L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in A01AC.profile.u50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
positive regulation of cell proliferation	Any process that activates or increases the rate or extent of cell proliferation.	338	0.84	6	7.18	2.25e-04
positive regulation of B cell proliferation	Any process that activates or increases the rate or extent of B cell proliferation.	10	0.02	2	80.91	2.71e-04
regulation of B cell proliferation	Any process that modulates the frequency, rate or extent of B cell proliferation.	16	0.04	2	50.57	7.17e-04
negative regulation of transcription	Any process that stops, prevents or reduces the frequency, rate or extent of transcription.	439	1.09	6	5.53	8.83e-04
regulation of isotype switching	Any process that modulates the frequency, rate or extent of isotype switching.	18	0.04	2	44.95	9.11e-04
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	478	1.18	6	5.08	1.36e-03
positive regulation of B cell activation	Any process that activates or increases the frequency, rate or extent of B cell activation.	25	0.06	2	32.36	1.77e-03
B cell proliferation	The rapid expansion of a B cell population by cell division. Follows B cell activation.	27	0.07	2	29.97	2.06e-03
negative regulation of cellular metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.	536	1.32	6	4.53	2.41e-03
somatic recombination of immunoglobulin genes during immune response	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.	30	0.07	2	26.97	2.54e-03
somatic diversification of immunoglobulins during immune response	The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.	30	0.07	2	26.97	2.54e-03
immunoglobulin production during immune response	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	30	0.07	2	26.97	2.54e-03
isotype switching	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.	30	0.07	2	26.97	2.54e-03
somatic diversification of immune receptors via germline recombination within a single locus	The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.	31	0.08	2	26.10	2.71e-03
somatic cell DNA recombination	Recombination occurring within or between DNA molecules in somatic cells.	31	0.08	2	26.10	2.71e-03
somatic recombination of immunoglobulin gene segments	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.	31	0.08	2	26.10	2.71e-03
response to external stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.	759	1.88	7	3.73	3.17e-03
somatic diversification of immune receptors	The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.	34	0.08	2	23.80	3.25e-03
circadian rhythm	The biological processes in an organism that recur with a regularity of approximately 24 hours.	34	0.08	2	23.80	3.25e-03
somatic diversification of immunoglobulins	The somatic process by means of which sequence diversity of immunoglobulins is generated.	34	0.08	2	23.80	3.25e-03
regulation of B cell activation	Any process that modulates the frequency, rate or extent of B cell activation.	38	0.09	2	21.29	4.05e-03
regulation of cytokine production	Any process that modulates the frequency, rate, or extent of production of a cytokine.	39	0.10	2	20.75	4.26e-03
immunoglobulin production	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	39	0.10	2	20.75	4.26e-03
negative regulation of metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.	615	1.52	6	3.95	4.69e-03
positive regulation of mononuclear cell proliferation	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.	43	0.11	2	18.82	5.16e-03
positive regulation of lymphocyte proliferation	Any process that activates or increases the rate or extent of lymphocyte proliferation.	43	0.11	2	18.82	5.16e-03
negative regulation of transcription, DNA-dependent	Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription.	292	0.72	4	5.54	6.31e-03
protein amino acid lipidation	The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein.	49	0.12	2	16.51	6.65e-03
lipoprotein biosynthetic process	The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	49	0.12	2	16.51	6.65e-03
production of molecular mediator of immune response	The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.	51	0.13	2	15.86	7.19e-03
regulation of signal transduction	Any process that modulates the frequency, rate or extent of signal transduction.	682	1.69	6	3.56	7.61e-03
positive regulation of cellular process	Any process that activates or increases the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1371	3.39	9	2.66	8.05e-03
regulation of cell proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.	704	1.74	6	3.45	8.81e-03
cell proliferation	The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.	1154	2.85	8	2.80	8.93e-03

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

338

0.84

6

7.18

2.25e-04

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

10

0.02

2

80.91

2.71e-04

regulation of B cell proliferation

Any process that modulates the frequency, rate or extent of B cell proliferation.

16

0.04

2

50.57

7.17e-04

negative regulation of transcription

Any process that stops, prevents or reduces the frequency, rate or extent of transcription.

439

1.09

6

5.53

8.83e-04

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

18

0.04

2

44.95

9.11e-04

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

478

1.18

6

5.08

1.36e-03

positive regulation of B cell activation

Any process that activates or increases the frequency, rate or extent of B cell activation.

25

0.06

2

32.36

1.77e-03

B cell proliferation

The rapid expansion of a B cell population by cell division. Follows B cell activation.

27

0.07

2

29.97

2.06e-03

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

536

1.32

6

4.53

2.41e-03

somatic recombination of immunoglobulin genes during immune response

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.

30

0.07

2

26.97

2.54e-03

somatic diversification of immunoglobulins during immune response

The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.

30

0.07

2

26.97

2.54e-03

immunoglobulin production during immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

30

0.07

2

26.97

2.54e-03

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

30

0.07

2

26.97

2.54e-03

somatic diversification of immune receptors via germline recombination within a single locus

The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

31

0.08

2

26.10

2.71e-03

somatic cell DNA recombination

Recombination occurring within or between DNA molecules in somatic cells.

31

0.08

2

26.10

2.71e-03

somatic recombination of immunoglobulin gene segments

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

31

0.08

2

26.10

2.71e-03

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

759

1.88

7

3.73

3.17e-03

somatic diversification of immune receptors

The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

34

0.08

2

23.80

3.25e-03

circadian rhythm

The biological processes in an organism that recur with a regularity of approximately 24 hours.

34

0.08

2

23.80

3.25e-03

somatic diversification of immunoglobulins

The somatic process by means of which sequence diversity of immunoglobulins is generated.

34

0.08

2

23.80

3.25e-03

regulation of B cell activation

Any process that modulates the frequency, rate or extent of B cell activation.

38

0.09

2

21.29

4.05e-03

regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.

39

0.10

2

20.75

4.26e-03

immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

39

0.10

2

20.75

4.26e-03

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

615

1.52

6

3.95

4.69e-03

positive regulation of mononuclear cell proliferation

Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.

43

0.11

2

18.82

5.16e-03

positive regulation of lymphocyte proliferation

Any process that activates or increases the rate or extent of lymphocyte proliferation.

43

0.11

2

18.82

5.16e-03

negative regulation of transcription, DNA-dependent

Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription.

292

0.72

4

5.54

6.31e-03

protein amino acid lipidation

The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein.

49

0.12

2

16.51

6.65e-03

lipoprotein biosynthetic process

The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

49

0.12

2

16.51

6.65e-03

production of molecular mediator of immune response

The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.

51

0.13

2

15.86

7.19e-03

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

682

1.69

6

3.56

7.61e-03

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

1371

3.39

9

2.66

8.05e-03

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

704

1.74

6

3.45

8.81e-03