L2L Microarray Analysis Tool
Results for L04AA.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L04AA.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 22 | 4.86 | 2.92e-09 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 23 | 3.97 | 5.11e-08 |
| brca_brca1_pos | Genes whose expression is consistently positively correlated with brca1 germline status in breast cancer - higher expression is associated with sporadic tumors | 182 | 0.45 | 7 | 15.56 | 4.51e-07 |
| igf1_nih3t3_up | Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| cantharidin_dn | Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin | 83 | 0.21 | 3 | 14.62 | 1.20e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 7 | 4.38 | 1.30e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 11 | 2.93 | 1.73e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 8 | 3.62 | 2.01e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 6 | 4.58 | 2.28e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 4 | 7.39 | 2.28e-03 |
| brca1_overexp_dn | Downregulated by induction of exogenous BRCA1 in EcR-293 cells | 220 | 0.54 | 4 | 7.36 | 2.32e-03 |
| insulin_nih3t3_up | Up-regulated by treatment with insulin of NIH3T3 cells overexpressing insulin receptor | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| uvc_high_d1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| insulin_adip_insens_up | Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| cmv_24hrs_up | Upregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 0.72 | 4 | 5.54 | 6.31e-03 |
| et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 0.75 | 4 | 5.32 | 7.25e-03 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.40 | 3 | 7.45 | 7.98e-03 |
| cmv_all_up | Upregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 173 | 0.43 | 3 | 7.02 | 9.38e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 5 | 3.96 | 9.41e-03 |