L2L Microarray Analysis Tool
Results for L01X.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in L01X.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 17 | 5.80 | 1.33e-08 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 17 | 5.80 | 1.33e-08 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 5 | 29.75 | 7.29e-07 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 5 | 12.97 | 4.62e-05 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 18 | 2.76 | 1.53e-04 |
| uvc_xpcs_all_dn | Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 1048 | 5.18 | 15 | 2.90 | 3.13e-04 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 8 | 4.66 | 3.91e-04 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 8 | 4.66 | 3.91e-04 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 12 | 3.23 | 4.64e-04 |
| hsc_lateprogenitors_shared | Up-regulated in mouse hematopoietic late progenitors from both adult bone marrow and fetal liver (Cluster vi, Late Progenitors Shared) | 549 | 2.71 | 10 | 3.68 | 4.99e-04 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 4 | 10.93 | 5.22e-04 |
| hsc_lateprogenitors_adult | Up-regulated in mouse hematopoietic late progenitors from adult bone marrow (Late Progenitors Shared + Adult) | 558 | 2.76 | 10 | 3.62 | 5.66e-04 |
| hsc_lateprogenitors_fetal | Up-regulated in mouse hematopoietic late progenitors from fetal liver (Late Progenitors Shared + Fetal) | 558 | 2.76 | 10 | 3.62 | 5.66e-04 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 7 | 4.60 | 9.68e-04 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.44 | 4 | 9.09 | 1.04e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 7 | 4.44 | 1.18e-03 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| uvc_ttd_4hr_dn | Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 641 | 3.17 | 10 | 3.16 | 1.59e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| p21_any_dn | Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 50 | 0.25 | 3 | 12.14 | 1.99e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 5 | 5.71 | 2.00e-03 |
| uvc_ttd_all_dn | Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 780 | 3.86 | 11 | 2.85 | 2.09e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 1.30 | 6 | 4.61 | 2.16e-03 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 1.32 | 6 | 4.53 | 2.37e-03 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| hsc_lthsc_fetal | Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) | 272 | 1.34 | 6 | 4.46 | 2.55e-03 |
| hsc_lthsc_shared | Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) | 272 | 1.34 | 6 | 4.46 | 2.55e-03 |
| pubertal_mammary_4-5wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. | 368 | 1.82 | 7 | 3.85 | 2.64e-03 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| p21_early_dn | Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 120 | 0.59 | 4 | 6.74 | 3.11e-03 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 2.41 | 8 | 3.32 | 3.35e-03 |
| hsc_lthsc_adult | Up-regulated in mouse long-term functional hematopoietic stem cells from adult bone marrow (LT-HSC Shared + Adult) | 385 | 1.90 | 7 | 3.68 | 3.38e-03 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| bay_pbmc_4hr_dn | Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 400 | 1.98 | 7 | 3.54 | 4.16e-03 |
| nf90_dn | Downregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| uvc_low_c1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c1) | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 6.23 | 14 | 2.25 | 4.88e-03 |
| pod1_ko_dn | Down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 1135 | 5.61 | 13 | 2.32 | 5.11e-03 |
| hdaci_colon_cur12hrs_up | Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells | 22 | 0.11 | 2 | 18.39 | 5.29e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 6 | 3.82 | 5.42e-03 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| uvc_xpcs_8hr_dn | Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 911 | 4.50 | 11 | 2.44 | 6.57e-03 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| cmv_hcmv_timecourse_4hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| tpa_sens_early_dn | Downregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells | 564 | 2.79 | 8 | 2.87 | 7.78e-03 |
| uvc_ttd-xpcs_common_dn | Down-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC | 344 | 1.70 | 6 | 3.53 | 7.84e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 4 | 5.06 | 8.54e-03 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 3 | 7.06 | 9.11e-03 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 4.10 | 10 | 2.44 | 9.34e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |