L2L Microarray Analysis Tool
Results for L01AD.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in L01AD.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 21 | 14.33 | 1.09e-17 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 21 | 14.33 | 1.09e-17 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 9 | 46.68 | 5.39e-13 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 16 | 12.21 | 8.68e-13 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 11 | 25.14 | 1.41e-12 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 14 | 11.92 | 3.09e-11 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 20 | 6.12 | 3.19e-10 |
| bap_hepg2_up | Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 83 | 0.21 | 7 | 34.12 | 1.99e-09 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 8 | 23.12 | 3.12e-09 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 12 | 9.46 | 1.01e-08 |
| pgj2_up | Upregulated by treatment with the prostaglandin 15d-PGJ2 | 12 | 0.03 | 4 | 134.85 | 1.82e-08 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 4 | 85.17 | 1.40e-07 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 12 | 7.19 | 1.95e-07 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.41 | 7 | 16.96 | 2.53e-07 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 11 | 6.89 | 9.45e-07 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 4 | 50.57 | 1.27e-06 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 11 | 5.93 | 3.96e-06 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 4 | 35.96 | 5.13e-06 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 7 | 10.65 | 5.57e-06 |
| h2o2_csbrescued_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1) | 101 | 0.25 | 5 | 20.03 | 6.00e-06 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 9 | 7.14 | 6.81e-06 |
| h2o2_csbrescued_c2_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 2) | 17 | 0.04 | 3 | 71.39 | 1.00e-05 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 8 | 6.33 | 5.07e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 8 | 5.95 | 7.82e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 7 | 5.96 | 2.14e-04 |
| genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| gamma-uv_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 4 | 11.81 | 4.04e-04 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 4 | 11.56 | 4.38e-04 |
| et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 9 | 4.07 | 4.77e-04 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 5 | 7.72 | 5.40e-04 |
| uvc_high_b2_up | Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| tsa_hepatoma_up | Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 7 | 4.67 | 9.00e-04 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 5.17 | 14 | 2.71 | 9.41e-04 |
| brca1_mes_up | Genes with reduced expression in mouse embryonic stem cells with a targeted deletion of BRCA1, whose expression was rescued by ectopic expression of a BRCA1 transgene | 86 | 0.21 | 3 | 14.11 | 1.33e-03 |
| bap_mcf7_up | Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| inos_all_up | Upregulated following iNOS induction in hepatocytes (Tables 3-17) | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 4 | 8.43 | 1.42e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| cantharidin_up | Upregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| tgfb_mammary_dn | Down-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
| scchn_hpvneg_up | Up-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 0.57 | 4 | 7.04 | 2.72e-03 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 1.37 | 6 | 4.38 | 2.83e-03 |
| p53genes_all | p53 transcriptional targets | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| dixoin_chloracne_pbmnc_up | Up-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| cmv_hcmv_timecourse_24hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 123 | 0.30 | 3 | 9.87 | 3.66e-03 |
| ifn_beta_glioma_up | Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta | 124 | 0.31 | 3 | 9.79 | 3.75e-03 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| tsa_cd4_up | Up-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| brg1_sw13_up | Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 0.75 | 4 | 5.32 | 7.25e-03 |
| hdaci_colon_cursul_up | Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| alzheimers_incipient_dn | Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 312 | 0.77 | 4 | 5.19 | 7.92e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| cmv_8hrs_up | Upregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| aged_mouse_hippocampus_any_dn | Down-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |