L2L Microarray Analysis Tool
Results for N05AA.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in N05AA.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 19 | 14.50 | 3.03e-16 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 17 | 13.46 | 3.60e-14 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 17 | 10.65 | 1.50e-12 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 11 | 22.03 | 5.93e-12 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 15 | 8.99 | 3.07e-10 |
| cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.16 | 7 | 44.25 | 3.10e-10 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 13 | 11.07 | 3.81e-10 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 11 | 12.82 | 1.85e-09 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 11 | 12.82 | 1.85e-09 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 13 | 9.67 | 1.94e-09 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 12 | 9.52 | 9.51e-09 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 7 | 25.98 | 1.35e-08 |
| cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 5 | 63.21 | 1.76e-08 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 7 | 16.00 | 3.74e-07 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 11 | 7.34 | 5.09e-07 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 9 | 9.68 | 5.74e-07 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 5 | 30.65 | 7.28e-07 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 5 | 30.65 | 7.28e-07 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 4 | 57.79 | 7.29e-07 |
| tsa_panc50_up | 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 77 | 0.19 | 5 | 26.27 | 1.57e-06 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 8 | 10.15 | 1.72e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 15 | 4.59 | 1.78e-06 |
| as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 4 | 35.18 | 5.61e-06 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 6 | 10.88 | 2.30e-05 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 10 | 5.39 | 2.41e-05 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 8 | 6.81 | 3.04e-05 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 0.83 | 6 | 7.22 | 2.18e-04 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 4 | 13.48 | 2.44e-04 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 8 | 4.95 | 2.71e-04 |
| bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.12 | 3 | 24.27 | 2.71e-04 |
| hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.13 | 3 | 23.80 | 2.88e-04 |
| scw_joint_react_dn | Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 231 | 0.57 | 5 | 8.76 | 3.05e-04 |
| hdaci_colon_tsa48hrs_dn | Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 11 | 0.03 | 2 | 73.55 | 3.31e-04 |
| bap_hepg2_dn | Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 56 | 0.14 | 3 | 21.67 | 3.80e-04 |
| et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| csb_reliable_dn | Down-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 558 | 1.38 | 7 | 5.07 | 5.57e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 5 | 7.60 | 5.78e-04 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 4 | 10.18 | 7.06e-04 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.17 | 3 | 17.34 | 7.31e-04 |
| dixoin_pbmnc_up | Up-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| cox1_ko_hippocampus_dn | Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. | 77 | 0.19 | 3 | 15.76 | 9.64e-04 |
| stress_tpa_specific_up | Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
| tafi_kd_up | Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 7 | 4.47 | 1.16e-03 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 2.05 | 8 | 3.90 | 1.25e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 8 | 3.86 | 1.35e-03 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 842 | 2.08 | 8 | 3.84 | 1.38e-03 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 4 | 8.21 | 1.56e-03 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| vegf_huvec_up | 20 genes with the largest fold-change up-regulation at any time point (30min to 24 hours) after VEGF treatment in human umbilical vein endothelial cells | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| tpa_resist_middle_dn | Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells | 209 | 0.52 | 4 | 7.74 | 1.93e-03 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| cocaine_brain_5d_up | Up-regulated in the nucleus accumbens of mice after 5 days of cocaine treatment | 113 | 0.28 | 3 | 10.74 | 2.89e-03 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 0.61 | 4 | 6.55 | 3.51e-03 |
| but_tsa_up | Upregulated by the combination of TSA and butyrate in HT-29 cells | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| bcnu_glioma_mgmt_48hrs_dn | Down-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 253 | 0.63 | 4 | 6.40 | 3.82e-03 |
| bcrabl_hl60_cdna_up | Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by spotted cDNA arrays | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| aom-dss_colon_5wks_up | Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
| hsc_hsc_shared | Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) | 270 | 0.67 | 4 | 5.99 | 4.80e-03 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 3 | 8.86 | 4.95e-03 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 4 | 5.70 | 5.73e-03 |
| idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.37 | 3 | 8.15 | 6.24e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 11 | 2.43 | 6.82e-03 |
| rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.38 | 3 | 7.83 | 6.95e-03 |
| pubertal_mammary_3-4wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. | 301 | 0.74 | 4 | 5.38 | 7.01e-03 |
| hsc_hsc_fetal | Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) | 303 | 0.75 | 4 | 5.34 | 7.17e-03 |
| aged_mouse_muscle_up | Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| brg1_sw13_up | Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 4 | 5.25 | 7.58e-03 |
| igf_vs_pdgf_dn | Down-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 5 | 4.14 | 7.82e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| tsadac_panc50_up | 50 "most interesting" genes upregulated by the combination of TSA and DAC in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| brca1_overexp_up | Upregulated by induction of exogenous BRCA1 in EcR-293 cells | 328 | 0.81 | 4 | 4.93 | 9.39e-03 |