L2L L2L Microarray Analysis Tool

Results for C10AA.profile.ud50

Results summary View all lists in L2L MDB View all genes in C10AA.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
cmv_hcmv_timecourse_6hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 95 0.47 8 17.03 2.96e-08
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 1.08 10 9.24 1.94e-07
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 9 10.28 3.20e-07
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 8 8.99 3.92e-06
il6_scar_fibro_dn Downregulated following IL-6 treatment in hypertrophic scar fibroblasts 22 0.11 3 27.58 1.73e-04
idx_tsa_dn_cluster3 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.53 5 9.36 2.16e-04
dnmt1_ko_up Upregulated following conditional knock-out of DNMT1 in MEFs 117 0.58 5 8.64 3.13e-04
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.32 4 12.45 3.18e-04
cantharidin_up Upregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 27 0.13 3 22.47 3.23e-04
fsh_ovary_mcv152_up Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.59 5 8.43 3.51e-04
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13 11 3.51 4.01e-04
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 1.32 7 5.28 4.29e-04
cmv-uv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 1.02 6 5.86 6.37e-04
uvc_high_d3_dn Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d3) 90 0.44 4 8.99 1.09e-03
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 4.15 12 2.89 1.20e-03
uv-cmv_unique_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.81 5 6.17 1.43e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.23 3 13.19 1.56e-03
tnfa_nfkb_ind_up Up-regulated at any timepoint following TNFa treatment, independent of NFkB function 14 0.07 2 28.90 2.14e-03
p21_early_dn Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 16 0.08 2 25.28 2.80e-03
dixoin_pbmnc_dn Down-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 117 0.58 4 6.92 2.84e-03
gh_igf_chondrocytes_up Up-regulated in cultured human chondrocytes by both GH and IGF-1 17 0.08 2 23.80 3.16e-03
preadip_vs_fibro_dn Downregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 17 0.08 2 23.80 3.16e-03
scar_fibro_dn Downregulated in hypertrophic scar fibroblasts, compared to normal skin fibroblasts 17 0.08 2 23.80 3.16e-03
brca1ko_mef_up Up-regulated in mouse embryonic fibroblasts following targeted deletion of BRCA1 (exon 11) compared to wild-type MEFs 19 0.09 2 21.29 3.95e-03
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.32 3 9.48 4.02e-03
tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 1237 6.12 14 2.29 4.17e-03
ad12_48hrs_dn Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection 21 0.10 2 19.26 4.82e-03
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.35 3 8.67 5.17e-03
heatshock_hela_2hr_dn Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 223 1.10 5 4.54 5.34e-03
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 1.57 6 3.82 5.42e-03
5azac_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 9.05 18 1.99 5.48e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.58 6 3.80 5.50e-03
p21_p53_early_dn Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 23 0.11 2 17.59 5.77e-03
ad12_24hrs_dn Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection 24 0.12 2 16.86 6.28e-03
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.12 2 16.86 6.28e-03
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.38 3 7.88 6.73e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 9 2.70 7.25e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.40 3 7.59 7.48e-03
ad12_32hrs_dn Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection 27 0.13 2 14.98 7.90e-03
hbx_nl_dn Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.13 2 14.98 7.90e-03

Raw data (tab-delimited .txt)