L2L Microarray Analysis Tool

ribonucleoprotein complex biogenesis and assembly

14.45

2.92e-05

The cellular process by which a complex containing RNA and proteins, is synthesized, aggregates, and bonds together.

239

0.59

6

10.16

3.39e-05

ribosome biogenesis and assembly

The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis.

89

0.22

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

18.18

7.71e-05

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

4320

10.68

25

2.34

1.25e-04

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

1307

3.23

12

3.71

1.37e-04

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

1144

2.83

11

3.89

1.73e-04

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

44

0.11

biopolymer metabolic process

27.58

1.85e-04

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

5812

14.37

29

2.02

4.39e-04

DNA recombination

The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

158

0.39

10.24

6.89e-04

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

474

1.17

6

5.12

1.30e-03

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

347

0.86

5.83

1.87e-03

tRNA metabolic process

The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.

100

0.25

12.14

2.04e-03

chromatin assembly

The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.

108

0.27

11.24

2.54e-03

M phase

Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis.

375

0.93

5.39

2.61e-03

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

382

0.94

5.30

2.83e-03

mismatch repair

A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

34

0.08

protein kinase C activation

23.80

3.25e-03

The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

35

0.09

maintenance of fidelity during DNA-dependent DNA replication

23.12

3.44e-03

The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair.

35

0.09

response to DNA damage stimulus

23.12

3.44e-03

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

412

1.02

primary metabolic process

4.91

3.89e-03

Reactions involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

8941

22.10

36

1.63

3.98e-03

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates.

7752

19.16

32

1.67

4.46e-03

lipid modification

The covalent alteration of one or more fatty acids in a lipid, resulting in a change in that lipid.

41

0.10

response to endogenous stimulus

19.73

4.70e-03

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus.

453

1.12

4.47

5.77e-03

mRNA metabolic process

The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

453

1.12

cellular metabolic process

4.47

5.77e-03

The chemical reactions and pathways by which individual cells transform chemical substances.

8889

21.97

35

1.59

6.19e-03

tRNA processing

The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

48

0.12

16.86

6.39e-03

cell division

The processes resulting in the physical partitioning and separation of a cell into daughter cells.

297

0.73

regulation of progression through cell cycle

5.45

6.69e-03

Any process that modulates the rate or extent of progression through the cell cycle.

875

2.16

7

3.24

6.76e-03

regulation of cell cycle

A cell cycle process that modulates the rate, extent or mode of the cell cycle.

880

2.18

7

3.22

6.96e-03

chromosome organization and biogenesis (sensu Eukaryota)

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of eukaryotic chromosomes, structures composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).

477

1.18

chromosome organization and biogenesis

4.24

7.13e-03

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

493

1.22

chromatin assembly or disassembly

4.10

8.15e-03

The formation or destruction of chromatin structures.

171

0.42

7.10

9.09e-03

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

325

0.80

4.98

9.11e-03

spliceosome assembly

The aggregation and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

59

0.15