L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in D10AA.profile.u50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
positive regulation of B cell proliferation	Any process that activates or increases the rate or extent of B cell proliferation.	10	0.02	2	80.91	2.71e-04
regulation of B cell proliferation	Any process that modulates the frequency, rate or extent of B cell proliferation.	16	0.04	2	50.57	7.17e-04
regulation of isotype switching	Any process that modulates the frequency, rate or extent of isotype switching.	18	0.04	2	44.95	9.11e-04
response to metal ion	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.	21	0.05	2	38.53	1.24e-03
positive regulation of B cell activation	Any process that activates or increases the frequency, rate or extent of B cell activation.	25	0.06	2	32.36	1.77e-03
response to inorganic substance	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.	27	0.07	2	29.97	2.06e-03
B cell proliferation	The rapid expansion of a B cell population by cell division. Follows B cell activation.	27	0.07	2	29.97	2.06e-03
somatic recombination of immunoglobulin genes during immune response	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.	30	0.07	2	26.97	2.54e-03
somatic diversification of immunoglobulins during immune response	The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.	30	0.07	2	26.97	2.54e-03
immunoglobulin production during immune response	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	30	0.07	2	26.97	2.54e-03
isotype switching	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.	30	0.07	2	26.97	2.54e-03
somatic diversification of immune receptors via germline recombination within a single locus	The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.	31	0.08	2	26.10	2.71e-03
somatic cell DNA recombination	Recombination occurring within or between DNA molecules in somatic cells.	31	0.08	2	26.10	2.71e-03
somatic recombination of immunoglobulin gene segments	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.	31	0.08	2	26.10	2.71e-03
somatic diversification of immune receptors	The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.	34	0.08	2	23.80	3.25e-03
circadian rhythm	The biological processes in an organism that recur with a regularity of approximately 24 hours.	34	0.08	2	23.80	3.25e-03
somatic diversification of immunoglobulins	The somatic process by means of which sequence diversity of immunoglobulins is generated.	34	0.08	2	23.80	3.25e-03
regulation of B cell activation	Any process that modulates the frequency, rate or extent of B cell activation.	38	0.09	2	21.29	4.05e-03
regulation of cytokine production	Any process that modulates the frequency, rate, or extent of production of a cytokine.	39	0.10	2	20.75	4.26e-03
immunoglobulin production	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	39	0.10	2	20.75	4.26e-03
negative regulation of transcription	Any process that stops, prevents or reduces the frequency, rate or extent of transcription.	439	1.09	5	4.61	5.07e-03
positive regulation of mononuclear cell proliferation	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.	43	0.11	2	18.82	5.16e-03
positive regulation of lymphocyte proliferation	Any process that activates or increases the rate or extent of lymphocyte proliferation.	43	0.11	2	18.82	5.16e-03
cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.38	3	7.93	6.71e-03
production of molecular mediator of immune response	The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.	51	0.13	2	15.86	7.19e-03
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.	478	1.18	5	4.23	7.19e-03
respiratory gaseous exchange	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.	52	0.13	2	15.56	7.46e-03
erythrocyte differentiation	The process by which a myeloid precursor cell acquires specializes features of an erythrocyte.	54	0.13	2	14.98	8.03e-03
transition metal ion homeostasis	The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	55	0.14	2	14.71	8.32e-03

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

10

0.02

2

80.91

2.71e-04

regulation of B cell proliferation

Any process that modulates the frequency, rate or extent of B cell proliferation.

16

0.04

2

50.57

7.17e-04

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

18

0.04

2

44.95

9.11e-04

response to metal ion

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

21

0.05

2

38.53

1.24e-03

positive regulation of B cell activation

Any process that activates or increases the frequency, rate or extent of B cell activation.

25

0.06

2

32.36

1.77e-03

response to inorganic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

27

0.07

2

29.97

2.06e-03

B cell proliferation

The rapid expansion of a B cell population by cell division. Follows B cell activation.

27

0.07

2

29.97

2.06e-03

somatic recombination of immunoglobulin genes during immune response

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.

30

0.07

2

26.97

2.54e-03

somatic diversification of immunoglobulins during immune response

The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.

30

0.07

2

26.97

2.54e-03

immunoglobulin production during immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

30

0.07

2

26.97

2.54e-03

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

30

0.07

2

26.97

2.54e-03

somatic diversification of immune receptors via germline recombination within a single locus

The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

31

0.08

2

26.10

2.71e-03

somatic cell DNA recombination

Recombination occurring within or between DNA molecules in somatic cells.

31

0.08

2

26.10

2.71e-03

somatic recombination of immunoglobulin gene segments

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

31

0.08

2

26.10

2.71e-03

somatic diversification of immune receptors

The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

34

0.08

2

23.80

3.25e-03

circadian rhythm

The biological processes in an organism that recur with a regularity of approximately 24 hours.

34

0.08

2

23.80

3.25e-03

somatic diversification of immunoglobulins

The somatic process by means of which sequence diversity of immunoglobulins is generated.

34

0.08

2

23.80

3.25e-03

regulation of B cell activation

Any process that modulates the frequency, rate or extent of B cell activation.

38

0.09

2

21.29

4.05e-03

regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.

39

0.10

2

20.75

4.26e-03

immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

39

0.10

2

20.75

4.26e-03

negative regulation of transcription

Any process that stops, prevents or reduces the frequency, rate or extent of transcription.

439

1.09

5

4.61

5.07e-03

positive regulation of mononuclear cell proliferation

Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.

43

0.11

2

18.82

5.16e-03

positive regulation of lymphocyte proliferation

Any process that activates or increases the rate or extent of lymphocyte proliferation.

43

0.11

2

18.82

5.16e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.38

3

7.93

6.71e-03

production of molecular mediator of immune response

The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels.

51

0.13

2

15.86

7.19e-03

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

478

1.18

5

4.23

7.19e-03

respiratory gaseous exchange

The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.

52

0.13

2

15.56

7.46e-03

erythrocyte differentiation

The process by which a myeloid precursor cell acquires specializes features of an erythrocyte.

54

0.13

2

14.98

8.03e-03

transition metal ion homeostasis

The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

55

0.14

2

14.71

8.32e-03

Results for D10AA.profile.u50