L2L Microarray Analysis Tool
Results for P02CA.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in P02CA.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 8 | 8.21 | 7.60e-06 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.13 | 4 | 31.12 | 8.19e-06 |
| tpa_sens_early_up | Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells | 97 | 0.48 | 6 | 12.51 | 9.82e-06 |
| uvb_nhek3_c3 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 37 | 0.18 | 4 | 21.87 | 3.46e-05 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.24 | 4 | 16.86 | 9.77e-05 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 12 | 3.76 | 1.20e-04 |
| hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.25 | 4 | 15.86 | 1.24e-04 |
| vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 3.73 | 13 | 3.49 | 1.33e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 10 | 4.26 | 1.61e-04 |
| nf90_up | Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 56 | 0.28 | 4 | 14.45 | 1.79e-04 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.30 | 4 | 13.48 | 2.34e-04 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 4 | 13.26 | 2.49e-04 |
| tpa_sens_middle_up | Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells | 114 | 0.56 | 5 | 8.87 | 2.77e-04 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 7.51 | 19 | 2.53 | 2.95e-04 |
| adip_vs_fibro_dn | Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 64 | 0.32 | 4 | 12.64 | 3.00e-04 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 3.23 | 11 | 3.40 | 5.18e-04 |
| bcnu_glioma_mgmt_48hrs_up | Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 33 | 0.16 | 3 | 18.39 | 5.90e-04 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 11 | 3.30 | 6.71e-04 |
| dex_keratinocyte_1hr_up | Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| as3_fibro_c4 | Downregulated early by sodium arsenite in fibroblasts (Cluster 4) | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 7 | 4.74 | 8.15e-04 |
| adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.42 | 4 | 9.63 | 8.41e-04 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 9 | 3.71 | 8.96e-04 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 1.51 | 7 | 4.63 | 9.32e-04 |
| creb_brain_2wks_up | Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB | 39 | 0.19 | 3 | 15.56 | 9.67e-04 |
| aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 232 | 1.15 | 6 | 5.23 | 1.15e-03 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 6 | 5.21 | 1.17e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 9 | 3.56 | 1.18e-03 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 4 | 8.52 | 1.33e-03 |
| cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.48 | 4 | 8.26 | 1.49e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 9 | 3.43 | 1.51e-03 |
| igfr_vs_ir_up | Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 4.44 | 12 | 2.70 | 2.11e-03 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| o6bg_resist_medulloblastoma_dn | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
| camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.26 | 3 | 11.67 | 2.23e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.57 | 4 | 7.04 | 2.67e-03 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.29 | 3 | 10.28 | 3.20e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
| bay-il2_pbmc_late_dn | Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 205 | 1.01 | 5 | 4.93 | 3.75e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 8 | 2.97 | 6.33e-03 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| middleage_up | Upregulated in fibroblasts from middle-age individuals, compared to young | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| tnfa_nfkb_dep_up | Up-regulated at any timepoint following TNFa treatment, only with functional NFkB | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| hbx_nl_dn | Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| heatshock_old_up | Upregulated after heat shock in lymphocytes from old individuals, compared to young | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 1.22 | 5 | 4.09 | 8.12e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 4 | 5.06 | 8.54e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |