L2L Microarray Analysis Tool
Results for L01D.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in L01D.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 4 | 67.42 | 2.86e-07 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.28 | 5 | 18.06 | 9.15e-06 |
| et743_sarcoma_72hrs_up | Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines | 106 | 0.52 | 6 | 11.45 | 1.63e-05 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 7 | 8.85 | 1.74e-05 |
| hypoxia_fibro_up | Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) | 34 | 0.17 | 4 | 23.80 | 2.46e-05 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.19 | 4 | 21.29 | 3.86e-05 |
| bleo_human_lymph_high_4hrs_dn | Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 3 | 37.93 | 6.45e-05 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 2.68 | 11 | 4.11 | 1.06e-04 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 5 | 10.65 | 1.18e-04 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 1.08 | 7 | 6.47 | 1.26e-04 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 3 | 28.90 | 1.50e-04 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 5 | 9.28 | 2.25e-04 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 11 | 3.75 | 2.29e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 11 | 3.75 | 2.29e-04 |
| et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.55 | 5 | 9.11 | 2.45e-04 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.55 | 5 | 9.03 | 2.55e-04 |
| hif1_targets | Hif-1 (hypoxia-inducible factor 1) transcripional targets | 67 | 0.33 | 4 | 12.08 | 3.57e-04 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| hdaci_colon_cur24hrs_up | Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells | 73 | 0.36 | 4 | 11.08 | 4.95e-04 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 5 | 7.49 | 6.01e-04 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 1.02 | 6 | 5.86 | 6.37e-04 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 384 | 1.90 | 8 | 4.21 | 7.56e-04 |
| ad12_12hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.19 | 3 | 15.97 | 8.96e-04 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 4 | 9.30 | 9.59e-04 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.44 | 4 | 9.09 | 1.04e-03 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 6 | 5.21 | 1.17e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 16 | 2.45 | 1.18e-03 |
| vegf_hmmec_3hrs_up | Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 99 | 0.49 | 4 | 8.17 | 1.55e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.23 | 3 | 12.91 | 1.67e-03 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 7 | 4.15 | 1.73e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.86 | 5 | 5.81 | 1.86e-03 |
| hdaci_colon_cur2hrs_up | Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.53 | 4 | 7.49 | 2.13e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 1.30 | 6 | 4.61 | 2.16e-03 |
| uvc_high_d4_dn | Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d4) | 110 | 0.54 | 4 | 7.36 | 2.27e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| 5azac-tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 1966 | 9.72 | 20 | 2.06 | 2.47e-03 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| h2o2_csbrescued_c2_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 2) | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| tnfalpha_all_up | Upregulated at any timepoint after TNF-alpha treatment of HeLa cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| oxstress_rpethree_dn | Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 9 | 3.00 | 3.67e-03 |
| tnfalpha_4hrs_up | Upregulated 4hrs after TNF-alpha treatment of HeLa cells | 62 | 0.31 | 3 | 9.79 | 3.68e-03 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.63 | 4 | 6.37 | 3.81e-03 |
| 5azac_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1630 | 8.06 | 17 | 2.11 | 3.90e-03 |
| platelet_expressed | Fifty genes most strongly expressed in human platlets from three healthy donors | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| tsa_hepatoma_up | Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| alzheimers_incipient_dn | Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 312 | 1.54 | 6 | 3.89 | 4.95e-03 |
| methotrexate_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 22 | 0.11 | 2 | 18.39 | 5.29e-03 |
| uvc_xpcs_4hr_up | Up-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| vegf_hmmec_all_up | Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells | 147 | 0.73 | 4 | 5.50 | 6.37e-03 |
| idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.74 | 4 | 5.43 | 6.68e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| hippocampus_development_postnatal | Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| cancerdrugs_probcell_dn | Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 1.24 | 5 | 4.05 | 8.53e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.44 | 3 | 6.90 | 9.70e-03 |