L2L Microarray Analysis Tool
Results for C05AD.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in C05AD.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 11 | 6.97 | 7.86e-07 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 7 | 12.99 | 1.38e-06 |
| hdaci_colon_tsa48hrs_dn | Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 11 | 0.05 | 3 | 55.16 | 1.94e-05 |
| as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.06 | 3 | 50.57 | 2.57e-05 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.11 | 3 | 26.38 | 1.99e-04 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| heatshock_hela_30min_dn | Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 67 | 0.33 | 4 | 12.08 | 3.57e-04 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 3 | 21.67 | 3.61e-04 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 6 | 6.01 | 5.60e-04 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 9 | 3.56 | 1.18e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 10 | 3.13 | 1.68e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 3 | 12.38 | 1.88e-03 |
| bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.25 | 3 | 12.14 | 1.99e-03 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 8 | 3.30 | 3.47e-03 |
| 17aag_ovca_dn | Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 129 | 0.64 | 4 | 6.27 | 4.03e-03 |
| aom-dss_colon_10wks_up | Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 22 | 0.11 | 2 | 18.39 | 5.29e-03 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 5 | 4.54 | 5.34e-03 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 9.04 | 18 | 1.99 | 5.45e-03 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 9.83 | 19 | 1.93 | 5.96e-03 |
| erm_ko_testes_dn | Down-regulated in testes from 4 week old ERM knockout mice, compared to wild-type controls | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 232 | 1.15 | 5 | 4.36 | 6.29e-03 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 2.20 | 7 | 3.17 | 7.38e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 1.22 | 5 | 4.09 | 8.12e-03 |