L2L L2L Microarray Analysis Tool

Results for D10AA.profile.d50

Results summary View all lists in L2L MDB View all genes in D10AA.profile.d50
List Name Description Total
probes		 Expected
matches		 Actual
matches		 Fold
Enrichment		 Binomial
p-value
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 10 13.53 6.02e-09
hpv_hnscc_up Up-regulated in HPV-positive head and neck squamous cell carcinomas (HNSCC) compared to HPV-negative HNSCC. 68 0.17 4 23.80 2.68e-05
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 5 11.83 7.54e-05
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 7 5.96 2.14e-04
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 3 25.28 2.40e-04
adipocyte_brca_dn Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 13 0.03 2 62.24 4.68e-04
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.18 3 16.40 8.59e-04
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 7 4.38 1.30e-03
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 8 3.86 1.35e-03
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 4 8.21 1.56e-03
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 5 5.93 1.73e-03
cmv_hcmv_timecourse_6hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 95 0.23 3 12.77 1.76e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 6 4.58 2.28e-03
idx_tsa_dn_cluster3 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.27 3 11.24 2.54e-03
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 6 4.01 4.37e-03
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 3 8.92 4.85e-03
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.35 3 8.49 5.57e-03
genotoxins_all_4hrs_reg Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.11 2 17.98 5.64e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 5 4.41 6.09e-03
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 5 4.26 7.01e-03
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.76 4 5.25 7.58e-03
ifnalpha_nl_up Upregulated by interferon alpha treatment in normal primary hepatocytes 53 0.13 2 15.27 7.74e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
brca_prognosis_neg Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis 166 0.41 3 7.31 8.38e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 3 7.31 8.38e-03
caries_pulp_high_up Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.42 3 7.22 8.66e-03
h2o2_csbdiff_c1 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.14 2 13.95 9.21e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 5 3.97 9.34e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 5 3.96 9.41e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 5 3.94 9.56e-03

Raw data (tab-delimited .txt)