L2L Microarray Analysis Tool
Results for R01AD.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in R01AD.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 10 | 7.93 | 8.35e-07 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 11 | 6.89 | 9.45e-07 |
| cmv_all_dn | Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 213 | 0.53 | 7 | 13.29 | 1.29e-06 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 9 | 7.66 | 3.86e-06 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 9 | 6.87 | 9.24e-06 |
| cmv_24hrs_dn | Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 140 | 0.35 | 5 | 14.45 | 2.92e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 8 | 5.95 | 7.82e-05 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 1.37 | 8 | 5.84 | 8.86e-05 |
| ribavirin_rsv_dn | Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin | 101 | 0.25 | 4 | 16.02 | 1.26e-04 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 6 | 7.93 | 1.32e-04 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 105 | 0.26 | 4 | 15.41 | 1.46e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 7 | 5.96 | 2.14e-04 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 3 | 25.28 | 2.40e-04 |
| sarcomas_synovial_up | Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 6 | 5.44 | 9.57e-04 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| calres_mouse_dn | Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.20 | 3 | 14.80 | 1.16e-03 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 6 | 4.78 | 1.85e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 4 | 7.82 | 1.86e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 6 | 4.75 | 1.90e-03 |
| cpr_null_liver_dn | Down-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 384 | 0.95 | 5 | 5.27 | 2.89e-03 |
| cmv_hcmv_timecourse_24hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 123 | 0.30 | 3 | 9.87 | 3.66e-03 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 6 | 4.09 | 3.94e-03 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 6 | 4.01 | 4.37e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| cpr_low_liver_dn | Down-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.35 | 3 | 8.49 | 5.57e-03 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 9 | 2.76 | 6.41e-03 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 3 | 7.40 | 8.11e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| cmv_8hrs_up | Upregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| caries_pulp_high_up | Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 168 | 0.42 | 3 | 7.22 | 8.66e-03 |