586988	0	0	1	L01D.profile.d50
inner ear receptor cell differenation	GO:0060113	The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.	20	0.049438868838681	0	0	1	L01D.profile.d50
intracellular protein transport across a membrane	GO:0065002	The directed movement of proteins in a cell, from one side of a membrane to another.	40	0.098877737677362	1	10.1135	0.094257427418219	L01D.profile.d50
macromolecular complex assembly	GO:0065003	The aggregation and bonding together of a set of macromolecules to form a complex.	740	1.8292381470312	1	0.546675675675676	0.839827315308396	L01D.profile.d50
protein-DNA complex assembly	GO:0065004	The aggregation and bonding together of proteins and DNA molecules to form a protein-DNA complex.	161	0.397982894151382	0	0	1	L01D.profile.d50
biological regulation	GO:0065007	Any process that modulates the frequency, rate or extent of any biological process, quality or function.	6089	15.0516636179364	25	1.66094596813927	0.0115057181754759	L01D.profile.d50
regulation of biological quality	GO:0065008	Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.	832	2.05665694368913	2	0.972451923076923	0.609456267637904	L01D.profile.d50
regulation of a molecular function	GO:0065009	Any process that modulates the frequency, rate or extent of molecular functions. Molecular functions are elemental biological activities occurring at the molecular level, such as catalysis or binding.	636	1.57215602907005	3	1.90820754716981	0.209335492249982	L01D.profile.d50