L2L Microarray Analysis Tool
Results for D01AE.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D01AE.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 9 | 6.09 | 2.28e-05 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 7 | 6.35 | 1.41e-04 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 8 | 5.25 | 1.77e-04 |
| stress_tpa_specific_dn | Genes down-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 5 | 0.02 | 2 | 80.91 | 2.42e-04 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.69 | 5 | 7.22 | 7.09e-04 |
| tnfalpha_tgz_adip_dn | Downregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha | 39 | 0.19 | 3 | 15.56 | 9.67e-04 |
| tnfalpha_adip_dn | Downregulated in mature, differentiated adipocytes following treatment with TNFalpha | 101 | 0.50 | 4 | 8.01 | 1.67e-03 |
| adipocyte_brca_dn | Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| hsc_lateprogenitors_fetal | Up-regulated in mouse hematopoietic late progenitors from fetal liver (Late Progenitors Shared + Fetal) | 558 | 2.76 | 9 | 3.26 | 2.14e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| dnmt1_ko_up | Upregulated following conditional knock-out of DNMT1 in MEFs | 117 | 0.58 | 4 | 6.92 | 2.84e-03 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
| adip_diff_up | Upregulated in mature adipocytes following diffferentiation from 3T3-L1 fibroblasts | 123 | 0.61 | 4 | 6.58 | 3.40e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 8 | 3.17 | 4.35e-03 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 2.54 | 8 | 3.15 | 4.50e-03 |
| hif1_targets | Hif-1 (hypoxia-inducible factor 1) transcripional targets | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 8 | 2.97 | 6.33e-03 |
| hsc_lateprogenitors_shared | Up-regulated in mouse hematopoietic late progenitors from both adult bone marrow and fetal liver (Cluster vi, Late Progenitors Shared) | 549 | 2.71 | 8 | 2.95 | 6.67e-03 |
| myc_targets | Myc-responsive genes reported in multiple systems | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 2.74 | 8 | 2.92 | 7.03e-03 |
| hsc_lateprogenitors_adult | Up-regulated in mouse hematopoietic late progenitors from adult bone marrow (Late Progenitors Shared + Adult) | 558 | 2.76 | 8 | 2.90 | 7.32e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 1.22 | 5 | 4.09 | 8.12e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| h2o2_csbrescued_c1_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| bap_mcf7_up | Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.82 | 4 | 4.87 | 9.68e-03 |