L2L Microarray Analysis Tool
Results for G01AF.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in G01AF.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 23 | 15.69 | 4.30e-20 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 23 | 15.69 | 4.30e-20 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 17 | 19.82 | 6.44e-17 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 17 | 19.82 | 6.44e-17 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 26 | 7.96 | 2.05e-15 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 12 | 9.52 | 9.51e-09 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 5 | 63.21 | 1.76e-08 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 12 | 8.01 | 6.19e-08 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 11 | 8.18 | 1.77e-07 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 7 | 17.81 | 1.81e-07 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 6 | 24.52 | 2.10e-07 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 7 | 16.00 | 3.74e-07 |
| hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 4 | 40.45 | 3.18e-06 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 9 | 7.10 | 7.14e-06 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 10 | 5.99 | 9.75e-06 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 6 | 12.64 | 9.90e-06 |
| bay-il2_pbmc_late_dn | Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 205 | 0.51 | 6 | 11.84 | 1.44e-05 |
| hdaci_colon_sul16hrs_up | Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells | 67 | 0.17 | 4 | 24.15 | 2.53e-05 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 5 | 14.45 | 2.92e-05 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 18 | 3.11 | 3.55e-05 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 8 | 6.59 | 3.84e-05 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 4 | 20.75 | 4.60e-05 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 9 | 5.57 | 4.73e-05 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 2.05 | 10 | 4.88 | 5.48e-05 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 4 | 19.73 | 5.60e-05 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 3 | 39.15 | 6.45e-05 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 8 | 6.11 | 6.53e-05 |
| p53genes_all | p53 transcriptional targets | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| irs_ko_adip_up | Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) | 36 | 0.09 | 3 | 33.71 | 1.01e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 4 | 14.58 | 1.81e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 5 | 8.95 | 2.76e-04 |
| ifn_beta_glioma_up | Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta | 124 | 0.31 | 4 | 13.05 | 2.77e-04 |
| baf57_bt549_up | Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 364 | 0.90 | 6 | 6.67 | 3.33e-04 |
| il1_cornea_up | Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) | 136 | 0.34 | 4 | 11.90 | 3.93e-04 |
| et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 9 | 4.07 | 4.77e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 5 | 7.60 | 5.78e-04 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 6 | 5.92 | 6.21e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 8 | 4.31 | 6.70e-04 |
| hdaci_colon_cur24hrs_up | Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells | 73 | 0.18 | 3 | 16.62 | 8.25e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| tafi_kd_up | Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 4 | 8.21 | 1.56e-03 |
| cmv_hcmv_timecourse_16hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours | 93 | 0.23 | 3 | 13.05 | 1.66e-03 |
| et743_resist_dn | Down-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| adip_diff_cluster1 | Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) | 96 | 0.24 | 3 | 12.64 | 1.82e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 6 | 4.75 | 1.90e-03 |
| hdaci_colon_sul24hrs_up | Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 102 | 0.25 | 3 | 11.90 | 2.16e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| ifna_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha | 103 | 0.25 | 3 | 11.78 | 2.22e-03 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| uv_unique_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 3 | 11.24 | 2.54e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| cocaine_brain_5d_up | Up-regulated in the nucleus accumbens of mice after 5 days of cocaine treatment | 113 | 0.28 | 3 | 10.74 | 2.89e-03 |
| brca1_sw480_dn | Down-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| cortex_enrichment_late_up | Up-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 2 or 14 days | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 4 | 6.18 | 4.32e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| hsc_mature_adult | Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) | 427 | 1.06 | 5 | 4.74 | 4.52e-03 |
| pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 3.11 | 9 | 2.89 | 4.77e-03 |
| pod1_ko_most_dn | Most strongly down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
| cmv_hcmv_timecourse_12hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| genotoxins_all_4hrs_reg | Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 4 | 5.70 | 5.73e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 6 | 3.76 | 5.91e-03 |
| ifna_uv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| uvb_nhek3_c6 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| brca1_sw480_up | Up-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| pubertal_mammary_3-4wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. | 301 | 0.74 | 4 | 5.38 | 7.01e-03 |
| tsa_hepatoma_cancer_dn | Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| hdaci_colon_cursul_up | Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.41 | 3 | 7.36 | 8.25e-03 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| adip_vs_fibro_up | Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 3 | 6.97 | 9.52e-03 |