L2L Microarray Analysis Tool
Results for A01AB.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in A01AB.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 17 | 9.91 | 3.91e-12 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 17 | 9.91 | 3.91e-12 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 20 | 6.82 | 4.42e-11 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 20 | 6.82 | 4.42e-11 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 8 | 10.18 | 1.56e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 21 | 3.22 | 4.86e-06 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 7 | 8.00 | 3.32e-05 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| hsc_mature_fetal | Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) | 376 | 1.86 | 9 | 4.84 | 1.31e-04 |
| hsc_mature_shared | Up-regulated in mouse mature bood cells from both adult bone marrow and fetal liver, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared) | 309 | 1.53 | 8 | 5.24 | 1.80e-04 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.12 | 3 | 24.27 | 2.56e-04 |
| hsc_mature_adult | Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) | 427 | 2.11 | 9 | 4.26 | 3.33e-04 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 1.32 | 7 | 5.32 | 4.10e-04 |
| vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 3.73 | 12 | 3.22 | 4.81e-04 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| irs_ko_adip_up | Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
| p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.18 | 3 | 16.40 | 8.28e-04 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 3 | 13.79 | 1.38e-03 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.82 | 5 | 6.13 | 1.47e-03 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.49 | 4 | 8.17 | 1.55e-03 |
| genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 1.30 | 6 | 4.61 | 2.16e-03 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 10 | 3.00 | 2.31e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| adipogenesis_hmsc_class2_up | Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 7 | 3.77 | 2.97e-03 |
| uvb_nhek3_c8 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 | 132 | 0.65 | 4 | 6.13 | 4.37e-03 |
| nf90_dn | Downregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 7.51 | 16 | 2.13 | 4.56e-03 |
| bap_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| bleo_mouse_lymph_high_24hrs_dn | Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 71 | 0.35 | 3 | 8.55 | 5.38e-03 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 11.58 | 21 | 1.81 | 7.94e-03 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 3 | 7.06 | 9.11e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.82 | 4 | 4.87 | 9.68e-03 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 10.34 | 19 | 1.84 | 9.80e-03 |