L2L Microarray Analysis Tool
Results for C05AA.profile.ud50
| Results summary | View all lists in GO:BiolProc | View all genes in C05AA.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| transcription from RNA polymerase II promoter | The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). | 997 | 4.93 | 17 | 3.45 | 1.55e-05 |
| regulation of transcription from RNA polymerase II promoter | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 701 | 3.47 | 13 | 3.75 | 6.49e-05 |
| negative regulation of transcription | Any process that stops, prevents or reduces the frequency, rate or extent of transcription. | 439 | 2.17 | 10 | 4.61 | 8.49e-05 |
| negative regulation of cellular metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 536 | 2.65 | 11 | 4.15 | 9.63e-05 |
| negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 478 | 2.36 | 10 | 4.23 | 1.69e-04 |
| negative regulation of metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 615 | 3.04 | 11 | 3.62 | 3.12e-04 |
| B cell proliferation | The rapid expansion of a B cell population by cell division. Follows B cell activation. | 27 | 0.13 | 3 | 22.47 | 3.23e-04 |
| developmental process | A biological process whose specific outcome is the progression of an integrated living unit: a cell, tissue, organ, or organism over time from an initial condition to a later condition. | 4255 | 21.04 | 38 | 1.81 | 5.34e-04 |
| negative regulation of transcription from RNA polymerase II promoter | Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 201 | 0.99 | 6 | 6.04 | 5.46e-04 |
| organ development | Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. | 1733 | 8.57 | 20 | 2.33 | 5.68e-04 |
| regulation of interleukin-6 biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| negative regulation of transcription, DNA-dependent | Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription. | 292 | 1.44 | 7 | 4.85 | 7.10e-04 |
| negative regulation of cellular process | Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. | 1642 | 8.12 | 19 | 2.34 | 7.44e-04 |
| multicellular organismal development | The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 3036 | 15.01 | 29 | 1.93 | 8.42e-04 |
| regulation of Rho GTPase activity | Any process that modulates the activity of a GTPase of the Rho family. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| glucose metabolic process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. | 150 | 0.74 | 5 | 6.74 | 9.65e-04 |
| positive regulation of B cell proliferation | Any process that activates or increases the rate or extent of B cell proliferation. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| interleukin-6 production | The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| interleukin-6 biosynthetic process | The chemical reactions and pathways resulting in the formation of interleukin-6. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| negative regulation of biological process | Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. | 1697 | 8.39 | 19 | 2.26 | 1.09e-03 |
| negative regulation of cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. | 90 | 0.44 | 4 | 8.99 | 1.09e-03 |
| anatomical structure development | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. | 2828 | 13.98 | 27 | 1.93 | 1.25e-03 |
| anatomical structure morphogenesis | The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. | 1460 | 7.22 | 17 | 2.36 | 1.28e-03 |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| negative regulation of B cell activation | Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| regulation of cell-matrix adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| regulation of T-helper cell differentiation | Any process that modulates the frequency, rate or extent of T-helper cell differentiation. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| cell differentiation | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. | 2359 | 11.66 | 23 | 1.97 | 2.10e-03 |
| cellular developmental process | A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. | 2359 | 11.66 | 23 | 1.97 | 2.11e-03 |
| cytokine production during immune response | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| regulation of production of molecular mediator of immune response | Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| regulation of cytokine production during immune response | Any process that modulates the frequency, rate, or extent of cytokine production during immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 5.70 | 14 | 2.46 | 2.24e-03 |
| death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 5.70 | 14 | 2.46 | 2.24e-03 |
| negative regulation of developmental process | Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 110 | 0.54 | 4 | 7.36 | 2.27e-03 |
| multicellular organismal process | The biological processes, occurring at the level of the organism, pertinent to the function of the organism. | 4325 | 21.38 | 36 | 1.68 | 2.35e-03 |
| erythrocyte differentiation | The process by which a myeloid precursor cell acquires specializes features of an erythrocyte. | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. | 115 | 0.57 | 4 | 7.04 | 2.67e-03 |
| regulation of B cell proliferation | Any process that modulates the frequency, rate or extent of B cell proliferation. | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| B cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell. | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| blood vessel development | The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. | 283 | 1.40 | 6 | 4.29 | 3.09e-03 |
| cell activation during immune response | A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| lymphocyte activation during immune response | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T cell activation during immune response | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T cell differentiation during immune response | The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| CD4-positive, alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| leukocyte activation during immune response | A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T-helper cell differentiation | The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| regulation of metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 3184 | 15.74 | 28 | 1.78 | 3.23e-03 |
| vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. | 288 | 1.42 | 6 | 4.21 | 3.37e-03 |
| regulation of Ras GTPase activity | Any process that modulates the activity of a GTPase of the Ras superfamily. | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
| regulation of isotype switching | Any process that modulates the frequency, rate or extent of isotype switching. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| CD4-positive, alpha beta T cell differentiation | The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. | 19 | 0.09 | 2 | 21.29 | 3.95e-03 |
| negative regulation of immune system process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| regulation of immune effector process | Any process that modulates the frequency, rate, or extent of an immune effector process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| T-helper 2 type immune response | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| negative regulation of immune response | Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| system development | The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. | 2362 | 11.68 | 22 | 1.88 | 4.39e-03 |
| regulation of transcription, DNA-dependent | Any process that modulates the frequency, rate or extent of DNA-dependent transcription. | 2510 | 12.41 | 23 | 1.85 | 4.41e-03 |
| hexose metabolic process | The chemical reactions and pathways involving a hexose, any aldose with a chain of six carbon atoms in the molecule. | 215 | 1.06 | 5 | 4.70 | 4.59e-03 |
| actin cytoskeleton organization and biogenesis | A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. | 313 | 1.55 | 6 | 3.88 | 5.03e-03 |
| monosaccharide metabolic process | The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. | 220 | 1.09 | 5 | 4.60 | 5.05e-03 |
| response to external stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. | 759 | 3.75 | 10 | 2.66 | 5.21e-03 |
| regulation of transcription | Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. | 2702 | 13.36 | 24 | 1.80 | 5.36e-03 |
| cellular carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. | 423 | 2.09 | 7 | 3.35 | 5.60e-03 |
| regulation of adaptive immune response | Any process that modulates the frequency, rate, or extent of an adaptive immune response. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of actin filament length | Any process that controls the length of actin filaments in a cell. | 73 | 0.36 | 3 | 8.31 | 5.81e-03 |
| regulation of hydrolase activity | Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. | 230 | 1.14 | 5 | 4.40 | 6.07e-03 |
| regulation of cellular metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 3041 | 15.03 | 26 | 1.73 | 6.23e-03 |
| transcription, DNA-dependent | The synthesis of RNA on a template of DNA. | 2588 | 12.79 | 23 | 1.80 | 6.26e-03 |
| RNA biosynthetic process | The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. | 2591 | 12.81 | 23 | 1.80 | 6.34e-03 |
| regulation of cell differentiation | Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. | 233 | 1.15 | 5 | 4.34 | 6.40e-03 |
| regulation of defense response | Any process that modulates the frequency, rate or extent of a defense response. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of B cell activation | Any process that activates or increases the frequency, rate or extent of B cell activation. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of the movement of a cell. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| cytokine production | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 153 | 0.76 | 4 | 5.29 | 7.32e-03 |
| actin filament-based process | Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. | 339 | 1.68 | 6 | 3.58 | 7.32e-03 |
| apoptotic mitochondrial changes | The morphological and physiological alterations undergone by mitochondria during apoptosis. | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| negative regulation of apoptosis | Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. | 345 | 1.71 | 6 | 3.52 | 7.94e-03 |
| regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 2802 | 13.85 | 24 | 1.73 | 8.14e-03 |
| negative regulation of programmed cell death | Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| organ morphogenesis | Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. | 569 | 2.81 | 8 | 2.84 | 8.17e-03 |
| blood vessel morphogenesis | The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood. | 248 | 1.23 | 5 | 4.08 | 8.26e-03 |
| alpha-beta T cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell. | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 5.33 | 12 | 2.25 | 8.59e-03 |
| transcription | The synthesis of either RNA on a template of DNA or DNA on a template of RNA. | 2826 | 13.97 | 24 | 1.72 | 8.96e-03 |
| programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 5.37 | 12 | 2.24 | 9.07e-03 |
| embryo implantation | Attachment of the blastocyst to the uterine lining. | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| regulation of lymphocyte differentiation | Any process that modulates the frequency, rate or extent of lymphocyte differentiation. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |