L2L Microarray Analysis Tool
Results for L04AX.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L04AX.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 14 | 8.93 | 1.28e-09 |
| cmv_hcmv_timecourse_20hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours | 174 | 0.43 | 7 | 16.27 | 3.33e-07 |
| uvc_ttd_4hr_dn | Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 641 | 1.58 | 11 | 6.94 | 8.77e-07 |
| uvc_ttd_all_dn | Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 780 | 1.93 | 12 | 6.22 | 8.84e-07 |
| uvc_high_d5_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d5) | 74 | 0.18 | 5 | 27.33 | 1.29e-06 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 18 | 3.98 | 1.32e-06 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 7 | 12.70 | 1.75e-06 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 8 | 9.49 | 2.81e-06 |
| uvc_xpcs_8hr_dn | Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 911 | 2.25 | 12 | 5.33 | 4.29e-06 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 6 | 14.19 | 5.12e-06 |
| uvc_xpcs_all_dn | Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 1048 | 2.59 | 12 | 4.63 | 1.71e-05 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 11 | 4.97 | 2.00e-05 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 6 | 11.08 | 2.08e-05 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 16 | 3.54 | 2.09e-05 |
| oldwerner_fibro_up | Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 30 | 0.07 | 3 | 40.45 | 5.83e-05 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 1.34 | 8 | 5.97 | 7.62e-05 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 6 | 8.12 | 1.16e-04 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 16 | 2.76 | 3.43e-04 |
| uvc_xpcs_4hr_dn | Down-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 519 | 1.28 | 7 | 5.46 | 3.63e-04 |
| gamma-uv_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 5 | 7.60 | 5.78e-04 |
| uvc_high_d6_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d6) | 65 | 0.16 | 3 | 18.67 | 5.88e-04 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.40 | 4 | 9.93 | 7.74e-04 |
| bleo_mouse_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.19 | 3 | 15.97 | 9.28e-04 |
| et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 0.75 | 5 | 6.65 | 1.05e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 1.13 | 6 | 5.29 | 1.11e-03 |
| werner_fibro_up | Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals | 81 | 0.20 | 3 | 14.98 | 1.12e-03 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 3137 | 7.75 | 17 | 2.19 | 2.70e-03 |
| human_tissue_testis | Genes expressed specifically in human testis tissue | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 3 | 8.92 | 4.85e-03 |
| microrna_human | Predicted human MicroRNA targets | 2276 | 5.63 | 13 | 2.31 | 5.28e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 10 | 2.66 | 5.29e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |