L2L Microarray Analysis Tool
Results for N06A.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in N06A.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 21 | 3.63 | 8.04e-07 |
| stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 22 | 3.17 | 3.76e-06 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 18 | 3.66 | 4.15e-06 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 7 | 8.30 | 2.75e-05 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 15 | 3.32 | 7.58e-05 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
| hdaci_three_dn | Downregulated in several cell lines by all of TSA, SAHA, and MS-275 | 10 | 0.02 | 2 | 80.91 | 2.71e-04 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 4 | 11.90 | 3.93e-04 |
| preadip_vs_fibro_dn | Downregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 4 | 9.46 | 9.25e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 5 | 6.76 | 9.75e-04 |
| hdaci_colon_cluster4 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 4) | 19 | 0.05 | 2 | 42.58 | 1.02e-03 |
| uvc_high_d2_dn | Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) | 82 | 0.20 | 3 | 14.80 | 1.16e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 7 | 4.47 | 1.16e-03 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 0.85 | 5 | 5.88 | 1.80e-03 |
| hsc_earlyprogenitors_fetal | Up-regulated in mouse hematopoietic early progenitors from fetal liver (Early Progenitors Shared) | 520 | 1.29 | 6 | 4.67 | 2.07e-03 |
| hsc_earlyprogenitors_shared | Up-regulated in mouse hematopoietic early progenitors from both adult bone marrow and fetal liver (Cluster iv, Early Progenitors Shared) | 520 | 1.29 | 6 | 4.67 | 2.07e-03 |
| hsc_earlyprogenitors_adult | Up-regulated in mouse hematopoietic early progenitors from adult bone marrow (Early Progenitors Shared + Adult) | 526 | 1.30 | 6 | 4.61 | 2.19e-03 |
| brca1_irradiated_up | Up-regulated in germline-mutant BRCA1 tumor cells compared to non-BRCA1 control tumors, following 15 Gy irradiation. | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 1.37 | 6 | 4.38 | 2.83e-03 |
| hdaci_colon_but_dn | Downregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 387 | 0.96 | 5 | 5.23 | 2.99e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 0.61 | 4 | 6.55 | 3.51e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| hdaci_colon_but16hrs_dn | Downregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
| h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |