L2L Microarray Analysis Tool
Results for R06AX.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in R06AX.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 19 | 6.48 | 3.12e-10 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 19 | 6.48 | 3.12e-10 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 28 | 4.29 | 3.42e-10 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 14 | 8.16 | 3.63e-09 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 14 | 8.16 | 3.63e-09 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 16 | 6.11 | 1.73e-08 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 15 | 5.94 | 6.84e-08 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 6 | 18.39 | 1.03e-06 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 6 | 18.39 | 1.03e-06 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 13 | 5.54 | 1.09e-06 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.34 | 6 | 17.85 | 1.23e-06 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 14 | 4.67 | 3.05e-06 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 6 | 14.80 | 3.71e-06 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 6 | 11.13 | 1.91e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 12 | 4.46 | 2.37e-05 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 13 | 4.07 | 2.85e-05 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 7 | 8.00 | 3.32e-05 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 9 | 5.71 | 3.76e-05 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.07 | 3 | 43.34 | 4.22e-05 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 11 | 4.36 | 6.22e-05 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.49 | 5 | 10.22 | 1.44e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 7 | 6.26 | 1.53e-04 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.79 | 6 | 7.59 | 1.62e-04 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.13 | 3 | 23.34 | 2.89e-04 |
| tnfa_nfkb_dep_up | Up-regulated at any timepoint following TNFa treatment, only with functional NFkB | 26 | 0.13 | 3 | 23.34 | 2.89e-04 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 6 | 6.74 | 3.05e-04 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 1.66 | 8 | 4.82 | 3.16e-04 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 8 | 4.58 | 4.38e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 12 | 3.23 | 4.64e-04 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.97 | 6 | 6.16 | 4.91e-04 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 11 | 3.30 | 6.71e-04 |
| uvc_high_d2_dn | Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 9 | 3.71 | 8.96e-04 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 3 | 13.79 | 1.38e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 10 | 3.19 | 1.47e-03 |
| as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.86 | 5 | 5.81 | 1.86e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 1.30 | 6 | 4.63 | 2.12e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 1.79 | 7 | 3.90 | 2.45e-03 |
| adipogenesis_hmsc_class2_up | Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.28 | 3 | 10.84 | 2.75e-03 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| uv-cmv_unique_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 194 | 0.96 | 5 | 5.21 | 2.97e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 7 | 3.77 | 2.97e-03 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 2.41 | 8 | 3.32 | 3.35e-03 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.30 | 3 | 10.11 | 3.35e-03 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.63 | 4 | 6.37 | 3.81e-03 |
| cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 6 | 3.94 | 4.66e-03 |
| tnfalpha_30min_up | Upregulated 30min after TNF-alpha treatment of HeLa cells | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 9.83 | 19 | 1.93 | 5.96e-03 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| uvb_nhek1_c3 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| cis_xpc_up | Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 242 | 1.20 | 5 | 4.18 | 7.47e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| ifn_gamma_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 4 | 5.09 | 8.35e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 1.24 | 5 | 4.05 | 8.53e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 10.34 | 19 | 1.84 | 9.80e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.83 | 4 | 4.84 | 9.88e-03 |