L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in R01AD.profile.ud50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
regulation of interleukin-6 biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.04	3	75.85	6.64e-06
interleukin-6 production	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.05	3	60.68	1.41e-05
interleukin-6 biosynthetic process	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.05	3	60.68	1.41e-05
response to metal ion	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.	21	0.10	3	28.90	1.50e-04
response to inorganic substance	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.	27	0.13	3	22.47	3.23e-04
positive regulation of interleukin-6 biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	7	0.03	2	57.79	5.05e-04
transcription from RNA polymerase II promoter	The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	997	4.93	14	2.84	5.86e-04
circadian rhythm	The biological processes in an organism that recur with a regularity of approximately 24 hours.	34	0.17	3	17.85	6.45e-04
regulation of chemokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.	8	0.04	2	50.57	6.71e-04
chemokine production	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	9	0.04	2	44.95	8.60e-04
chemokine biosynthetic process	The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.04	2	44.95	8.60e-04
chemokine metabolic process	The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.04	2	44.95	8.60e-04
regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	701	3.47	11	3.17	9.09e-04
negative regulation of biological process	Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	1697	8.39	19	2.26	1.09e-03
acute-phase response	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	44	0.22	3	13.79	1.38e-03
thermoregulation	A homeostatic process by which an organism modulates its internal body temperature.	12	0.06	2	33.71	1.56e-03
negative regulation of cellular process	Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1642	8.12	18	2.22	1.81e-03
cell death	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1152	5.70	14	2.46	2.24e-03
death	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.	1152	5.70	14	2.46	2.24e-03
apoptosis	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.	1078	5.33	13	2.44	3.36e-03
response to chemical stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.	603	2.98	9	3.02	3.56e-03
programmed cell death	Cell death resulting from activation of endogenous cellular processes.	1086	5.37	13	2.42	3.57e-03
heme biosynthetic process	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.	19	0.09	2	21.29	3.95e-03
regulation of transcription, DNA-dependent	Any process that modulates the frequency, rate or extent of DNA-dependent transcription.	2510	12.41	23	1.85	4.41e-03
porphyrin biosynthetic process	The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	21	0.10	2	19.26	4.82e-03
tetrapyrrole biosynthetic process	The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	21	0.10	2	19.26	4.82e-03
response to external stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.	759	3.75	10	2.66	5.21e-03
transcription, DNA-dependent	The synthesis of RNA on a template of DNA.	2588	12.79	23	1.80	6.26e-03
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	24	0.12	2	16.86	6.28e-03
RNA biosynthetic process	The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.	2591	12.81	23	1.80	6.34e-03
biological regulation	Any process that modulates the frequency, rate or extent of any biological process, quality or function.	6089	30.10	45	1.49	6.51e-03
cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.76	4	5.29	7.32e-03
negative regulation of myeloid cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.	27	0.13	2	14.98	7.90e-03
negative regulation of apoptosis	Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.	345	1.71	6	3.52	7.94e-03
signal transduction	The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.	4207	20.80	33	1.59	8.00e-03
negative regulation of programmed cell death	Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	347	1.72	6	3.50	8.16e-03
regulation of cellular process	Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	5188	25.65	39	1.52	8.25e-03
heme metabolic process	The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.	28	0.14	2	14.45	8.48e-03
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.	252	1.25	5	4.01	8.81e-03
regulation of cytokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	85	0.42	3	7.14	8.83e-03
embryo implantation	Attachment of the blastocyst to the uterine lining.	29	0.14	2	13.95	9.08e-03
regulation of cell proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.	704	3.48	9	2.59	9.37e-03
porphyrin metabolic process	The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	30	0.15	2	13.48	9.70e-03
tetrapyrrole metabolic process	The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.	30	0.15	2	13.48	9.70e-03

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.04

3

75.85

6.64e-06

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.05

3

60.68

1.41e-05

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.05

3

60.68

1.41e-05

response to metal ion

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

21

0.10

3

28.90

1.50e-04

response to inorganic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

27

0.13

3

22.47

3.23e-04

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

7

0.03

2

57.79

5.05e-04

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

997

4.93

14

2.84

5.86e-04

circadian rhythm

The biological processes in an organism that recur with a regularity of approximately 24 hours.

34

0.17

3

17.85

6.45e-04

regulation of chemokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

8

0.04

2

50.57

6.71e-04

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

9

0.04

2

44.95

8.60e-04

chemokine biosynthetic process

The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.04

2

44.95

8.60e-04

chemokine metabolic process

The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.04

2

44.95

8.60e-04

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

701

3.47

11

3.17

9.09e-04

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

1697

8.39

19

2.26

1.09e-03

acute-phase response

Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

44

0.22

3

13.79

1.38e-03

thermoregulation

A homeostatic process by which an organism modulates its internal body temperature.

12

0.06

2

33.71

1.56e-03

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

1642

8.12

18

2.22

1.81e-03

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1152

5.70

14

2.46

2.24e-03

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

1152

5.70

14

2.46

2.24e-03

apoptosis

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.

1078

5.33

13

2.44

3.36e-03

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

603

2.98

9

3.02

3.56e-03

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

1086

5.37

13

2.42

3.57e-03

heme biosynthetic process

The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

19

0.09

2

21.29

3.95e-03

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

2510

12.41

23

1.85

4.41e-03

porphyrin biosynthetic process

The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

21

0.10

2

19.26

4.82e-03

tetrapyrrole biosynthetic process

The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

21

0.10

2

19.26

4.82e-03

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

759

3.75

10

2.66

5.21e-03

transcription, DNA-dependent

The synthesis of RNA on a template of DNA.

2588

12.79

23

1.80

6.26e-03

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

24

0.12

2

16.86

6.28e-03

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

2591

12.81

23

1.80

6.34e-03

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

6089

30.10

45

1.49

6.51e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.76

4

5.29

7.32e-03

negative regulation of myeloid cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.

27

0.13

2

14.98

7.90e-03

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

345

1.71

6

3.52

7.94e-03

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

4207

20.80

33

1.59

8.00e-03

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

347

1.72

6

3.50

8.16e-03

regulation of cellular process

Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

5188

25.65

39

1.52

8.25e-03

heme metabolic process

The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

28

0.14

2

14.45

8.48e-03

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

252

1.25

5

4.01

8.81e-03

regulation of cytokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

85

0.42

3

7.14

8.83e-03

embryo implantation

Attachment of the blastocyst to the uterine lining.

29

0.14

2

13.95

9.08e-03

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

704

3.48

9

2.59

9.37e-03

porphyrin metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

30

0.15

2

13.48

9.70e-03

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

30

0.15

2

13.48

9.70e-03

Results for R01AD.profile.ud50