L2L Microarray Analysis Tool
Results for A10BG.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in A10BG.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 16 | 8.61 | 1.32e-10 |
| cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.16 | 6 | 37.93 | 1.19e-08 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 12 | 7.61 | 9.91e-08 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 16 | 5.10 | 1.95e-07 |
| cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.32 | 6 | 18.96 | 8.56e-07 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 5 | 22.47 | 3.06e-06 |
| ad12_48hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection | 21 | 0.10 | 4 | 38.53 | 3.34e-06 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.23 | 5 | 21.99 | 3.42e-06 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 13 | 4.96 | 3.58e-06 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 15 | 4.04 | 7.84e-06 |
| et743_resist_dn | Down-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines | 95 | 0.47 | 6 | 12.77 | 8.71e-06 |
| ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.13 | 4 | 29.97 | 9.57e-06 |
| scw_joint_react_dn | Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 231 | 1.14 | 8 | 7.01 | 2.39e-05 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 11 | 4.68 | 3.30e-05 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 13 | 3.90 | 4.45e-05 |
| ad12_any_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 42 | 0.21 | 4 | 19.26 | 5.75e-05 |
| rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.77 | 6 | 7.83 | 1.36e-04 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 6 | 7.59 | 1.62e-04 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 5 | 9.28 | 2.25e-04 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 11 | 3.75 | 2.29e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 11 | 3.75 | 2.29e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 11 | 3.67 | 2.75e-04 |
| uvc_high_d7_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d7) | 63 | 0.31 | 4 | 12.84 | 2.82e-04 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 3 | 21.67 | 3.61e-04 |
| dex_keratinocyte_4hr_dn | Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 69 | 0.34 | 4 | 11.73 | 4.00e-04 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 4 | 11.56 | 4.22e-04 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 6 | 6.01 | 5.60e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 9 | 3.83 | 7.11e-04 |
| uvc_ttd_8hr_dn | Down-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 382 | 1.89 | 8 | 4.24 | 7.31e-04 |
| pubertal_mammary_3-4wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. | 301 | 1.49 | 7 | 4.70 | 8.47e-04 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 2.41 | 9 | 3.73 | 8.59e-04 |
| idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.74 | 5 | 6.79 | 9.37e-04 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 4.10 | 12 | 2.93 | 1.08e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 4.15 | 12 | 2.89 | 1.20e-03 |
| hdaci_colon_tsa48hrs_dn | Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| hsc_intermediateprogenitors_adult | Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) | 161 | 0.80 | 5 | 6.28 | 1.32e-03 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.81 | 5 | 6.20 | 1.40e-03 |
| pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 6.23 | 15 | 2.41 | 1.94e-03 |
| uvc_ttd_all_dn | Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 780 | 3.86 | 11 | 2.85 | 2.09e-03 |
| hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.25 | 3 | 11.90 | 2.11e-03 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.59 | 4 | 6.74 | 3.11e-03 |
| igf1_nih3t3_up | Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 1.44 | 6 | 4.16 | 3.60e-03 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 842 | 4.16 | 11 | 2.64 | 3.72e-03 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
| tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 1237 | 6.12 | 14 | 2.29 | 4.17e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 8 | 3.17 | 4.40e-03 |
| heatshock_hela_30min_dn | Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| tsa_hepatoma_up | Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| adip_diff_cluster3 | Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 5 | 4.54 | 5.34e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 9 | 2.82 | 5.51e-03 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| ad12_24hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| cox1_ko_hippocampus_dn | Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| tsa_panc50_up | 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| hsc_intermediateprogenitors_shared | Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) | 151 | 0.75 | 4 | 5.36 | 6.99e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 14 | 2.14 | 7.23e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 6.58 | 14 | 2.13 | 7.69e-03 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 11.58 | 21 | 1.81 | 7.94e-03 |
| mammary_dev_up | Up-regulated in the intact developing mouse mammary gland; higher expression in 5/6 week pubertal glands than in 3 week, mid-pregnant, lactating, involuting or resuckled glands | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 2.27 | 7 | 3.08 | 8.56e-03 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 6 | 3.44 | 8.83e-03 |
| cis_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| hsc_intermediateprogenitors_fetal | Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) | 167 | 0.83 | 4 | 4.84 | 9.88e-03 |