#list name	reference	description	total probes	expected	actual	enrichment	bin prob	analysis_name
mannosyltransferase activity	GO:0000030	Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.	9	0.0222474909774064	0	0	1	R03B.profile.u50
tRNA binding	GO:0000049	Interacting selectively with transfer RNA.	20	0.049438868838681	0	0	1	R03B.profile.u50
acyl-CoA binding	GO:0000062	Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.	13	0.0321352647451426	0	0	1	R03B.profile.u50
microfilament motor activity	GO:0000146	Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).	23	0.0568546991644831	0	0	1	R03B.profile.u50
SNARE binding	GO:0000149	Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.	20	0.049438868838681	0	0	1	R03B.profile.u50
two-component sensor activity	GO:0000155	Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell.	6	0.0148316606516043	0	0	1	R03B.profile.u50
nucleotide binding	GO:0000166	Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety.	2671	6.60256093340584	4	0.605825533508049	0.895305778059213	R03B.profile.u50
3'-5'-exoribonuclease activity	GO:0000175	Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.	14	0.0346072081870767	0	0	1	R03B.profile.u50
magnesium ion binding	GO:0000287	Interacting selectively with magnesium (Mg) ions.	436	1.07776734068325	0	0	1	R03B.profile.u50
RNA cap binding	GO:0000339	Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule.	16	0.0395510950709448	0	0	1	R03B.profile.u50
beta-amyloid binding	GO:0001540	Interacting selectively with beta-amyloid peptide/protein and/or its precursor.	19	0.0469669253967469	0	0	1	R03B.profile.u50
phorbol ester receptor activity	GO:0001565	Combining with a phorbol ester to initiate a change in cell activity.	19	0.0469669253967469	1	21.2915789473684	0.0459365220634866	R03B.profile.u50
rhodopsin-like receptor activity	GO:0001584	A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor.	405	1.00113709398329	1	0.998864197530864	0.632993791456762	R03B.profile.u50
angiotensin receptor activity	GO:0001595	Combining with angiotensin to initiate a change in cell activity.	11	0.0271913778612745	0	0	1	R03B.profile.u50
nucleotide receptor activity, G-protein coupled	GO:0001608	A GPCR that binds a nucleotide or nucleotide derivative as its ligand.	22	0.0543827557225491	0	0	1	R03B.profile.u50
purinergic nucleotide receptor activity	GO:0001614		22	0.0543827557225491	0	0	1	R03B.profile.u50
lysosphingolipid and lysophosphatidic acid receptor activity	GO:0001619	Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.	12	0.0296633213032086	0	0	1	R03B.profile.u50
secretin-like receptor activity	GO:0001633	A G-protein coupled receptor that is structurally/functionally related to the secretin receptor.	37	0.0914619073515598	0	0	1	R03B.profile.u50
G-protein chemoattractant receptor activity	GO:0001637		33	0.0815741335838236	0	0	1	R03B.profile.u50
peptide receptor activity	GO:0001653	Combining with an extracellular or intracellular peptide to initiate a change in cell activity.	142	0.351015968754635	1	2.84887323943662	0.296333341111219	R03B.profile.u50
G-protein-coupled receptor binding	GO:0001664	Interacting selectively with a G-protein-coupled receptor.	78	0.192811588470856	0	0	1	R03B.profile.u50
lipid kinase activity	GO:0001727	Catalysis of the phosphorylation of a simple or complex lipid.	29	0.0716863598160874	0	0	1	R03B.profile.u50
phosphatidylserine binding	GO:0001786	Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.	8	0.0197755475354724	0	0	1	R03B.profile.u50
pattern binding	GO:0001871	Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.	186	0.459781480199733	2	4.34989247311828	0.0780679337003647	R03B.profile.u50
glycoprotein binding	GO:0001948	Interacting selectively with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.	10	0.0247194344193405	0	0	1	R03B.profile.u50
nucleic acid binding	GO:0003676	Interacting selectively with any nucleic acid.	3764	9.30439511543976	11	1.18223698193411	0.330549791546704	R03B.profile.u50
DNA binding	GO:0003677	Interacting selectively with DNA (deoxyribonucleic acid).	2546	6.29356800316409	10	1.58892380204242	0.105348124367069	R03B.profile.u50
DNA helicase activity	GO:0003678	Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix.	55	0.135956889306373	0	0	1	R03B.profile.u50
chromatin binding	GO:0003682	Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase.	162	0.400454837593316	0	0	1	R03B.profile.u50
damaged DNA binding	GO:0003684	Interacting selectively with damaged DNA.	56	0.138428832748307	0	0	1	R03B.profile.u50
double-stranded DNA binding	GO:0003690	Interacting selectively with double-stranded DNA.	88	0.217531022890196	0	0	1	R03B.profile.u50
single-stranded DNA binding	GO:0003697	Interacting selectively with single-stranded DNA.	72	0.177979927819252	0	0	1	R03B.profile.u50
transcription factor activity	GO:0003700	The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.	1230	3.04049043357888	9	2.9600487804878	0.00408931278010157	R03B.profile.u50
RNA polymerase II transcription factor activity	GO:0003702	Functions to initiate or regulate RNA polymerase II transcription.	356	0.880011865328521	0	0	1	R03B.profile.u50
specific RNA polymerase II transcription factor activity	GO:0003704	Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.	63	0.155732436841845	0	0	1	R03B.profile.u50
RNA polymerase II transcription factor activity, enhancer binding	GO:0003705	Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA.	40	0.098877737677362	0	0	1	R03B.profile.u50
ligand-regulated transcription factor activity	GO:0003706		21	0.051910812280615	0	0	1	R03B.profile.u50
steroid hormone receptor activity	GO:0003707	Combining with a steroid hormone to initiate a change in cell activity.	118	0.291689326148218	0	0	1	R03B.profile.u50
retinoic acid receptor activity	GO:0003708	Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A.	18	0.0444949819548129	0	0	1	R03B.profile.u50
RNA polymerase III transcription factor activity	GO:0003709	Functions to initiate or regulate RNA polymerase III transcription.	18	0.0444949819548129	0	0	1	R03B.profile.u50
transcriptional elongation regulator activity	GO:0003711	Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.	23	0.0568546991644831	0	0	1	R03B.profile.u50
transcription cofactor activity	GO:0003712	The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.	482	1.19147673901221	2	1.67858921161826	0.334375638199422	R03B.profile.u50
transcription coactivator activity	GO:0003713	The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself.	295	0.729223315370544	2	2.74264406779661	0.16590608545351	R03B.profile.u50
transcription corepressor activity	GO:0003714	The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.	169	0.417758441686854	0	0	1	R03B.profile.u50
RNA binding	GO:0003723	Interacting selectively with an RNA molecule or a portion thereof.	982	2.42744845997924	0	0	1	R03B.profile.u50
RNA helicase activity	GO:0003724	Catalysis of the unwinding of an RNA helix.	50	0.123597172096702	0	0	1	R03B.profile.u50
double-stranded RNA binding	GO:0003725	Interacting selectively with double-stranded RNA.	58	0.143372719632175	0	0	1	R03B.profile.u50
single-stranded RNA binding	GO:0003727	Interacting selectively with single-stranded RNA.	24	0.0593266426064172	0	0	1	R03B.profile.u50
mRNA binding	GO:0003729	Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA).	74	0.18292381470312	0	0	1	R03B.profile.u50
mRNA 3'-UTR binding	GO:0003730	Interacting selectively with the 3' untranslated region of an mRNA molecule.	16	0.0395510950709448	0	0	1	R03B.profile.u50
structural constituent of ribosome	GO:0003735	The action of a molecule that contributes to the structural integrity of the ribosome.	219	0.541355613783557	0	0	1	R03B.profile.u50
translation initiation factor activity	GO:0003743	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.	75	0.185395758145054	0	0	1	R03B.profile.u50
translation elongation factor activity	GO:0003746	Functions in chain elongation during polypeptide synthesis at the ribosome.	19	0.0469669253967469	0	0	1	R03B.profile.u50
translation release factor activity	GO:0003747	Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.	9	0.0222474909774064	0	0	1	R03B.profile.u50
peptidyl-prolyl cis-trans isomerase activity	GO:0003755	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).	57	0.140900776190241	1	7.09719298245614	0.131576007610459	R03B.profile.u50
protein disulfide isomerase activity	GO:0003756	Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.	17	0.0420230385128788	0	0	1	R03B.profile.u50
motor activity	GO:0003774	Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.	168	0.41528649824492	0	0	1	R03B.profile.u50
microtubule motor activity	GO:0003777	Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).	76	0.187867701586988	0	0	1	R03B.profile.u50
actin binding	GO:0003779	Interacting selectively with monomeric or multimeric forms of actin, including actin filaments.	398	0.983833489889751	1	1.01643216080402	0.626580000166261	R03B.profile.u50
lysozyme activity	GO:0003796	Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins.	3	0.00741583032580215	0	0	1	R03B.profile.u50
protein-glutamine gamma-glutamyltransferase activity	GO:0003810	Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.	11	0.0271913778612745	0	0	1	R03B.profile.u50
antigen binding	GO:0003823	Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.	91	0.224946853215998	0	0	1	R03B.profile.u50
catalytic activity	GO:0003824	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.	6002	14.8366045384882	9	0.606607797400866	0.959429859223123	R03B.profile.u50
gamma-glutamyltransferase activity	GO:0003840	Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.	7	0.0173036040935383	0	0	1	R03B.profile.u50
1-acylglycerol-3-phosphate O-acyltransferase activity	GO:0003841	Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.	10	0.0247194344193405	0	0	1	R03B.profile.u50
3-beta-hydroxy-delta5-steroid dehydrogenase activity	GO:0003854	Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+.	4	0.00988777376773619	0	0	1	R03B.profile.u50
3-hydroxyacyl-CoA dehydrogenase activity	GO:0003857	Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.	10	0.0247194344193405	0	0	1	R03B.profile.u50
DNA-directed DNA polymerase activity	GO:0003887	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template or primer.	27	0.0667424729322193	0	0	1	R03B.profile.u50
DNA-directed RNA polymerase activity	GO:0003899	Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.	45	0.111237454887032	0	0	1	R03B.profile.u50
DNA-(apurinic or apyrimidinic site) lyase activity	GO:0003906	Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.	7	0.0173036040935383	0	0	1	R03B.profile.u50
DNA topoisomerase activity	GO:0003916	Catalysis of a topological transformation in double-stranded DNA by a covalent or non-covalent mechanism.	12	0.0296633213032086	0	0	1	R03B.profile.u50
GTPase activity	GO:0003924	Catalysis of the reaction: GTP + H2O = GDP + phosphate.	299	0.739111089138281	0	0	1	R03B.profile.u50
NAD+ ADP-ribosyltransferase activity	GO:0003950	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.	27	0.0667424729322193	1	14.982962962963	0.0646412195945478	R03B.profile.u50
NADH dehydrogenase activity	GO:0003954	Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.	39	0.0964057942354279	0	0	1	R03B.profile.u50
RNA-directed DNA polymerase activity	GO:0003964	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.	7	0.0173036040935383	0	0	1	R03B.profile.u50
acid phosphatase activity	GO:0003993	Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.	12	0.0296633213032086	0	0	1	R03B.profile.u50
aconitate hydratase activity	GO:0003994	Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.	3	0.00741583032580215	0	0	1	R03B.profile.u50
acyl-CoA dehydrogenase activity	GO:0003995	Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.	26	0.0642705294902853	0	0	1	R03B.profile.u50
adenosine deaminase activity	GO:0004000	Catalysis of the reaction: adenosine + H2O = inosine + NH3.	9	0.0222474909774064	0	0	1	R03B.profile.u50
ATP-dependent DNA helicase activity	GO:0004003	Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix.	34	0.0840460770257577	0	0	1	R03B.profile.u50
ATP-dependent RNA helicase activity	GO:0004004	Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix.	35	0.0865180204676917	0	0	1	R03B.profile.u50
phospholipid-translocating ATPase activity	GO:0004012	Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.	21	0.051910812280615	0	0	1	R03B.profile.u50
adenylate cyclase activity	GO:0004016	Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.	18	0.0444949819548129	0	0	1	R03B.profile.u50
adenylate kinase activity	GO:0004017	Catalysis of the reaction: ATP + AMP = 2 ADP.	12	0.0296633213032086	0	0	1	R03B.profile.u50
alcohol dehydrogenase activity	GO:0004022	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.	10	0.0247194344193405	0	0	1	R03B.profile.u50
3-chloroallyl aldehyde dehydrogenase activity	GO:0004028	Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.	12	0.0296633213032086	0	0	1	R03B.profile.u50
aldehyde dehydrogenase (NAD) activity	GO:0004029	Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.	14	0.0346072081870767	0	0	1	R03B.profile.u50
aldehyde dehydrogenase [NAD(P)+] activity	GO:0004030	Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.	10	0.0247194344193405	0	0	1	R03B.profile.u50
aldo-keto reductase activity	GO:0004033	Catalysis of the NADPH-dependent reduction of carbonyl compounds.	12	0.0296633213032086	0	0	1	R03B.profile.u50
amidase activity	GO:0004040	Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.	4	0.00988777376773619	0	0	1	R03B.profile.u50
aminomethyltransferase activity	GO:0004047	Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.	7	0.0173036040935383	0	0	1	R03B.profile.u50
arylsulfatase activity	GO:0004065	Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate).	10	0.0247194344193405	0	0	1	R03B.profile.u50
carbonate dehydratase activity	GO:0004089	Catalysis of the reaction: H2CO3 = CO2 + H2O.	24	0.0593266426064172	0	0	1	R03B.profile.u50
carboxylesterase activity	GO:0004091	Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion.	118	0.291689326148218	0	0	1	R03B.profile.u50
cyclic-nucleotide phosphodiesterase activity	GO:0004112	Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.	41	0.101349681119296	0	0	1	R03B.profile.u50
3',5'-cyclic-nucleotide phosphodiesterase activity	GO:0004114	Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.	40	0.098877737677362	0	0	1	R03B.profile.u50
3',5'-cyclic-AMP phosphodiesterase activity	GO:0004115	Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.	17	0.0420230385128788	0	0	1	R03B.profile.u50
cytochrome-b5 reductase activity	GO:0004128	Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).	12	0.0296633213032086	0	0	1	R03B.profile.u50
cytochrome-c oxidase activity	GO:0004129	Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.	36	0.0889899639096258	0	0	1	R03B.profile.u50
diacylglycerol kinase activity	GO:0004143	Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.	15	0.0370791516290107	0	0	1	R03B.profile.u50
endopeptidase activity	GO:0004175	Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.	432	1.06787956691551	0	0	1	R03B.profile.u50
ATP-dependent peptidase activity	GO:0004176		3	0.00741583032580215	0	0	1	R03B.profile.u50
aminopeptidase activity	GO:0004177	Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides.	47	0.1161813417709	0	0	1	R03B.profile.u50
membrane alanyl aminopeptidase activity	GO:0004179	Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.	13	0.0321352647451426	0	0	1	R03B.profile.u50
carboxypeptidase activity	GO:0004180	Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.	40	0.098877737677362	0	0	1	R03B.profile.u50
metallocarboxypeptidase activity	GO:0004181	Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.	31	0.0766302466999555	0	0	1	R03B.profile.u50
carboxypeptidase A activity	GO:0004182	Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	22	0.0543827557225491	0	0	1	R03B.profile.u50
aspartic-type endopeptidase activity	GO:0004190	Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.	9	0.0222474909774064	0	0	1	R03B.profile.u50
pepsin A activity	GO:0004194	Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.	6	0.0148316606516043	0	0	1	R03B.profile.u50
cysteine-type endopeptidase activity	GO:0004197	Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.	105	0.259554061403075	0	0	1	R03B.profile.u50
calpain activity	GO:0004198	Catalysis of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.	20	0.049438868838681	0	0	1	R03B.profile.u50
ubiquitin thiolesterase activity	GO:0004221	Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.	74	0.18292381470312	0	0	1	R03B.profile.u50
metalloendopeptidase activity	GO:0004222	Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.	125	0.308992930241756	0	0	1	R03B.profile.u50
neprilysin activity	GO:0004245	Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.	8	0.0197755475354724	0	0	1	R03B.profile.u50
serine-type endopeptidase activity	GO:0004252	Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).	165	0.407870667919118	0	0	1	R03B.profile.u50
dipeptidyl-peptidase IV activity	GO:0004274	Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.	7	0.0173036040935383	0	0	1	R03B.profile.u50
subtilase activity	GO:0004289		16	0.0395510950709448	0	0	1	R03B.profile.u50
threonine endopeptidase activity	GO:0004298	Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.	26	0.0642705294902853	0	0	1	R03B.profile.u50
enoyl-CoA hydratase activity	GO:0004300	Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.	8	0.0197755475354724	0	0	1	R03B.profile.u50
estradiol 17-beta-dehydrogenase activity	GO:0004303	Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.	8	0.0197755475354724	0	0	1	R03B.profile.u50
exo-alpha-sialidase activity	GO:0004308	Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.	5	0.0123597172096702	0	0	1	R03B.profile.u50
fructose-2,6-bisphosphate 2-phosphatase activity	GO:0004331	Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.	7	0.0173036040935383	0	0	1	R03B.profile.u50
glucan 1,4-alpha-glucosidase activity	GO:0004339	Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.	3	0.00741583032580215	0	0	1	R03B.profile.u50
glutathione transferase activity	GO:0004364	Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.	19	0.0469669253967469	0	0	1	R03B.profile.u50
glycine hydroxymethyltransferase activity	GO:0004372	Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.	14	0.0346072081870767	0	0	1	R03B.profile.u50
guanylate cyclase activity	GO:0004383	Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	R03B.profile.u50
guanylate kinase activity	GO:0004385	Catalysis of the reaction: ATP + GMP = ADP + GDP.	19	0.0469669253967469	0	0	1	R03B.profile.u50
helicase activity	GO:0004386	Catalysis of the unwinding of a DNA or RNA duplex.	206	0.509220349038414	1	1.96378640776699	0.399414802614256	R03B.profile.u50
histone acetyltransferase activity	GO:0004402	Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.	42	0.10382162456123	0	0	1	R03B.profile.u50
histone deacetylase activity	GO:0004407	Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.	14	0.0346072081870767	0	0	1	R03B.profile.u50
hyalurononglucosaminidase activity	GO:0004415	Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.	10	0.0247194344193405	0	0	1	R03B.profile.u50
inositol or phosphatidylinositol kinase activity	GO:0004428	Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.	34	0.0840460770257577	0	0	1	R03B.profile.u50
inositol or phosphatidylinositol phosphodiesterase activity	GO:0004434		34	0.0840460770257577	0	0	1	R03B.profile.u50
phosphoinositide phospholipase C activity	GO:0004435	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.	34	0.0840460770257577	0	0	1	R03B.profile.u50
inositol or phosphatidylinositol phosphatase activity	GO:0004437	Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.	58	0.143372719632175	0	0	1	R03B.profile.u50
inositol-polyphosphate 5-phosphatase activity	GO:0004445	Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.	9	0.0222474909774064	0	0	1	R03B.profile.u50
lactate dehydrogenase activity	GO:0004457	Catalysis of the oxidation of lactate to produce pyruvate.	9	0.0222474909774064	0	0	1	R03B.profile.u50
L-lactate dehydrogenase activity	GO:0004459	Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.	9	0.0222474909774064	0	0	1	R03B.profile.u50
long-chain-fatty-acid-CoA ligase activity	GO:0004467	Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.	16	0.0395510950709448	0	0	1	R03B.profile.u50
lysine N-acetyltransferase activity	GO:0004468	Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.	42	0.10382162456123	0	0	1	R03B.profile.u50
monooxygenase activity	GO:0004497	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.	133	0.328768477777228	0	0	1	R03B.profile.u50
dimethylaniline monooxygenase (N-oxide-forming) activity	GO:0004499	Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.	8	0.0197755475354724	0	0	1	R03B.profile.u50
nuclease activity	GO:0004518	Catalysis of the hydrolysis of ester linkages within nucleic acids.	161	0.397982894151382	0	0	1	R03B.profile.u50
endonuclease activity	GO:0004519	Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.	99	0.244722400751471	0	0	1	R03B.profile.u50
endodeoxyribonuclease activity	GO:0004520	Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.	22	0.0543827557225491	0	0	1	R03B.profile.u50
endoribonuclease activity	GO:0004521	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.	48	0.118653285212834	0	0	1	R03B.profile.u50
pancreatic ribonuclease activity	GO:0004522	Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.	12	0.0296633213032086	0	0	1	R03B.profile.u50
ribonuclease H activity	GO:0004523	Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.	8	0.0197755475354724	0	0	1	R03B.profile.u50
ribonuclease P activity	GO:0004526	Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.	10	0.0247194344193405	0	0	1	R03B.profile.u50
exonuclease activity	GO:0004527	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.	61	0.150788549957977	0	0	1	R03B.profile.u50
exodeoxyribonuclease activity	GO:0004529	Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.	12	0.0296633213032086	0	0	1	R03B.profile.u50
exoribonuclease activity	GO:0004532	Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.	15	0.0370791516290107	0	0	1	R03B.profile.u50
deoxyribonuclease activity	GO:0004536	Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.	39	0.0964057942354279	0	0	1	R03B.profile.u50
ribonuclease activity	GO:0004540	Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.	67	0.165620210609581	0	0	1	R03B.profile.u50
tRNA-specific ribonuclease activity	GO:0004549	Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.	13	0.0321352647451426	0	0	1	R03B.profile.u50
nucleoside diphosphate kinase activity	GO:0004550	Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.	9	0.0222474909774064	0	0	1	R03B.profile.u50
nucleotide diphosphatase activity	GO:0004551	Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.	6	0.0148316606516043	0	0	1	R03B.profile.u50
hydrolase activity, hydrolyzing O-glycosyl compounds	GO:0004553	Catalysis of the hydrolysis of any O-glycosyl bond.	103	0.254610174519207	0	0	1	R03B.profile.u50
alpha-mannosidase activity	GO:0004559	Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.	7	0.0173036040935383	0	0	1	R03B.profile.u50
beta-galactosidase activity	GO:0004565	Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.	6	0.0148316606516043	0	0	1	R03B.profile.u50
chitinase activity	GO:0004568	Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.	10	0.0247194344193405	0	0	1	R03B.profile.u50
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	GO:0004571	Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).	14	0.0346072081870767	0	0	1	R03B.profile.u50
oligosaccharyl transferase activity	GO:0004576	Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.	13	0.0321352647451426	0	0	1	R03B.profile.u50
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	GO:0004579	Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.	11	0.0271913778612745	0	0	1	R03B.profile.u50
peroxidase activity	GO:0004601	Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O.	39	0.0964057942354279	0	0	1	R03B.profile.u50
glutathione peroxidase activity	GO:0004602	Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.	9	0.0222474909774064	0	0	1	R03B.profile.u50
phospholipase activity	GO:0004620	Catalysis of the hydrolysis of a glycerophospholipid.	79	0.19528353191279	0	0	1	R03B.profile.u50
lysophospholipase activity	GO:0004622	Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.	10	0.0247194344193405	0	0	1	R03B.profile.u50
phospholipase A2 activity	GO:0004623	Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.	25	0.0617985860483512	0	0	1	R03B.profile.u50
phospholipase C activity	GO:0004629	Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.	38	0.0939338507934939	0	0	1	R03B.profile.u50
polypeptide N-acetylgalactosaminyltransferase activity	GO:0004653	Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.	17	0.0420230385128788	0	0	1	R03B.profile.u50
prenyltransferase activity	GO:0004659	Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).	19	0.0469669253967469	0	0	1	R03B.profile.u50
protein geranylgeranyltransferase activity	GO:0004661	Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.	9	0.0222474909774064	0	0	1	R03B.profile.u50
protein kinase activity	GO:0004672	Catalysis of the transfer of a phosphate group, usually from ATP, to a protein substrate.	869	2.14811885104069	3	1.39657077100115	0.363393665851818	R03B.profile.u50
protein histidine kinase activity	GO:0004673	Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.	14	0.0346072081870767	0	0	1	R03B.profile.u50
protein serine/threonine kinase activity	GO:0004674	Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate.	618	1.52766104711524	2	1.30919093851133	0.451606044893653	R03B.profile.u50
transmembrane receptor protein serine/threonine kinase activity	GO:0004675		24	0.0593266426064172	0	0	1	R03B.profile.u50
casein kinase activity	GO:0004680		18	0.0444949819548129	0	0	1	R03B.profile.u50
cyclic nucleotide-dependent protein kinase activity	GO:0004690	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide.	11	0.0271913778612745	0	0	1	R03B.profile.u50
cAMP-dependent protein kinase activity	GO:0004691	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP.	8	0.0197755475354724	0	0	1	R03B.profile.u50
cyclin-dependent protein kinase activity	GO:0004693	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).	16	0.0395510950709448	0	0	1	R03B.profile.u50
protein kinase C activity	GO:0004697		19	0.0469669253967469	1	21.2915789473684	0.0459365220634866	R03B.profile.u50
receptor signaling protein serine/threonine kinase activity	GO:0004702		78	0.192811588470856	0	0	1	R03B.profile.u50
G-protein coupled receptor kinase activity	GO:0004703	Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity.	12	0.0296633213032086	0	0	1	R03B.profile.u50
MAP kinase activity	GO:0004707	Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.	24	0.0593266426064172	0	0	1	R03B.profile.u50
MAP kinase kinase activity	GO:0004708	Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.	19	0.0469669253967469	1	21.2915789473684	0.0459365220634866	R03B.profile.u50
MAP kinase kinase kinase activity	GO:0004709	Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.	22	0.0543827557225491	0	0	1	R03B.profile.u50
protein threonine/tyrosine kinase activity	GO:0004712		20	0.049438868838681	1	20.227	0.0482949130209605	R03B.profile.u50
protein-tyrosine kinase activity	GO:0004713	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.	299	0.739111089138281	2	2.70595317725752	0.16939372587243	R03B.profile.u50
transmembrane receptor protein tyrosine kinase activity	GO:0004714		139	0.343600138428833	0	0	1	R03B.profile.u50
non-membrane spanning protein tyrosine kinase activity	GO:0004715		25	0.0617985860483512	0	0	1	R03B.profile.u50
receptor signaling protein tyrosine kinase activity	GO:0004716		22	0.0543827557225491	0	0	1	R03B.profile.u50
protein-lysine 6-oxidase activity	GO:0004720	Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2.	7	0.0173036040935383	0	0	1	R03B.profile.u50
phosphoprotein phosphatase activity	GO:0004721	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.	236	0.583378652296435	1	1.71415254237288	0.442393009174827	R03B.profile.u50
protein serine/threonine phosphatase activity	GO:0004722	Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.	71	0.175507984377317	0	0	1	R03B.profile.u50
protein tyrosine phosphatase activity	GO:0004725	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.	150	0.370791516290107	1	2.69693333333333	0.310128934718548	R03B.profile.u50
non-membrane spanning protein tyrosine phosphatase activity	GO:0004726		18	0.0444949819548129	1	22.4744444444444	0.0435722868502822	R03B.profile.u50
pseudouridylate synthase activity	GO:0004730	Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O.	5	0.0123597172096702	0	0	1	R03B.profile.u50
retinol dehydrogenase activity	GO:0004745	Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.	8	0.0197755475354724	0	0	1	R03B.profile.u50
sphingomyelin phosphodiesterase activity	GO:0004767	Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.	8	0.0197755475354724	0	0	1	R03B.profile.u50
steroid delta-isomerase activity	GO:0004769	Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.	6	0.0148316606516043	0	0	1	R03B.profile.u50
triacylglycerol lipase activity	GO:0004806	Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion.	11	0.0271913778612745	0	0	1	R03B.profile.u50
aminoacyl-tRNA ligase activity	GO:0004812	Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.	54	0.133484945864439	0	0	1	R03B.profile.u50
tubulin-tyrosine ligase activity	GO:0004835	Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.	11	0.0271913778612745	0	0	1	R03B.profile.u50
ubiquitin-protein ligase activity	GO:0004842	Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.	175	0.432590102338459	0	0	1	R03B.profile.u50
ubiquitin-specific protease activity	GO:0004843	Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.	79	0.19528353191279	0	0	1	R03B.profile.u50
enzyme inhibitor activity	GO:0004857	Stops, prevents or reduces the activity of an enzyme.	333	0.823157166164038	1	1.21483483483483	0.561403860494024	R03B.profile.u50
phospholipase inhibitor activity	GO:0004859	Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.	11	0.0271913778612745	0	0	1	R03B.profile.u50
protein kinase inhibitor activity	GO:0004860	Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.	58	0.143372719632175	1	6.9748275862069	0.133722702603265	R03B.profile.u50
cyclin-dependent protein kinase inhibitor activity	GO:0004861	Stops, prevents or reduces the activity of a cyclin-dependent protein kinase.	19	0.0469669253967469	0	0	1	R03B.profile.u50
protein phosphatase inhibitor activity	GO:0004864	Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins.	34	0.0840460770257577	0	0	1	R03B.profile.u50
type 1 serine/threonine specific protein phosphatase inhibitor activity	GO:0004865		7	0.0173036040935383	0	0	1	R03B.profile.u50
endopeptidase inhibitor activity	GO:0004866	Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.	156	0.385623176941712	0	0	1	R03B.profile.u50
serine-type endopeptidase inhibitor activity	GO:0004867	Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.	98	0.242250457309537	0	0	1	R03B.profile.u50
cysteine protease inhibitor activity	GO:0004869		28	0.0692144163741534	0	0	1	R03B.profile.u50
signal transducer activity	GO:0004871	Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.	2506	6.19469026548673	10	1.61428571428571	0.0977156042406087	R03B.profile.u50
receptor activity	GO:0004872	Combining with an extracellular or intracellular messenger to initiate a change in cell activity.	1863	4.60523063232313	5	1.0857219538379	0.487886902688481	R03B.profile.u50
ligand-dependent nuclear receptor activity	GO:0004879	A ligand-dependent receptor found in the nucleus of the cell.	131	0.32382459089336	0	0	1	R03B.profile.u50
thyroid hormone receptor activity	GO:0004887	Combining with thyroid hormone to initiate a change in cell activity.	15	0.0370791516290107	0	0	1	R03B.profile.u50
transmembrane receptor activity	GO:0004888	Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.	1150	2.84273495822416	3	1.05532173913043	0.54091610373927	R03B.profile.u50
nicotinic acetylcholine-activated cation-selective channel activity	GO:0004889		23	0.0568546991644831	0	0	1	R03B.profile.u50
GABA-A receptor activity	GO:0004890	Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.	22	0.0543827557225491	0	0	1	R03B.profile.u50
hematopoietin/interferon-class (D200-domain) cytokine receptor activity	GO:0004896		90	0.222474909774064	1	4.49488888888889	0.199685366259419	R03B.profile.u50
interleukin receptor activity	GO:0004907	Combining with an interleukin to initiate a change in cell activity.	46	0.113709398328966	1	8.79434782608696	0.107608348847919	R03B.profile.u50
interleukin-1 receptor activity	GO:0004908	Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.	11	0.0271913778612745	0	0	1	R03B.profile.u50
non-G-protein coupled 7TM receptor activity	GO:0004926		14	0.0346072081870767	0	0	1	R03B.profile.u50
G-protein coupled receptor activity	GO:0004930	A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.	515	1.27305087259603	1	0.785514563106796	0.72046476370109	R03B.profile.u50
adrenoceptor activity	GO:0004935		17	0.0420230385128788	0	0	1	R03B.profile.u50
alpha-adrenergic receptor activity	GO:0004936		10	0.0247194344193405	0	0	1	R03B.profile.u50
angiotensin type II receptor activity	GO:0004945		11	0.0271913778612745	0	0	1	R03B.profile.u50
chemokine receptor activity	GO:0004950	Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.	33	0.0815741335838236	0	0	1	R03B.profile.u50
dopamine receptor activity	GO:0004952	Combining with the neurotransmitter dopamine to initiate a change in cell activity.	9	0.0222474909774064	0	0	1	R03B.profile.u50
icosanoid receptor activity	GO:0004953	Combining with an icosanoid to initiate a change in cell activity.	33	0.0815741335838236	0	0	1	R03B.profile.u50
prostanoid receptor activity	GO:0004954	Combining with a prostanoid, any compound based on or derive4d from the prostanoate structure, to initiate a change in cell activity.	33	0.0815741335838236	0	0	1	R03B.profile.u50
prostaglandin receptor activity	GO:0004955	Combining with a prostaglandin (PG) to initiate a change in cell activity.	28	0.0692144163741534	0	0	1	R03B.profile.u50
prostaglandin E receptor activity	GO:0004957	Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.	20	0.049438868838681	0	0	1	R03B.profile.u50
histamine receptor activity	GO:0004969	Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.	9	0.0222474909774064	0	0	1	R03B.profile.u50
ionotropic glutamate receptor activity	GO:0004970	Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.	26	0.0642705294902853	0	0	1	R03B.profile.u50
melanocortin receptor activity	GO:0004977	Combining with melanocortin to initiate a change in cell activity.	9	0.0222474909774064	0	0	1	R03B.profile.u50
muscarinic acetylcholine receptor activity	GO:0004981		5	0.0123597172096702	0	0	1	R03B.profile.u50
N-formyl peptide receptor activity	GO:0004982	Combining with an N-formyl peptide to initiate a change in cell activity.	9	0.0222474909774064	0	0	1	R03B.profile.u50
neuropeptide Y receptor activity	GO:0004983	Combining with neuropeptide Y to initiate a change in cell activity.	7	0.0173036040935383	0	0	1	R03B.profile.u50
olfactory receptor activity	GO:0004984	Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell.	39	0.0964057942354279	0	0	1	R03B.profile.u50
opioid receptor activity	GO:0004985	Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity.	14	0.0346072081870767	0	0	1	R03B.profile.u50
serotonin receptor activity	GO:0004993	Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.	19	0.0469669253967469	0	0	1	R03B.profile.u50
vasoactive intestinal polypeptide receptor activity	GO:0004999		9	0.0222474909774064	0	0	1	R03B.profile.u50
transmembrane receptor protein tyrosine phosphatase activity	GO:0005001		32	0.0791021901418896	0	0	1	R03B.profile.u50
ephrin receptor activity	GO:0005003	Combining with an ephrin to initiate a change in cell activity.	25	0.0617985860483512	0	0	1	R03B.profile.u50
vascular endothelial growth factor receptor activity	GO:0005021	Combining with vascular endothelial growth factor to initiate a change in cell activity.	22	0.0543827557225491	0	0	1	R03B.profile.u50
transforming growth factor beta receptor activity	GO:0005024	Combining with transforming growth factor beta to initiate a change in cell activity.	24	0.0593266426064172	0	0	1	R03B.profile.u50
transforming growth factor beta receptor activity, type I	GO:0005025	Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I TGF-beta receptor.	10	0.0247194344193405	0	0	1	R03B.profile.u50
tumor necrosis factor receptor activity	GO:0005031	Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.	11	0.0271913778612745	0	0	1	R03B.profile.u50
death receptor activity	GO:0005035		12	0.0296633213032086	0	0	1	R03B.profile.u50
low-density lipoprotein receptor activity	GO:0005041	Combining with a low-density lipoprotein to initiate a change in cell activity.	16	0.0395510950709448	0	0	1	R03B.profile.u50
scavenger receptor activity	GO:0005044	Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.	34	0.0840460770257577	0	0	1	R03B.profile.u50
signal sequence binding	GO:0005048	Interacting selectively with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.	51	0.126069115538636	1	7.9321568627451	0.118583662293142	R03B.profile.u50
receptor signaling protein activity	GO:0005057		246	0.608098086715776	0	0	1	R03B.profile.u50
transmembrane receptor protein tyrosine kinase signaling protein activity	GO:0005066		15	0.0370791516290107	0	0	1	R03B.profile.u50
SH3/SH2 adaptor activity	GO:0005070	Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).	77	0.190339645028922	1	5.25376623376623	0.173516468788228	R03B.profile.u50
transmembrane receptor protein serine/threonine kinase signaling protein activity	GO:0005071		10	0.0247194344193405	0	0	1	R03B.profile.u50
protein kinase C binding	GO:0005080	Interacting selectively with protein kinase C.	28	0.0692144163741534	0	0	1	R03B.profile.u50
small GTPase regulator activity	GO:0005083	Modulates the rate of GTP hydrolysis by a small monomeric GTPase.	311	0.768774410441489	1	1.30077170418006	0.536860124054598	R03B.profile.u50
guanyl-nucleotide exchange factor activity	GO:0005085	Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.	198	0.489444801502942	0	0	1	R03B.profile.u50
ARF guanyl-nucleotide exchange factor activity	GO:0005086	Stimulates the exchange of guanyl nucleotides by the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.	24	0.0593266426064172	0	0	1	R03B.profile.u50
Ras guanyl-nucleotide exchange factor activity	GO:0005088	Stimulates the exchange of guanyl nucleotides by a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.	124	0.306520986799822	0	0	1	R03B.profile.u50
Rho guanyl-nucleotide exchange factor activity	GO:0005089	Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.	104	0.257082117961141	0	0	1	R03B.profile.u50
GDP-dissociation inhibitor activity	GO:0005092	Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.	11	0.0271913778612745	0	0	1	R03B.profile.u50
GTPase inhibitor activity	GO:0005095	Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.	16	0.0395510950709448	0	0	1	R03B.profile.u50
GTPase activator activity	GO:0005096	Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.	259	0.640233351460919	2	3.123861003861	0.135168553210314	R03B.profile.u50
Rab GTPase activator activity	GO:0005097	Increases the rate of GTP hydrolysis by a GTPase of the Rab family.	48	0.118653285212834	1	8.42791666666667	0.11201477926423	R03B.profile.u50
Ras GTPase activator activity	GO:0005099	Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily.	111	0.274385722054679	1	3.6445045045045	0.240219280999167	R03B.profile.u50
Rho GTPase activator activity	GO:0005100	Increases the rate of GTP hydrolysis by a GTPase of the Rho family.	34	0.0840460770257577	0	0	1	R03B.profile.u50
receptor binding	GO:0005102	Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	989	2.44475206407277	2	0.818078867542973	0.701554999476418	R03B.profile.u50
fibroblast growth factor receptor binding	GO:0005104	Interacting selectively with the fibroblast growth factor receptor (FGFR).	11	0.0271913778612745	0	0	1	R03B.profile.u50
Notch binding	GO:0005112	Interacting selectively with the Notch (N) protein, a surface receptor.	14	0.0346072081870767	0	0	1	R03B.profile.u50
death receptor binding	GO:0005123	Interacting selectively with a death receptor.	10	0.0247194344193405	0	0	1	R03B.profile.u50
cytokine activity	GO:0005125	Functions to control the survival, growth, differentiation and effector function of tissues and cells.	287	0.709447767835072	0	0	1	R03B.profile.u50
hematopoietin/interferon-class (D200-domain) cytokine receptor binding	GO:0005126		52	0.128541058980571	0	0	1	R03B.profile.u50
interferon-alpha/beta receptor binding	GO:0005132	Interacting selectively with the interferon-alpha/beta receptor.	9	0.0222474909774064	0	0	1	R03B.profile.u50
interleukin-1 receptor binding	GO:0005149	Interacting selectively with the interleukin-1 receptor.	18	0.0444949819548129	0	0	1	R03B.profile.u50
interleukin-1 receptor antagonist activity	GO:0005152	Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.	10	0.0247194344193405	0	0	1	R03B.profile.u50
epidermal growth factor receptor binding	GO:0005154	Interacting selectively with the epidermal growth factor receptor.	15	0.0370791516290107	0	0	1	R03B.profile.u50
insulin receptor binding	GO:0005158	Interacting selectively with the insulin receptor.	26	0.0642705294902853	2	31.1184615384615	0.00190901944923783	R03B.profile.u50
insulin-like growth factor receptor binding	GO:0005159	Interacting selectively with the insulin-like growth factor receptor.	18	0.0444949819548129	0	0	1	R03B.profile.u50
transforming growth factor beta receptor binding	GO:0005160	Interacting selectively with the transforming growth factor beta receptor.	14	0.0346072081870767	0	0	1	R03B.profile.u50
tumor necrosis factor receptor binding	GO:0005164	Interacting selectively with the tumor necrosis factor receptor.	29	0.0716863598160874	0	0	1	R03B.profile.u50
integrin binding	GO:0005178	Interacting selectively with an integrin.	84	0.20764324912246	0	0	1	R03B.profile.u50
hormone activity	GO:0005179	The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects.	131	0.32382459089336	0	0	1	R03B.profile.u50
neuropeptide hormone activity	GO:0005184	The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.	28	0.0692144163741534	0	0	1	R03B.profile.u50
structural molecule activity	GO:0005198	The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.	937	2.3162110050922	2	0.863479188900747	0.673239019369684	R03B.profile.u50
structural constituent of cytoskeleton	GO:0005200	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.	156	0.385623176941712	0	0	1	R03B.profile.u50
extracellular matrix structural constituent	GO:0005201	The action of a molecule that contributes to the structural integrity of the extracellular matrix.	163	0.40292678103525	1	2.48184049079755	0.331972280041138	R03B.profile.u50
structural constituent of eye lens	GO:0005212	The action of a molecule that contributes to the structural integrity of the lens of an eye.	17	0.0420230385128788	0	0	1	R03B.profile.u50
transporter activity	GO:0005215	Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	1472	3.63870074652692	0	0	1	R03B.profile.u50
ion channel activity	GO:0005216	Allows the regulatable energy-independent passage of ions across a lipid bilayer down a concentration gradient.	403	0.996193207099422	0	0	1	R03B.profile.u50
intracellular ligand-gated ion channel activity	GO:0005217		23	0.0568546991644831	0	0	1	R03B.profile.u50
calcium activated cation channel activity	GO:0005227	The transporter activity that allows the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.	14	0.0346072081870767	0	0	1	R03B.profile.u50
extracellular ligand-gated ion channel activity	GO:0005230		80	0.197755475354724	0	0	1	R03B.profile.u50
excitatory extracellular ligand-gated ion channel activity	GO:0005231		63	0.155732436841845	0	0	1	R03B.profile.u50
glutamate-gated ion channel activity	GO:0005234		26	0.0642705294902853	0	0	1	R03B.profile.u50
inward rectifier potassium channel activity	GO:0005242		27	0.0667424729322193	0	0	1	R03B.profile.u50
gap-junction forming channel activity	GO:0005243		15	0.0370791516290107	0	0	1	R03B.profile.u50
voltage-gated ion channel activity	GO:0005244	A channel in a cell membrane whose opening is governed by the membrane potential.	201	0.496860631828744	0	0	1	R03B.profile.u50
voltage-gated calcium channel activity	GO:0005245	Allows movement of calcium across a cell membrane through a transmembrane channel whose opening and closing is responsive to changes in membrane potential.	39	0.0964057942354279	0	0	1	R03B.profile.u50
calcium channel regulator activity	GO:0005246		16	0.0395510950709448	0	0	1	R03B.profile.u50
voltage-gated chloride channel activity	GO:0005247		26	0.0642705294902853	0	0	1	R03B.profile.u50
voltage-gated sodium channel activity	GO:0005248		18	0.0444949819548129	0	0	1	R03B.profile.u50
voltage-gated potassium channel activity	GO:0005249		105	0.259554061403075	0	0	1	R03B.profile.u50
delayed rectifier potassium channel activity	GO:0005251		17	0.0420230385128788	0	0	1	R03B.profile.u50
anion channel activity	GO:0005253	The transporter activity that allows the energy-independent passage of anions across a lipid bilayer down a concentration gradient.	76	0.187867701586988	0	0	1	R03B.profile.u50
chloride channel activity	GO:0005254		68	0.168092154051515	0	0	1	R03B.profile.u50
cation channel activity	GO:0005261	The transporter activity that allows the energy-independent passage of cations across a lipid bilayer down a concentration gradient.	277	0.684728333415731	0	0	1	R03B.profile.u50
calcium channel activity	GO:0005262		89	0.22000296633213	0	0	1	R03B.profile.u50
potassium channel activity	GO:0005267		121	0.29910515647402	0	0	1	R03B.profile.u50
sodium channel activity	GO:0005272		34	0.0840460770257577	0	0	1	R03B.profile.u50
amine transporter activity	GO:0005275	Enables the directed movement of amines, including polyamines, into, out of, within or between cells. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.	83	0.205171305680526	0	0	1	R03B.profile.u50
amino acid-polyamine transporter activity	GO:0005279		26	0.0642705294902853	0	0	1	R03B.profile.u50
sodium:amino acid symporter activity	GO:0005283	Catalysis of the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).	9	0.0222474909774064	0	0	1	R03B.profile.u50
dicarboxylic acid transporter activity	GO:0005310	Enables the directed movement of dicarboxylic acids into, out of, within or between cells. A dicarboxylic acid is an organic acid with two COOH groups.	18	0.0444949819548129	0	0	1	R03B.profile.u50
L-glutamate transporter activity	GO:0005313	Enables the directed movement of L-glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells.	13	0.0321352647451426	0	0	1	R03B.profile.u50
lipid transporter activity	GO:0005319	Enables the directed movement of lipids into, out of, within or between cells.	105	0.259554061403075	0	0	1	R03B.profile.u50
neurotransmitter transporter activity	GO:0005326	Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.	27	0.0667424729322193	0	0	1	R03B.profile.u50
neurotransmitter:sodium symporter activity	GO:0005328	Catalysis of the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).	25	0.0617985860483512	0	0	1	R03B.profile.u50
nucleoside transporter activity	GO:0005337	Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells.	8	0.0197755475354724	0	0	1	R03B.profile.u50
nucleotide-sugar transporter activity	GO:0005338	Enables the directed movement of nucleotide-sugars into, out of, within or between cells. A nucleotide-sugars is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.	13	0.0321352647451426	0	0	1	R03B.profile.u50
organic acid transporter activity	GO:0005342	Enables the directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells.	103	0.254610174519207	0	0	1	R03B.profile.u50
organic acid:sodium symporter activity	GO:0005343	Catalysis of the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).	28	0.0692144163741534	0	0	1	R03B.profile.u50
oxygen transporter activity	GO:0005344	Enables the directed movement of oxygen into, out of, within or between cells.	14	0.0346072081870767	0	0	1	R03B.profile.u50
sugar porter activity	GO:0005351	Catalysis of the reaction: sugar(out) + H+(out) = sugar(in) + H+(in).	43	0.106293568003164	0	0	1	R03B.profile.u50
glucose transporter activity	GO:0005355	Enables the directed movement of the hexose monosaccharide glucose into, out of, within or between cells.	18	0.0444949819548129	0	0	1	R03B.profile.u50
water transporter activity	GO:0005372	Enables the directed movement of water (H2O) into, out of, within or between cells.	18	0.0444949819548129	0	0	1	R03B.profile.u50
copper ion transporter activity	GO:0005375	Enables the directed movement of copper (Cu) ions into, out of, within or between cells.	10	0.0247194344193405	0	0	1	R03B.profile.u50
carrier activity	GO:0005386	Catalysis of the transfer of a specific substance or related group of substances from one side of the membrane to the other.	397	0.981361546447817	0	0	1	R03B.profile.u50
calcium-transporting ATPase activity	GO:0005388	Catalysis of the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).	26	0.0642705294902853	0	0	1	R03B.profile.u50
sodium:potassium-exchanging ATPase activity	GO:0005391	Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).	12	0.0296633213032086	0	0	1	R03B.profile.u50
cation:amino acid symporter activity	GO:0005416	Catalysis of the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in).	10	0.0247194344193405	0	0	1	R03B.profile.u50
sodium:phosphate symporter activity	GO:0005436	Catalysis of the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).	7	0.0173036040935383	0	0	1	R03B.profile.u50
monovalent cation:proton antiporter activity	GO:0005451	Catalysis of the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out).	8	0.0197755475354724	0	0	1	R03B.profile.u50
inorganic anion exchanger activity	GO:0005452		13	0.0321352647451426	0	0	1	R03B.profile.u50
intracellular transporter activity	GO:0005478	Enables the directed movement of substances within a cell.	54	0.133484945864439	0	0	1	R03B.profile.u50
SNAP receptor activity	GO:0005484	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.	19	0.0469669253967469	0	0	1	R03B.profile.u50
nucleocytoplasmic transporter activity	GO:0005487	Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.	14	0.0346072081870767	0	0	1	R03B.profile.u50
binding	GO:0005488	The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.	13359	33.022692440797	39	1.18100606332809	0.169053377921894	R03B.profile.u50
steroid binding	GO:0005496	Interacting selectively with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.	79	0.19528353191279	0	0	1	R03B.profile.u50
retinoid binding	GO:0005501	Interacting selectively with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.	13	0.0321352647451426	0	0	1	R03B.profile.u50
fatty acid binding	GO:0005504	Interacting selectively with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.	28	0.0692144163741534	0	0	1	R03B.profile.u50
iron ion binding	GO:0005506	Interacting selectively with iron (Fe) ions.	372	0.919562960399466	0	0	1	R03B.profile.u50
copper ion binding	GO:0005507	Interacting selectively with copper (Cu) ions.	74	0.18292381470312	6	32.8005405405405	3.65970328773611e-08	R03B.profile.u50
calcium ion binding	GO:0005509	Interacting selectively with calcium ions (Ca2+).	1112	2.74880110743066	1	0.363794964028777	0.936212890667151	R03B.profile.u50
protein binding	GO:0005515	Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	8108	20.0425174272013	23	1.14756043413912	0.282478496717675	R03B.profile.u50
calmodulin binding	GO:0005516	Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.	227	0.561131161319029	0	0	1	R03B.profile.u50
collagen binding	GO:0005518	Interacting selectively with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).	34	0.0840460770257577	0	0	1	R03B.profile.u50
insulin-like growth factor binding	GO:0005520	Interacting selectively with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.	36	0.0889899639096258	0	0	1	R03B.profile.u50
tropomyosin binding	GO:0005523	Interacting selectively with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.	19	0.0469669253967469	0	0	1	R03B.profile.u50
ATP binding	GO:0005524	Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	1792	4.42972264794582	4	0.902991071428571	0.64601400397857	R03B.profile.u50
GTP binding	GO:0005525	Interacting selectively with GTP, guanosine triphosphate.	449	1.10990260542839	0	0	1	R03B.profile.u50
macrolide binding	GO:0005527	Interacting selectively with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	R03B.profile.u50
FK506 binding	GO:0005528	Interacting selectively with the immunosuppressant FK506.	12	0.0296633213032086	1	33.7116666666667	0.0292633326652399	R03B.profile.u50
sugar binding	GO:0005529	Interacting selectively with any mono-, di- or trisaccharide carbohydrate.	190	0.469669253967469	0	0	1	R03B.profile.u50
mannose binding	GO:0005537	Interacting selectively with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.	14	0.0346072081870767	0	0	1	R03B.profile.u50
glycosaminoglycan binding	GO:0005539	Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.	171	0.422702328570722	1	2.36573099415205	0.345069161677589	R03B.profile.u50
hyaluronic acid binding	GO:0005540	Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.	33	0.0815741335838236	0	0	1	R03B.profile.u50
folic acid binding	GO:0005542	Interacting selectively with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.	14	0.0346072081870767	0	0	1	R03B.profile.u50
phospholipid binding	GO:0005543	Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.	296	0.731695258812478	1	1.36668918918919	0.519342877724214	R03B.profile.u50
calcium-dependent phospholipid binding	GO:0005544	Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.	30	0.0741583032580215	0	0	1	R03B.profile.u50
phosphatidylinositol binding	GO:0005545	Interacting selectively with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.	18	0.0444949819548129	0	0	1	R03B.profile.u50
phosphatidylinositol-3,4,5-triphosphate binding	GO:0005547	Interacting selectively with phosphatidylinositol-3,4,5-triphosphate, the triphosphorylated derivative of phosphatidylinositol.	7	0.0173036040935383	0	0	1	R03B.profile.u50
phospholipid transporter activity	GO:0005548	Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.	36	0.0889899639096258	0	0	1	R03B.profile.u50
chemokine activity	GO:0008009	The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.	56	0.138428832748307	0	0	1	R03B.profile.u50
beta-catenin binding	GO:0008013	Interacting selectively with the beta subunit of the catenin complex.	10	0.0247194344193405	0	0	1	R03B.profile.u50
microtubule binding	GO:0008017	Interacting selectively with microtubules, filaments composed of tubulin monomers.	73	0.180451871261186	0	0	1	R03B.profile.u50
G-protein coupled photoreceptor activity	GO:0008020	A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light.	6	0.0148316606516043	0	0	1	R03B.profile.u50
protein C-terminus binding	GO:0008022	Interacting selectively with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	88	0.217531022890196	0	0	1	R03B.profile.u50
ATP-dependent helicase activity	GO:0008026	Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix.	137	0.338656251544965	0	0	1	R03B.profile.u50
monocarboxylic acid transporter activity	GO:0008028	Enables the directed movement of monocarboxylic acids into, out of, within or between cells. A monocarboxylic acid is an organic acid with one COOH group.	28	0.0692144163741534	0	0	1	R03B.profile.u50
lipoprotein binding	GO:0008034	Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	39	0.0964057942354279	0	0	1	R03B.profile.u50
enzyme activator activity	GO:0008047	Increases the activity of an enzyme.	397	0.981361546447817	2	2.03798488664987	0.257376134191125	R03B.profile.u50
glutamate receptor activity	GO:0008066	Combining with glutamate to initiate a change in cell activity.	52	0.128541058980571	0	0	1	R03B.profile.u50
metabotropic glutamate, GABA-B-like receptor activity	GO:0008067	A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor.	26	0.0642705294902853	0	0	1	R03B.profile.u50
translation termination factor activity	GO:0008079	Functions in the termination of translation.	9	0.0222474909774064	0	0	1	R03B.profile.u50
N-acetyltransferase activity	GO:0008080	Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.	64	0.158204380283779	0	0	1	R03B.profile.u50
phosphoric diester hydrolase activity	GO:0008081	Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.	108	0.266969891728877	0	0	1	R03B.profile.u50
growth factor activity	GO:0008083	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.	247	0.61057003015771	0	0	1	R03B.profile.u50
cytoskeletal protein binding	GO:0008092	Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).	618	1.52766104711524	3	1.96378640776699	0.197979715762231	R03B.profile.u50
cytoskeletal adaptor activity	GO:0008093	The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way.	20	0.049438868838681	0	0	1	R03B.profile.u50
DNA-dependent ATPase activity	GO:0008094	Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction.	71	0.175507984377317	0	0	1	R03B.profile.u50
ubiquinol-cytochrome-c reductase activity	GO:0008121	Catalysis of the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c.	10	0.0247194344193405	0	0	1	R03B.profile.u50
transcription factor binding	GO:0008134	Interacting selectively with a transcription factor, any protein required to initiate or regulate transcription.	612	1.51282938646364	4	2.6440522875817	0.0670289410998867	R03B.profile.u50
translation factor activity, nucleic acid binding	GO:0008135	Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome.	118	0.291689326148218	0	0	1	R03B.profile.u50
NADH dehydrogenase (ubiquinone) activity	GO:0008137	Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.	39	0.0964057942354279	0	0	1	R03B.profile.u50
protein tyrosine/serine/threonine phosphatase activity	GO:0008138		61	0.150788549957977	1	6.63180327868852	0.140131000967157	R03B.profile.u50
nuclear localization sequence binding	GO:0008139	Interacting selectively with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.	29	0.0716863598160874	1	13.9496551724138	0.0692598120867805	R03B.profile.u50
drug binding	GO:0008144	Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.	35	0.0865180204676917	1	11.5582857142857	0.0829792059813095	R03B.profile.u50
sulfotransferase activity	GO:0008146	Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.	47	0.1161813417709	0	0	1	R03B.profile.u50
hedgehog receptor activity	GO:0008158	Combining with the hedgehog protein to initiate a change in cell activity.	7	0.0173036040935383	0	0	1	R03B.profile.u50
positive transcription elongation factor activity	GO:0008159	Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.	10	0.0247194344193405	0	0	1	R03B.profile.u50
methyltransferase activity	GO:0008168	Catalysis of the transfer of a methyl group to an acceptor molecule.	157	0.388095120383646	0	0	1	R03B.profile.u50
N-methyltransferase activity	GO:0008170	Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.	45	0.111237454887032	0	0	1	R03B.profile.u50
O-methyltransferase activity	GO:0008171	Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.	16	0.0395510950709448	0	0	1	R03B.profile.u50
S-methyltransferase activity	GO:0008172	Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.	6	0.0148316606516043	0	0	1	R03B.profile.u50
RNA methyltransferase activity	GO:0008173	Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.	23	0.0568546991644831	0	0	1	R03B.profile.u50
tRNA methyltransferase activity	GO:0008175	Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.	10	0.0247194344193405	0	0	1	R03B.profile.u50
RNA-dependent ATPase activity	GO:0008186	Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction.	39	0.0964057942354279	0	0	1	R03B.profile.u50
neuropeptide receptor activity	GO:0008188	Combining with a neuropeptide to initiate a change in cell activity.	39	0.0964057942354279	0	0	1	R03B.profile.u50
metalloendopeptidase inhibitor activity	GO:0008191	Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.	20	0.049438868838681	0	0	1	R03B.profile.u50
UDP-glycosyltransferase activity	GO:0008194	Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.	119	0.294161269590152	0	0	1	R03B.profile.u50
ferric iron binding	GO:0008199	Interacting selectively with ferric iron, Fe(III).	9	0.0222474909774064	0	0	1	R03B.profile.u50
ion channel inhibitor activity	GO:0008200		13	0.0321352647451426	0	0	1	R03B.profile.u50
heparin binding	GO:0008201	Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.	131	0.32382459089336	1	3.08809160305344	0.276912824738315	R03B.profile.u50
amine receptor activity	GO:0008227	Combining with a biogenic amine to initiate a change in cell activity.	56	0.138428832748307	0	0	1	R03B.profile.u50
peptidase activity	GO:0008233	Catalysis of the hydrolysis of peptide bonds.	636	1.57215602907005	0	0	1	R03B.profile.u50
cysteine-type peptidase activity	GO:0008234	Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.	180	0.444949819548129	0	0	1	R03B.profile.u50
metalloexopeptidase activity	GO:0008235	Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.	63	0.155732436841845	0	0	1	R03B.profile.u50
serine-type peptidase activity	GO:0008236	Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).	180	0.444949819548129	0	0	1	R03B.profile.u50
metallopeptidase activity	GO:0008237		209	0.516636179364216	0	0	1	R03B.profile.u50
exopeptidase activity	GO:0008238	Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.	104	0.257082117961141	0	0	1	R03B.profile.u50
dipeptidyl-peptidase activity	GO:0008239	Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.	12	0.0296633213032086	0	0	1	R03B.profile.u50
omega peptidase activity	GO:0008242	Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of a-carboxyl to a-amino groups).	5	0.0123597172096702	0	0	1	R03B.profile.u50
nucleotidase activity	GO:0008252	Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.	5	0.0123597172096702	0	0	1	R03B.profile.u50
5'-nucleotidase activity	GO:0008253	Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.	3	0.00741583032580215	0	0	1	R03B.profile.u50
zinc ion binding	GO:0008270	Interacting selectively with zinc (Zn) ions.	2200	5.43827557225491	16	2.94210909090909	0.00017265530769935	R03B.profile.u50
sulfate porter activity	GO:0008271		10	0.0247194344193405	0	0	1	R03B.profile.u50
protein methyltransferase activity	GO:0008276	Catalysis of the transfer of a methyl group (CH3-) to a protein.	43	0.106293568003164	0	0	1	R03B.profile.u50
lipid binding	GO:0008289	Interacting selectively with a lipid.	539	1.33237751520245	2	1.50107606679035	0.384748573813608	R03B.profile.u50
DNA bending activity	GO:0008301	The function of causing local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified.	14	0.0346072081870767	0	0	1	R03B.profile.u50
structural constituent of muscle	GO:0008307	The action of a molecule that contributes to the structural integrity of a muscle fiber.	70	0.173036040935383	1	5.77914285714286	0.159072863337331	R03B.profile.u50
voltage-gated ion-selective channel activity	GO:0008308		8	0.0197755475354724	0	0	1	R03B.profile.u50
protein prenyltransferase activity	GO:0008318	Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.	11	0.0271913778612745	0	0	1	R03B.profile.u50
cation transporter activity	GO:0008324	Enables the directed movement of atoms or small molecules with a positive charge into, out of, within or between cells.	627	1.54990853809265	0	0	1	R03B.profile.u50
pattern recognition receptor activity	GO:0008329	Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens.	8	0.0197755475354724	1	50.5675	0.0196052966743015	R03B.profile.u50
bacterial binding	GO:0008367	Interacting selectively with any part of a bacterial cell.	13	0.0321352647451426	1	31.1184615384615	0.0316629388039029	R03B.profile.u50
sialyltransferase activity	GO:0008373	Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.	22	0.0543827557225491	0	0	1	R03B.profile.u50
O-acyltransferase activity	GO:0008374	Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.	30	0.0741583032580215	0	0	1	R03B.profile.u50
acetylglucosaminyltransferase activity	GO:0008375	Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide.	40	0.098877737677362	0	0	1	R03B.profile.u50
acetylgalactosaminyltransferase activity	GO:0008376	Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.	29	0.0716863598160874	0	0	1	R03B.profile.u50
galactosyltransferase activity	GO:0008378	Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.	35	0.0865180204676917	0	0	1	R03B.profile.u50
steroid hydroxylase activity	GO:0008395	Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.	15	0.0370791516290107	0	0	1	R03B.profile.u50
3'-5' exonuclease activity	GO:0008408	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.	35	0.0865180204676917	0	0	1	R03B.profile.u50
acyltransferase activity	GO:0008415	Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier.	192	0.474613140851337	0	0	1	R03B.profile.u50
fucosyltransferase activity	GO:0008417	Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.	27	0.0667424729322193	0	0	1	R03B.profile.u50
selenium binding	GO:0008430	Interacting selectively with selenium (Se).	27	0.0667424729322193	0	0	1	R03B.profile.u50
inositol trisphosphate 3-kinase activity	GO:0008440	Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.	5	0.0123597172096702	0	0	1	R03B.profile.u50
phosphofructokinase activity	GO:0008443	Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule.	9	0.0222474909774064	0	0	1	R03B.profile.u50
transaminase activity	GO:0008483	Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.	36	0.0889899639096258	0	0	1	R03B.profile.u50
sulfuric ester hydrolase activity	GO:0008484	Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2.	32	0.0791021901418896	0	0	1	R03B.profile.u50
tetracycline transporter activity	GO:0008493	Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).	3	0.00741583032580215	0	0	1	R03B.profile.u50
translation activator activity	GO:0008494	Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.	8	0.0197755475354724	0	0	1	R03B.profile.u50
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	GO:0008499	Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.	8	0.0197755475354724	0	0	1	R03B.profile.u50
benzodiazepine receptor activity	GO:0008503	Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.	6	0.0148316606516043	0	0	1	R03B.profile.u50
bile acid:sodium symporter activity	GO:0008508	Catalysis of the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).	3	0.00741583032580215	0	0	1	R03B.profile.u50
anion transporter activity	GO:0008509	Enables the directed movement of atoms or small molecules with a negative charge into, out of, within or between cells.	165	0.407870667919118	0	0	1	R03B.profile.u50
organic anion transporter activity	GO:0008514	Enables the directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.	16	0.0395510950709448	0	0	1	R03B.profile.u50
phosphatidylinositol transporter activity	GO:0008526	Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.	8	0.0197755475354724	0	0	1	R03B.profile.u50
taste receptor activity	GO:0008527	Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.	10	0.0247194344193405	0	0	1	R03B.profile.u50
peptide receptor activity, G-protein coupled	GO:0008528		142	0.351015968754635	1	2.84887323943662	0.296333341111219	R03B.profile.u50
astacin activity	GO:0008533	Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.	10	0.0247194344193405	0	0	1	R03B.profile.u50
Ran GTPase binding	GO:0008536	Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.	25	0.0617985860483512	0	0	1	R03B.profile.u50
hydrogen-exporting ATPase activity, phosphorylative mechanism	GO:0008553	Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism.	8	0.0197755475354724	0	0	1	R03B.profile.u50
protein transporter activity	GO:0008565	Enables the directed movement of proteins into, out of, within or between cells.	135	0.333712364661097	0	0	1	R03B.profile.u50
protein phosphatase type 2A regulator activity	GO:0008601	Modulation of the activity of the enzyme protein phosphatase type 2A.	36	0.0889899639096258	0	0	1	R03B.profile.u50
cAMP-dependent protein kinase regulator activity	GO:0008603	Modulation of the activity of the enzyme cAMP-dependent protein kinase.	17	0.0420230385128788	0	0	1	R03B.profile.u50
small protein conjugating enzyme activity	GO:0008639	Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.	180	0.444949819548129	0	0	1	R03B.profile.u50
small protein activating enzyme activity	GO:0008641	Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.	2	0.0049438868838681	0	0	1	R03B.profile.u50
caspase activator activity	GO:0008656	Increases the rate of proteolysis catalyzed by a caspase.	23	0.0568546991644831	0	0	1	R03B.profile.u50
D-alanyl-D-alanine endopeptidase activity	GO:0008717		4	0.00988777376773619	0	0	1	R03B.profile.u50
S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.	79	0.19528353191279	0	0	1	R03B.profile.u50
glycerophosphodiester phosphodiesterase activity	GO:0008889	Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.	5	0.0123597172096702	0	0	1	R03B.profile.u50
signal peptidase activity	GO:0009003	Catalysis of the cleavage of a signal peptide from a protein precursor.	7	0.0173036040935383	0	0	1	R03B.profile.u50
electron carrier activity	GO:0009055	Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system.	188	0.464725367083601	0	0	1	R03B.profile.u50
photoreceptor activity	GO:0009881	The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.	7	0.0173036040935383	0	0	1	R03B.profile.u50
cyclase activity	GO:0009975	Catalysis of a ring closure reaction.	33	0.0815741335838236	1	12.2587878787879	0.078428692949341	R03B.profile.u50
pseudouridine synthase activity	GO:0009982	Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.	26	0.0642705294902853	0	0	1	R03B.profile.u50
FMN binding	GO:0010181	Interacting selectively with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.	13	0.0321352647451426	0	0	1	R03B.profile.u50
heme-copper terminal oxidase activity	GO:0015002	Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane.	36	0.0889899639096258	0	0	1	R03B.profile.u50
glucuronosyltransferase activity	GO:0015020	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.	21	0.051910812280615	0	0	1	R03B.profile.u50
coreceptor activity	GO:0015026	Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.	27	0.0667424729322193	0	0	1	R03B.profile.u50
protein disulfide oxidoreductase activity	GO:0015035		15	0.0370791516290107	0	0	1	R03B.profile.u50
disulfide oxidoreductase activity	GO:0015036		21	0.051910812280615	0	0	1	R03B.profile.u50
ion transporter activity	GO:0015075	Enables the directed movement of charged atoms or small charged molecules into, out of, within or between cells.	812	2.00721807485045	0	0	1	R03B.profile.u50
monovalent inorganic cation transporter activity	GO:0015077	Enables the directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	144	0.355959855638503	0	0	1	R03B.profile.u50
hydrogen ion transporter activity	GO:0015078	Enables the directed movement of hydrogen ions into, out of, within or between cells.	127	0.313936817125624	0	0	1	R03B.profile.u50
di-, tri-valent inorganic cation transporter activity	GO:0015082	Enables the directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	69	0.170564097493449	0	0	1	R03B.profile.u50
calcium ion transporter activity	GO:0015085	Enables the directed movement of calcium (Ca) ions into, out of, within or between cells.	39	0.0964057942354279	0	0	1	R03B.profile.u50
organic cation transporter activity	GO:0015101	Enables the directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.	12	0.0296633213032086	0	0	1	R03B.profile.u50
inorganic anion transporter activity	GO:0015103	Enables the directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.	41	0.101349681119296	0	0	1	R03B.profile.u50
bicarbonate transporter activity	GO:0015106	Enables the directed movement of bicarbonate into, out of, within or between cells. Bicarbonate is the hydrogencarbonate ion, HCO3-.	15	0.0370791516290107	0	0	1	R03B.profile.u50
chloride transporter activity	GO:0015108	Enables the directed movement of chloride ions into, out of, within or between cells.	18	0.0444949819548129	0	0	1	R03B.profile.u50
phosphate transporter activity	GO:0015114	Enables the directed movement of phosphate (PO4 3-) ions into, out of, within or between cells.	15	0.0370791516290107	0	0	1	R03B.profile.u50
sulfate transporter activity	GO:0015116	Enables the directed movement of sulfate ions (SO4 2-) into, out of, within or between cells.	10	0.0247194344193405	0	0	1	R03B.profile.u50
bile acid transporter activity	GO:0015125	Enables the directed movement of bile acid into, out of, within or between cells. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.	6	0.0148316606516043	0	0	1	R03B.profile.u50
carbohydrate transporter activity	GO:0015144	Enables the directed movement of carbohydrate into, out of, within or between cells.	48	0.118653285212834	0	0	1	R03B.profile.u50
monosaccharide transporter activity	GO:0015145	Enables the directed movement of monosaccharide into, out of, within or between cells.	20	0.049438868838681	0	0	1	R03B.profile.u50
hexose transporter activity	GO:0015149	Enables the directed movement of a hexose sugar, a monosaccharide with 6 carbon atoms, into, out of, within or between cells.	20	0.049438868838681	0	0	1	R03B.profile.u50
pyrimidine nucleotide sugar transporter activity	GO:0015165	Enables the directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.	10	0.0247194344193405	0	0	1	R03B.profile.u50
amino acid transporter activity	GO:0015171	Enables the directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells.	67	0.165620210609581	0	0	1	R03B.profile.u50
acidic amino acid transporter activity	GO:0015172	Enables the directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells.	14	0.0346072081870767	0	0	1	R03B.profile.u50
basic amino acid transporter activity	GO:0015174	Enables the directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells.	12	0.0296633213032086	0	0	1	R03B.profile.u50
neutral amino acid transporter activity	GO:0015175	Enables the directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells.	23	0.0568546991644831	0	0	1	R03B.profile.u50
L-amino acid transporter activity	GO:0015179	Enables the directed movement of L-amino acids into, out of, within or between cells.	40	0.098877737677362	0	0	1	R03B.profile.u50
peptide transporter activity	GO:0015197	Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells.	13	0.0321352647451426	0	0	1	R03B.profile.u50
oligopeptide transporter activity	GO:0015198	Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.	10	0.0247194344193405	0	0	1	R03B.profile.u50
polyamine transporter activity	GO:0015203	Enables the directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells.	26	0.0642705294902853	0	0	1	R03B.profile.u50
drug transporter activity	GO:0015238	Enables the directed movement of a drug into, out of, within or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.	16	0.0395510950709448	0	0	1	R03B.profile.u50
aminophospholipid transporter activity	GO:0015247	Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.	21	0.051910812280615	0	0	1	R03B.profile.u50
sterol transporter activity	GO:0015248	Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	9	0.0222474909774064	0	0	1	R03B.profile.u50
water channel activity	GO:0015250		15	0.0370791516290107	0	0	1	R03B.profile.u50
channel or pore class transporter activity	GO:0015267	Allows facilitated diffusion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without a carrier-mediated mechanism. They do not exhibit stereospecificity but may be specific for a particular molecular species or class of molecules.	458	1.13215009640579	0	0	1	R03B.profile.u50
alpha-type channel activity	GO:0015268	Allows the movement of solutes by energy-independent process by passage through a transmembrane aqueous pore. Usually consist of alpha-helical membrane spanners, although beta-strands may be present and contribute to channel.	440	1.08765511445098	0	0	1	R03B.profile.u50
calcium-activated potassium channel activity	GO:0015269	The transporter activity that allows the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.	12	0.0296633213032086	0	0	1	R03B.profile.u50
dihydropyridine-sensitive calcium channel activity	GO:0015270		13	0.0321352647451426	0	0	1	R03B.profile.u50
ligand-gated ion channel activity	GO:0015276		143	0.353487912196569	0	0	1	R03B.profile.u50
kainate selective glutamate receptor activity	GO:0015277		14	0.0346072081870767	0	0	1	R03B.profile.u50
calcium-release channel activity	GO:0015278		14	0.0346072081870767	0	0	1	R03B.profile.u50
store-operated calcium channel activity	GO:0015279		10	0.0247194344193405	0	0	1	R03B.profile.u50
amiloride-sensitive sodium channel activity	GO:0015280		11	0.0271913778612745	0	0	1	R03B.profile.u50
connexon channel activity	GO:0015285		15	0.0370791516290107	0	0	1	R03B.profile.u50
porin activity	GO:0015288	Allows the energy independent passage of small (less than 1000 Da) solutes across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.	29	0.0716863598160874	0	0	1	R03B.profile.u50
electrochemical potential-driven transporter activity	GO:0015290	Catalysis of the carrier-mediated transfer of one or more substances across a membrane. Transport occurs in three ways: uniport, a single species is transported by facilitated diffusion in a process not coupled to the utilization of a primary source of energy; antiport, two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy; and symport, two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.	240	0.593266426064172	0	0	1	R03B.profile.u50
porter activity	GO:0015291	A transporter of solutes that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane.	238	0.588322539180304	0	0	1	R03B.profile.u50
symporter activity	GO:0015293	Catalyze the transport of two or more molecular species across a membrane, transport being in the same direction.	133	0.328768477777228	0	0	1	R03B.profile.u50
solute:cation symporter activity	GO:0015294	Catalysis of the reaction: solute(out) + cation(out) = solute(in) + cation(in).	64	0.158204380283779	0	0	1	R03B.profile.u50
anion:cation symporter activity	GO:0015296	Catalysis of the reaction: anion(out) + cation(out) = anion(in) + cation(in).	45	0.111237454887032	0	0	1	R03B.profile.u50
antiporter activity	GO:0015297	Catalysis of the exchange of one or more molecular species for another across a membrane.	52	0.128541058980571	0	0	1	R03B.profile.u50
solute:cation antiporter activity	GO:0015298	Catalysis of the reaction: solute(out) + cation(in) = solute(in) + cation(out).	11	0.0271913778612745	0	0	1	R03B.profile.u50
solute:hydrogen antiporter activity	GO:0015299	Catalysis of the reaction: solute(out) + H+(in) = solute(in) + H+(out).	11	0.0271913778612745	0	0	1	R03B.profile.u50
solute:solute antiporter activity	GO:0015300	Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).	21	0.051910812280615	0	0	1	R03B.profile.u50
anion:anion antiporter activity	GO:0015301	Catalysis of the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).	17	0.0420230385128788	0	0	1	R03B.profile.u50
drug:hydrogen antiporter activity	GO:0015307	Catalysis of the reaction: H+(out) + drug(in) = H+(in) + drug(out).	2	0.0049438868838681	0	0	1	R03B.profile.u50
amino acid permease activity	GO:0015359	Catalysis of the stereospecific transfer of amino acids, organic acids containing one or more amino substituents, across a biological membrane.	16	0.0395510950709448	0	0	1	R03B.profile.u50
calcium:cation antiporter activity	GO:0015368	Catalysis of the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in).	11	0.0271913778612745	0	0	1	R03B.profile.u50
solute:sodium symporter activity	GO:0015370	Catalysis of the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).	59	0.145844663074109	0	0	1	R03B.profile.u50
cation:chloride symporter activity	GO:0015377	Catalysis of the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).	12	0.0296633213032086	0	0	1	R03B.profile.u50
anion exchanger activity	GO:0015380		15	0.0370791516290107	0	0	1	R03B.profile.u50
sodium:hydrogen antiporter activity	GO:0015385	Catalysis of the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).	8	0.0197755475354724	0	0	1	R03B.profile.u50
primary active transporter activity	GO:0015399	Catalysis of transport of a solute against a concentration gradient using a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources.	139	0.343600138428833	0	0	1	R03B.profile.u50
P-P-bond-hydrolysis-driven transporter activity	GO:0015405	Catalysis of the transport of a solute, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.	139	0.343600138428833	0	0	1	R03B.profile.u50
protein translocase activity	GO:0015450		14	0.0346072081870767	0	0	1	R03B.profile.u50
auxiliary transport protein activity	GO:0015457	Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation.	57	0.140900776190241	0	0	1	R03B.profile.u50
potassium channel regulator activity	GO:0015459		29	0.0716863598160874	0	0	1	R03B.profile.u50
acetylcholine receptor activity	GO:0015464	Combining with acetylcholine to initiate a change in cell activity.	25	0.0617985860483512	0	0	1	R03B.profile.u50
cholesterol binding	GO:0015485	Interacting selectively with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.	8	0.0197755475354724	0	0	1	R03B.profile.u50
cation:cation antiporter activity	GO:0015491	Catalysis of the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out).	19	0.0469669253967469	0	0	1	R03B.profile.u50
tetracycline:hydrogen antiporter activity	GO:0015520	Catalysis of the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out).	2	0.0049438868838681	0	0	1	R03B.profile.u50
tubulin binding	GO:0015631	Interacting selectively with monomeric or multimeric forms of tubulin, including microtubules.	99	0.244722400751471	0	0	1	R03B.profile.u50
fatty-acid ligase activity	GO:0015645	Catalysis of the ligation of a long-chain carboxylic acid to an acceptor, coupled to the hydrolysis of ATP.	16	0.0395510950709448	0	0	1	R03B.profile.u50
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO:0015662	Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.	77	0.190339645028922	0	0	1	R03B.profile.u50
mannosidase activity	GO:0015923	Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative.	22	0.0543827557225491	0	0	1	R03B.profile.u50
mannosyl-oligosaccharide mannosidase activity	GO:0015924	Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides.	17	0.0420230385128788	0	0	1	R03B.profile.u50
galactosidase activity	GO:0015925	Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative.	7	0.0173036040935383	0	0	1	R03B.profile.u50
glucosidase activity	GO:0015926	Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.	12	0.0296633213032086	0	0	1	R03B.profile.u50
hexosaminidase activity	GO:0015929	Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides.	24	0.0593266426064172	0	0	1	R03B.profile.u50
nucleobase, nucleoside, nucleotide and nucleic acid transporter activity	GO:0015932	Enables the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells.	16	0.0395510950709448	0	0	1	R03B.profile.u50
cyclosporin A binding	GO:0016018	Interacting selectively with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.	14	0.0346072081870767	0	0	1	R03B.profile.u50
lipoxygenase activity	GO:0016165	Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.	11	0.0271913778612745	0	0	1	R03B.profile.u50
AMP binding	GO:0016208	Interacting selectively with AMP, adenosine monophosphate.	19	0.0469669253967469	0	0	1	R03B.profile.u50
antioxidant activity	GO:0016209	Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.	57	0.140900776190241	0	0	1	R03B.profile.u50
steroid dehydrogenase activity	GO:0016229		20	0.049438868838681	0	0	1	R03B.profile.u50
channel regulator activity	GO:0016247		53	0.131013002422505	0	0	1	R03B.profile.u50
channel inhibitor activity	GO:0016248		13	0.0321352647451426	0	0	1	R03B.profile.u50
general RNA polymerase II transcription factor activity	GO:0016251	Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF).	38	0.0939338507934939	0	0	1	R03B.profile.u50
lysine N-methyltransferase activity	GO:0016278	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.	21	0.051910812280615	0	0	1	R03B.profile.u50
protein-lysine N-methyltransferase activity	GO:0016279	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.	21	0.051910812280615	0	0	1	R03B.profile.u50
alanine aminopeptidase activity	GO:0016284	Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide.	13	0.0321352647451426	0	0	1	R03B.profile.u50
CoA hydrolase activity	GO:0016289	Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group.	11	0.0271913778612745	0	0	1	R03B.profile.u50
palmitoyl-CoA hydrolase activity	GO:0016290	Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.	5	0.0123597172096702	0	0	1	R03B.profile.u50
acyl-CoA thioesterase activity	GO:0016291	Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA.	8	0.0197755475354724	0	0	1	R03B.profile.u50
lipase activity	GO:0016298	Catalysis of the hydrolysis of a lipid or phospholipid.	96	0.237306570425669	0	0	1	R03B.profile.u50
regulator of G-protein signaling activity	GO:0016299	Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form.	9	0.0222474909774064	0	0	1	R03B.profile.u50
kinase activity	GO:0016301	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	1123	2.77599248529194	4	1.44092609082814	0.302664336381521	R03B.profile.u50
1-phosphatidylinositol-3-kinase activity	GO:0016303	Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.	16	0.0395510950709448	0	0	1	R03B.profile.u50
phosphatidylinositol phosphate kinase activity	GO:0016307	Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate.	10	0.0247194344193405	0	0	1	R03B.profile.u50
1-phosphatidylinositol-4-phosphate 5-kinase activity	GO:0016308	Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.	7	0.0173036040935383	0	0	1	R03B.profile.u50
CoA-ligase activity	GO:0016405	Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.	7	0.0173036040935383	0	0	1	R03B.profile.u50
carnitine O-acyltransferase activity	GO:0016406	Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule.	9	0.0222474909774064	0	0	1	R03B.profile.u50
acetyltransferase activity	GO:0016407	Catalysis of the transfer of an acetyl group to an acceptor molecule.	81	0.200227418796658	0	0	1	R03B.profile.u50
C-acyltransferase activity	GO:0016408	Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule.	23	0.0568546991644831	0	0	1	R03B.profile.u50
palmitoyltransferase activity	GO:0016409	Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.	20	0.049438868838681	0	0	1	R03B.profile.u50
N-acyltransferase activity	GO:0016410	Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.	76	0.187867701586988	0	0	1	R03B.profile.u50
acylglycerol O-acyltransferase activity	GO:0016411	Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule.	13	0.0321352647451426	0	0	1	R03B.profile.u50
S-acyltransferase activity	GO:0016417	Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule.	9	0.0222474909774064	0	0	1	R03B.profile.u50
CoA carboxylase activity	GO:0016421		12	0.0296633213032086	0	0	1	R03B.profile.u50
tRNA-pseudouridine synthase activity	GO:0016439	Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.	25	0.0617985860483512	0	0	1	R03B.profile.u50
RNA polymerase II transcription mediator activity	GO:0016455	Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex.	12	0.0296633213032086	0	0	1	R03B.profile.u50
pyrophosphatase activity	GO:0016462	Catalysis of the hydrolysis of a pyrophosphate bond between two phosphoric groups, leaving one phosphate on each of the two fragments.	816	2.01710584861818	1	0.495759803921569	0.867291866953237	R03B.profile.u50
oxidoreductase activity	GO:0016491	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.	874	2.16047856825036	0	0	1	R03B.profile.u50
C-C chemokine receptor activity	GO:0016493	Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.	18	0.0444949819548129	0	0	1	R03B.profile.u50
C-X-C chemokine receptor activity	GO:0016494	Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.	15	0.0370791516290107	0	0	1	R03B.profile.u50
protein-hormone receptor activity	GO:0016500	Combining with a protein hormone to initiate a change in cell activity.	22	0.0543827557225491	0	0	1	R03B.profile.u50
nucleotide receptor activity	GO:0016502	Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.	22	0.0543827557225491	0	0	1	R03B.profile.u50
pheromone receptor activity	GO:0016503	Combining with a pheromone to initiate a change in cell activity.	1	0.00247194344193405	0	0	1	R03B.profile.u50
protease activator activity	GO:0016504	Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.	27	0.0667424729322193	0	0	1	R03B.profile.u50
apoptotic protease activator activity	GO:0016505		26	0.0642705294902853	0	0	1	R03B.profile.u50
latrotoxin receptor activity	GO:0016524	Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity.	13	0.0321352647451426	0	0	1	R03B.profile.u50
cyclin-dependent protein kinase regulator activity	GO:0016538	Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.	7	0.0173036040935383	0	0	1	R03B.profile.u50
transcriptional activator activity	GO:0016563	Any transcription regulator activity required for initiation or upregulation of transcription.	471	1.16428536115094	3	2.57668789808917	0.112642513573837	R03B.profile.u50
transcriptional repressor activity	GO:0016564	Any transcription regulator activity that prevents or downregulates transcription.	329	0.813269392396302	0	0	1	R03B.profile.u50
specific transcriptional repressor activity	GO:0016566	Any activity that stops or downregulates transcription of specific genes or sets of genes.	21	0.051910812280615	0	0	1	R03B.profile.u50
amino acid binding	GO:0016597	Interacting selectively with an amino acid, organic acids containing one or more amino substituents.	18	0.0444949819548129	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on CH-OH group of donors	GO:0016614	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	133	0.328768477777228	0	0	1	R03B.profile.u50
malate dehydrogenase activity	GO:0016615	Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.	12	0.0296633213032086	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0016616	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.	123	0.304049043357888	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0016620	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.	39	0.0964057942354279	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	GO:0016624	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide.	10	0.0247194344193405	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-CH group of donors	GO:0016627	Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	64	0.158204380283779	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	GO:0016628	Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.	21	0.051910812280615	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	GO:0016634	Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen.	13	0.0321352647451426	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-NH2 group of donors	GO:0016638	Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	23	0.0568546991644831	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	GO:0016641	Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.	18	0.0444949819548129	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-NH group of donors	GO:0016645	Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	38	0.0939338507934939	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	GO:0016646	Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.	22	0.0543827557225491	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on NADH or NADPH	GO:0016651	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	77	0.190339645028922	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	GO:0016653	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein.	14	0.0346072081870767	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	GO:0016655	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.	45	0.111237454887032	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on sulfur group of donors	GO:0016667	Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	14	0.0346072081870767	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	GO:0016668	Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP.	7	0.0173036040935383	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on heme group of donors	GO:0016675	Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	36	0.0889899639096258	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	GO:0016676	Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen.	36	0.0889899639096258	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on diphenols and related substances as donors	GO:0016679	Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	10	0.0247194344193405	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	GO:0016681	Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome.	10	0.0247194344193405	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on peroxide as acceptor	GO:0016684	Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.	39	0.0964057942354279	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	GO:0016701	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.	63	0.155732436841845	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO:0016702	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.	63	0.155732436841845	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.	163	0.40292678103525	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	GO:0016706	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.	36	0.0889899639096258	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	GO:0016709	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.	35	0.0865180204676917	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.	55	0.135956889306373	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	GO:0016714	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor.	5	0.0123597172096702	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	GO:0016717	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.	13	0.0321352647451426	0	0	1	R03B.profile.u50
oxidoreductase activity, oxidizing metal ions	GO:0016722	Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered.	11	0.0271913778612745	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on CH2 groups	GO:0016725	Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	7	0.0173036040935383	0	0	1	R03B.profile.u50
transferase activity	GO:0016740	Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.	2063	5.09961932070994	5	0.980465341735337	0.57704307078587	R03B.profile.u50
transferase activity, transferring one-carbon groups	GO:0016741	Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).	161	0.397982894151382	0	0	1	R03B.profile.u50
hydroxymethyl-, formyl- and related transferase activity	GO:0016742		9	0.0222474909774064	0	0	1	R03B.profile.u50
transferase activity, transferring acyl groups	GO:0016746	Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).	207	0.511692292480348	0	0	1	R03B.profile.u50
transferase activity, transferring groups other than amino-acyl groups	GO:0016747	Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).	194	0.479557027735205	0	0	1	R03B.profile.u50
transferase activity, transferring amino-acyl groups	GO:0016755	Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor).	19	0.0469669253967469	0	0	1	R03B.profile.u50
transferase activity, transferring glycosyl groups	GO:0016757	Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).	270	0.667424729322193	1	1.4982962962963	0.487395665600401	R03B.profile.u50
transferase activity, transferring hexosyl groups	GO:0016758	Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).	188	0.464725367083601	0	0	1	R03B.profile.u50
transferase activity, transferring pentosyl groups	GO:0016763	Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).	55	0.135956889306373	1	7.35527272727273	0.127266645466854	R03B.profile.u50
transferase activity, transferring alkyl or aryl (other than methyl) groups	GO:0016765	Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).	50	0.123597172096702	0	0	1	R03B.profile.u50
transferase activity, transferring nitrogenous groups	GO:0016769	Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).	46	0.113709398328966	0	0	1	R03B.profile.u50
transferase activity, transferring phosphorus-containing groups	GO:0016772	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).	1266	3.12948039748851	4	1.27816745655608	0.381786418295003	R03B.profile.u50
phosphotransferase activity, alcohol group as acceptor	GO:0016773	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).	993	2.45463983784051	3	1.2221752265861	0.44464520828111	R03B.profile.u50
phosphotransferase activity, nitrogenous group as acceptor	GO:0016775	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor).	17	0.0420230385128788	0	0	1	R03B.profile.u50
phosphotransferase activity, phosphate group as acceptor	GO:0016776	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).	44	0.108765511445098	0	0	1	R03B.profile.u50
diphosphotransferase activity	GO:0016778	Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor).	7	0.0173036040935383	0	0	1	R03B.profile.u50
nucleotidyltransferase activity	GO:0016779	Catalysis of the transfer of a nucleotidyl group to a reactant.	129	0.318880704009492	0	0	1	R03B.profile.u50
phosphotransferase activity, for other substituted phosphate groups	GO:0016780	Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).	16	0.0395510950709448	0	0	1	R03B.profile.u50
transferase activity, transferring sulfur-containing groups	GO:0016782	Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor).	53	0.131013002422505	0	0	1	R03B.profile.u50
hydrolase activity	GO:0016787	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.	2507	6.19716220892866	2	0.322728360590347	0.985433283982697	R03B.profile.u50
hydrolase activity, acting on ester bonds	GO:0016788	Catalysis of the hydrolysis of any ester bond.	774	1.91328422405695	1	0.52266149870801	0.85275433454693	R03B.profile.u50
thiolester hydrolase activity	GO:0016790	Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.	91	0.224946853215998	0	0	1	R03B.profile.u50
phosphoric monoester hydrolase activity	GO:0016791	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.	328	0.810797448954368	1	1.23335365853659	0.555942502562463	R03B.profile.u50
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016796	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.	25	0.0617985860483512	0	0	1	R03B.profile.u50
hydrolase activity, acting on glycosyl bonds	GO:0016798	Catalysis of the hydrolysis of any glycosyl bond.	133	0.328768477777228	0	0	1	R03B.profile.u50
hydrolase activity, hydrolyzing N-glycosyl compounds	GO:0016799		22	0.0543827557225491	0	0	1	R03B.profile.u50
hydrolase activity, acting on ether bonds	GO:0016801	Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively.	12	0.0296633213032086	0	0	1	R03B.profile.u50
dipeptidase activity	GO:0016805	Catalysis of the hydrolysis of a dipeptide.	12	0.0296633213032086	0	0	1	R03B.profile.u50
dipeptidyl-peptidase and tripeptidyl-peptidase activity	GO:0016806	Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain.	12	0.0296633213032086	0	0	1	R03B.profile.u50
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO:0016810	Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.	120	0.296633213032086	0	0	1	R03B.profile.u50
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	GO:0016811	Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.	58	0.143372719632175	0	0	1	R03B.profile.u50
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO:0016812	Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.	7	0.0173036040935383	0	0	1	R03B.profile.u50
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	GO:0016813	Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2.	19	0.0469669253967469	0	0	1	R03B.profile.u50
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	GO:0016814	Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.	30	0.0741583032580215	0	0	1	R03B.profile.u50
hydrolase activity, acting on acid anhydrides	GO:0016817	Catalysis of the hydrolysis of any acid anhydride.	820	2.02699362238592	1	0.493341463414634	0.868599197481348	R03B.profile.u50
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.	818	2.02204973550205	1	0.494547677261614	0.867947150037962	R03B.profile.u50
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	GO:0016820	Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane.	180	0.444949819548129	0	0	1	R03B.profile.u50
lyase activity	GO:0016829	Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.	190	0.469669253967469	1	2.12915789473684	0.375154406582244	R03B.profile.u50
carbon-carbon lyase activity	GO:0016830	Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.	50	0.123597172096702	0	0	1	R03B.profile.u50
carboxy-lyase activity	GO:0016831	Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.	38	0.0939338507934939	0	0	1	R03B.profile.u50
carbon-oxygen lyase activity	GO:0016835	Catalysis of the breakage of a carbon-oxygen bond.	69	0.170564097493449	0	0	1	R03B.profile.u50
hydro-lyase activity	GO:0016836	Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.	60	0.148316606516043	0	0	1	R03B.profile.u50
carbon-nitrogen lyase activity	GO:0016840	Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).	11	0.0271913778612745	0	0	1	R03B.profile.u50
carbon-sulfur lyase activity	GO:0016846	Catalysis of the elimination of H2S or substituted H2S.	12	0.0296633213032086	0	0	1	R03B.profile.u50
1-aminocyclopropane-1-carboxylate synthase activity	GO:0016847	Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.	5	0.0123597172096702	0	0	1	R03B.profile.u50
phosphorus-oxygen lyase activity	GO:0016849		31	0.0766302466999555	1	13.0496774193548	0.0738555990020986	R03B.profile.u50
isomerase activity	GO:0016853	Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.	189	0.467197310525535	2	4.28084656084656	0.0802311961363017	R03B.profile.u50
racemase and epimerase activity	GO:0016854	Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule.	14	0.0346072081870767	0	0	1	R03B.profile.u50
racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0016857	Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.	6	0.0148316606516043	0	0	1	R03B.profile.u50
cis-trans isomerase activity	GO:0016859	Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers.	58	0.143372719632175	1	6.9748275862069	0.133722702603265	R03B.profile.u50
intramolecular oxidoreductase activity	GO:0016860	Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.	56	0.138428832748307	1	7.22392857142857	0.12942399295915	R03B.profile.u50
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	GO:0016861		8	0.0197755475354724	0	0	1	R03B.profile.u50
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	GO:0016862		18	0.0444949819548129	0	0	1	R03B.profile.u50
intramolecular oxidoreductase activity, transposing C=C bonds	GO:0016863		18	0.0444949819548129	0	0	1	R03B.profile.u50
intramolecular oxidoreductase activity, transposing S-S bonds	GO:0016864		17	0.0420230385128788	0	0	1	R03B.profile.u50
intramolecular transferase activity	GO:0016866	Catalysis of the transfer of a functional group from one position to another within a single molecule.	38	0.0939338507934939	0	0	1	R03B.profile.u50
intramolecular transferase activity, phosphotransferases	GO:0016868	Catalysis of the transfer of a phosphate group from one position to another within a single molecule.	7	0.0173036040935383	0	0	1	R03B.profile.u50
ligase activity	GO:0016874	Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.	425	1.05057596282197	0	0	1	R03B.profile.u50
ligase activity, forming carbon-oxygen bonds	GO:0016875	Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	54	0.133484945864439	0	0	1	R03B.profile.u50
ligase activity, forming aminoacyl-tRNA and related compounds	GO:0016876	Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound.	54	0.133484945864439	0	0	1	R03B.profile.u50
ligase activity, forming carbon-sulfur bonds	GO:0016877	Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	23	0.0568546991644831	0	0	1	R03B.profile.u50
acid-thiol ligase activity	GO:0016878	Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	8	0.0197755475354724	0	0	1	R03B.profile.u50
ligase activity, forming carbon-nitrogen bonds	GO:0016879	Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	266	0.657536955554457	0	0	1	R03B.profile.u50
acid-amino acid ligase activity	GO:0016881	Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	222	0.548771444109359	0	0	1	R03B.profile.u50
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	GO:0016884	Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.	9	0.0222474909774064	0	0	1	R03B.profile.u50
ligase activity, forming carbon-carbon bonds	GO:0016885	Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	13	0.0321352647451426	0	0	1	R03B.profile.u50
ligase activity, forming phosphoric ester bonds	GO:0016886	Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.	10	0.0247194344193405	0	0	1	R03B.profile.u50
ATPase activity	GO:0016887	Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction.	431	1.06540762347357	0	0	1	R03B.profile.u50
endoribonuclease activity, producing 5'-phosphomonoesters	GO:0016891	Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.	30	0.0741583032580215	0	0	1	R03B.profile.u50
endoribonuclease activity, producing 3'-phosphomonoesters	GO:0016892	Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.	15	0.0370791516290107	0	0	1	R03B.profile.u50
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016893	Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.	31	0.0766302466999555	0	0	1	R03B.profile.u50
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	GO:0016894	Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters.	18	0.0444949819548129	0	0	1	R03B.profile.u50
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	GO:0016895	Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.	12	0.0296633213032086	0	0	1	R03B.profile.u50
exoribonuclease activity, producing 5'-phosphomonoesters	GO:0016896	Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.	15	0.0370791516290107	0	0	1	R03B.profile.u50
oxidoreductase activity, acting on the aldehyde or oxo group of donors	GO:0016903	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	51	0.126069115538636	0	0	1	R03B.profile.u50
SAP kinase activity	GO:0016909	Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines.	14	0.0346072081870767	0	0	1	R03B.profile.u50
GABA receptor activity	GO:0016917	Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.	27	0.0667424729322193	0	0	1	R03B.profile.u50
retinal binding	GO:0016918	Interacting selectively with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.	8	0.0197755475354724	0	0	1	R03B.profile.u50
transcription initiation factor activity	GO:0016986		10	0.0247194344193405	0	0	1	R03B.profile.u50
alpha-sialidase activity	GO:0016997	Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids.	5	0.0123597172096702	0	0	1	R03B.profile.u50
activin receptor activity	GO:0017002	Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity.	10	0.0247194344193405	0	0	1	R03B.profile.u50
Ras GTPase binding	GO:0017016	Interacting selectively with any member of the Ras superfamily of monomeric GTPases.	89	0.22000296633213	0	0	1	R03B.profile.u50
MAP kinase phosphatase activity	GO:0017017	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).	14	0.0346072081870767	1	28.8957142857143	0.0340566132519083	R03B.profile.u50
myosin binding	GO:0017022	Interacting selectively with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.	30	0.0741583032580215	0	0	1	R03B.profile.u50
ceramidase activity	GO:0017040	Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.	9	0.0222474909774064	0	0	1	R03B.profile.u50
Rho GTPase binding	GO:0017048	Interacting selectively with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.	29	0.0716863598160874	0	0	1	R03B.profile.u50
snRNA binding	GO:0017069	Interacting selectively with a small nuclear RNA (snRNA).	7	0.0173036040935383	0	0	1	R03B.profile.u50
purine nucleotide binding	GO:0017076	Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.	2328	5.75468433282247	4	0.695085910652921	0.825869553136222	R03B.profile.u50
nucleoside-diphosphatase activity	GO:0017110	Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.	9	0.0222474909774064	0	0	1	R03B.profile.u50
nucleoside-triphosphatase activity	GO:0017111	Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.	787	1.9454194888021	1	0.514027954256671	0.857416565041311	R03B.profile.u50
SH3 domain binding	GO:0017124	Interacting selectively with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.	21	0.051910812280615	0	0	1	R03B.profile.u50
Rab GTPase binding	GO:0017137	Interacting selectively with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.	23	0.0568546991644831	0	0	1	R03B.profile.u50
sodium:dicarboxylate symporter activity	GO:0017153	Catalysis of the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).	15	0.0370791516290107	0	0	1	R03B.profile.u50
semaphorin receptor activity	GO:0017154		13	0.0321352647451426	0	0	1	R03B.profile.u50
CDP-alcohol phosphatidyltransferase activity	GO:0017169	Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol.	9	0.0222474909774064	0	0	1	R03B.profile.u50
serine hydrolase activity	GO:0017171	Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).	182	0.449893706431997	0	0	1	R03B.profile.u50
histone-lysine N-methyltransferase activity	GO:0018024	Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.	21	0.051910812280615	0	0	1	R03B.profile.u50
guanyl nucleotide binding	GO:0019001	Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.	460	1.13709398328966	0	0	1	R03B.profile.u50
GMP binding	GO:0019002	Interacting selectively with GMP, guanosine monophosphate.	11	0.0271913778612745	0	0	1	R03B.profile.u50
DNA N-glycosylase activity	GO:0019104	Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.	19	0.0469669253967469	0	0	1	R03B.profile.u50
transmembrane receptor protein phosphatase activity	GO:0019198	The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner.	32	0.0791021901418896	0	0	1	R03B.profile.u50
transmembrane receptor protein kinase activity	GO:0019199		163	0.40292678103525	0	0	1	R03B.profile.u50
carbohydrate kinase activity	GO:0019200	Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.	34	0.0840460770257577	0	0	1	R03B.profile.u50
nucleotide kinase activity	GO:0019201	Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.	33	0.0815741335838236	0	0	1	R03B.profile.u50
carbohydrate phosphatase activity	GO:0019203	Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate.	8	0.0197755475354724	0	0	1	R03B.profile.u50
nucleobase, nucleoside, nucleotide kinase activity	GO:0019205	Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate.	54	0.133484945864439	0	0	1	R03B.profile.u50
nucleoside kinase activity	GO:0019206	Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.	20	0.049438868838681	0	0	1	R03B.profile.u50
kinase regulator activity	GO:0019207	Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	123	0.304049043357888	1	3.28894308943089	0.262452996931924	R03B.profile.u50
phosphatase regulator activity	GO:0019208	Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.	77	0.190339645028922	0	0	1	R03B.profile.u50
kinase activator activity	GO:0019209	Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	19	0.0469669253967469	0	0	1	R03B.profile.u50
kinase inhibitor activity	GO:0019210	Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	65	0.160676323725713	1	6.22369230769231	0.148601717620338	R03B.profile.u50
phosphatase inhibitor activity	GO:0019212	Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.	37	0.0914619073515598	0	0	1	R03B.profile.u50
deacetylase activity	GO:0019213	Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.	18	0.0444949819548129	0	0	1	R03B.profile.u50
deaminase activity	GO:0019239	Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).	26	0.0642705294902853	0	0	1	R03B.profile.u50
small conjugating protein-specific protease activity	GO:0019783	Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups.	80	0.197755475354724	0	0	1	R03B.profile.u50
small conjugating protein ligase activity	GO:0019787	Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.	201	0.496860631828744	0	0	1	R03B.profile.u50
procollagen-proline dioxygenase activity	GO:0019798	Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule.	7	0.0173036040935383	0	0	1	R03B.profile.u50
oxygen binding	GO:0019825	Interacting selectively with oxygen (O2).	56	0.138428832748307	0	0	1	R03B.profile.u50
cation-transporting ATPase activity	GO:0019829	Catalysis of the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).	86	0.212587136006328	0	0	1	R03B.profile.u50
growth factor binding	GO:0019838	Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.	114	0.281801552380482	1	3.54859649122807	0.245839769442211	R03B.profile.u50
isoprenoid binding	GO:0019840	Interacting selectively with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.	13	0.0321352647451426	0	0	1	R03B.profile.u50
retinol binding	GO:0019841	Interacting selectively with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.	6	0.0148316606516043	0	0	1	R03B.profile.u50
vitamin binding	GO:0019842	Interacting selectively with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.	94	0.232362683541801	0	0	1	R03B.profile.u50
rRNA binding	GO:0019843	Interacting selectively with ribosomal RNA.	22	0.0543827557225491	0	0	1	R03B.profile.u50
IgG binding	GO:0019864	Interacting selectively with an immunoglobulin of an IgG isotype.	8	0.0197755475354724	0	0	1	R03B.profile.u50
immunoglobulin binding	GO:0019865	Interacting selectively with an immunoglobulin.	23	0.0568546991644831	0	0	1	R03B.profile.u50
protein kinase regulator activity	GO:0019887	Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.	103	0.254610174519207	1	3.92757281553398	0.225025679531416	R03B.profile.u50
protein phosphatase regulator activity	GO:0019888	Modulation of the activity of a protein phosphatase enzyme.	72	0.177979927819252	0	0	1	R03B.profile.u50
kinesin binding	GO:0019894	Interacting selectively and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules.	16	0.0395510950709448	1	25.28375	0.0388262256909156	R03B.profile.u50
enzyme binding	GO:0019899	Interacting selectively with any enzyme.	411	1.01596875463489	5	4.92141119221411	0.00385140171742658	R03B.profile.u50
kinase binding	GO:0019900	Interacting selectively with a kinase, any enzyme that catalyzes the transfer of a phosphate group.	149	0.368319572848173	3	8.14510067114094	0.00623942980928371	R03B.profile.u50
protein kinase binding	GO:0019901	Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.	130	0.321352647451426	3	9.33553846153846	0.00427729907826354	R03B.profile.u50
phosphatase binding	GO:0019902	Interacting selectively with any phosphatase.	32	0.0791021901418896	0	0	1	R03B.profile.u50
protein phosphatase binding	GO:0019903	Interacting selectively with any protein phosphatase.	20	0.049438868838681	0	0	1	R03B.profile.u50
protein domain specific binding	GO:0019904	Interacting selectively with a specific domain of a protein.	133	0.328768477777228	0	0	1	R03B.profile.u50
syntaxin binding	GO:0019905	Interacting selectively with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.	14	0.0346072081870767	0	0	1	R03B.profile.u50
cytokine binding	GO:0019955	Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	110	0.271913778612745	1	3.67763636363636	0.238336491885323	R03B.profile.u50
chemokine binding	GO:0019956	Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	35	0.0865180204676917	0	0	1	R03B.profile.u50
C-C chemokine binding	GO:0019957	Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.	18	0.0444949819548129	0	0	1	R03B.profile.u50
C-X-C chemokine binding	GO:0019958	Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.	16	0.0395510950709448	0	0	1	R03B.profile.u50
interleukin binding	GO:0019965	Interacting selectively with an interleukin.	50	0.123597172096702	1	8.0908	0.116399451712513	R03B.profile.u50
interleukin-1 binding	GO:0019966	Interacting selectively with interleukin-1.	13	0.0321352647451426	0	0	1	R03B.profile.u50
diacylglycerol binding	GO:0019992	Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids.	83	0.205171305680526	1	4.87397590361446	0.185699087804022	R03B.profile.u50
heme binding	GO:0020037	Interacting selectively with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.	145	0.358431799080437	0	0	1	R03B.profile.u50
extracellular matrix structural constituent conferring compression resistance	GO:0030021	A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.	7	0.0173036040935383	0	0	1	R03B.profile.u50
manganese ion binding	GO:0030145	Interacting selectively with manganese (Mn) ions.	166	0.410342611361052	0	0	1	R03B.profile.u50
molybdenum ion binding	GO:0030151	Interacting selectively with molybdenum (Mo) ions.	9	0.0222474909774064	0	0	1	R03B.profile.u50
receptor signaling complex scaffold activity	GO:0030159	Functions to provide a physical suport for the assembly of a multiprotein receptor signaling complex.	40	0.098877737677362	1	10.1135	0.094257427418219	R03B.profile.u50
PDZ domain binding	GO:0030165	Interacting selectively with a PDZ domain of a protein, a domain found in diverse signaling proteins.	24	0.0593266426064172	0	0	1	R03B.profile.u50
low-density lipoprotein binding	GO:0030169	Interacting selectively with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans).	20	0.049438868838681	0	0	1	R03B.profile.u50
pyridoxal phosphate binding	GO:0030170	Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.	20	0.049438868838681	0	0	1	R03B.profile.u50
chaperone regulator activity	GO:0030188	Modulates the activity of a molecular chaperone.	7	0.0173036040935383	0	0	1	R03B.profile.u50
lipoprotein receptor activity	GO:0030228	Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triacylglycerol, cholesterol, or phospholipid, or a combination of these.	16	0.0395510950709448	0	0	1	R03B.profile.u50
enzyme regulator activity	GO:0030234	Modulates the activity of an enzyme.	1023	2.52879814109853	3	1.18633431085044	0.463719357436781	R03B.profile.u50
carbohydrate binding	GO:0030246	Interacting selectively with any carbohydrate.	357	0.882483808770455	1	1.13316526610644	0.586697841390713	R03B.profile.u50
polysaccharide binding	GO:0030247	Interacting selectively with any polysaccharide.	174	0.430118158896524	1	2.32494252873563	0.349914021669067	R03B.profile.u50
guanylate cyclase regulator activity	GO:0030249	Modulates the activity of guanylate cyclase.	7	0.0173036040935383	0	0	1	R03B.profile.u50
guanylate cyclase activator activity	GO:0030250	Increases the activity of guanylate cyclase.	6	0.0148316606516043	0	0	1	R03B.profile.u50
LIM domain binding	GO:0030274	Interacting selectively with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.	8	0.0197755475354724	0	0	1	R03B.profile.u50
clathrin binding	GO:0030276	Interacting selectively with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.	11	0.0271913778612745	0	0	1	R03B.profile.u50
structural constituent of epidermis	GO:0030280	The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.	9	0.0222474909774064	0	0	1	R03B.profile.u50
protein kinase activator activity	GO:0030295	Increases the activity of a protein kinase, an enzyme which phosphorylates a protein.	14	0.0346072081870767	0	0	1	R03B.profile.u50
estrogen receptor binding	GO:0030331	Interacting selectively with an estrogen receptor.	6	0.0148316606516043	0	0	1	R03B.profile.u50
fibroblast growth factor receptor antagonist activity	GO:0030353	Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.	10	0.0247194344193405	0	0	1	R03B.profile.u50
ligand-dependent nuclear receptor transcription coactivator activity	GO:0030374		21	0.051910812280615	0	0	1	R03B.profile.u50
protease inhibitor activity	GO:0030414	Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.	157	0.388095120383646	0	0	1	R03B.profile.u50
thiol-disulfide exchange intermediate activity	GO:0030508	Functions as an exchange intermediate in thiol-disulfide exchange reactions.	8	0.0197755475354724	0	0	1	R03B.profile.u50
snoRNA binding	GO:0030515	Interacting selectively with small nucleolar RNA.	8	0.0197755475354724	0	0	1	R03B.profile.u50
transcription regulator activity	GO:0030528	Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor.	1862	4.6027586888812	9	1.95534908700322	0.0449995564972301	R03B.profile.u50
receptor regulator activity	GO:0030545	The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.	22	0.0543827557225491	0	0	1	R03B.profile.u50
receptor inhibitor activity	GO:0030547	The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased.	15	0.0370791516290107	0	0	1	R03B.profile.u50
cyclic nucleotide binding	GO:0030551	Interacting selectively with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.	28	0.0692144163741534	0	0	1	R03B.profile.u50
cAMP binding	GO:0030552	Interacting selectively with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).	17	0.0420230385128788	0	0	1	R03B.profile.u50
cGMP binding	GO:0030553	Interacting selectively with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).	11	0.0271913778612745	0	0	1	R03B.profile.u50
adenyl nucleotide binding	GO:0030554	Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.	1902	4.70163642655856	4	0.850767613038906	0.690905116199566	R03B.profile.u50
neurotransmitter receptor activity	GO:0030594	Combining with a neurotransmitter to initiate a change in cell activity.	105	0.259554061403075	0	0	1	R03B.profile.u50
protein binding, bridging	GO:0030674	Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.	127	0.313936817125624	1	3.18535433070866	0.2697186986707	R03B.profile.u50
caspase activity	GO:0030693	Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.	40	0.098877737677362	0	0	1	R03B.profile.u50
GTPase regulator activity	GO:0030695	Modulates the rate of GTP hydrolysis by a GTPase.	482	1.19147673901221	2	1.67858921161826	0.334375638199422	R03B.profile.u50
GTP-dependent protein binding	GO:0030742	Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.	11	0.0271913778612745	0	0	1	R03B.profile.u50
potassium ion binding	GO:0030955	Interacting selectively with potassium (K+) ions.	127	0.313936817125624	0	0	1	R03B.profile.u50
mismatched DNA binding	GO:0030983	Interacting selectively with double-stranded DNA containing one or more mismatches.	26	0.0642705294902853	0	0	1	R03B.profile.u50
heat shock protein binding	GO:0031072	Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock.	66	0.163148267167647	0	0	1	R03B.profile.u50
phosphopantetheine binding	GO:0031177	Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).	4	0.00988777376773619	0	0	1	R03B.profile.u50
RNA splicing factor activity, transesterification mechanism	GO:0031202	An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced.	38	0.0939338507934939	0	0	1	R03B.profile.u50
small GTPase binding	GO:0031267	Interacting selectively with a small monomeric GTPase.	102	0.252138231077273	0	0	1	R03B.profile.u50
sodium ion binding	GO:0031402	Interacting selectively with sodium ions (Na+).	102	0.252138231077273	0	0	1	R03B.profile.u50
chloride ion binding	GO:0031404	Interacting selectively with chloride ions (Cl-).	80	0.197755475354724	1	5.05675	0.179630392212937	R03B.profile.u50
lipoic acid binding	GO:0031405	Interacting selectively with lipoic acid, 1,2-dithiolane-3-pentanoic acid.	8	0.0197755475354724	0	0	1	R03B.profile.u50
carboxylic acid binding	GO:0031406	Interacting selectively with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).	12	0.0296633213032086	0	0	1	R03B.profile.u50
L-ascorbic acid binding	GO:0031418	Interacting selectivzely with L-ascorbic acid, a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs.	19	0.0469669253967469	0	0	1	R03B.profile.u50
alkali metal ion binding	GO:0031420	Interacting selectively with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen.	213	0.526523953131952	0	0	1	R03B.profile.u50
peptidyl-proline dioxygenase activity	GO:0031543	Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein.	7	0.0173036040935383	0	0	1	R03B.profile.u50
small conjugating protein binding	GO:0032182	Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein.	28	0.0692144163741534	0	0	1	R03B.profile.u50
MHC class I receptor activity	GO:0032393	Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.	32	0.0791021901418896	0	0	1	R03B.profile.u50
MHC class II receptor activity	GO:0032395	Combining with an MHC class II protein complex to initiate a change in cellular activity.	30	0.0741583032580215	0	0	1	R03B.profile.u50
protein complex binding	GO:0032403	Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).	147	0.363375685964305	2	5.50394557823129	0.051811114431537	R03B.profile.u50
mismatch repair complex binding	GO:0032404	Interacting selectively with a mismatch repair complex.	11	0.0271913778612745	0	0	1	R03B.profile.u50
MutLalpha complex binding	GO:0032405	Interacting selectively with the mismatch repair complex MutLalpha.	9	0.0222474909774064	0	0	1	R03B.profile.u50
demethylase activity	GO:0032451	Catalysis of the removal of a methyl group from a substrate.	7	0.0173036040935383	0	0	1	R03B.profile.u50
tumor necrosis factor receptor superfamily binding	GO:0032813	Interacting selectively with any member of the tumor necrosis factor receptor superfamily.	32	0.0791021901418896	0	0	1	R03B.profile.u50
sterol binding	GO:0032934	Interacting selectively with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.	18	0.0444949819548129	0	0	1	R03B.profile.u50
protein complex scaffold	GO:0032947	Functions to provide a physical suport for the assembly of a multiprotein receptor signaling complex.	40	0.098877737677362	1	10.1135	0.094257427418219	R03B.profile.u50
phosphoinositide 3-kinase activity	GO:0035004	Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].	16	0.0395510950709448	0	0	1	R03B.profile.u50
phosphoinositide 3-kinase regulator activity	GO:0035014	Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.	8	0.0197755475354724	0	0	1	R03B.profile.u50
histone acetyltransferase binding	GO:0035035	Interacting selectively with the enzyme histone acetyltransferase.	13	0.0321352647451426	0	0	1	R03B.profile.u50
phosphoinositide binding	GO:0035091	Interacting selectively with any inositol-containing glycerophospholipid.	222	0.548771444109359	1	1.82225225225225	0.422733259034578	R03B.profile.u50
dopamine binding	GO:0035240	Interacting selectively with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.	9	0.0222474909774064	0	0	1	R03B.profile.u50
UDP-galactosyltransferase activity	GO:0035250	Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.	27	0.0667424729322193	0	0	1	R03B.profile.u50
UDP-glucosyltransferase activity	GO:0035251	Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule.	12	0.0296633213032086	0	0	1	R03B.profile.u50
nuclear hormone receptor binding	GO:0035257	Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.	70	0.173036040935383	0	0	1	R03B.profile.u50
steroid hormone receptor binding	GO:0035258	Interacting selectively with a steroid hormone receptor.	48	0.118653285212834	0	0	1	R03B.profile.u50
neurexin binding	GO:0042043	Interacting selectively with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.	4	0.00988777376773619	0	0	1	R03B.profile.u50
histone methyltransferase activity	GO:0042054	Catalysis of the transfer of a methyl group (CH3-) to a histone.	29	0.0716863598160874	0	0	1	R03B.profile.u50
chemoattractant activity	GO:0042056	Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.	4	0.00988777376773619	0	0	1	R03B.profile.u50
telomeric DNA binding	GO:0042162	Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences.	13	0.0321352647451426	0	0	1	R03B.profile.u50
neurotransmitter binding	GO:0042165	Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.	110	0.271913778612745	0	0	1	R03B.profile.u50
acetylcholine binding	GO:0042166	Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.	27	0.0667424729322193	0	0	1	R03B.profile.u50
SH2 domain binding	GO:0042169	Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.	29	0.0716863598160874	0	0	1	R03B.profile.u50
peptide binding	GO:0042277	Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.	254	0.627873634251248	2	3.18535433070866	0.131007658050042	R03B.profile.u50
MHC protein binding	GO:0042287	Interacting selectively with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.	31	0.0766302466999555	0	0	1	R03B.profile.u50
MHC class I protein binding	GO:0042288	Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.	16	0.0395510950709448	0	0	1	R03B.profile.u50
chemokine receptor binding	GO:0042379	Interacting selectively with any chemokine receptor.	56	0.138428832748307	0	0	1	R03B.profile.u50
histone binding	GO:0042393	Interacting selectively with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.	19	0.0469669253967469	0	0	1	R03B.profile.u50
hormone binding	GO:0042562	Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.	26	0.0642705294902853	1	15.5592307692308	0.0623233359141062	R03B.profile.u50
lipid phosphatase activity	GO:0042577	Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.	28	0.0692144163741534	0	0	1	R03B.profile.u50
phosphoric ester hydrolase activity	GO:0042578	Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.	428	1.05799179314777	1	0.94518691588785	0.653302140433057	R03B.profile.u50
peptide antigen binding	GO:0042605	Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.	29	0.0716863598160874	0	0	1	R03B.profile.u50
ATPase activity, coupled	GO:0042623	Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.	377	0.931922677609136	0	0	1	R03B.profile.u50
ATPase activity, coupled to transmembrane movement of ions	GO:0042625	Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane.	125	0.308992930241756	0	0	1	R03B.profile.u50
ATPase activity, coupled to transmembrane movement of substances	GO:0042626	Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance across a membrane.	178	0.440005932664261	0	0	1	R03B.profile.u50
elastase activity	GO:0042708	Catalysis of the hydrolysis of elastin.	8	0.0197755475354724	0	0	1	R03B.profile.u50
identical protein binding	GO:0042802	Interacting selectively with an identical protein or proteins.	463	1.14450981361546	2	1.74747300215983	0.3172961228689	R03B.profile.u50
protein homodimerization activity	GO:0042803	Interacting selectively with an identical protein to form a homodimer.	223	0.551243387551293	1	1.81408071748879	0.424160229769154	R03B.profile.u50
vitamin D receptor binding	GO:0042809	Interacting selectively with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.	6	0.0148316606516043	0	0	1	R03B.profile.u50
Wnt receptor activity	GO:0042813	Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity.	11	0.0271913778612745	0	0	1	R03B.profile.u50
histone deacetylase binding	GO:0042826	Interacting selectively with the enzyme histone deacetylase.	13	0.0321352647451426	0	0	1	R03B.profile.u50
peptidoglycan binding	GO:0042834	Interacting selectively, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.	9	0.0222474909774064	1	44.9488888888889	0.0220287769316943	R03B.profile.u50
antibiotic transporter activity	GO:0042895	The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells.	3	0.00741583032580215	0	0	1	R03B.profile.u50
neuropeptide binding	GO:0042923	Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).	39	0.0964057942354279	0	0	1	R03B.profile.u50
gamma-tubulin binding	GO:0043015	Interacting selectively with the microtubule constituent protein gamma-tubulin.	9	0.0222474909774064	0	0	1	R03B.profile.u50
ribonucleoprotein binding	GO:0043021	Interacting selectively with any complex of RNA and protein.	17	0.0420230385128788	0	0	1	R03B.profile.u50
ribosome binding	GO:0043022	Interacting selectively with any part of a ribosome.	9	0.0222474909774064	0	0	1	R03B.profile.u50
caspase inhibitor activity	GO:0043027	Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	8	0.0197755475354724	0	0	1	R03B.profile.u50
caspase regulator activity	GO:0043028	Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	32	0.0791021901418896	0	0	1	R03B.profile.u50
tumor necrosis factor binding	GO:0043120	Interacting selectively with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.	12	0.0296633213032086	0	0	1	R03B.profile.u50
ubiquitin binding	GO:0043130	Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.	22	0.0543827557225491	0	0	1	R03B.profile.u50
ion binding	GO:0043167	Interacting selectively with ions, charged atoms or groups of atoms.	4408	10.8963266920453	18	1.65193284936479	0.029629764198149	R03B.profile.u50
anion binding	GO:0043168	Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge.	80	0.197755475354724	1	5.05675	0.179630392212937	R03B.profile.u50
cation binding	GO:0043169	Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge.	3965	9.8012557472685	17	1.73447162673392	0.0228334586537539	R03B.profile.u50
amine binding	GO:0043176	Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.	48	0.118653285212834	0	0	1	R03B.profile.u50
ATPase activity, coupled to movement of substances	GO:0043492	Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance.	180	0.444949819548129	0	0	1	R03B.profile.u50
ADP binding	GO:0043531	Interacting selectively with ADP, adenosine 5'-diphosphate.	17	0.0420230385128788	0	0	1	R03B.profile.u50
insulin receptor substrate binding	GO:0043560	Interacting selectively with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.	12	0.0296633213032086	0	0	1	R03B.profile.u50
sequence-specific DNA binding	GO:0043565	Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.	613	1.51530132990557	3	1.97980424143556	0.19485223013042	R03B.profile.u50
structure-specific DNA binding	GO:0043566	Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.	142	0.351015968754635	0	0	1	R03B.profile.u50
purinergic nucleotide receptor activity, G-protein coupled	GO:0045028		22	0.0543827557225491	0	0	1	R03B.profile.u50
bioactive lipid receptor activity	GO:0045125		12	0.0296633213032086	0	0	1	R03B.profile.u50
translation regulator activity	GO:0045182	Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.	132	0.326296534335294	0	0	1	R03B.profile.u50
cadherin binding	GO:0045296	Interacting selectively with cadherin, a type I membrane protein involved in cell adhesion.	13	0.0321352647451426	0	0	1	R03B.profile.u50
protein phosphorylated amino acid binding	GO:0045309	Interacting selectively with a phosphorylated amino acid residue within a protein.	9	0.0222474909774064	0	0	1	R03B.profile.u50
inositol trisphosphate phosphatase activity	GO:0046030	Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate.	9	0.0222474909774064	0	0	1	R03B.profile.u50
SMAD binding	GO:0046332	Interacting selectively with a SMAD signaling protein.	20	0.049438868838681	0	0	1	R03B.profile.u50
glucosyltransferase activity	GO:0046527	Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.	13	0.0321352647451426	0	0	1	R03B.profile.u50
cadmium ion binding	GO:0046870	Interacting selectively with cadmium (Cd) ions.	9	0.0222474909774064	5	224.744444444444	1.15340363639031e-11	R03B.profile.u50
metal ion binding	GO:0046872	Interacting selectively with any metal ion.	4298	10.6244129134325	17	1.60008841321545	0.0430944501464043	R03B.profile.u50
metal ion transporter activity	GO:0046873	Enables the directed movement of metal ions into, out of, within or between cells.	93	0.229890740099867	0	0	1	R03B.profile.u50
ephrin receptor binding	GO:0046875	Interacting selectively with an ephrin receptor.	11	0.0271913778612745	0	0	1	R03B.profile.u50
tetrapyrrole binding	GO:0046906	Interacting selectively with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position.	145	0.358431799080437	0	0	1	R03B.profile.u50
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	GO:0046912	Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.	11	0.0271913778612745	0	0	1	R03B.profile.u50
transition metal ion binding	GO:0046914	Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	2770	6.84728333415732	16	2.33669314079422	0.00191537887277839	R03B.profile.u50
transition metal ion transporter activity	GO:0046915	Enables the directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	28	0.0692144163741534	0	0	1	R03B.profile.u50
alpha(1,3)-fucosyltransferase activity	GO:0046920	Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage.	13	0.0321352647451426	0	0	1	R03B.profile.u50
hydrogen ion transporting ATP synthase activity, rotational mechanism	GO:0046933	Catalysis of the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism.	52	0.128541058980571	0	0	1	R03B.profile.u50
carboxylic acid transporter activity	GO:0046943	Enables the directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).	103	0.254610174519207	0	0	1	R03B.profile.u50
hydrogen ion transporting ATPase activity, rotational mechanism	GO:0046961	Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.	55	0.135956889306373	0	0	1	R03B.profile.u50
thyroid hormone receptor binding	GO:0046966	Interacting selectively with a thyroid hormone receptor.	23	0.0568546991644831	0	0	1	R03B.profile.u50
protein heterodimerization activity	GO:0046982	Interacting selectively with a nonidentical protein to form a heterodimer.	159	0.393039007267514	1	2.54427672955975	0.325325950527263	R03B.profile.u50
protein dimerization activity	GO:0046983	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.	447	1.10495871854452	2	1.81002237136465	0.302833380603367	R03B.profile.u50
protein N-terminus binding	GO:0047485	Interacting selectively with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	20	0.049438868838681	0	0	1	R03B.profile.u50
3',5'-cyclic-GMP phosphodiesterase activity	GO:0047555	Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.	6	0.0148316606516043	0	0	1	R03B.profile.u50
receptor antagonist activity	GO:0048019	Interacts with receptors to reduce the action of another ligand, the agonist.	15	0.0370791516290107	0	0	1	R03B.profile.u50
monosaccharide binding	GO:0048029	Interacting selectively with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.	20	0.049438868838681	0	0	1	R03B.profile.u50
cofactor binding	GO:0048037	Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.	219	0.541355613783557	0	0	1	R03B.profile.u50
activin binding	GO:0048185	Interacting selectively with activin.	12	0.0296633213032086	0	0	1	R03B.profile.u50
calcium-dependent protein binding	GO:0048306	Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.	9	0.0222474909774064	0	0	1	R03B.profile.u50
beta-tubulin binding	GO:0048487	Interacting selectively with the microtubule constituent protein beta-tubulin.	8	0.0197755475354724	0	0	1	R03B.profile.u50
GPI anchor binding	GO:0048503	Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.	146	0.360903742522371	1	2.77082191780822	0.303265281781765	R03B.profile.u50
beta-1,3-galactosyltransferase activity	GO:0048531	Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage.	9	0.0222474909774064	0	0	1	R03B.profile.u50
NADH dehydrogenase (quinone) activity	GO:0050136	Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.	39	0.0964057942354279	0	0	1	R03B.profile.u50
unspecific monooxygenase activity	GO:0050381	Catalysis of the reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.	44	0.108765511445098	0	0	1	R03B.profile.u50
FAD binding	GO:0050660	Interacting selectively with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.	81	0.200227418796658	0	0	1	R03B.profile.u50
NADP binding	GO:0050661	Interacting selectively with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH.	29	0.0716863598160874	0	0	1	R03B.profile.u50
coenzyme binding	GO:0050662	Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	191	0.472141197409403	0	0	1	R03B.profile.u50
androgen receptor binding	GO:0050681	Interacting selectively with an androgen receptor.	42	0.10382162456123	0	0	1	R03B.profile.u50
low-density lipoprotein receptor binding	GO:0050750	Interacting selectively with a low density lipoprotein receptor.	16	0.0395510950709448	0	0	1	R03B.profile.u50
GABA receptor binding	GO:0050811	Interacting selectively with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.	10	0.0247194344193405	0	0	1	R03B.profile.u50
cell adhesion molecule binding	GO:0050839	Interacting selectively with a cell adhesion molecule.	14	0.0346072081870767	0	0	1	R03B.profile.u50
cobalt ion binding	GO:0050897	Interacting selectively with a cobalt (Co) ion.	15	0.0370791516290107	0	0	1	R03B.profile.u50
actin filament binding	GO:0051015	Interacting selectively with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.	63	0.155732436841845	0	0	1	R03B.profile.u50
protein kinase A binding	GO:0051018	Interacting selectively with protein kinase A.	14	0.0346072081870767	0	0	1	R03B.profile.u50
GTPase binding	GO:0051020	Interacting selectively with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.	113	0.279329608938548	0	0	1	R03B.profile.u50
NF-kappaB binding	GO:0051059	Interacting selectively with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.	13	0.0321352647451426	1	31.1184615384615	0.0316629388039029	R03B.profile.u50
unfolded protein binding	GO:0051082	Interacting selectively with an unfolded protein.	148	0.365847629406239	0	0	1	R03B.profile.u50
chaperone binding	GO:0051087	Interacting selectively with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.	17	0.0420230385128788	0	0	1	R03B.profile.u50
sugar transporter activity	GO:0051119	Enables the directed movement of a sugar into, out of, within or between cells. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides.	46	0.113709398328966	0	0	1	R03B.profile.u50
vitamin transporter activity	GO:0051183	Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.	12	0.0296633213032086	0	0	1	R03B.profile.u50
cofactor transporter activity	GO:0051184	Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein.	18	0.0444949819548129	0	0	1	R03B.profile.u50
dioxygenase activity	GO:0051213	Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate.	63	0.155732436841845	0	0	1	R03B.profile.u50
phosphoprotein binding	GO:0051219	Interacting selectively with a phosphorylated protein.	15	0.0370791516290107	0	0	1	R03B.profile.u50
NAD binding	GO:0051287	Interacting selectively with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH.	47	0.1161813417709	0	0	1	R03B.profile.u50
hormone receptor binding	GO:0051427	Interacting selectively with a receptor for hormones.	71	0.175507984377317	0	0	1	R03B.profile.u50
iron-sulfur cluster binding	GO:0051536	Interacting selectively with an iron-sulfur cluster, a combination of iron and sulfur atoms.	41	0.101349681119296	0	0	1	R03B.profile.u50
2 iron, 2 sulfur cluster binding	GO:0051537	Interacting selectively with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.	13	0.0321352647451426	0	0	1	R03B.profile.u50
4 iron, 4 sulfur cluster binding	GO:0051539	Interacting selectively with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.	21	0.051910812280615	0	0	1	R03B.profile.u50
metal cluster binding	GO:0051540	Interacting selectively with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters.	41	0.101349681119296	0	0	1	R03B.profile.u50
inositol trisphosphate kinase activity	GO:0051766	Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP.	5	0.0123597172096702	0	0	1	R03B.profile.u50
peroxiredoxin activity	GO:0051920	Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.	10	0.0247194344193405	0	0	1	R03B.profile.u50
molecular transducer activity	GO:0060089	The molecular function that accepts an input of one form and creates an output of a different form.	2506	6.19469026548673	10	1.61428571428571	0.0977156042406087	R03B.profile.u50
molecular adaptor activity	GO:0060090	The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way.	101	0.249666287635339	1	4.00534653465346	0.221180040732672	R03B.profile.u50