L2L Microarray Analysis Tool
Results for R03A.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in R03A.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 15 | 5.01 | 5.89e-07 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 13 | 5.16 | 2.36e-06 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.12 | 4 | 32.36 | 6.95e-06 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 12 | 4.46 | 2.37e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 10 | 4.93 | 4.84e-05 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 7 | 6.16 | 1.70e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 12 | 3.60 | 1.79e-04 |
| dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.18 | 3 | 16.40 | 8.28e-04 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 9 | 3.56 | 1.18e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 5 | 6.32 | 1.29e-03 |
| il2_pbmc_6hr_dn | Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 9 | 3.43 | 1.51e-03 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 2.63 | 9 | 3.43 | 1.53e-03 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 10 | 3.13 | 1.68e-03 |
| igfr_vs_ir_up | Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 7 | 4.08 | 1.91e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 7 | 4.08 | 1.91e-03 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| calres_rhesus_dn | Downregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls | 110 | 0.54 | 4 | 7.36 | 2.27e-03 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 1.32 | 6 | 4.53 | 2.37e-03 |
| space_up | Upregulated in space-flown fibroblasts | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 8 | 3.41 | 2.85e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 15 | 2.30 | 3.01e-03 |
| h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.29 | 3 | 10.46 | 3.04e-03 |
| bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 2.39 | 8 | 3.35 | 3.15e-03 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 9 | 3.07 | 3.19e-03 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 9 | 3.07 | 3.19e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 5 | 5.01 | 3.53e-03 |
| hdaci_colon_cluster8 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 8) | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 1.44 | 6 | 4.16 | 3.60e-03 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 2.49 | 8 | 3.22 | 4.01e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| alzheimers_incipient_up | Upregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 754 | 3.73 | 10 | 2.68 | 4.98e-03 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 3 | 8.67 | 5.17e-03 |
| tnfalpha_adip_up | Upregulated in mature, differentiated adipocytes following treatment with TNFalpha | 22 | 0.11 | 2 | 18.39 | 5.29e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 6 | 3.82 | 5.42e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 8 | 3.05 | 5.45e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 5 | 4.47 | 5.64e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| tnfalpha_tgz_adip_up | Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| scchn_hpvneg_up | Up-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |