L2L Microarray Analysis Tool
Results for A01AB.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in A01AB.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 16 | 18.65 | 1.34e-15 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 16 | 18.65 | 1.34e-15 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 16 | 10.92 | 4.63e-12 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 16 | 10.92 | 4.63e-12 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 8 | 20.35 | 8.48e-09 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 16 | 4.90 | 3.55e-07 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 6 | 13.71 | 6.23e-06 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.06 | 3 | 48.54 | 3.34e-05 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 6 | 9.12 | 6.13e-05 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.41 | 5 | 12.26 | 6.37e-05 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 3 | 39.15 | 6.45e-05 |
| irs_ko_adip_up | Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) | 36 | 0.09 | 3 | 33.71 | 1.01e-04 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 8 | 5.34 | 1.63e-04 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 4 | 14.58 | 1.81e-04 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 3 | 27.58 | 1.85e-04 |
| genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 5.17 | 15 | 2.90 | 3.14e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 8 | 4.79 | 3.34e-04 |
| uvb_nhek3_c8 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 | 132 | 0.33 | 4 | 12.26 | 3.51e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 8 | 4.31 | 6.70e-04 |
| hsc_mature_adult | Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) | 427 | 1.06 | 6 | 5.68 | 7.66e-04 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.41 | 4 | 9.75 | 8.28e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| hsc_mature_shared | Up-regulated in mouse mature bood cells from both adult bone marrow and fetal liver, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared) | 309 | 0.76 | 5 | 6.55 | 1.13e-03 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.21 | 3 | 14.11 | 1.33e-03 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 4 | 8.43 | 1.42e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 11 | 2.93 | 1.73e-03 |
| adip_diff_cluster1 | Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) | 96 | 0.24 | 3 | 12.64 | 1.82e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 6 | 4.76 | 1.88e-03 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 6 | 4.46 | 2.59e-03 |
| hsc_mature_fetal | Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| hdaci_colon_but_dn | Downregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 387 | 0.96 | 5 | 5.23 | 2.99e-03 |
| hypoxia_fibro_up | Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 5 | 4.54 | 5.41e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
| hdaci_colon_cur_dn | Downregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 4 | 5.07 | 8.55e-03 |
| adip_vs_fibro_up | Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |