L2L Microarray Analysis Tool
Results for G01AF.profile.ud50
| Results summary | View all lists in GO:BiolProc | View all genes in G01AF.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| DNA replication | The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. | 277 | 1.37 | 13 | 9.49 | 2.14e-09 |
| DNA-dependent DNA replication | The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | 140 | 0.69 | 9 | 13.00 | 4.32e-08 |
| DNA replication initiation | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. | 44 | 0.22 | 5 | 22.99 | 2.73e-06 |
| DNA metabolic process | The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. | 922 | 4.56 | 17 | 3.73 | 5.74e-06 |
| response to stress | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). | 1358 | 6.71 | 19 | 2.83 | 7.26e-05 |
| DNA unwinding during replication | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| DNA geometric change | The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| DNA duplex unwinding | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. | 24 | 0.12 | 3 | 25.28 | 2.26e-04 |
| regulation of cyclin-dependent protein kinase activity | Any process that modulates the frequency, rate or extent of CDK activity. | 65 | 0.32 | 4 | 12.45 | 3.18e-04 |
| negative regulation of DNA metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 28 | 0.14 | 3 | 21.67 | 3.61e-04 |
| programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 5.37 | 15 | 2.79 | 4.51e-04 |
| response to UV | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. | 32 | 0.16 | 3 | 18.96 | 5.38e-04 |
| mismatch repair | A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
| immunoglobulin mediated immune response | An immune response mediated by immunoglobulins, whether cell-bound or in solution. | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
| B cell mediated immunity | Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
| maintenance of fidelity during DNA-dependent DNA replication | The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair. | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
| death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 5.70 | 15 | 2.63 | 8.16e-04 |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. | 319 | 1.58 | 7 | 4.44 | 1.18e-03 |
| response to DNA damage stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. | 412 | 2.04 | 8 | 3.93 | 1.18e-03 |
| apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 5.33 | 14 | 2.63 | 1.22e-03 |
| response to hypoxia | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. | 43 | 0.21 | 3 | 14.11 | 1.29e-03 |
| response to endogenous stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus. | 453 | 2.24 | 8 | 3.57 | 2.13e-03 |
| sequestering of calcium ion | The process of binding or confining calcium ions such that they are separated from other components of a biological system. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| regulation of programmed cell death | Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 793 | 3.92 | 11 | 2.81 | 2.37e-03 |
| lymphocyte mediated immunity | Any process involved in the carrying out of an immune response by a lymphocyte. | 116 | 0.57 | 4 | 6.97 | 2.76e-03 |
| adaptive immune response | An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). | 119 | 0.59 | 4 | 6.80 | 3.02e-03 |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). | 119 | 0.59 | 4 | 6.80 | 3.02e-03 |
| leukocyte mediated immunity | Any process involved in the carrying out of an immune response by a leukocyte. | 124 | 0.61 | 4 | 6.52 | 3.50e-03 |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. | 602 | 2.98 | 9 | 3.02 | 3.52e-03 |
| regulation of DNA recombination | Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| sequestering of metal ion | The process of binding or confining metal ions such that they are separated from other components of a biological system. | 19 | 0.09 | 2 | 21.29 | 3.95e-03 |
| regulation of protein kinase activity | Any process that modulates the frequency, rate or extent of protein kinase activity. | 300 | 1.48 | 6 | 4.05 | 4.11e-03 |
| ER-nuclear signaling pathway | Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| regulation of kinase activity | Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. | 305 | 1.51 | 6 | 3.98 | 4.44e-03 |
| regulation of transferase activity | Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. | 306 | 1.51 | 6 | 3.97 | 4.52e-03 |
| cofactor biosynthetic process | The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. | 134 | 0.66 | 4 | 6.04 | 4.61e-03 |
| regulation of a molecular function | Any process that modulates the frequency, rate or extent of molecular functions. Molecular functions are elemental biological activities occurring at the molecular level, such as catalysis or binding. | 636 | 3.14 | 9 | 2.86 | 5.00e-03 |
| immune effector process | Any process of the immune system that occurs as part of an immune response. | 143 | 0.71 | 4 | 5.66 | 5.79e-03 |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | 325 | 1.61 | 6 | 3.73 | 6.01e-03 |
| regulation of caspase activity | Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. | 75 | 0.37 | 3 | 8.09 | 6.26e-03 |
| regulation of apoptosis | Any process that modulates the occurrence or rate of cell death by apoptosis. | 785 | 3.88 | 10 | 2.58 | 6.53e-03 |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| regulation of DNA metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| response to light stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. | 81 | 0.40 | 3 | 7.49 | 7.74e-03 |
| DNA recombination | The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. | 158 | 0.78 | 4 | 5.12 | 8.18e-03 |
| response to unfolded protein | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. | 83 | 0.41 | 3 | 7.31 | 8.27e-03 |
| response to protein stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus. | 83 | 0.41 | 3 | 7.31 | 8.27e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |