L2L Microarray Analysis Tool
Results for L01DB.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in L01DB.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 4 | 134.85 | 1.82e-08 |
| et743_sarcoma_72hrs_up | Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines | 106 | 0.26 | 6 | 22.90 | 3.15e-07 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 5 | 36.12 | 3.17e-07 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 4 | 42.58 | 2.58e-06 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 6 | 15.17 | 3.49e-06 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 5 | 21.29 | 4.44e-06 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 3 | 75.85 | 8.26e-06 |
| et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.27 | 5 | 18.22 | 9.51e-06 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 3 | 57.79 | 1.94e-05 |
| 5azac_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1630 | 4.03 | 15 | 3.72 | 2.09e-05 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 5 | 14.98 | 2.45e-05 |
| hif1_targets | Hif-1 (hypoxia-inducible factor 1) transcripional targets | 67 | 0.17 | 4 | 24.15 | 2.53e-05 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 4 | 18.18 | 7.71e-05 |
| hypoxia_fibro_up | Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
| 5azac-tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 1966 | 4.86 | 15 | 3.09 | 1.64e-04 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 4 | 14.58 | 1.81e-04 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 4 | 14.45 | 1.87e-04 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 4 | 12.74 | 3.03e-04 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 5 | 8.68 | 3.17e-04 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 0.62 | 5 | 8.09 | 4.37e-04 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 384 | 0.95 | 6 | 6.32 | 4.41e-04 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| oxstress_rpethree_dn | Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.37 | 4 | 10.86 | 5.54e-04 |
| platelet_expressed | Fifty genes most strongly expressed in human platlets from three healthy donors | 66 | 0.16 | 3 | 18.39 | 6.15e-04 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.17 | 3 | 17.85 | 6.71e-04 |
| hdaci_colon_cur24hrs_up | Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells | 73 | 0.18 | 3 | 16.62 | 8.25e-04 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| hippocampus_development_postnatal | Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| alzheimers_incipient_dn | Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 312 | 0.77 | 5 | 6.48 | 1.18e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| methotrexate_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 22 | 0.05 | 2 | 36.78 | 1.37e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.22 | 3 | 13.79 | 1.42e-03 |
| cancerdrugs_probcell_dn | Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| vegf_hmmec_3hrs_up | Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| uvc_ttd_4hr_up | Up-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 3 | 11.24 | 2.54e-03 |
| ventricle_up | Upregulated in the ventricles of healthy hearts, compared to atria | 373 | 0.92 | 5 | 5.42 | 2.55e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| htert_dn | Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| tgfb_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). | 118 | 0.29 | 3 | 10.28 | 3.26e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| uvb_nhek2_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 125 | 0.31 | 3 | 9.71 | 3.83e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| elongina_ko_dn | Downregulated in MES cells from elongin-A knockout mice | 267 | 0.66 | 4 | 6.06 | 4.62e-03 |
| pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 3.11 | 9 | 2.89 | 4.77e-03 |
| uvc_ttd_all_up | Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 4 | 5.70 | 5.73e-03 |
| vegf_hmmec_all_up | Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells | 147 | 0.36 | 3 | 8.26 | 6.01e-03 |
| hdaci_colon_cur2hrs_up | Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
| igf_vs_pdgf_dn | Down-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| tsadac_panc50_up | 50 "most interesting" genes upregulated by the combination of TSA and DAC in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| tpa_resist_early_up | Upregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 5 | 3.97 | 9.34e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 3 | 6.97 | 9.52e-03 |