L2L Microarray Analysis Tool
Results for N05AA.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in N05AA.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 8 | 9.49 | 2.81e-06 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 6 | 12.32 | 1.15e-05 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 5 | 11.83 | 7.54e-05 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 6 | 8.12 | 1.16e-04 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.19 | 3 | 15.97 | 9.28e-04 |
| hpv_high-risk_up | Up-regulated in both HPV16- and HPV18-positive cervical tumors compared to normal cervial tissue. | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| p21_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
| scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| cis_xpc_up | Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 242 | 0.60 | 4 | 6.69 | 3.26e-03 |
| p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 3 | 8.92 | 4.85e-03 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| p21_any_dn | Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |