L2L Microarray Analysis Tool

regulation of isotype switching

16.62

8.25e-04

Any process that modulates the frequency, rate or extent of isotype switching.

18

0.04

transcription from RNA polymerase II promoter

44.95

9.11e-04

The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

997

2.46

9

3.65

1.01e-03

negative regulation of immune system process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.

20

0.05

T-helper 2 type immune response

40.45

1.13e-03

An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.

20

0.05

negative regulation of immune response

40.45

1.13e-03

Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

20

0.05

actin cytoskeleton organization and biogenesis

40.45

1.13e-03

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

313

0.77

6.46

1.19e-03

response to metal ion

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

21

0.05

regulation of adaptive immune response

38.53

1.24e-03

Any process that modulates the frequency, rate, or extent of an adaptive immune response.

23

0.06

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.

35.18

1.49e-03

Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.

23

0.06

negative regulation of cell differentiation

35.18

1.49e-03

Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.

90

0.22

actin filament-based process

13.48

1.51e-03

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

339

0.84

immune system development

5.97

1.69e-03

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

346

0.86

regulation of transcription from RNA polymerase II promoter

5.85

1.85e-03

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

701

1.73

7

4.04

2.05e-03

response to inorganic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

27

0.07

negative regulation of myeloid cell differentiation

29.97

2.06e-03

Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.

27

0.07

somatic recombination of immunoglobulin genes during immune response

29.97

2.06e-03

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.

30

0.07

somatic diversification of immunoglobulins during immune response

26.97

2.54e-03

The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.

30

0.07

immunoglobulin production during immune response

26.97

2.54e-03

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

30

0.07

26.97

2.54e-03

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

30

0.07

negative regulation of developmental process

26.97

2.54e-03

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

110

0.27

somatic diversification of immune receptors via germline recombination within a single locus

11.03

2.68e-03

The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

31

0.08

somatic cell DNA recombination

26.10

2.71e-03

Recombination occurring within or between DNA molecules in somatic cells.

31

0.08

somatic recombination of immunoglobulin gene segments

26.10

2.71e-03

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

31

0.08

26.10

2.71e-03

B cell activation

The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

115

0.28

somatic diversification of immune receptors

10.55

3.03e-03

The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

34

0.08

23.80

3.25e-03

circadian rhythm

The biological processes in an organism that recur with a regularity of approximately 24 hours.

34

0.08

somatic diversification of immunoglobulins

23.80

3.25e-03

The somatic process by means of which sequence diversity of immunoglobulins is generated.

34

0.08

negative regulation of biological process

23.80

3.25e-03

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

1697

4.19

11

2.62

3.98e-03

regulation of B cell activation

Any process that modulates the frequency, rate or extent of B cell activation.

38

0.09

regulation of cytokine production

21.29

4.05e-03

Any process that modulates the frequency, rate, or extent of production of a cytokine.

39

0.10

immunoglobulin production

20.75

4.26e-03

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

39

0.10

regulation of transcription, DNA-dependent

20.75

4.26e-03

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

2510

6.20

negative regulation of transcription

2.26

4.77e-03

Any process that stops, prevents or reduces the frequency, rate or extent of transcription.

439

1.09

myeloid cell differentiation

4.61

5.07e-03

The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

142

0.35

negative regulation of multicellular organismal process

8.55

5.46e-03

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

46

0.11

transcription, DNA-dependent

17.59

5.88e-03

The synthesis of RNA on a template of DNA.

2588

6.40

2.19

6.16e-03

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

2591

6.40

cytoskeleton organization and biogenesis

2.19

6.22e-03

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

661

1.63

6

3.67

6.58e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.38

production of molecular mediator of immune response

7.93

6.71e-03

hemopoiesis

The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.

303

0.75

4

5.34

7.17e-03

The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.

51

0.13

insulin receptor signaling pathway

15.86

7.19e-03

The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.

51

0.13

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

15.86

7.19e-03

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

478

1.18

erythrocyte differentiation

4.23

7.19e-03

The process by which a myeloid precursor cell acquires specializes features of an erythrocyte.

54

0.13

regulation of transcription

14.98

8.03e-03

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

2702

6.68

negative regulation of cellular process

2.10

8.77e-03

Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

1642

4.06

10

2.46

8.85e-03

B cell differentiation

The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell.

57

0.14