L2L Microarray Analysis Tool
Results for G01AF.profile.d50
| Results summary | View all lists in GO:BiolProc | View all genes in G01AF.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| DNA replication | The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. | 277 | 0.68 | 13 | 18.99 | 4.79e-13 |
| DNA-dependent DNA replication | The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | 140 | 0.35 | 9 | 26.01 | 1.13e-10 |
| DNA metabolic process | The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. | 922 | 2.28 | 16 | 7.02 | 2.72e-09 |
| DNA replication initiation | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. | 44 | 0.11 | 5 | 45.97 | 9.25e-08 |
| DNA unwinding during replication | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| DNA geometric change | The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| DNA duplex unwinding | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| negative regulation of DNA metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| response to UV | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. | 32 | 0.08 | 3 | 37.93 | 7.10e-05 |
| mismatch repair | A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| maintenance of fidelity during DNA-dependent DNA replication | The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair. | 35 | 0.09 | 3 | 34.67 | 9.32e-05 |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. | 382 | 0.94 | 6 | 6.35 | 4.29e-04 |
| regulation of cyclin-dependent protein kinase activity | Any process that modulates the frequency, rate or extent of CDK activity. | 65 | 0.16 | 3 | 18.67 | 5.88e-04 |
| response to DNA damage stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. | 412 | 1.02 | 6 | 5.89 | 6.37e-04 |
| DNA recombination | The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. | 158 | 0.39 | 4 | 10.24 | 6.89e-04 |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 4320 | 10.68 | 23 | 2.15 | 6.99e-04 |
| regulation of DNA recombination | Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. | 18 | 0.04 | 2 | 44.95 | 9.11e-04 |
| biopolymer metabolic process | The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. | 5812 | 14.37 | 28 | 1.95 | 9.14e-04 |
| cell division | The processes resulting in the physical partitioning and separation of a cell into daughter cells. | 297 | 0.73 | 5 | 6.81 | 9.46e-04 |
| response to endogenous stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus. | 453 | 1.12 | 6 | 5.36 | 1.04e-03 |
| mRNA metabolic process | The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. | 453 | 1.12 | 6 | 5.36 | 1.04e-03 |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. | 622 | 1.54 | 7 | 4.55 | 1.04e-03 |
| regulation of DNA metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| response to light stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. | 81 | 0.20 | 3 | 14.98 | 1.12e-03 |
| negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 478 | 1.18 | 6 | 5.08 | 1.36e-03 |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | 325 | 0.80 | 5 | 6.22 | 1.41e-03 |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. | 1307 | 3.23 | 10 | 3.10 | 1.86e-03 |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| negative regulation of cellular metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 536 | 1.32 | 6 | 4.53 | 2.41e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| cell cycle process | A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. | 1144 | 2.83 | 9 | 3.18 | 2.56e-03 |
| somatic diversification of immune receptors via germline recombination within a single locus | The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic cell DNA recombination | Recombination occurring within or between DNA molecules in somatic cells. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic recombination of immunoglobulin gene segments | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| cell cycle checkpoint | A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| response to radiation | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
| somatic diversification of immune receptors | The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| somatic diversification of immunoglobulins | The somatic process by means of which sequence diversity of immunoglobulins is generated. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| aging | The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| DNA damage response, signal transduction resulting in induction of apoptosis | A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death). | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| immunoglobulin production | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| negative regulation of metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 615 | 1.52 | 6 | 3.95 | 4.69e-03 |
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
| regulation of progression through cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. | 875 | 2.16 | 7 | 3.24 | 6.76e-03 |
| regulation of cell cycle | A cell cycle process that modulates the rate, extent or mode of the cell cycle. | 880 | 2.18 | 7 | 3.22 | 6.96e-03 |
| production of molecular mediator of immune response | The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| induction of apoptosis by intracellular signals | Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis. | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |