L2L Microarray Analysis Tool
Results for R06A.profile.ud50
| Results summary | View all lists in GO:BiolProc | View all genes in R06A.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| DNA replication | The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. | 277 | 1.37 | 8 | 5.84 | 8.55e-05 |
| negative regulation of I-kappaB kinase/NF-kappaB cascade | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. | 5 | 0.02 | 2 | 80.91 | 2.42e-04 |
| apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 5.33 | 15 | 2.81 | 4.19e-04 |
| programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 5.37 | 15 | 2.79 | 4.51e-04 |
| regulation of epidermal cell differentiation | Any process that modulates the frequency, rate or extent of epidermal cell differentiation. | 7 | 0.03 | 2 | 57.79 | 5.05e-04 |
| mismatch repair | A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
| aging | The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| maintenance of fidelity during DNA-dependent DNA replication | The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair. | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| DNA-dependent DNA replication | The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | 140 | 0.69 | 5 | 7.22 | 7.09e-04 |
| cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
| death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
| regulation of epidermis development | Any process that modulates the frequency, rate or extent of epidermis development. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| histone deacetylation | The modification of histones by removal of acetyl groups. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| regulation of apoptosis | Any process that modulates the occurrence or rate of cell death by apoptosis. | 785 | 3.88 | 11 | 2.83 | 2.20e-03 |
| regulation of programmed cell death | Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 793 | 3.92 | 11 | 2.81 | 2.37e-03 |
| lymphocyte mediated immunity | Any process involved in the carrying out of an immune response by a lymphocyte. | 116 | 0.57 | 4 | 6.97 | 2.76e-03 |
| protein amino acid deacetylation | The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| ER to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. | 119 | 0.59 | 4 | 6.80 | 3.02e-03 |
| parturition | The process of giving birth to live offspring or eggs. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| induction of apoptosis by intracellular signals | Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis. | 59 | 0.29 | 3 | 10.28 | 3.20e-03 |
| leukocyte mediated immunity | Any process involved in the carrying out of an immune response by a leukocyte. | 124 | 0.61 | 4 | 6.52 | 3.50e-03 |
| regulation of DNA recombination | Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| natural killer cell mediated immunity | The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| natural killer cell mediated cytotoxicity | The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| leukocyte mediated cytotoxicity | The directed killing of a target cell by a leukocyte. | 21 | 0.10 | 2 | 19.26 | 4.82e-03 |
| response to DNA damage stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. | 412 | 2.04 | 7 | 3.44 | 4.87e-03 |
| regulation of progression through cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. | 875 | 4.33 | 11 | 2.54 | 4.92e-03 |
| regulation of cell cycle | A cell cycle process that modulates the rate, extent or mode of the cell cycle. | 880 | 4.35 | 11 | 2.53 | 5.13e-03 |
| cell cycle process | A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. | 1144 | 5.66 | 13 | 2.30 | 5.45e-03 |
| cell development | The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. | 1692 | 8.37 | 17 | 2.03 | 5.57e-03 |
| immune effector process | Any process of the immune system that occurs as part of an immune response. | 143 | 0.71 | 4 | 5.66 | 5.79e-03 |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. | 1307 | 6.46 | 14 | 2.17 | 6.63e-03 |
| epidermal cell differentiation | The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| cell killing | Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| induction of apoptosis | A process that directly activates any of the steps required for cell death by apoptosis. | 341 | 1.69 | 6 | 3.56 | 7.53e-03 |
| induction of programmed cell death | A process which directly activates any of the steps required for programmed cell death. | 343 | 1.70 | 6 | 3.54 | 7.73e-03 |
| response to endogenous stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus. | 453 | 2.24 | 7 | 3.13 | 8.00e-03 |
| DNA recombination | The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. | 158 | 0.78 | 4 | 5.12 | 8.18e-03 |
| negative regulation of DNA metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| nucleotide-excision repair | In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |