L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in R01AD.profile.d50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
positive regulation of interleukin-6 biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	7	0.02	2	115.58	1.27e-04
regulation of chemokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.	8	0.02	2	101.14	1.69e-04
regulation of interleukin-6 biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.02	2	101.14	1.69e-04
chemokine production	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	9	0.02	2	89.90	2.17e-04
chemokine biosynthetic process	The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.02	2	89.90	2.17e-04
chemokine metabolic process	The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.02	2	89.90	2.17e-04
interleukin-6 production	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.02	2	80.91	2.71e-04
interleukin-6 biosynthetic process	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.02	2	80.91	2.71e-04
thermoregulation	A homeostatic process by which an organism modulates its internal body temperature.	12	0.03	2	67.42	3.97e-04
heme biosynthetic process	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.	19	0.05	2	42.58	1.02e-03
porphyrin biosynthetic process	The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	21	0.05	2	38.53	1.24e-03
tetrapyrrole biosynthetic process	The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	21	0.05	2	38.53	1.24e-03
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	24	0.06	2	33.71	1.63e-03
apoptosis	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.	1078	2.66	9	3.38	1.72e-03
regulation of progression through cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.	875	2.16	8	3.70	1.75e-03
programmed cell death	Cell death resulting from activation of endogenous cellular processes.	1086	2.68	9	3.35	1.81e-03
regulation of cell cycle	A cell cycle process that modulates the rate, extent or mode of the cell cycle.	880	2.18	8	3.68	1.81e-03
heme metabolic process	The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.	28	0.07	2	28.90	2.21e-03
porphyrin metabolic process	The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	30	0.07	2	26.97	2.54e-03
tetrapyrrole metabolic process	The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	30	0.07	2	26.97	2.54e-03
cell cycle process	A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.	1144	2.83	9	3.18	2.56e-03
cell death	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1152	2.85	9	3.16	2.68e-03
death	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.	1152	2.85	9	3.16	2.68e-03
leukocyte chemotaxis	The movement of a leukocyte in response to an external stimulus.	32	0.08	2	25.28	2.88e-03
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.	252	0.62	4	6.42	3.77e-03
cell development	The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.	1692	4.18	11	2.63	3.90e-03
leukocyte migration	The movement of leukocytes within or between different tissues and organs of the body.	39	0.10	2	20.75	4.26e-03
anti-apoptosis	A process which directly inhibits any of the steps required for cell death by apoptosis.	278	0.69	4	5.82	5.32e-03
acute-phase response	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	44	0.11	2	18.39	5.40e-03
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	1307	3.23	9	2.79	6.00e-03
pigment biosynthetic process	The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.	49	0.12	2	16.51	6.65e-03
positive regulation of cytokine biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	58	0.14	2	13.95	9.21e-03
pigment metabolic process	The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.	58	0.14	2	13.95	9.21e-03

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

7

0.02

2

115.58

1.27e-04

regulation of chemokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

8

0.02

2

101.14

1.69e-04

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.02

2

101.14

1.69e-04

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

9

0.02

2

89.90

2.17e-04

chemokine biosynthetic process

The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

2

89.90

2.17e-04

chemokine metabolic process

The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

2

89.90

2.17e-04

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.02

2

80.91

2.71e-04

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.02

2

80.91

2.71e-04

thermoregulation

A homeostatic process by which an organism modulates its internal body temperature.

12

0.03

2

67.42

3.97e-04

heme biosynthetic process

The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

19

0.05

2

42.58

1.02e-03

porphyrin biosynthetic process

The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

21

0.05

2

38.53

1.24e-03

tetrapyrrole biosynthetic process

The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

21

0.05

2

38.53

1.24e-03

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

24

0.06

2

33.71

1.63e-03

apoptosis

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.

1078

2.66

9

3.38

1.72e-03

regulation of progression through cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

875

2.16

8

3.70

1.75e-03

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

1086

2.68

9

3.35

1.81e-03

regulation of cell cycle

A cell cycle process that modulates the rate, extent or mode of the cell cycle.

880

2.18

8

3.68

1.81e-03

heme metabolic process

The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

28

0.07

2

28.90

2.21e-03

porphyrin metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

30

0.07

2

26.97

2.54e-03

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

30

0.07

2

26.97

2.54e-03

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

1144

2.83

9

3.18

2.56e-03

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1152

2.85

9

3.16

2.68e-03

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

1152

2.85

9

3.16

2.68e-03

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

32

0.08

2

25.28

2.88e-03

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

252

0.62

4

6.42

3.77e-03

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

1692

4.18

11

2.63

3.90e-03

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

39

0.10

2

20.75

4.26e-03

anti-apoptosis

A process which directly inhibits any of the steps required for cell death by apoptosis.

278

0.69

4

5.82

5.32e-03

acute-phase response

Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

44

0.11

2

18.39

5.40e-03

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

1307

3.23

9

2.79

6.00e-03

pigment biosynthetic process

The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.

49

0.12

2

16.51

6.65e-03

positive regulation of cytokine biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

58

0.14

2

13.95

9.21e-03