L2L Microarray Analysis Tool
Results for D11AX.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in D11AX.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| human_tissue_testis | Genes expressed specifically in human testis tissue | 122 | 0.30 | 4 | 13.26 | 2.60e-04 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.18 | 3 | 16.40 | 8.59e-04 |
| stress_genotoxic_specific_dn | Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 74 | 0.18 | 3 | 16.40 | 8.59e-04 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.19 | 3 | 15.76 | 9.64e-04 |
| brca1_overexp_up | Upregulated by induction of exogenous BRCA1 in EcR-293 cells | 328 | 0.81 | 5 | 6.17 | 1.46e-03 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| dnmt1_ko_dn | Downregulated following conditional knock-out of DNMT1 in MEFs | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| caries_pulp_dn | Down-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 131 | 0.32 | 3 | 9.26 | 4.37e-03 |
| genotoxins_all_4hrs_reg | Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| hg_progeria_dn | Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| jnk_dn | Downregulated by expression of constitutively active JNK in 3T3 cells | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 3 | 7.10 | 9.09e-03 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 5 | 3.98 | 9.19e-03 |
| adip_vs_fibro_up | Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |